Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (58992); Uniprot accession (7858); PDB accession (472); 3D entries (111); cryst (2)
All (54201) Archaea (381) Bacteria (50596) Eukaryota (3094) unclassified (130) Structure (111 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 31 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 α-amylase (fragment)   Acanthochitona fascicularis ACA34373.1 D2YVN1  
 α-amylase (fragment)   Acanthochitona fascicularis ACA34376.1 D2YVN4  
 α-amylase (fragment)   Acanthochitona fascicularis ACA34378.1 D2YVN6  
 α-amylase (fragment)   Acanthochitona fascicularis ACA34382.1 D2YVP0  
 α-amylase (fragment)   Acanthochitona fascicularis ACA34384.1 D2YVP2  
 α-amylase (fragment)   Acanthochitona fascicularis ACA34385.1 D2YVP3  
 α-amylase 2, partial (AmY) (fragment)   Acanthochitona sp. AEA72219.1    
 AmY (fragment)   Acanthochitona sp. JLDL-2011 AEA72218.1    
 α-amylase / allergen (Aca s 4) 3.2.1.1 Acarus siro ABL09312.1 B0KZK1   24
 secreted protein   Achlya hypogyna ATCC 48635 AIG56379.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56379.1     1
 α-amylase (plastid) (Amy3)   Actinidia chinensis AFO84072.1
AAX33233.1
CAW95501.1
CAX01336.1
CAX06581.1
CAX06912.1
CBD14454.1
Q5BLY1   6
 α-amylase (Amy1)   Actinidia chinensis AFO84070.1     6
 α-amylase (Amy2)   Actinidia chinensis AFO84071.1     6
 ISA2   Actinidia deliciosa AOQ26242.1    
 ISA1   Actinidia deliciosa AOQ26241.1     11
 ISA3   Actinidia deliciosa AOQ26243.1     11
 PUL1   Actinidia deliciosa AOQ26240.1     13
 sucrase / α-glucosidase (S1;APS1) 3.2.1.20 Acyrthosiphon pisum ABB55878.1 Q0H3F1   17
 ACYPI004887 (fragment)   Acyrthosiphon pisum LSR1 BAH72207.1 C4WWD7   8
 ACYPI000002 (fragment)   Acyrthosiphon pisum LSR1 BAH72291.1 C4WWM1   17
 α-amylase (amy) (fragment)   Aedes aegypti AAA03321.1 Q16901  
 α-amylase I (AmyI) 3.2.1.1 Aedes aegypti AAA29343.1
AAA29344.1
AAA29345.1
AAB60935.1
O02413
P53354
  15
 α-amylase II (AmyII) 3.2.1.1 Aedes aegypti AAB60934.1 O02652   15
 α-glucosidase (Mal1;MalI; AAEL009524-PA)   Aedes aegypti AAA29352.1
AAA29351.1
ABM68601.1
ACC76784.1
ACC76785.1
ACC76786.1
CBF79241.1
P13080   17
 α-glucosidase (Aam1;AaeL_AAEL010537)   Aedes aegypti Liverpool XP_001660909.1     17
 ORF   Aedes albopictus AAV90637.1
CAZ78874.1
Q5MIZ5   17
 α-amylase 3.2.1.1 Aedes atropalpus AAA03322.1 Q16924   15
 isoamylase   Aegilops tauschii AAP44579.1 Q7XA16   11
 Sequence 6 from patent US 6916976   Aegilops tauschii ABA16971.1     8
 Sequence 12 from patent US 6916976   Aegilops tauschii ABA16972.1     8
 Sequence 71 from patent US 6916976   Aegilops tauschii ABA16992.1     8
 starch branching enzyme IIb (SBE II-DB1) (fragments)   Aegilops tauschii AAW80632.1
AAW80633.1
Q24M32   8
 SBE-I   Aegilops tauschii subsp. strangulata AAD30187.1 Q6KFU0   8
 starch branching enzyme (SbE)   Amaranthus caudatus BAR73032.1     8
 starch branching enzyme (SbE)   Amaranthus hybridus subsp. cruentus BAR73033.1     8
 isoamylase1-type starch debranching enzyme (Dbe1;DBE)   Amaranthus hybridus subsp. cruentus BAP91163.1     11
 isoamylase-type starch debranching enzyme 3 (Isa3;CrISA3) 3.2.1.68 Amaranthus hybridus subsp. cruentus BAQ22171.1     11
 starch branching enzyme (SbE)   Amaranthus hypochondriacus BAR73034.1     8
 ORF   Amblyomma maculatum AEO34594.1    
 ORF   Amblyomma maculatum AEO36080.1     8
 ORF (fragment)   Amblyomma maculatum AEO32115.1     24
 α-amylase (fragment)   Amphipholis squamata ACA34390.1 D2YVP8  
 α-amylase (Amy) (fragment)   Anatalanta aptera AAY88824.1 Q3SCC4   15
 α-amylase (Amy) 3.2.1.1 Anguilla japonica BAB85635.1 Q8QGW2   24
 α-amylase   Anisakis simplex APP18134.1    
 glycogen-debranching enzyme (AgL)   Anisakis simplex APP18135.1     25
 1,4-α-glucan branching enzyme (GbE)   Anisakis simplex APP18136.1     8
 α-amylase (Aamy1) 3.2.1.20 Anopheles albimanus ADD81256.1 D4N3A2   17
 salivary ORF (fragment)   Anopheles darlingi ACI30109.1 B6DDW2  
 salivary ORF (fragment)   Anopheles darlingi ACI30110.1 B6DDW3   17
 salivary ORF (fragment)   Anopheles darlingi ACI30111.1 B6DDW4  
 salivary ORF (fragment)   Anopheles darlingi ACI30112.1 B6DDW5  
 salivary ORF (fragment)   Anopheles darlingi ACI30114.1 B6DDW7  
 salivary maltase   Anopheles darlingi ACI30102.1 B7T4S1   17
 salivary maltase (fragment)   Anopheles funestus ABI83755.1 Q06DJ2  
 amylase (fragment)   Anopheles gambiae AAL68692.1 Q8WQZ0  
 α-amylase (Amy)   Anopheles gambiae AAA29357.1 Q17023   15
 α-glucosidase (fragment)   Anopheles gambiae G3 CAA93821.1 Q17032  
 α-glucosidase (Agm1) 3.2.1.20 Anopheles gambiae G3 CAA60857.1 Q17021   17
 α-glucosidase (Agm2) 3.2.1.20 Anopheles gambiae G3 CAA60858.1
CBF79157.1
Q17022   17
 α-glucosidase / binding-toxin receptor (Agm3;AgAgm3) 3.2.1.20 Anopheles gambiae G3 ABW98683.1 A9YDV2   17
 unnamed protein product   Anopheles gambiae str. PEST CAZ78774.1     17
 unnamed protein product (fragment)   Anopheles gambiae str. PEST CAZ78775.1     17
 α-amylase 3.2.1.1 Anopheles merus AAA03323.1 Q17059   15
 alpha amylase 2 (Amy2)   Anoplarchus purpurescens AMQ67314.1     24
 α-amylase (fragment)   Anoplarchus purpurescens ABJ97443.1 A0FCQ4   24
 α-amylase   Antheraea pernyi Shenhuang No.2 AJR29308.1     17
 α-amylase (Amylag1) 3.2.1.1 Anthonomus grandis AAN77138.1
AOG18226.1
Q8I9K6   15
 α-amylase (Amylag2) 3.2.1.1 Anthonomus grandis AAN77139.1 Q8I9K5   15
 ACCB10398   Apis cerana AEY60887.1     15
 ACCB00300.1   Apis cerana AEY57597.1     8
 α-glucosidase (Hbg2) (fragment)   Apis cerana cerana ABR24827.1 A6NAF4   17
 α-glucosidase II   Apis cerana indica AFR59339.1     17
 α-glucosidase I   Apis cerana indica AGE11865.1     17
 α-glucosidase 3.2.1.20 Apis cerana indica ABO27432.1 A4GVI6   17
 sucrase / α-glucosidase II (JBgII;HBGaseII) 3.2.1.20
3.2.1.-
Apis cerana japonica ACN63343.1 C0LQJ2   17
 α-glucosidase III (JBgIII)   Apis cerana japonica ACQ45697.1 C3VPV8   17
 α-glucosidase I (JBgI) 3.2.1.20 Apis cerana japonica BAF44218.1 A1IHL0   17
 α-glucosidase III 3.2.1.20 Apis dorsata ADB11049.1 D2XNP9   17
 α-glucosidase III (Hbg3;HBG-III;Loc406131) 3.2.1.20 Apis mellifera BAA11466.1
BAE86928.1
CBF79234.1
NP_001011608.1
XP_392790.1
Q17058 cryst 17
 α-glucosidase I (Hbg1;HBG-I;Loc409889) 3.2.1.20 Apis mellifera BAE86926.1
XP_393379.2
Q25BT8   17
 α-glucosidase II (Hbg2;HBG-II;Loc411257) 3.2.1.20 Apis mellifera BAE86927.1
CBF79049.1
XP_394730.1
Q25BT7   17
 α-amylase (LOC406114)   Apis mellifera mellifera AAM20738.1
XP_391983.1
Q8N0N7   15
 pullulanase / isoamylase (Lda;AtPU1;AtLDA;LDA1;At5g04360) 3.2.1.41
3.2.1.68
Arabidopsis thaliana AAO00771.1
AED90732.1
ANM68325.1
NP_196056.1
Q8GTR4   13
 branching-enzyme 2 (BE2;Sbe2-1;Sbe2.1;At2g36390) 2.4.1.18 Arabidopsis thaliana AAD24644.1
AAB03099.1
AAM97077.1
ABC04873.1
AEC09247.1
BAE98973.1
CAA04134.1
NP_181180.1
O23647
Q42526
  8
 branching-enzyme 3 (BE3;sbe2-2;sbe2.2;At5g03650) 2.4.1.18 Arabidopsis thaliana CAB82930.1
AAB03100.1
ABC04874.1
AED90637.1
BAC42378.1
NP_195985.1
Q42531
Q8GYC4
Q9LZS3
  8
 α-amylase (AtAmy1;At4g25000) (apoplast) 3.2.1.1 Arabidopsis thaliana CAB36742.1
AAL38709.1
AAM51369.1
AAM64582.1
AEE84990.1
CAB79409.1
NP_567714.1
Q8LBS5
Q8VZ56
Q9SW26
  6
 At1g03310 (chloroplastic isoamylase 2;AtISA2;Iso1 subunit;DBE1) 3.2.1.68 Arabidopsis thaliana AAC72113.1
AAM98123.1
AEE27557.1
AEE27558.1
NP_171830.1
Q8L735
Q9ZVT2
  11
 At2g39930 (chloroplastic isoamylase 2;AtISA1;Iso1 subunit) 3.2.1.68 Arabidopsis thaliana AAB95278.1
AAN17420.1
AAQ56791.1
AEC09752.1
ANM62439.1
ANM62440.1
NP_181522.1
O04196   11
 α-amylase (AMY3;AtAMY3;At1g69830)   Arabidopsis thaliana AAK91414.1
AAF07390.1
AAG52558.1
AAN18209.1
AEE34983.1
CAW95489.1
CAX01331.1
CAX06576.1
CAX06907.1
CBD14444.1
NP_564977.1
Q94A41
Q9CAR6
  6
 At1g76130 (AtAMY2)   Arabidopsis thaliana AAM61434.1
AAF17626.1
ABF58978.1
AEE35800.1
ANM61100.1
BAD94995.1
NP_177740.1
Q8LFG1
Q9SGS0
  6
 chloroplastic isoamylase 3 (Isa3;AtISA3;At4g09020) 3.2.1.68 Arabidopsis thaliana CAB78026.1
AAM13879.1
AAM91673.1
AEE82713.1
BAE99109.1
NP_192641.1
Q8RWW6
Q9M0S5
  11
 branching-enzyme 1 (Be1;AtSBEIII;At3g20440) (AtBEI) 2.4.1.18 Arabidopsis thaliana BAC43378.1
ADB29066.1
AEE76378.1
AEE76379.1
AEE76380.1
BAB02827.1
NP_188679.1
D2WL32
Q8GWK4
Q9LTP8
  8
 1,4-α-glucan starch branching enzyme (fragment)   Artemia franciscana ABK91832.1 A1DU42  
 EGX51283.1   Arthrobotrys oligospora ATCC 24927 EGX51283.1     8
 EGX51015.1   Arthrobotrys oligospora ATCC 24927 EGX51015.1     25
 EGX47164.1   Arthrobotrys oligospora ATCC 24927 EGX47164.1     40
 EGX46868.1   Arthrobotrys oligospora ATCC 24927 EGX46868.1     5
 EGX42980.1   Arthrobotrys oligospora ATCC 24927 EGX42980.1    
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