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Glycoside Hydrolase Family 5

Activities in Family[retaining] arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-);
β-1,3-mannanase (EC 3.2.1.-);
β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-);
Glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Mannan exo-β-1,4-mannosidase (EC 3.2.1.-);
Steryl β-glucosidase (EC 3.2.1.104);
Endoglycosylceramidase (EC 3.2.1.123);
Chitosanase (EC 3.2.1.132);
β-D-galactofuranosidase (EC 3.2.1.146);
β-primeverosidase (EC 3.2.1.149);
Oligoxyloglucan reducing-end-specific cellobiohydrolase (EC 3.2.1.150);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168);
β-glucosidase (EC 3.2.1.21);
β-galactosidase (EC 3.2.1.23);
β-mannosidase (EC 3.2.1.25);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
Endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39);
Endo-β-1,4-glucanase (EC 3.2.1.4);
β-glucosylceramidase (EC 3.2.1.45);
β-galactosylceramidase (EC 3.2.1.46);
β-N-acetylhexosaminidase (EC 3.2.1.52);
α-L-arabinofuranosidase (EC 3.2.1.55);
Exo-β-1,3-glucanase (EC 3.2.1.58);
Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (31209); Uniprot accession (673); PDB accession (296); 3D entries (110); cryst (0)
Summary
Download GH5 (44468) Taxonomic display Structure (110) Characterized (624)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 endo-β-1,3(4)-glucanase (EXO02C10-ORF13;En5) 3.2.1.6 pubmed
 uncultured bacterium AEV59735.1
AGO64722.1
AGO64723.1
AGO64724.1
AGO64725.1
AGO64726.1
AGO64727.1
AGO64728.1
AGO64729.1
AGO64730.1
AGO64731.1
AGO64732.1		 G9BYB6
S4VGU8
S4VGV3
S4VJK3
S4VJK8
S4VMG2
S4VMG6		   4
 endo-β-1,4-glucanase (En3;CMC6A4-ORF12) 3.2.1.4 pubmed
 uncultured bacterium AEV59725.1 G9BYA6   4
 cellobiohydrolase (Scaffold00024.3;En4) 3.2.1.91 pubmed
 uncultured bacterium AEV59731.1 G9BYB2   37
 cellulase (Exo2b;EXO02C10-ORF14) 3.2.1.4 pubmed
 uncultured bacterium AEV59736.1 G9BYB7   4
 cellulase (YBcontig404-00027-37) 3.2.1.4 pubmed
 uncultured bacterium ADU86901.1 H2BCH0   4
 cellulase (YBcontig310-00038-19) 3.2.1.4 pubmed
 uncultured bacterium ADU86902.1 H2BCH1   4
 endo-β-1,4-glucanase (YBcontig310-00424-17) 3.2.1.4 pubmed
 uncultured bacterium ADU86909.1 H2BCH8 6XSO[A,B] 4
 β-glucanase (UmCel5G;RC1) 3.2.1.4 pubmed
 uncultured bacterium ABA42184.1 Q3HXC4   2
 β-glucanase (UmCel5H;RC2) 3.2.1.4 pubmed
 uncultured bacterium ABA42185.1 Q3HXC3   2
 endo-β-1,4-glucanase (UmCel5A) (Cel5A) 3.2.1.4 pubmed
 uncultured bacterium ABB51612.1 Q308B6   5
 endo-β-1,4-glucanase (CRS200) (Cel5B) 3.2.1.4 URL
 uncultured bacterium AFJ44728.1 I2B2S2   2
 endoglucanase / cellulase (cMGL504) (Cel5A) 3.2.1.4 pubmed
 uncultured bacterium AFJ05146.1 I6PLH5 4HTY[A]
4HU0[A] 		26
 cellulase-xylanase A (Cel5A) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium AFO64636.1 I7D7K5   4
 cellulase-xylanase B (Cel5B) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium AFO64637.1 I7CY19   4
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4
3.2.1.73		 pubmed
pubmed
 uncultured bacterium ABA02176.1 Q2I8W1   26
 endoglycosidase (GH6248) (Cel5A) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 uncultured bacterium ABB46200.1 Q283N5   4
 endo-β-1,4-glucanase (UmCel5F) 3.2.1.4 pubmed
 uncultured bacterium ABE60666.1     39
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 pubmed
 uncultured bacterium ABE60714.1 Q1PDD8   25
 cellodextrinase (UmCel5M) 3.2.1.74 pubmed
 uncultured bacterium ABE60715.1 Q1PDD7   52
 endo-β-1,4-glucanase (CelWS3) 3.2.1.4 pubmed
 uncultured bacterium AFX88673.1 M4I2I3   2
 endo-β-1,4-glucanase (CelWS14) 3.2.1.4 pubmed
 uncultured bacterium AFX88668.1 M4I2I2   2
 endo-β-1,4-glucanase (CelWS6) 3.2.1.4 pubmed
 uncultured bacterium AFX88666.1 M4I2R3   2
 endo-β-1,4-glucanase (CelWS36) 3.2.1.4 pubmed
 uncultured bacterium AFX88672.1 M4I2J6   2
 endo-β-1,4-glucanase (CelWS7) 3.2.1.4 pubmed
 uncultured bacterium AFX88667.1 M4I2J5   2
 cellulase (CS10;CelCS10) 3.2.1.4 pubmed
 uncultured bacterium AGL50932.1 R4P2Q6   2
 endo-β-1,4-glucanase (RC3) 3.2.1.4 pubmed
 uncultured bacterium ABI94085.1 Q06B38   2
 endo-β-1,4-glucanase (RC5) 3.2.1.4 pubmed
 uncultured bacterium ABI94086.1 Q06B37   2
 cellulase (CelE1) 3.2.1.4 pubmed
 uncultured bacterium AHA42547.2
AHA42547.1		 A0A0R5P8X1
V5KYY9		 4M1R[A,B] 2
 cellulase (C1A1) 3.2.1.4 pubmed
 uncultured bacterium BAO65790.1     2
 endoglucanase (C1A2) 3.2.1.4 pubmed
 uncultured bacterium BAO65795.1     2
 cellulase (C2A3) 3.2.1.4 pubmed
 uncultured bacterium BAO65801.1     2
 endoglucanase (C2A1) 3.2.1.4 pubmed
 uncultured bacterium BAO65799.1     5
 cellulase (C2P3) 3.2.1.4 pubmed
 uncultured bacterium BAO65808.1     25
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 pubmed
 uncultured bacterium AID57617.1 A0A068F0I2   25
 β-1,4-glucanase (4348JG28_001) 3.2.1.4 pubmed
 uncultured bacterium ABW39345.1 A9LDT9   52
 β-1,4-glucanase (4348JG48_005) 3.2.1.4 pubmed
 uncultured bacterium ABW39351.1 A9LDU5   52
 endoglucanase 3.2.1.4 pubmed
 uncultured bacterium Contig15 AHF23845.1 W0FLK6   37
 endoglucanase 3.2.1.4 pubmed
 uncultured bacterium Contig33 AHF24998.1 W0FJI5   4
 endoglucanase 3.2.1.4 pubmed
 uncultured bacterium Contig783 AHF24720.1 W0FP00   4
 endoglucanase (partial) 3.2.1.4 pubmed
 uncultured bacterium Contigcl_8 AHF25528.1 W0FKV0   4
 r_06-02 3.2.1.4 pubmed
 uncultured bacterium r_06 AFN57700.1 I6YKE5   4
 endoglucanase (GH5_h) 3.2.1.4
3.2.1.78		 pubmed
pubmed
 uncultured Bacteroidetes bacterium AIT97141.1 A0A097KUR6   4
 endoglucanase (GH5_g) 3.2.1.73 pubmed
 uncultured Bacteroidetes bacterium AIT97140.1 A0A097KUQ0   4
 endoglucanase (EglDG) (fragment) 3.2.1.4 doi
 uncultured Dictyoglomus sp. ARO76321.1 A0A1W6S733   25
 endoglucanase (Cel1; GC_Cel1) 3.2.1.4
3.2.1.151		 pubmed
pubmed
 uncultured Dictyoglomus sp. QRN45942.1 A0A891XJN2   4
 endoglucanase (Cel4; GC_Cel4) 3.2.1.4 pubmed
 uncultured Dictyoglomus sp. QRN45943.1 A0A891XJK4   25
 endoglucanase (RuCelB;RuCel5B;6C6) (Cel5B) 3.2.1.4 doi
 uncultured rumen bacterium ADM89627.1 G3BJX5   26
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4 pubmed
 uncultured rumen bacterium CAP07661.1 A8E1B1   26
 endo-β-1,4-glucanase (CelA;Cel) 3.2.1.4 pubmed
 unidentified bacterium AAA91966.1 Q60054   37
 β-1,4-mannanase 5C (Man5C) 3.2.1.78 pubmed
 Vibrio sp. MA-138 BAG69482.2
BAG69482.1		 B5BQ69   7
 β-mannanase (ManA) 3.2.1.78 doi
 Vibrio sp. MA-138 BAA25188.1 O69347   8
 endo-β-1,4-glucanase (Cel5A) (Cel5A) 3.2.1.4 pubmed
 Vibrio xiamenensis G21 ADJ93836.1 D8V609   2
 β-mannosidase (Vvad_PD2954) 3.2.1.25 pubmed
 Victivallis vadensis ZP_06241352.1
PVY35568.1
WP_116885687.1		 A0A2U1AGP1  
 β-endoglucanase (EgxA;Eng) (frameshift) 3.2.1.4 doi
 Xanthomonas albilineans XAI-I AAA27599.1 Q60100   26
 endo-β-1,4-glucanase (EngXCA;EngA) (frameshift) 3.2.1.4 pubmed
 Xanthomonas campestris pv. campestris CAC18529.1
AAA27612.1		 P19487
Q9EVR6		 4TUF[A,B,C,D] 1
 endo-β-1,4-mannosidase (ManA;XCC1778) 3.2.1.78 pubmed
 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41068.1
NP_637144.1		 Q8P9S0   8
 endo-β-1,4-glucanase (EngXCA;XccEG;XCC3521) 3.2.1.4 doi
 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42791.1
NP_638867.1		 P19487   1
 β-mannanase (XcGH5_8; TP37_09655) 3.2.1.78 pubmed
 Xanthomonas citri pv. aurantifolii FDC 1559 AMU98328.1     8
 endo-β-1,4-glucanase 3.2.1.4 pubmed
 Xanthomonas sp. EC102 ACU30064.1 C7FFK1   1
 endo-β-1,4-glucanase (PRU_1856) 3.2.1.4 doi
 Xylanibacter ruminicola 23 ADE83057.1
BAA74515.1		 D5EU37
Q9ZN63		   38
 xylanase / endoglucanase (PRU_2231) 3.2.1.4
3.2.1.8		 pubmed
pubmed
 Xylanibacter ruminicola 23 AAC36862.1
ADE83418.1		 D5EV54
Q45397		   4
 endoglucanase (CelA;BrEND) 3.2.1.4 pubmed
 Xylanibacter ruminicola AR20 1814455A     4
 endoglucanase (XF0818) 3.2.1.4 pubmed
 Xylella fastidiosa 9a5c AAF83628.1
NP_298108.1		 Q9PF60   1
 endo-β-1,3-1,4-glucanase (EngA; ZgEngA; zobellia_208) 3.2.1.6 pubmed
 Zobellia galactanivorans DsijT CAZ94281.1 G0L8Z3 6GL0[A,B,C]
6GL2[A] 		4
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 6-O-α-L-rhamnosyl-β-glucosidase I (?R?GI) 3.2.1.168 pubmed
 Acremonium sp. DSM 24697 SES201 AMD11613.1 A0A286JZ59   23
 β-1,6-glucanase (BGN6.1) 3.2.1.75 doi
 Acremonium sp. OXF C13 AAT97707.1 Q68GV7   15
 β-mannanase (Cel4A) 3.2.1.78 pubmed
 Agaricus bisporus C54-CARB8 CAB76904.1
ABJ41267.1		 Q9P893   7
 β-mannanase (Cel4;Cel4b) 3.2.1.78 pubmed
 Agaricus bisporus D649 CAA90423.1 Q92401   7
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 pubmed
 Anoplophora chinensis AFN89566.1 K4GMM5   2
 endo-β-1,4-mannanase (AkMan;AkManA) 3.2.1.78 pubmed
 Aplysia kurodai BAJ60954.1 E5RSM0 3VUP[A,B] 10
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 pubmed
 Apriona germarii AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 pubmed
 Apriona japonica AHI15751.1 X2D6U4   2
 endo-?-1,4-xylanase (AJAGH5_2-1) 3.2.1.8 pubmed
 Apriona japonica AHI15746.1 X2D6U2   2
 endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310) 3.2.1.78 pubmed
 Arabidopsis thaliana AAN72165.1
AAG00883.1
AAL91241.1
AEE27414.1
ANM59069.1
NP_171733.1
NP_171733.2		 A0A178WL81
A0A654E7D2
Q9FZ29		   7
 β-mannanase 2 (AtMan2;AtMan5-2;At2g20680) 3.2.1.78 doi
 Arabidopsis thaliana AAP40422.1
AAD20927.1
ABG25077.1
AEC07056.1
BAF00487.1
NP_179660.2		 Q7Y223
Q9SKU9		   7
 β-mannanase (PM;Man47;AtMAN47) 3.2.1.78 pubmed
 Armillariella tabescens EJLY2098 ABB88954.1 A1X5Y1   7
 β-mannanase (Man1) 3.2.1.78 pubmed
 Aspergillus aculeatus KSM 510 / MRC11624 AAA67426.1 Q00012   7
 β-mannanase (Man5P1;NFIA_113780) 3.2.1.78 pubmed
 Aspergillus fischeri NRRL 181 NRRL 181 / P1 XP_001262744.1 A1D8Y6   7
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 pubmed
 Aspergillus fumigatus BAL46041.1 H1AE13 8EXD[A,B,C,D] 12
 endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030) 3.2.1.78 pubmed
 Aspergillus fumigatus Af293 EAL85463.1 Q4WBS1   7
 endo-β-1,4-mannanase (ManF;Man I;Man II) (partial) 3.2.1.78 pubmed
 Aspergillus fumigatus IMI 385708 ACH58410.1
ACH58411.1		 B5LZ77
B5LZ78
Q4WBS1		   7
 endoglucanase / cellulase (Egl2) 3.2.1.4 pubmed
 Aspergillus fumigatus Z5 ADX78144.1 F1DGF4   5
 endoglucanase / cellulase (Egl3) 3.2.1.4 pubmed
 Aspergillus fumigatus Z5 ADX78145.1 F1DGF5   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 pubmed
 Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-mannanase (ManAK; AKAW_07239 3.2.1.78 pubmed
 Aspergillus luchuensis IFO 4308 GAA89125.1     7
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 pubmed
 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1		 Q5BDU5   5
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 pubmed
 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1		 Q1HFS8   5
 exo-β-1,3-glucanase (Anid-Bgl502;AN7533) 3.2.1.58 pubmed
 Aspergillus nidulans FGSC A4 EAA62113.1
ABF50886.1		 C8VBL9
Q5AVZ7		   9
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 pubmed
 Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1		 Q5B7X2   7
 β-1,6-glucanase (Anid-Bgl503;AN3777) 3.2.1.75 pubmed
 Aspergillus nidulans FGSC A4 EAA59985.1
ABF50867.1		 C8V716
Q5B6Q3		   15
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 pubmed
 Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1		 Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 pubmed
 Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1		 Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) 3.2.1.78 pubmed
 Aspergillus nidulans XZ3 AGG69666.1 S4TZC3   7
 endoglucanase B (EglB) 3.2.1.4 pubmed
 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 pubmed
 Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 endo-β-1,6-galactanase (An03g01050) 3.2.1.164 doi
 Aspergillus niger CBS 513.88 CAK38078.1 A2QFW8   16
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 pubmed
 Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 endo-β-1,4-glucanase (Eng1; EgI; AnCel5A) 3.2.1.4 pubmed
 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7		 5I77[A]
5I78[A,B]
5I79[A,B] 		5
 β-rutinosidase (AnRut) 3.2.1.168 pubmed
 Aspergillus niger K2     6I1A[B]
6I1A[A] 		23
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 pubmed
 Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1		 G5CJA5
H2E6Y8		   7
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