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Glycoside Hydrolase Family 5

Activities in Family[retaining] arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-);
β-1,3-mannanase (EC 3.2.1.-);
β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-);
Glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Mannan exo-β-1,4-mannosidase (EC 3.2.1.-);
Steryl β-glucosidase (EC 3.2.1.104);
Endoglycosylceramidase (EC 3.2.1.123);
Chitosanase (EC 3.2.1.132);
β-D-galactofuranosidase (EC 3.2.1.146);
β-primeverosidase (EC 3.2.1.149);
Oligoxyloglucan reducing-end-specific cellobiohydrolase (EC 3.2.1.150);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168);
β-glucosidase (EC 3.2.1.21);
β-galactosidase (EC 3.2.1.23);
β-mannosidase (EC 3.2.1.25);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
Endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39);
Endo-β-1,4-glucanase (EC 3.2.1.4);
β-glucosylceramidase (EC 3.2.1.45);
β-galactosylceramidase (EC 3.2.1.46);
β-N-acetylhexosaminidase (EC 3.2.1.52);
α-L-arabinofuranosidase (EC 3.2.1.55);
Exo-β-1,3-glucanase (EC 3.2.1.58);
Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (30664); Uniprot accession (670); PDB accession (295); 3D entries (109); cryst (0)
Summary
Download GH5 (43911) Taxonomic display Structure (109) Characterized (622)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 exo-1,3-glucanase (Exg1) 3.2.1.58 pubmed
 Pichia angusta ATCC 14754 CAA86948.1 Q12626   9
 endoglucanase A (CelA;EglA) (partial) 3.2.1.4 doi
 Piromyces rhizinflatus 2301 AAF00074.2 Q9URH5 3AYR[A]
3AYS[A] 		4
 endoglucanase (Egl-1) (Cel5B) 3.2.1.4 pubmed
 Piromyces rhizinflatus 2301 AAD43818.1 Q9Y870   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4
3.2.1.73		 pubmed
pubmed
 Piromyces sp. equi CAB92326.1 Q9P867   4
 endo-β-1,4-mannanase (PaMan5A;Pa_6_490) (Man5A) 3.2.1.78 pubmed
 Podospora anserina S mat+ CAP71606.1
ADO14134.1
CDP31001.1		 B2B3C0 3ZIZ[A] 7
 endo-β-1,4-mannanase (Man6;PtrMan6) 3.2.1.78 pubmed
 Populus trichocarpa AFX59322.1
EEF05441.1		 K7WJ21   7
 endo-β-1,4-glucanase (PpCel5A) (Cel5A) 3.2.1.4 pubmed
 Postia placenta Mad-698-R ADH51729.1 D7REW2   5
 endo-β-1,4-glucanase (PpCel5B) (Cel5B) 3.2.1.4 pubmed
 Postia placenta Mad-698-R XP_002475436.1
ADH51730.1		 B8PID6
D7REW3		   5
 endoglucanase / cellulase (PhEG) 3.2.1.4 pubmed
 Psacothea hilaris BAB86867.1 Q8T890   2
 β-1,3-mannanase / β-1,3-glucomannanase (Man5C) 3.2.1.- pubmed
 Purpureocillium lilacinum ATCC 36010 BAD06516.1 Q76G11   31
 broad specificity endo-β-glucanase (Egl5A; TeEgl5A) 3.2.1.4 pubmed
 Rasamsonia emersonii CBS 394.64 AHV83755.1
CAJ75961.1		 X4YXV3   5
 endo-β-1,4-glucanase (Eg1) 3.2.1.4 pubmed
 Rasamsonia emersonii IMI 392299 AAL33639.2
AAL33630.1
AAL33630.2
AAL33639.1		 Q8WZD7   5
 β-mannanase (RmMan5B) (Man5B) 3.2.1.78 pubmed
 Rhizomucor miehei CAU432 AGV01048.1 A0A075C6T6 4LYP[A,B]
4LYQ[A]
4LYR[A]
4NRR[A,B]
4NRS[A,B] 		7
 β-mannanase (RmMan5A) (Man5A) 3.2.1.78 pubmed
 Rhizomucor miehei CAU432 / CGMCC 4967 AGC24277.1 L7SVX1 4L3M[A]
4QP0[A] 		7
 β-glucosylceramidase (EGCrP1;RO3G_04172) 3.2.1.45 pubmed
 Rhizopus delemar RA 99-880 EIE79467.1 I1BTD7   12
 endo-β-1,4-glucanase I (Eg1) 3.2.1.4 pubmed
 Robillarda sp. Y-20 BAA90480.1
JX0131		 P23044
Q9P981		   5
 exo-β-1,3-glucanase (sporulation) (Spr1;Ssg1) 3.2.1.58 pubmed
 Saccharomyces cerevisiae GRF88 AAB24895.1
CAA41952.1
CAA99399.1		 P32603   9
 exo-β-1,3-glucanase / β-glucosidase (sporulation) (Ssg1;Spr1;YOR190W) 3.2.1.21
3.2.1.58		 pubmed
pubmed
 Saccharomyces cerevisiae S288c AAU09785.1
NP_014833.1		 P32603   9
 exo-β-1,3-glucanase 1 / flavonoid β-glucosidase (Exg1;Bgl1;Scw6;YLR300W) 3.2.1.21
3.2.1.58		 doi
pubmed
 Saccharomyces cerevisiae S288c AAA34599.1
AAB67345.1
AAT93088.1
NP_013403.1		 P23776 1H4P[A,B] 9
 exo-1,3-glucanase 2 (Exg2;YDR261c) 3.2.1.58 pubmed
 Saccharomyces cerevisiae S288c CAA86950.1
CAA92719.1
CAA94100.1
NP_010547.1		 P52911   9
 β-glucosidase (YIR007W;YIB7W) 3.2.1.21 pubmed
 Saccharomyces cerevisiae S288c NP_012272.1
CAA86077.1
CAA86209.1		 P40566   12
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 pubmed
 Saitozyma flava MUT-6 AAC60541.1
BAA03070.1		 Q04469   5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 pubmed
 Schizophyllum commune H4-8 EFI96731.1 D8Q439
P81190		   5
 endo-β-1,6-glucanase (Exg3;SPBC2D10.05) 3.2.1.75 pubmed
 Schizosaccharomyces pombe 972h- CAA21163.1
NP_596224.1		 O74799  
 endo-β-1,6-glucanase (Exg1;SPBC1105.05) 3.2.1.75 pubmed
 Schizosaccharomyces pombe 972h- CAB50968.1
NP_596461.1		 Q9URU6   9
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 pubmed
 Schwanniomyces occidentalis ATCC 26077 CAA86951.1 Q12700   9
 endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4; LeMan4; LeMAN4a; LeMAN4i; MTH) 3.2.1.78 pubmed
 Solanum lycopersicum AAK97760.1
AAK56557.1
AAK97759.2		 Q8L5J1
Q8RVL3
Q93WT4		 1RH9[A] 7
 β-mannanase (Man1;LeMAN1) 3.2.1.78 pubmed
 Solanum lycopersicum AAB87859.2 O48540   7
 endo-β-1,4-mannanase (Man5;LeMAN5) 3.2.1.78 pubmed
 Solanum lycopersicum AAM26920.1 Q6YM50   7
 endo-β-1,4-mannanase (Man2;LeMAN2) 3.2.1.78 pubmed
 Solanum lycopersicum AAG00315.2
AAG00315.1		 Q9FZ03   7
 cellulase (CFP-EG1) 3.2.1.4 pubmed
 Spirotrichonympha leidyi BAD90558.1 Q5DWF1   2
 cellulase (SoCel5) 3.2.1.4 pubmed
 Stegonsporium opalus ARO48344.1     5
 endoglucanase 2 (Eg2; EG2) 3.2.1.4 doi
 Talaromyces amestolkiae ATY39124.1 A0A2H4R4J8   5
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 pubmed
 Talaromyces cellulolyticus Y-94 GAM33994.1 A0A698XMA4   5
 β-mannanase (Man5C1) (acidic) 3.2.1.78 pubmed
 Talaromyces pinophilus C1 AEV40667.1 G9BRM6   7
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 doi
 Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 β-mannanase 3.2.1.78 doi
 Talaromyces trachyspermus ATCC 24792 BAP19029.1 A0A077JNB5
A0A087WNH1		 3WFL[A] 7
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 pubmed
 Talaromyces verruculosus B221-151   A0A1U7Q1U3 5L9C[A,B,C,D]
6T9F[A,B,C,D]
6T9G[A,B,C,D]
6TPC[A,C]
6YON[A,B,C,D]
5I6S[A] 		5
 endo-β-1,4-glucanase (Eg1; Eng1; TaCel5A) (Cel5A) 3.2.1.4 pubmed
 Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1		 Q8TG26
Q96UI5		 1GZJ[A,B]
1H1N[A,B]
7R28[A,B]
7R29[A,B]
7R2A[A,B]
7R2C[A,B]
7R2D[A,B] 		5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 pubmed
 Thermothelomyces thermophilus ATCC 42464 AEO53769.1
AEM23898.1		 G2Q5D8
H2B658		   5
 β-mannanase (Man2;bMan2) 3.2.1.78 pubmed
 Thermothelomyces thermophilus C1 AFJ59924.1 I2C091   7
 β-mannanase (Man5;Man5XZ7) 3.2.1.78 pubmed
 Thielavia arenaria XZ7 AGG69667.1 S4TZ32   7
 endoglucanase (Eg-1) 3.2.1.4 pubmed
 Trametes hirsuta BAD01163.1
BAD01164.1		 Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 pubmed
 Trametes versicolor XP_008039932.1     5
 β-mannanase (Man446; TaMan5) 3.2.1.78 pubmed
 Trichoderma asperellum ND-1 UNE56028.1     7
 endo-β-1,6-glucanase (Bgn16.2;B16-2) 3.2.1.75 pubmed
 Trichoderma harzianum CAA55789.1
ACM42428.1
CAA55788.1		 B9VQ16
Q12711
Q12712		   15
 β-mannanase (ThMan5A) (Man5A) 3.2.1.78 pubmed
 Trichoderma harzianum MGQ2 AGH62580.1 M4T2Q5   7
 β-mannanase (Man1) 3.2.1.78 doi
 Trichoderma longibrachiatum DSM 63060 ADN93457.1 E2FZU3   7
 endo-β-1,4-glucanase II (EG2; EGII; Egl2 ;EG-II; TrEGII; TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 pubmed
 Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1		 P07982
Q2F8H3		 3QR3[A,B] 5
 β-mannanase (Man1; TrMan5A) (Man5A) 3.2.1.78 doi
 Trichoderma reesei RUTC-30 AAA34208.1
ABJ41268.1		 Q99036 1QNO[A]
1QNP[A]
1QNQ[A]
1QNR[A]
1QNS[A] 		7
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 pubmed
 Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 β-1,6-glucanase (Bgn3) 3.2.1.75 pubmed
 Trichoderma virens AAL84696.1
ABV71387.1		 A8HZK0
Q8TG97		   15
 endoglucanase III (EG3;EGIII) 3.2.1.4 pubmed
 Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
 endoglucanase VIII (EgvIII) 3.2.1.4 pubmed
 Trichoderma viride AS 3.3711 ACD36972.1 B4YEW2   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 pubmed
 Trichoderma viride MC300-1 BAA36216.1 O93833   5
 endoglucanase TmEgl5A 3.2.1.4 pubmed
 Tricholoma matsutake NBRC 30605 BBG31500.1 A0A387K9G9   5
 endo-xyloglucanase (Type 1-7.1;partial) 3.2.1.151 pubmed
 uncultured bovine rumen ciliate AEQ16450.1 G5DDB8 6XRK[A,B] 4
 NT0285A72 3.2.1.4 pubmed
 uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57328.1 A4UWR8   2
 endoglucanase I (EG1;EGI) 3.2.1.4 pubmed
 Volvariella volvacea V14 AAG59832.1
AEQ58914.1		 G4WYN8
Q9C3Z8		   5
 endoglucanase I (EgI;NCel5A) (Cel5A) 3.2.1.4 pubmed
 Volvariella volvacea WX32 ACE06751.1 B3GQ73   5
 exo-β-1,3-glucanase (Exg2;PaEXG2;WaEXG2) 3.2.1.58 doi
 Wickerhamomyces anomalus K / NCYC 432 CAA11018.1 O93983   9
 exo-β-1,3-glucanase (Exg1;WsExg1) 3.2.1.58 pubmed
 Williopsis saturnus WC91-2 ACP74152.2
ACP74152.1		 C3VMY4   9
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 endo-β-1,4-mannanase 3.2.1.78 doi
 metagenome MCF0172482.1   8D89[A] 57
 ancestral endocellulase Cel5A (LFCA_EG) 3.2.1.4 doi
 synthetic construct     6GJF[B,C,D,E,F]
6GJF[A] 		2
 endoglucanase (umCel5N) 3.2.1.4 doi
 uncultured microorganism ACH67609.1 B5LZ80   37
 endo-β-1,4-glucanase (cel3623) 3.2.1.4 pubmed
 uncultured microorganism AOA60286.1     37
 endo-β-1,4-glucanase (cel36) 3.2.1.4 pubmed
 uncultured microorganism AOA60287.1     2
 endo-β-1,4-glucanase (cel7482) 3.2.1.4 pubmed
 uncultured microorganism AOA60285.1     37
 endoglucanase (UmCel5K) (Cel5K) 3.2.1.4 URL
 uncultured microorganism ADB80108.1 D3JVT9   26
 endoglucanase / xylanase (CelA;RuCelA) 3.2.1.73 pubmed
 uncultured microorganism ADK55024.1 E2DQY5   4
 cellulase (BT-01) (partial) 3.2.1.4 pubmed
 uncultured microorganism ADR64663.1 E5F2K8   4
 cellulase (Umcel5B29;UmCel5B_29) 3.2.1.4 pubmed
 uncultured microorganism AEK98797.1 G0Z5J9   4
 cellulase (Cel14b22) 3.2.1.4 pubmed
 uncultured microorganism AFQ39736.1 M4HLK8   4
 cellulase (Cel28A) 3.2.1.4 pubmed
 uncultured microorganism AHW46443.1 X5CIW4   4
 β-glucanase (RuCelA;C29-2) 3.2.1.4 pubmed
 uncultured microorganism ACA61132.1 B1PLH5   4
 β-glucanase (C35-2) 3.2.1.4 pubmed
 uncultured microorganism ACA61135.1 B1PLH8   4
 β-glucanase (C67-1) 3.2.1.4 pubmed
 uncultured microorganism ACA61137.1 B1PLI0   4
 β-glucanase (C5614-1) 3.2.1.4 pubmed
 uncultured microorganism ACA61140.1 B1PLI3   4
 β-glucanase (DC2-4) 3.2.1.4 pubmed
 uncultured microorganism ACA61145.1 B1PLI8   4
 β-glucanase (DC3-1) 3.2.1.4 pubmed
 uncultured microorganism ACA61149.1 B1PLJ2   4
 cellulase (DC9-2) 3.2.1.4 pubmed
 uncultured microorganism ACA61152.1 B1PLJ5   26
 β-glucanase (DC20-2) 3.2.1.73 pubmed
 uncultured microorganism ACA61156.1 B1PLJ9   26
 β-glucanase (DC23-3) 3.2.1.73 pubmed
 uncultured microorganism ACA61160.1 B1PLK3   4
 β-glucanase (M8-2) 3.2.1.73 pubmed
 uncultured microorganism ACA61165.1 B1PLK8   37
 β-glucanase (M11-2) 3.2.1.4 pubmed
 uncultured microorganism ACA61168.1 B1PLL1   26
 endo-β-1,4-glucanase (G08-17) (fragment) 3.2.1.4 pubmed
 uncultured organism ACY24829.1 D8VN44   26
 endo-β-1,4-glucanase (G10-10) 3.2.1.4 pubmed
 uncultured organism ACY24859.1 D8VN74   2
 β-glucanase 3.2.1.6 pubmed
 uncultured organism ADD61786.1 D9ZEN2   37
 β-glucanase 3.2.1.6 pubmed
 uncultured organism ADD61809.1 D9ZEQ5   4
 β-glucanase 3.2.1.4 pubmed
 uncultured organism ADD61853.1 D9ZEU9   1
 β-glucanase 3.2.1.4 pubmed
 uncultured organism ADD61911.1 D9ZF07   4
 SARM_0071 / 181694_69520 / TX-1 3.2.1.4 pubmed
 uncultured organism ADX05742.1 E9NSP7   4
 SARM_0068 / 3004993_158220 / TW-3 3.2.1.4 pubmed
 uncultured organism ADX05739.1 E9NSP4   37
 SARM_0054 / 1557092_108510 / MH-18 3.2.1.4 pubmed
 uncultured organism ADX05725.1 E9NSN0   38
 SARM_0047 / 1057205_158590 / TW-15 3.2.1.4 pubmed
 uncultured organism ADX05718.1 E9NSM3  
 SARM_0046 / 1029836_111030 / MH-2 3.2.1.73 pubmed
 uncultured organism ADX05717.1 E9NSM2   38
 SARM_0034 / 694713_55880 / TW-39 3.2.1.4 pubmed
 uncultured organism ADX05705.1 E9NSL0   4
 SARM_0032 / 558318_19410 / MH-20 3.2.1.4 pubmed
 uncultured organism ADX05703.1 E9NSK8   4
 SARM_0026 / 457020_01700 / TW-40 3.2.1.4 pubmed
 uncultured organism ADX05697.1 E9NSK2 5UHX[A]
5WH8[A] 		2
 endo-β-1,4-glucanase (SARM_0025;421339_68070;TW-2) 3.2.1.4 pubmed
 uncultured organism ADX05696.1 E9NSK1   46
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