Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (54252); Uniprot accession (7858); PDB accession (465); 3D entries (110); cryst (2)
All (49476) Archaea (367) Bacteria (45982) Eukaryota (2997) unclassified (130) Structure (110 - 2 cryst) Characterized (812)
| 1 | ... | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | ... | 30 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 Dbus_chr2Rg508   Drosophila busckii ALC40929.1     17
 Dbus_chr2Rg1656   Drosophila busckii ALC42077.1     15
 Dbus_chr3Rg1717   Drosophila busckii ALC46967.1    
 Dbus_chr2Rg509   Drosophila busckii ALC40930.1     17
 Dbus_chr2Rg5   Drosophila busckii ALC40426.1     15
 Amy (fragment)   Drosophila busckii AAQ13447.1 Q5NKY0   15
 alpha amylase-related-protein, partial (AmyreL) (fragment)   Drosophila buzzatii AHL43633.1     15
 alpha amylase, partial (fragment)   Drosophila buzzatii AHL43646.1     15
 Amyrel   Drosophila camargoi AAO14607.1 Q8I9R2   15
 alpha amylase-related-protein, partial (AmyreL) (fragment)   Drosophila canalinea 15050-1201.00 AHL43634.1     15
 alpha amylase, partial (fragment)   Drosophila canalinea 15050-1201.00 AHL43647.1     15
 Amyrel   Drosophila cardini AAO14608.1 Q8I9R1   15
 Amyrel   Drosophila caribiana AAW64453.1     15
 Amyrel   Drosophila cauverii AAL99397.1 Q8T7W3   15
 amylase (fragment)   Drosophila cauverii INDIA BAC53974.1 Q8IAE5   15
 Amyrel   Drosophila cf. bocqueti light form AAL99391.1     15
 amylase (fragment)   Drosophila cf. bocqueti light form BAB39198.1 Q8IAF6   15
 amylase (fragment)   Drosophila cf. lini light form BAB39184.1 Q8IAH0   15
 Amyrel (fragment)   Drosophila cf. nigrilineata AY-2009 ADA77350.1 D2IP59   15
 Amyrel   Drosophila cf. papuensis JLDL-2005 AAW66394.1     15
 Amyrel   Drosophila chauvacae AAL99580.1 Q8STF8   15
 Amy (fragment)   Drosophila constricta AEM77106.1     15
 AmyreL (fragment)   Drosophila constricta AEM77114.1     15
 Amy (fragment)   Drosophila curveadeagus AEM77097.1     15
 AmyreL (fragment)   Drosophila curveadeagus AEM77115.1     15
 Amyrel (fragment)   Drosophila daruma AAW66437.1     15
 Amyrel   Drosophila davidi AAL99399.1 Q8T7W1   15
 amylase (fragment)   Drosophila davidi 183.1 BAC53975.1 Q8IAE4   15
 amylase-related protein (fragment)   Drosophila dianensis AEL29510.1     15
 amylase distal, partial (Amy-D) (fragment)   Drosophila differens AFM76790.1     15
 Amyrel   Drosophila diplacantha AAL99402.1 Q8T7V8   15
 amylase (fragment)   Drosophila diplacantha 14028-0586.0 BAB39178.1
BAB39177.1
Q8I0R0   15
 α-amylase (fragment)   Drosophila dossoui AAM69520.1 Q8MX68   15
 α-amylase (fragment)   Drosophila dossoui AAM69521.1 Q8MX67   15
 α-amylase (fragment)   Drosophila dossoui AAM69522.1 Q8MX66   15
 putative amylase   Drosophila dossoui AAC39114.2 O77021   15
 Amy3 (fragment)   Drosophila dossoui PGE 274 AAG42557.1     15
 Amy4 (fragment)   Drosophila dossoui PGE 274 AAG42556.1
AAM69519.1
Q8MX69   15
 Amy1 (fragment)   Drosophila dossoui PGE 274 AAG42555.1     15
 Amy2 (fragment)   Drosophila dossoui PGE-274 AAG42547.1     15
 Amy / Amy3 (fragment)   Drosophila elegans BAA22487.1 O15953   15
 Amyrel   Drosophila elegans AAF25712.1
AAF25712.2
Q9NJP0   15
 Amyrel   Drosophila ercepeae AAC39105.2 O77012   15
 putative amylase (fragment)   Drosophila ercepeae AAC47355.1 Q23929  
 putative amylase (fragment)   Drosophila ercepeae AAC47356.1 Q23930  
 α-amylase (distal)   Drosophila erecta BAA04581.1
CAA55520.1
Q27923   15
 α-amylase (proximal) (Amy) 3.2.1.1 Drosophila erecta BAA04582.1 Q23932   15
 putative amylase   Drosophila erecta AAC39091.2 O76265   15
 putative amylase (fragment)   Drosophila erecta AAA28368.1
AAA28369.1
Q27424   15
 Amyrel   Drosophila eugracilis AAL99579.1 Q8T7X6   15
 amylase (Amy1) (fragment)   Drosophila eugracilis BAA22488.1
BAA22489.1
O15954
O15955
  15
 putative amylase (fragment)   Drosophila eugracilis AAC47375.1 Q23931  
 Amyrel   Drosophila ficusphila AAO14609.1 Q8I9R0   15
 putative amylase (fragment)   Drosophila ficusphila BAA22490.1
AAC47376.1
BAA22491.1
O15956
O15957
Q23937
  15
 putative amylase (fragment)   Drosophila fima AAC47377.1 Q23938  
 Amyrel   Drosophila flavohirta AAW64454.1     15
 Amyrel   Drosophila formosana AAO14610.1 Q8I9Q9   15
 Amyrel   Drosophila funebris AAO13292.1 Q8IA39   15
 α-amylase (Amy)   Drosophila funebris AAO13291.1
AAC47357.1
AAQ13448.1
Q23936
Q5NKX9
Q8IA40
  15
 alpha amylase, partial (fragment)   Drosophila funebris 151201911.01 AHL43648.1     15
 Amy / Amy1 (fragment)   Drosophila fuyamai BAA22492.1 O15958   15
 Amy / Amy2 (fragment)   Drosophila fuyamai BAA22493.1 O15959   15
 AmyreL (fragment)   Drosophila fuyamai AEM77116.1     15
 Amyrel   Drosophila gibberosa AAW64444.1     15
 Amyrel   Drosophila greeni AAO14611.1 Q8I9Q8   15
 Amy1 (fragment)   Drosophila greeni PGE 168-5 AAG42560.1     15
 Amy2 (fragment)   Drosophila greeni PGE-168-5 AAG42551.1
AAM69523.1
AAM69524.1
Q8MX64
Q8MX65
  15
 Amyrel (fragment)   Drosophila grimshawi AAW66438.1     15
 α-amylase (Amy) (fragment)   Drosophila guanche AAN16141.1     15
 amylase-related protein (Amyrel) (fragment)   Drosophila guanche AAN16167.1 Q71U24   15
 amylase-related protein (Amyrel) (fragment)   Drosophila guanche AAN16192.1     15
 putative amylase (fragment)   Drosophila guanche AAC47358.1 Q23942   15
 putative amylase (fragment)   Drosophila guanche AAC47359.1 Q23943  
 Amyrel   Drosophila guaru AAO84661.1 Q86N68   15
 amylase-related protein (Amyrel) (fragment)   Drosophila helvetica AAN16197.1     15
 α-amylase (fragment)   Drosophila helvetica GIF AAN16159.1     15
 amylase distal, partial (Amy-D) (fragment)   Drosophila hemipeza AFM76791.1     15
 amylase distal, partial (Amy-D) (fragment)   Drosophila heteroneura AFM76792.1     15
 α-amylase (Amy) (fragment)   Drosophila hubeiensis AAN16142.1     15
 amylase related protein (Amyrel) (fragment)   Drosophila hubeiensis AAN16156.1     15
 amylase-related protein (fragment)   Drosophila hubeiensis AEL29511.1     15
 Amy (fragment)   Drosophila hydei AAQ13445.1 Q5NKY2   15
 Amyrel   Drosophila hydei AAW64445.1     15
 Amyrel (fragment)   Drosophila hydeoides AAW66439.1     15
 amylase-related protein (fragment)   Drosophila hypercephala AEL29509.1     15
 Amyrel   Drosophila hypocausta AAW64446.1     15
 amylase distal, partial (Amy-D) (fragment)   Drosophila hystricosa AFM76793.1     15
 Amyrel   Drosophila imaii AAL99393.1
AAN16161.1
Q8T7W7   15
 α-amylase (Amy) (fragment)   Drosophila imaii AAN16143.1     15
 Amyrel   Drosophila immigrans AAO84662.1 Q86N67   15
 alpha amylase-related-protein, partial (AmyreL) (fragment)   Drosophila inca E012 AHL43635.1     15
 alpha amylase, partial (fragment)   Drosophila inca E012 AHL43649.1     15
 Amyrel   Drosophila iri AAO84663.1 Q86N66   15
 α-amylase (fragment)   Drosophila jambulina AAM69525.1 Q8MX63   15
 Amyrel   Drosophila jambulina AAG48524.1 Q9GQV3   15
 amylase (fragment)   Drosophila jambulina 14028-0531.0 BAB39180.1     15
 amylase (fragment)   Drosophila jambulina 14028-0531.0 BAB39179.1     15
 Amy2 (fragment)   Drosophila jambulina PGE AAG42562.1     15
 Amy1 (fragment)   Drosophila jambulina PGE AAG42561.1     15
 amylase (fragment)   Drosophila kanapiae 14028-0541.0.DUP BAB39182.1 Q8IAH2   15
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