Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 |
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 cellulase (DC9-2) 3.2.1.4 uncultured microorganism ACA61152.1 B1PLJ5   26
 β-glucanase (DC20-2) 3.2.1.- uncultured microorganism ACA61156.1 B1PLJ9   26
 β-glucanase (DC23-3) 3.2.1.- uncultured microorganism ACA61160.1 B1PLK3   4
 cellulase (DM1-1) 3.2.1.- uncultured microorganism ACA61162.1 B1PLK5   37
 β-glucanase (M8-2) 3.2.1.- uncultured microorganism ACA61165.1 B1PLK8   37
 β-glucanase (M11-2) 3.2.1.4 uncultured microorganism ACA61168.1 B1PLL1   26
 β-glucanase (M40-2) 3.2.1.- uncultured microorganism ACA61171.1 B1PLL4   38
 endo-β-1,4-glucanase (G08-17) (fragment) 3.2.1.4 uncultured organism ACY24829.1 D8VN44   26
 endo-β-1,4-glucanase (G10-10) 3.2.1.4 uncultured organism ACY24859.1 D8VN74   2
 β-glucanase 3.2.1.- uncultured organism ADD61786.1 D9ZEN2   37
 β-glucanase 3.2.1.- uncultured organism ADD61809.1 D9ZEQ5   4
 β-glucanase 3.2.1.4 uncultured organism ADD61853.1 D9ZEU9   1
 β-glucanase 3.2.1.4 uncultured organism ADD61911.1 D9ZF07   4
 multimodular β-glucanase 3.2.1.- uncultured organism ADD61840.1 D9ZET6   2
 SARM_0071 / 181694_69520 / TX-1 3.2.1.4 uncultured organism ADX05742.1     4
 SARM_0068 / 3004993_158220 / TW-3 3.2.1.4 uncultured organism ADX05739.1     37
 SARM_0054 / 1557092_108510 / MH-18 3.2.1.4 uncultured organism ADX05725.1     38
 SARM_0047 / 1057205_158590 / TW-15 3.2.1.4 uncultured organism ADX05718.1    
 SARM_0046 / 1029836_111030 / MH-2 3.2.1.4 uncultured organism ADX05717.1     38
 SARM_0034 / 694713_55880 / TW-39 3.2.1.4 uncultured organism ADX05705.1     4
 SARM_0032 / 558318_19410 / MH-20 3.2.1.4 uncultured organism ADX05703.1     4
 SARM_0026 / 457020_01700 / TW-40 3.2.1.4 uncultured organism ADX05697.1     2
 SARM_0026 / 457020_01700 / TW-40 3.2.1.4 uncultured organism ADX05697.1    
 SARM_0025 / 421339_68070 / TW-2 3.2.1.4 uncultured organism ADX05696.1     46
 SARM_0017 / 3953955_161040 / TW-49 3.2.1.4 uncultured organism ADX05688.1     4
 SARM_0013 / 3932955_213080 / TW-1 3.2.1.4 uncultured organism ADX05684.1     2
 SARM_0084 / 0_04358 / TW-56 (fragment; probable frameshift) 3.2.1.4 uncultured organism ADX05760.1     4
 SARM_0083 / 0_01399 / MH-11 (fragment; probable frameshift) 3.2.1.- uncultured organism ADX05757.1     52
 SARM_0085 / 0_04975 / TW-16 3.2.1.- uncultured organism ADX05752.1     52
 SARM_0081 / 0_14031 / TW-4 3.2.1.4 uncultured organism ADX05751.1     26
 SARM_0069 / 3271578_13460 / TW-9 3.2.1.- uncultured organism ADX05740.1     26
 SARM_0066 / 2698429_129360 / TW-22 3.2.1.- uncultured organism ADX05737.1     52
 SARM_0063 / 2527869_58630 / TW-33 3.2.1.4 uncultured organism ADX05734.1   4YHG[A,B] 4
 SARM_0061 / 2463295_41230 / MH-3 3.2.1.4 uncultured organism ADX05732.1     26
 SARM_0058 / 2395619_81340 / TW-44 3.2.1.4 uncultured organism ADX05729.1     4
 SARM_0016 /3953955_160820 / TW-27 (fragment) 3.2.1.- uncultured organism ADX05687.1     2
 exo-cellulase (CelEx-BR12) 3.2.1.- uncultured organism AGK74985.1     38
 β-glucanase (RR.01;RR.01-2) 3.2.1.- unidentified microorganism CAJ19135.1 Q2YI68   4
 glucanase (RR.02-2;BglC) 3.2.1.- unidentified microorganism CAJ19139.1 Q2YI64   4
 β-glucanase (RR.06;RR.06-1;BglC) 3.2.1.- unidentified microorganism CAJ19140.1 Q2YI63   4
 glucanase (RR.10;RR.10-1) 3.2.1.- unidentified microorganism CAJ19146.1 Q2YI57   4
 endoglucanase (RR.13;RR.13-2) 3.2.1.- unidentified microorganism CAJ19149.1 Q2YI54   2
 glucanase (RR.14;RR.14-2) (Cel5A) 3.2.1.4 unidentified microorganism CAJ19151.1 Q2YI52   4
 endo-β-1,4-glucanase (UmCel28;CC1) 3.2.1.4 unidentified microorganism ABX76045.1 A9UGW1   4
 endoglucanase (UmCelE2;EC2) 3.2.1.4 unidentified microorganism ABX76046.1 A9UGW2   4
 endoglucanase (UmCelS15;SC1) (fragment) 3.2.1.4 unidentified microorganism ABX76048.1 A9UGW4   4
 endoglucanase (UmCelC23;CC2) 3.2.1.4 unidentified microorganism ABX76050.1 A9UGW6   4
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