Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); β-glycosidase (EC 3.2.1.-); endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39); β-N-acetylhexosaminidase (EC 3.2.1.52); chitosanase (EC 3.2.1.132); β-D-galactofuranosidase (EC 3.2.1.146); β-galactosylceramidase (EC 3.2.1.46); ; β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-); α-L-arabinofuranosidase (EC 3.2.1.55); glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (24948); Uniprot accession (634); PDB accession (270); 3D entries (100); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 β-glucanase (UmCel5H;RC2) 3.2.1.4 pubmed
uncultured bacterium ABA42185.1 Q3HXC3   2
 endo-β-1,4-glucanase (UmCel5A) (Cel5A) 3.2.1.4 pubmed
uncultured bacterium ABB51612.1 Q308B6   5
 endo-β-1,4-glucanase (CRS200) (Cel5B) 3.2.1.4 URL
uncultured bacterium AFJ44728.1 I2B2S2   2
 endoglucanase / cellulase (cMGL504) (Cel5A) 3.2.1.4 pubmed
uncultured bacterium AFJ05146.1 I6PLH5 4HTY[A]
4HU0[A]
26
 cellulase-xylanase A (Cel5A) 3.2.1.- pubmed
uncultured bacterium AFO64636.1 I7D7K5   4
 cellulase-xylanase B (Cel5B) 3.2.1.- pubmed
uncultured bacterium AFO64637.1 I7CY19   4
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4
3.2.1.73
pubmed
pubmed
uncultured bacterium ABA02176.1 Q2I8W1   26
 endoglycosidase (GH6248) (Cel5A) 3.2.1.4
3.2.1.73
pubmed
pubmed
uncultured bacterium ABB46200.1 Q283N5   4
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 pubmed
uncultured bacterium ABE60714.1 Q1PDD8   25
 cellodextrinase (UmCel5M) 3.2.1.74 pubmed
uncultured bacterium ABE60715.1 Q1PDD7   52
 endo-β-1,4-glucanase (CelWS3) 3.2.1.4 pubmed
uncultured bacterium AFX88673.1 M4I2I3   2
 endo-β-1,4-glucanase (CelWS14) 3.2.1.4 pubmed
uncultured bacterium AFX88668.1 M4I2I2   2
 endo-β-1,4-glucanase (CelWS6) 3.2.1.4 pubmed
uncultured bacterium AFX88666.1 M4I2R3   2
 endo-β-1,4-glucanase (CelWS36) 3.2.1.4 pubmed
uncultured bacterium AFX88672.1 M4I2J6   2
 endo-β-1,4-glucanase (CelWS7) 3.2.1.4 pubmed
uncultured bacterium AFX88667.1 M4I2J5   2
 cellulase (CS10;CelCS10) 3.2.1.4 pubmed
uncultured bacterium AGL50932.1 R4P2Q6   2
 endo-β-1,4-glucanase (RC3) 3.2.1.4 pubmed
uncultured bacterium ABI94085.1 Q06B38   2
 endo-β-1,4-glucanase (RC5) 3.2.1.4 pubmed
uncultured bacterium ABI94086.1 Q06B37   2
 cellulase (CelE1) 3.2.1.4 pubmed
uncultured bacterium AHA42547.2
AHA42547.1
A0A0R5P8X1
V5KYY9
4M1R[A,B] 2
 endo-β-1,4-mannanase (ManEM1) 3.2.1.78 doi
uncultured bacterium AHC00282.1 V5W3I5   7
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 pubmed
uncultured bacterium AID57617.1 A0A068F0I2   25
 4348JG28_001 3.2.1.- pubmed
uncultured bacterium ABW39345.1 A9LDT9   52
 4348JG48_005 3.2.1.- pubmed
uncultured bacterium ABW39351.1 A9LDU5   52
 endoglucanase 3.2.1.4 pubmed
uncultured bacterium Contig15 AHF23845.1 W0FLK6   37
 endoglucanase 3.2.1.4 pubmed
uncultured bacterium Contig33 AHF24998.1 W0FJI5   4
 endoglucanase 3.2.1.4 pubmed
uncultured bacterium Contig783 AHF24720.1 W0FP00   4
 endoglucanase (partial) 3.2.1.4 pubmed
uncultured bacterium Contigcl_8 AHF25528.1 W0FKV0   4
 r_06-02 3.2.1.4 pubmed
uncultured bacterium r_06 AFN57700.1 I6YKE5   4
 endoglucanase (GH5_h) 3.2.1.- pubmed
uncultured Bacteroidetes bacterium AIT97141.1 A0A097KUR6   4
 endoglucanase (GH5_g) 3.2.1.- pubmed
uncultured Bacteroidetes bacterium AIT97140.1 A0A097KUQ0   4
 endoglucanase (EglDG) (fragment) 3.2.1.4 doi
uncultured Dictyoglomus sp. ARO76321.1     25
 endoglucanase (Cel1; GC_Cel1) 3.2.1.151
3.2.1.4
pubmed
pubmed
uncultured Dictyoglomus sp. QRN45942.1     4
 endoglucanase (Cel4; GC_Cel4) 3.2.1.4 pubmed
uncultured Dictyoglomus sp. QRN45943.1     25
 endoglucanase (RuCelB;RuCel5B;6C6) (Cel5B) 3.2.1.4 doi
uncultured rumen bacterium ADM89627.1 G3BJX5   26
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4 pubmed
uncultured rumen bacterium CAP07661.1 A8E1B1   26
 endo-β-1,4-glucanase (CelA;Cel) 3.2.1.4 pubmed
unidentified bacterium AAA91966.1 Q60054   37
 β-1,4-mannanase 5C (Man5C) 3.2.1.78 pubmed
Vibrio sp. MA-138 BAG69482.2
BAG69482.1
B5BQ69   7
 β-mannanase (ManA) 3.2.1.78 doi
Vibrio sp. MA-138 BAA25188.1 O69347   8
 endo-β-1,4-glucanase (Cel5A) (Cel5A) 3.2.1.4 pubmed
Vibrio xiamenensis G21 ADJ93836.1 D8V609   2
 β-mannosidase (Vvad_PD2954) 3.2.1.25 pubmed
Victivallis vadensis ZP_06241352.1
PVY35568.1
WP_116885687.1
A0A2U1AGP1  
 β-endoglucanase (EgxA;Eng) (frameshift) 3.2.1.4 doi
Xanthomonas albilineans XAI-I AAA27599.1 Q60100   26
 endo-β-1,4-glucanase (EngXCA;EngA) (frameshift) 3.2.1.4 pubmed
Xanthomonas campestris pv. campestris CAC18529.1
AAA27612.1
P19487
Q9EVR6
4TUF[A,B,C,D] 1
 endo-β-1,4-mannosidase (ManA;XCC1778) 3.2.1.78 pubmed
Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41068.1
NP_637144.1
Q8P9S0   8
 endo-β-1,4-glucanase (EngXCA;XccEG;XCC3521) 3.2.1.4 doi
Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42791.1
NP_638867.1
P19487   1
 β-mannanase (XcGH5_8; TP37_09655) 3.2.1.78 pubmed
Xanthomonas citri pv. aurantifolii FDC 1559 AMU98328.1     8
 endo-β-1,4-glucanase 3.2.1.4 pubmed
Xanthomonas sp. EC102 ACU30064.1 C7FFK1   1
 endoglucanase (XF0818) 3.2.1.4 pubmed
Xylella fastidiosa 9a5c AAF83628.1
NP_298108.1
Q9PF60   1
 endo-β-1,3-1,4-glucanase (EngA; ZgEngA; zobellia_208) 3.2.1.6 pubmed
Zobellia galactanivorans DsijT CAZ94281.1   6GL0[A,B,C]
6GL2[A]
4
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 hesperidin 6-O-α-L-rhamnosyl-β-glucosidase 3.2.1.168 pubmed
Acremonium sp. DSM 24697 SES201 AMD11613.1 A0A286JZ59   23
 β-1,6-glucanase (BGN6.1) 3.2.1.75 doi
Acremonium sp. OXF C13 AAT97707.1 Q68GV7   15
 β-mannanase (Cel4A) 3.2.1.78 pubmed
Agaricus bisporus C54-CARB8 CAB76904.1
ABJ41267.1
Q9P893   7
 β-mannanase (Cel4;Cel4b) 3.2.1.78 pubmed
Agaricus bisporus D649 CAA90423.1 Q92401   7
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 pubmed
Anoplophora chinensis AFN89566.1 K4GMM5   2
 endo-β-1,4-mannanase (AkMan;AkManA) 3.2.1.78 pubmed
Aplysia kurodai BAJ60954.1 E5RSM0 3VUP[A,B] 10
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 pubmed
Apriona germari AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 pubmed
Apriona japonica AHI15751.1 X2D6U4   2
 endo-?-1,4-xylanase (AJAGH5_2-1) 3.2.1.8 pubmed
Apriona japonica AHI15746.1 X2D6U2   2
 endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310) 3.2.1.78 pubmed
Arabidopsis thaliana AAN72165.1
AAG00883.1
AAL91241.1
AEE27414.1
ANM59069.1
NP_171733.1
NP_171733.2
A0A178WL81
A0A654E7D2
Q9FZ29
  7
 β-mannanase 2 (AtMan2;AtMan5-2;At2g20680) 3.2.1.78 doi
Arabidopsis thaliana AAP40422.1
AAD20927.1
ABG25077.1
AEC07056.1
BAF00487.1
NP_179660.2
Q7Y223
Q9SKU9
  7
 β-mannanase (PM;Man47;AtMAN47) 3.2.1.78 pubmed
Armillariella tabescens EJLY2098 ABB88954.1 A1X5Y1   7
 β-mannanase (Man1) 3.2.1.78 pubmed
Aspergillus aculeatus KSM 510 / MRC11624 AAA67426.1 Q00012   7
 β-mannanase (Man5P1;NFIA_113780) 3.2.1.78 pubmed
Aspergillus fischeri NRRL 181 NRRL 181 / P1 XP_001262744.1 A1D8Y6   7
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 pubmed
Aspergillus fumigatus BAL46041.1 H1AE13   12
 endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030) 3.2.1.78 pubmed
Aspergillus fumigatus Af293 EAL85463.1 Q4WBS1   7
 endo-β-1,4-mannanase (ManF;Man I;Man II) (partial) 3.2.1.78 pubmed
Aspergillus fumigatus IMI 385708 ACH58410.1
ACH58411.1
B5LZ77
B5LZ78
Q4WBS1
  7
 endoglucanase / cellulase (Egl2) 3.2.1.4 pubmed
Aspergillus fumigatus Z5 ADX78144.1 F1DGF4   5
 endoglucanase / cellulase (Egl3) 3.2.1.4 pubmed
Aspergillus fumigatus Z5 ADX78145.1 F1DGF5   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 pubmed
Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 pubmed
Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1
Q5BDU5   5
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 pubmed
Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1
Q1HFS8   5
 exo-β-1,3-glucanase (Anid-Bgl502;AN7533) 3.2.1.58 pubmed
Aspergillus nidulans FGSC A4 EAA62113.1
ABF50886.1
C8VBL9
Q5AVZ7
  9
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 pubmed
Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1
Q5B7X2   7
 β-1,6-glucanase (Anid-Bgl503;AN3777) 3.2.1.75 pubmed
Aspergillus nidulans FGSC A4 EAA59985.1
ABF50867.1
C8V716
Q5B6Q3
  15
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 pubmed
Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1
Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 pubmed
Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1
Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) 3.2.1.78 pubmed
Aspergillus nidulans XZ3 AGG69666.1 S4TZC3   7
 endoglucanase B (EglB) 3.2.1.4 pubmed
Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 pubmed
Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 endo-β-1,6-galactanase (An03g01050) 3.2.1.164 doi
Aspergillus niger CBS 513.88 CAK38078.1 A2QFW8   16
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 pubmed
Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 endo-β-1,4-glucanase (Eng1;EgI;AnCel5A) 3.2.1.4 pubmed
Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7
5I77[A]
5I78[A,B]
5I79[A,B]
5
 β-rutinosidase (AnRut) 3.2.1.- doi
Aspergillus niger K2     6I1A[A,B] 23
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 pubmed
Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1
G5CJA5
H2E6Y8
  7
 exo-β-1,3-glucanase (Exg1;ExgA) 3.2.1.58 pubmed
Aspergillus oryzae CBS 12559 CAC07551.1
AHH92832.1
CAD97460.1
Q7Z9L3   9
 exo-β-1,3-glucanase (Exg1;AO090003000990) 3.2.1.58 pubmed
Aspergillus oryzae RIB40 BAE58099.1 Q7Z9L3   9
 xyloglucan-specific endo-β-1,4-glucanase (xeg5A;AO090003001590) 3.2.1.151 pubmed
Aspergillus oryzae RIB40 EIT83526.1
BAE58401.1
BAE58402.1
    4
 endo-β-1,4-mannanase 3.2.1.78 pubmed
Aspergillus sp. T16 AHA38074.1 A0A0B4KYG3   7
 β-mannanase (MANN) 3.2.1.78 pubmed
Aspergillus sulphureus ABC59553.1 Q2LE69   7
 β-mannanase (AuMan5A) (Man5A) 3.2.1.78 pubmed
Aspergillus usamii E001 / YL-01-78 ADZ99027.1 F2XJJ2   7
 cellulase / CMCase (Cmc1) 3.2.1.4 doi
Aureobasidium pullulans 98 ACH69873.1
ACH63253.1
B5M499
B5M6A4
  22
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 pubmed
Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1 H2B656   5
 exo-β-1,3-glucanase (Exg2) 3.2.1.58 pubmed
Bipolaris zeicola AAF65310.1 Q9P8N7   9
 endo-β-1,4-mannanase (Man5) 3.2.1.78 pubmed
Bispora antennata CBS 126.38 AFJ68087.1 I2CMF4   7
 endo-β-1,4-mannanase 5A (Man5A) 3.2.1.78 pubmed
Bispora sp. MEY-1 ACH56965.1 B5LXD7   7
 β-mannanase (CMA3; CmacGH5-3; GH5-3) 3.2.1.78 pubmed
Callosobruchus maculatus ADU33273.1     10
 endo-β-1,4-xylanase (CMA2; CmacGH5-2; GH5-2) 3.2.1.37 pubmed
Callosobruchus maculatus ADU33272.1     10
 β-glucosidase 1 GH5 family (GH5BG1;CsGH5BG1) 3.2.1.21 pubmed
Camellia sinensis ARU79086.1 A0A1Y0K2D4   14
 exo-β-1,3-glucanase (Xog;Xog1;Exg;Ca49c10.05) 3.2.1.58 pubmed
Candida albicans CAA39908.1
AAV05307.1
CAA21969.1
P29717 1CZ1[A]
1EQC[A]
1EQP[A]
2PB1[A]
2PBO[A]
2PC8[A]
2PF0[A]
3N9K[A]
3O6A[A]
4M80[A]
4M81[A]
4M82[A]
9
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 pubmed
Candida oleophila AAM21469.1 Q8NKF9   9
 β-mannanase (CsMan5A) (Man5A) 3.2.1.78 doi
Chaetomium sp. CQ31 ADW82104.1 G9BZJ2   7
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