Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 β-1,6-glucanase (CG16) (peptide fragment) 3.2.1.75 Acremonium IMI 383068   P82288   15
 β-1,6-glucanase (BGN6.1) 3.2.1.75 Acremonium sp. OXF C13 AAT97707.1 Q68GV7   15
 β-mannanase (Cel4A) 3.2.1.78 Agaricus bisporus C54-CARB8 CAB76904.1
ABJ41267.1
Q9P893   7
 β-mannanase (Cel4;Cel4b) 3.2.1.78 Agaricus bisporus D649 CAA90423.1 Q92401   7
 exo-β-1,3-glucanase 1 (Exg1;AbEXG1) 3.2.1.58 Agaricus bisporus HORST U1 CAA63536.1 Q12539   9
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 Anoplophora chinensis AFN89566.1     2
 endo-β-1,4-mannanase (AkMan;AkManA) 3.2.1.78 Aplysia kurodai BAJ60954.1   3VUP[A,B] 10
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 Apriona germari AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 Apriona japonica AHI15751.1     2
 endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310) 3.2.1.78 Arabidopsis thaliana AAN72165.1
AAG00883.1
AAL91241.1
AEE27414.1
ANM59069.1
NP_171733.1
NP_171733.2
Q9FZ29   7
 β-mannanase 2 (AtMan2;AtMan5-2;At2g20680) 3.2.1.78 Arabidopsis thaliana AAP40422.1
AAD20927.1
ABG25077.1
AEC07056.1
BAF00487.1
NP_179660.2
Q7Y223
Q9SKU9
  7
 β-mannanase (PM;Man47;AtMAN47) 3.2.1.78 Armillariella tabescens EJLY2098 ABB88954.1 A1X5Y1   7
 endoglucanase 2 (Cmc2;FII-CMCase;FII CM-cellulase) 3.2.1.4 Aspergillus aculeatus F-50 BAA29030.1 O74169   5
 β-mannanase (Man1) 3.2.1.78 Aspergillus aculeatus KSM 510 / MRC11624 AAA67426.1 Q00012   7
 endo-β-1,4-glucanase V (FV CM-cellulase;Cel1) 3.2.1.4 Aspergillus aculeatus WO 94/14953 AAC08587.1 O59951   5
 β-mannanase (Man5P1;NFIA_113780) 3.2.1.78 Aspergillus fischeri NRRL 181 NRRL 181 / P1 XP_001262744.1     7
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 Aspergillus fumigatus BAL46041.1     12
 endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030) 3.2.1.78 Aspergillus fumigatus Af293 EAL85463.1 Q4WBS1   7
 endo-β-1,4-mannanase (ManF;Man I;Man II) (partial) 3.2.1.78 Aspergillus fumigatus IMI 385708 ACH58410.1
ACH58411.1
B5LZ77
B5LZ78
Q4WBS1
  7
 endoglucanase / cellulase (Egl2) 3.2.1.4 Aspergillus fumigatus Z5 ADX78144.1     5
 endoglucanase / cellulase (Egl3) 3.2.1.4 Aspergillus fumigatus Z5 ADX78145.1     5
 endo-β-1,4-glucanase C (EglC) (Cel5B) 3.2.1.4 Aspergillus kawachii BAB62319.1 Q96WQ8   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1
Q5BDU5   5
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1
Q1HFS8   5
 exo-β-1,3-glucanase (Anid-Bgl502;AN7533) 3.2.1.58 Aspergillus nidulans FGSC A4 EAA62113.1
ABF50886.1
C8VBL9
Q5AVZ7
  9
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1
Q5B7X2   7
 β-1,6-glucanase (Anid-Bgl503;AN3777) 3.2.1.75 Aspergillus nidulans FGSC A4 EAA59985.1
ABF50867.1
C8V716
Q5B6Q3
  15
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1
Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1
Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) (partial) 3.2.1.78 Aspergillus nidulans XZ3 AGG69666.1     7
 endoglucanase B (EglB) 3.2.1.4 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 endo-β-1,4-glucanase B (EglB) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60102.1
AAE84292.1
CAA03653.1
CAA03658.1
CAA11965.1
O74706   5
 endo-β-1,6-galactanase (An03g01050) 3.2.1.164 Aspergillus niger CBS 513.88 CAK38078.1 A2QFW8   16
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 endo-β-1,4-glucanase B (EglB;An07g08950) 3.2.1.4 Aspergillus niger CBS 513.88 CAK45103.1 A2QPC3   5
 An18g04100 (P2) 3.2.1.58 Aspergillus niger CBS 513.88 CAK43212.1 A2RAR6   9
 endo-β-1,4-glucanase (Eng1;EgI;AnCel5A) 3.2.1.4 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7
5I77[A]
5I78[A,B]
5I79[A,B]
5
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1
    7
 exo-β-1,3-glucanase (Exg1;ExgA) 3.2.1.58 Aspergillus oryzae CBS 12559 CAC07551.1
AHH92832.1
CAD97460.1
Q7Z9L3   9
 endo-β-1,4-glucanase (CelE) 3.2.1.4 Aspergillus oryzae KBN616 BAD72778.1 Q2UPQ4
Q5TKT6
  5
 exo-β-1,3-glucanase (Exg1;AO090003000990) 3.2.1.58 Aspergillus oryzae RIB40 BAE58099.1 Q7Z9L3   9
 endo-β-1,4-mannanase (partial) 3.2.1.78 Aspergillus sp. T16 AHA38074.1     7
 β-mannanase (MANN) 3.2.1.78 Aspergillus sulphureus ABC59553.1 Q2LE69   7
 β-mannanase (AuMan5A) (Man5A) 3.2.1.78 Aspergillus usamii E001 / YL-01-78 ADZ99027.1     7
 cellulase / CMCase (Cmc1) 3.2.1.4 Aureobasidium pullulans 98 ACH69873.1
ACH63253.1
B5M6A4   22
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1     5
 exo-β-1,3-glucanase (Exg2) 3.2.1.58 Bipolaris zeicola AAF65310.1 Q9P8N7   9
 endo-β-1,4-mannanase (Man5) 3.2.1.78 Bispora antennata CBS 126.38 AFJ68087.1     7
 endo-β-1,4-mannanase 5A (Man5A) 3.2.1.78 Bispora sp. MEY-1 ACH56965.1 B5LXD7   7
 β-glucosidase 1 GH5 family (GH5BG1;CsGH5BG1) 3.2.1.21 Camellia sinensis ARU79086.1     14
 exo-β-1,3-glucanase (Xog;Xog1;Exg;Ca49c10.05) 3.2.1.58 Candida albicans CAA39908.1
AAV05307.1
CAA21969.1
P29717 1CZ1[A]
1EQC[A]
1EQP[A]
2PB1[A]
2PBO[A]
2PC8[A]
2PF0[A]
3N9K[A]
3O6A[A]
4M80[A]
4M81[A]
4M82[A]
9
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 Candida oleophila AAM21469.1 Q8NKF9   9
 β-mannanase (CsMan5A) (Man5A) 3.2.1.78 Chaetomium sp. CQ31 ADW82104.1     7
 cellulase (CelA;CsCelA) 3.2.1.4 Ciboria shiraiana AIC79156.1     5
 endo-β-1,4-mannanase (ManA;CaMANA) 3.2.1.78 Coffea arabica CAC08208.1
AAX01860.1
Q9FT02   7
 endo-β-1-4-mannanase (ManB;CaMANB) 3.2.1.78 Coffea arabica CAC08442.1 Q9FT03   7
 β-glucocerebrosidase (EGCrP1;CNAG_00623) 3.2.1.45 Cryptococcus neoformans var. grubii H99 BAL46040.1
AFR92751.1
AFR92751.2
    12
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 Cryptococcus neoformans var. grubii H99 AFR99035.1     12
 carboxymethylcellulase (CsCMCase) 3.2.1.4 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 endo-β-1,4-mannanase (Man;CaMan) 3.2.1.78 Cryptopygus antarcticus ABV68808.1 B4XC07 4OOU[A,B]
4OOZ[A,B]
10
 endoglycoceramidase (EGCase) 3.2.1.123 Cyanea nozakii BAB16369.1
BAB16370.1
Q9GV15
Q9GV16
  27
 endo-β-mannanase (DcMan1) 3.2.1.78 Daucus carota AAN34823.1 Q8H6B4   7
 endoglucanase (Eng1;Dα-Eng1) 3.2.1.4 Ditylenchus africanus ABY52965.1 B6CI25   2
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae FL1 ABK27195.1 A0FJV0   15
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae var. lolii LP19 ABK27199.1 A0FJV4   15
 endo-β-1,4-glucanase (Epi3) (probable fragment) 3.2.1.4 Epidinium caudatum BAA76394.1 Q9XXV3   4
 CMCase (Cmc-06) (Cel5A) 3.2.1.4 Epidinium ecaudatum CAH69214.1
CAL91975.1
Q5F324   4
 β-1,6-galactanase (Gal1;FoGal1) 3.2.1.164 Fusarium oxysporum 12S BAF42338.1 A0ZSY6   16
 β-1,4-endoglucanase (GlCel5A;GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum     5D8W[A,B]
5D8Z[A,B]
5
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1
Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1
Q8MM50   2
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1
O16028
Q7KQF7
  2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1
O44078
O77094
  2
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194
  5
 β-mannanase (GLOTRDRAFT_110405) (Man5A) 3.2.1.78 Gloeophyllum trabeum ATCC 11539 / CBS900.73 EPQ57046.1     7
 endo-β-1,4-mannanase (GmMan1) 3.2.1.78 Glycine max ABG88068.1 Q0PKY2   7
 GpGH5 / M427DRAFT_29612 3.2.1.- Gonapodya prolifera JEL478 KXS18720.1     34
 endo-β-1,4-mannanase (Man1;HdMan) 3.2.1.78 Haliotis discus hannai BAE78456.1 Q2MH89   10
 endoglucanase 4 (Eng4;Eng-4) 3.2.1.4 Heterodera glycines AAK85303.1
AAP88024.1
Q7YZF3
Q95UR3
  2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1
O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1
O18454   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1
O77449   2
 endo-β-1,4-mannanase (Man1;HvMAN1) 3.2.1.78 Hordeum vulgare subsp. vulgare BAK05001.1
ABC87082.1
Q2I011   7
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 Humicola grisea var. thermoidea IFO9854 BAA12676.1     5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 Humicola insolens Y1 ADZ99301.1     7
 endoglycoceramidase (EGCase) 3.2.1.123 Hydra magnipapillata BAD20464.1 Q6L6S1   27
 β-mannanase (Man1;HhMAN1) 3.2.1.78 Hypothenemus hampei ACU52526.1
ACU52527.1
C8CAP6   8
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 exo-β-1,3-glucanase (Eg;Exg1) 3.2.1.58 Komagataella pastoris X-33 AAY28969.1 Q2TCV2   9
 PAS_chr2-1_0454 (Exg;Exg1) 3.2.1.58 Komagataella phaffii GS115 CAY69081.1
AOA67579.1
C4R0Q7   9
 endo-β-1,4-mannanase (Man1) 3.2.1.78 Lactuca sativa CAC51690.3 Q93X40   7
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 Lentinula edodes H600 BAD97445.1
BAD97446.1
Q53UH0   9
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 Macrophomina phaseolina AAB03889.1 Q12637   5
 endo-β-1,4-glucanase 1 (Eng-1) 3.2.1.4 Meloidogyne incognita AAD45868.1 Q9UA57   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
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