Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); β-glycosidase (EC 3.2.1.-); endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39); β-N-acetylhexosaminidase (EC 3.2.1.52); chitosanase (EC 3.2.1.132); β-D-galactofuranosidase (EC 3.2.1.146); β-galactosylceramidase (EC 3.2.1.46); ; β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-); α-L-arabinofuranosidase (EC 3.2.1.55); glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (24948); Uniprot accession (634); PDB accession (270); 3D entries (100); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 β-glucosidase (YIR007W;YIB7W) 3.2.1.21 pubmed
Saccharomyces cerevisiae S288c NP_012272.1
CAA86077.1
CAA86209.1
P40566   12
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 pubmed
Saitozyma flava MUT-6 AAC60541.1
BAA03070.1
Q04469   5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 pubmed
Schizophyllum commune H4-8 EFI96731.1 D8Q439
P81190
  5
 endo-β-1,6-glucanase (Exg3;SPBC2D10.05) 3.2.1.75 pubmed
Schizosaccharomyces pombe 972h- CAA21163.1
NP_596224.1
O74799  
 endo-β-1,6-glucanase (Exg1;SPBC1105.05) 3.2.1.75 pubmed
Schizosaccharomyces pombe 972h- CAB50968.1
NP_596461.1
Q9URU6   9
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 pubmed
Schwanniomyces occidentalis ATCC 26077 CAA86951.1 Q12700   9
 endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4;LeMan4;LeMAN4a;LeMAN4i;MTH) 3.2.1.78
2.4.1.-
pubmed
pubmed
Solanum lycopersicum AAK97760.1
AAK56557.1
AAK97759.2
Q8L5J1
Q8RVL3
Q93WT4
1RH9[A] 7
 β-mannanase (Man1;LeMAN1) 3.2.1.78 pubmed
Solanum lycopersicum AAB87859.2 O48540   7
 endo-β-1,4-mannanase (Man5;LeMAN5) 3.2.1.78 pubmed
Solanum lycopersicum AAM26920.1 Q6YM50   7
 endo-β-1,4-mannanase (Man2;LeMAN2) 3.2.1.78 pubmed
Solanum lycopersicum AAG00315.2
AAG00315.1
Q9FZ03   7
 cellulase (CFP-EG1) 3.2.1.4 pubmed
Spirotrichonympha leidyi BAD90558.1 Q5DWF1   2
 endoglucanase 2 (Eg2; EG2) 3.2.1.4   Talaromyces amestolkiae ATY39124.1     5
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 pubmed
Talaromyces cellulolyticus Y-94 GAM33994.1 A0A698XMA4   5
 β-mannanase (Man5C1) (acidic) 3.2.1.78 pubmed
Talaromyces pinophilus C1 AEV40667.1 G9BRM6   7
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 doi
Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 β-mannanase 3.2.1.78 doi
Talaromyces trachyspermus ATCC 24792 BAP19029.1 A0A077JNB5
A0A087WNH1
3WFL[A] 7
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 pubmed
Talaromyces verruculosus B221-151   A0A1U7Q1U3 5L9C[A,B,C,D]
6T9F[A,B,C,D]
6T9G[A,B,C,D]
6TPC[A,C]
6YON[A,B,C,D]
5I6S[A]
5
 endo-β-1,4-glucanase (Eg1;Eng1;TaCel5A) (Cel5A) 3.2.1.4 pubmed
Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1
Q8TG26
Q96UI5
1GZJ[A,B]
1H1N[A,B]
5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 pubmed
Thermothelomyces thermophilus ATCC 42464 AEO53769.1
AEM23898.1
G2Q5D8
H2B658
  5
 β-mannanase (Man2;bMan2) 3.2.1.78 pubmed
Thermothelomyces thermophilus C1 AFJ59924.1 I2C091   7
 β-mannanase (Man5;Man5XZ7) 3.2.1.78 pubmed
Thielavia arenaria XZ7 AGG69667.1 S4TZ32   7
 endoglucanase (Eg-1) 3.2.1.4 pubmed
Trametes hirsuta BAD01163.1
BAD01164.1
Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 pubmed
Trametes versicolor       5
 endo-β-1,6-glucanase (Bgn16.2;B16-2) 3.2.1.75 pubmed
Trichoderma harzianum CAA55789.1
ACM42428.1
CAA55788.1
B9VQ16
Q12711
Q12712
  15
 β-mannanase (ThMan5A) (Man5A) 3.2.1.78 pubmed
Trichoderma harzianum MGQ2 AGH62580.1 M4T2Q5   7
 β-mannanase (Man1) 3.2.1.78 doi
Trichoderma longibrachiatum DSM 63060 ADN93457.1 E2FZU3   7
 endo-β-1,4-glucanase II (EG2;EGII;Egl2;EG-II;TrEGII;TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 pubmed
Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1
P07982
Q2F8H3
3QR3[A,B] 5
 β-mannanase (TrMan5A) (Man5A) 3.2.1.78 doi
Trichoderma reesei RUTC-30 AAA34208.1
ABJ41268.1
Q99036 1QNO[A]
1QNP[A]
1QNQ[A]
1QNR[A]
1QNS[A]
7
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 pubmed
Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 β-1,6-glucanase (Bgn3) 3.2.1.75 pubmed
Trichoderma virens AAL84696.1
ABV71387.1
A8HZK0
Q8TG97
  15
 endoglucanase III (EG3;EGIII) 3.2.1.4 pubmed
Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
 endoglucanase VIII (EgvIII) 3.2.1.4 pubmed
Trichoderma viride AS 3.3711 ACD36972.1 B4YEW2   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 pubmed
Trichoderma viride MC300-1 BAA36216.1 O93833   5
 endoglucanase TmEgl5A 3.2.1.4 pubmed
Tricholoma matsutake NBRC 30605 BBG31500.1 A0A387K9G9   5
 endo-xyloglucanase (Type 1-7.1;partial) 3.2.1.151 pubmed
uncultured bovine rumen ciliate AEQ16450.1 G5DDB8 6XRK[A,B] 4
 NT0285A72 3.2.1.4 pubmed
uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57328.1 A4UWR8   2
 endoglucanase I (EG1;EGI) 3.2.1.4 pubmed
Volvariella volvacea V14 AAG59832.1
AEQ58914.1
G4WYN8
Q9C3Z8
  5
 endoglucanase I (EgI;NCel5A) (Cel5A) 3.2.1.4 pubmed
Volvariella volvacea WX32 ACE06751.1 B3GQ73   5
 exo-β-1,3-glucanase (Exg2;PaEXG2;WaEXG2) 3.2.1.58 doi
Wickerhamomyces anomalus K / NCYC 432 CAA11018.1 O93983   9
 exo-β-1,3-glucanase (Exg1;WsExg1) 3.2.1.58 pubmed
Williopsis saturnus WC91-2 ACP74152.2
ACP74152.1
C3VMY4   9
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 β-mannanase (derived from Aspergillus sulphureus) 3.2.1.78 pubmed
synthetic construct ABE73149.1     7
 endoglucanase (umCel5N) 3.2.1.4 doi
uncultured microorganism ACH67609.1 B5LZ80   37
 endoglucanase (UmCel5K) (Cel5K) 3.2.1.4 URL
uncultured microorganism ADB80108.1 D3JVT9   26
 endoglucanase / xylanase (CelA;RuCelA) 3.2.1.- pubmed
uncultured microorganism ADK55024.1 E2DQY5   4
 cellulase (BT-01) (partial) 3.2.1.4 pubmed
uncultured microorganism ADR64663.1 E5F2K8   4
 cellulase (Umcel5B29;UmCel5B_29) 3.2.1.4 pubmed
uncultured microorganism AEK98797.1 G0Z5J9   4
 cellulase (Cel14b22) 3.2.1.4 pubmed
uncultured microorganism AFQ39736.1 M4HLK8   4
 cellulase (Cel28A) 3.2.1.4 pubmed
uncultured microorganism AHW46443.1 X5CIW4   4
 β-glucanase (RuCelA;C29-2) 3.2.1.4
3.2.1.-
pubmed
pubmed
uncultured microorganism ACA61132.1 B1PLH5   4
 β-glucanase (C35-2) 3.2.1.4
3.2.1.-
pubmed
pubmed
uncultured microorganism ACA61135.1 B1PLH8   4
 β-glucanase (C67-1) 3.2.1.4
3.2.1.-
pubmed
pubmed
uncultured microorganism ACA61137.1 B1PLI0   4
 β-glucanase (C5614-1) 3.2.1.4
3.2.1.-
pubmed
pubmed
uncultured microorganism ACA61140.1 B1PLI3   4
 β-glucanase (DC2-4) 3.2.1.4
3.2.1.-
pubmed
pubmed
uncultured microorganism ACA61145.1 B1PLI8   4
 β-glucanase (DC3-1) 3.2.1.4 pubmed
uncultured microorganism ACA61149.1 B1PLJ2   4
 cellulase (DC9-2) 3.2.1.4 pubmed
uncultured microorganism ACA61152.1 B1PLJ5   26
 β-glucanase (DC20-2) 3.2.1.- pubmed
uncultured microorganism ACA61156.1 B1PLJ9   26
 β-glucanase (DC23-3) 3.2.1.- pubmed
uncultured microorganism ACA61160.1 B1PLK3   4
 cellulase (DM1-1) 3.2.1.- pubmed
uncultured microorganism ACA61162.1 B1PLK5   37
 β-glucanase (M8-2) 3.2.1.- pubmed
uncultured microorganism ACA61165.1 B1PLK8   37
 β-glucanase (M11-2) 3.2.1.4 pubmed
uncultured microorganism ACA61168.1 B1PLL1   26
 β-glucanase (M40-2) 3.2.1.- pubmed
uncultured microorganism ACA61171.1 B1PLL4   38
 endo-β-1,4-glucanase (G08-17) (fragment) 3.2.1.4 pubmed
uncultured organism ACY24829.1 D8VN44   26
 endo-β-1,4-glucanase (G10-10) 3.2.1.4 pubmed
uncultured organism ACY24859.1 D8VN74   2
 β-glucanase 3.2.1.- pubmed
uncultured organism ADD61786.1 D9ZEN2   37
 β-glucanase 3.2.1.- pubmed
uncultured organism ADD61809.1 D9ZEQ5   4
 β-glucanase 3.2.1.4 pubmed
uncultured organism ADD61853.1 D9ZEU9   1
 β-glucanase 3.2.1.4 pubmed
uncultured organism ADD61911.1 D9ZF07   4
 SARM_0071 / 181694_69520 / TX-1 3.2.1.4 pubmed
uncultured organism ADX05742.1 E9NSP7   4
 SARM_0068 / 3004993_158220 / TW-3 3.2.1.4 pubmed
uncultured organism ADX05739.1 E9NSP4   37
 SARM_0054 / 1557092_108510 / MH-18 3.2.1.4 pubmed
uncultured organism ADX05725.1 E9NSN0   38
 SARM_0047 / 1057205_158590 / TW-15 3.2.1.4 pubmed
uncultured organism ADX05718.1 E9NSM3  
 SARM_0046 / 1029836_111030 / MH-2 3.2.1.4 pubmed
uncultured organism ADX05717.1 E9NSM2   38
 SARM_0034 / 694713_55880 / TW-39 3.2.1.4 pubmed
uncultured organism ADX05705.1 E9NSL0   4
 SARM_0032 / 558318_19410 / MH-20 3.2.1.4 pubmed
uncultured organism ADX05703.1 E9NSK8   4
 SARM_0026 / 457020_01700 / TW-40 3.2.1.4 pubmed
uncultured organism ADX05697.1 E9NSK2 5UHX[A]
5WH8[A]
2
 endo-β-1,4-glucanase (SARM_0025;421339_68070;TW-2) 3.2.1.4 pubmed
uncultured organism ADX05696.1 E9NSK1   46
 SARM_0017 / 3953955_161040 / TW-49 3.2.1.4 pubmed
uncultured organism ADX05688.1 E9NSJ3   4
 SARM_0013 / 3932955_213080 / TW-1 3.2.1.4 pubmed
uncultured organism ADX05684.1 E9NSI9   2
 SARM_0084 / 0_04358 / TW-56 (fragment; probable frameshift) 3.2.1.4 pubmed
uncultured organism ADX05760.1 E9NSR5   4
 SARM_0085 / 0_04975 / TW-16 3.2.1.- pubmed
uncultured organism ADX05752.1 E9NSQ7   52
 SARM_0081 / 0_14031 / TW-4 3.2.1.4 pubmed
uncultured organism ADX05751.1 E9NSQ6   26
 SARM_0069 / 3271578_13460 / TW-9 3.2.1.- pubmed
uncultured organism ADX05740.1 E9NSP5   26
 SARM_0066 / 2698429_129360 / TW-22 3.2.1.- pubmed
uncultured organism ADX05737.1 E9NSP2   52
 SARM_0063 / 2527869_58630 / TW-33 3.2.1.4 pubmed
uncultured organism ADX05734.1 A0A076MPD7
E9NSN9
4YHG[A,B] 4
 SARM_0061 / 2463295_41230 / MH-3 3.2.1.4 pubmed
uncultured organism ADX05732.1 E9NSN7   26
 SARM_0058 / 2395619_81340 / TW-44 3.2.1.4 pubmed
uncultured organism ADX05729.1 E9NSN4   4
 cellulase 5K (Cel5K) 3.2.1.4 pubmed
uncultured organism AEC45566.1 F5CT74   1
 exo-cellulase (CelEx-BR12) 3.2.1.- pubmed
uncultured organism AGK74985.1 N0CH57   38
 β-glucanase (RR.01;RR.01-2) 3.2.1.- pubmed
unidentified microorganism CAJ19135.1 Q2YI68   4
 β-glucanase (RR.02-2;BglC) 3.2.1.- pubmed
unidentified microorganism CAJ19139.1 Q2YI64   4
 β-glucanase (RR.06;RR.06-1;BglC) 3.2.1.- pubmed
unidentified microorganism CAJ19140.1 Q2YI63   4
 glucanase (RR.10;RR.10-1) 3.2.1.- pubmed
unidentified microorganism CAJ19146.1 Q2YI57   4
 endoglucanase (RR.13;RR.13-2) 3.2.1.- pubmed
unidentified microorganism CAJ19149.1 Q2YI54   2
 glucanase (RR.14;RR.14-2) (Cel5A) 3.2.1.4 pubmed
pubmed
unidentified microorganism CAJ19151.1 Q2YI52   4
 endo-β-1,4-glucanase (UmCel28;CC1) 3.2.1.4 pubmed
unidentified microorganism ABX76045.1 A9UGW1   4
 endoglucanase (UmCelE2;EC2) 3.2.1.4 pubmed
unidentified microorganism ABX76046.1 A9UGW2   4
 endoglucanase (UmCelS15;SC1) (fragment) 3.2.1.4 pubmed
unidentified microorganism ABX76048.1 A9UGW4   4
 endoglucanase (UmCelC23;CC2) 3.2.1.4 pubmed
unidentified microorganism ABX76050.1 A9UGW6   4
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