Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (54252); Uniprot accession (7858); PDB accession (465); 3D entries (110); cryst (2)
All (49476) Archaea (367) Bacteria (45982) Eukaryota (2997) unclassified (130) Structure (110 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 30 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 4F2 cell-surface antigen heavy chain (4f2hC)   Canis lupus familiaris BAO65809.1     34
 amino acid transporter SLC3A1   Canis lupus familiaris MIXED BREED AAG34759.1 Q9GKM3   35
 alpha amylase 2 (Amy2)   Cebidichthys violaceus AMQ67308.1     24
 alpha amylase 2 (Amy2)   Cebidichthys violaceus AMQ67309.1     24
 α-amylase (fragment)   Cebidichthys violaceus ABK57091.1 A0MJA3   24
 α-amylase, partial (fragment)   Centropomus undecimalis AFP86439.1    
 α-amylase (fragment)   Cerastoderma edule ACA34380.1 D2YVN8  
 starch branching enzyme I, partial (chloroplast) (fragment)   Cerasus xueluoensis AMP82277.1     8
 α-amylase (Amy)   Ceratitis capitata AAO13691.1
AAC47371.1
Q17311
Q8IA48
  15
 Amyrel   Ceratitis capitata AAO13692.1 Q8IA47   15
 α-amylase (fragment)   Ceratopteris richardii ABC87289.1 Q0QJL6   6
 α-amylase (Amy) (fragment)   Chaetonerius sp. FM-2005a AAY88823.1 Q3SCC5   15
 α-amylase (Amy) (fragment)   Chaetonerius sp. FM-2005b AAY88832.1 Q3SCB6   15
 pancreatic α-amylase (Amy2) (fragment)   Chelon labrosus CAX64421.1 C0MQV6   24
 α-amylase   Chelon labrosus AIC81809.1     24
 isoamylase 1 (Isa1;CrISA1;Sta7) 3.2.1.68 Chlamydomonas reinhardtii CC425 AAP85534.1
AAP88032.1
CAZ78881.1
Q7X8Q2 4J7R[A,B]
4OKD[A,B]
11
 Amyrel (fragment)   Chymomyza amoena AAW66449.1     15
 ORF (fragment)   Cichlasoma urophthalmum CDJ79882.1     24
 α-amylase (fragment)   Cimex lectularius ACA34377.1 D2YVN5  
 amylase, partial (fragment)   Cirrhinus cirrhosus AHY00276.1     24
 α-amylase (fragment)   Citrus reticulata AAM18229.1 Q8RW88   6
 ORF (fragment)   Citrus sinensis AFD62766.1     6
 ORF (short fragment)   Citrus sinensis AFD62767.1     6
 amylase, partial (fragment)   Clarias batrachus ART46312.1     24
 1,4-α-glucan-branching enzyme   Cocos nucifera AIC82459.1     8
 α-amylase (Amy) (fragment)   Coelopa frigida AAY88833.1 Q3SCB5   15
 α-amylase (Amy) (fragment)   Coelopa frigida AAY88834.1 Q3SCB4   15
 AmY   Colobus angolensis ABW02886.1 A8HDI0   24
 starch branching enzyme A (SbeA)   Colocasia esculenta ABP96984.1
ANC33494.1
A5HSI0   8
 ORF (fragment)   Coptotermes formosanus AGM32281.1     17
 ORF (fragment)   Coptotermes formosanus AGM32321.1     17
 ORF (fragment)   Coptotermes formosanus AGM32822.1     17
 ORF (fragment)   Coptotermes formosanus AGM32823.1     17
 α-amylase (Amy)   Corbicula fluminea AAO17927.2 Q8I9P8  
 alpha amylase   Cosmopolites sordidus AKN63428.1     15
 ORF   Cotesia congregata CAR82255.1 B9W4L8   15
 starch branching enzyme I, partial (SbeI) (fragment)   Cotoneaster franchetii AMX81600.1     8
 starch branching enzyme I, partial (SbeI) (fragment)   Cotoneaster hebephyllus AMX81601.1     8
 starch branching enzyme I, partial (SbeI) (fragment)   Cotoneaster moupinensis AMX81602.1     8
 α-1,4-glucan-branching enzyme (GlgB)   Crassostrea angulata CCN27374.1     8
 ORF (fragment)   Crassostrea ariakensis AEF33381.1    
 α-amylase B (AmyB;Amy) 3.2.1.1 Crassostrea gigas AAL37207.1
ABB80387.1
ABB80388.1
ABR37235.1
ACC77978.1
ACC77979.1
ACC77980.1
CAD43101.1
CAD43102.1
CAD43103.1
CAD43104.1
Q8I7E4
Q8I7E5
Q8I7E6
Q8I7E7
Q8WSG9
  24
 α-amylase A (AmyA;Amy) 3.2.1.1 Crassostrea gigas AAL37183.1
ACB29736.1
ACC77975.1
ACC77976.1
ACC77977.1
CAA69658.1
CAD43095.1
CAD43096.1
CAD43097.1
CAD43098.1
CAD43099.1
CAD43100.1
O02622
Q8I080
Q8I0T4
Q8I7E8
Q8WSH2
  24
 Agl (fragment)   Crassostrea gigas CAD79439.1 Q86G99  
 AmY (fragment)   Crassostrea gigas AEA72216.1    
 starch branching enzyme I, partial (SbeI) (fragment)   Crataegus scabrifolia AMX81603.1     8
 CD98-related protein   Cricetulus griseus AAB97631.1 O55221   34
 CGB_A3550C   Cryptococcus gattii WM276 ADV19568.1     8
 CGB_F5660C   Cryptococcus gattii WM276 ADV23114.1     30
 CGB_B1340C   Cryptococcus gattii WM276 ADV20192.1     1
 CGB_E4540C   Cryptococcus gattii WM276 ADV22582.1     1
 CGB_J0390W   Cryptococcus gattii WM276 ADV24562.1     25
 CGB_G0540W   Cryptococcus gattii WM276 ADV23254.1     5
 CGB_G0300C   Cryptococcus gattii WM276 ADV23282.1     22
 CGB_J0550C   Cryptococcus gattii WM276 ADV24576.1     1
 CGB_E0010C (fragment)   Cryptococcus gattii WM276 ADV22324.1     40
 CGB_K1010W   Cryptococcus gattii WM276 ADV25090.1     1
 CNAG_05913   Cryptococcus neoformans var. grubii H99 AFR96233.1     30
 CNAG_00393   Cryptococcus neoformans var. grubii H99 AFR92526.1     8
 CNAG_00122   Cryptococcus neoformans var. grubii H99 AFR92258.1     1
 CNAG_02189   Cryptococcus neoformans var. grubii H99 AFR95631.1     1
 CNAG_03120   Cryptococcus neoformans var. grubii H99 AFR96345.1
AFR96345.2
AGV14519.1
    22
 CNAG_05264   Cryptococcus neoformans var. grubii H99 AFR94522.1
AGV14255.1
    1
 CNAG_03146   Cryptococcus neoformans var. grubii H99 AFR96372.1
AFR96372.2
    5
 CNAG_04879   Cryptococcus neoformans var. grubii H99 AFR97337.1
AFR97337.2
    25
 CNAG_06260   Cryptococcus neoformans var. grubii H99 AFR98494.1     40
 CNAG_01940   Cryptococcus neoformans var. grubii H99 AFR98135.1
AGV14739.1
    1
 CNG04200   Cryptococcus neoformans var. neoformans JEC21 AAW44866.1
AAW44867.1
Q5KDF2   5
 CNN00140   Cryptococcus neoformans var. neoformans JEC21 AAW47005.1
AAW47005.2
Q5K7E4   40
 CNA03810   Cryptococcus neoformans var. neoformans JEC21 AAW40900.1 P0CN82   8
 CNL03660   Cryptococcus neoformans var. neoformans JEC21 AAW46412.1 Q5K924   1
 CNK02760   Cryptococcus neoformans var. neoformans JEC21 AAW46356.1 Q5K993   1
 CNF00610   Cryptococcus neoformans var. neoformans JEC21 AAW43932.1 Q5KFT6   30
 CNJ03090   Cryptococcus neoformans var. neoformans JEC21 AAW45872.1 Q5KA48   25
 α-1,3-glucan synthase (Ags1;CNG04420) 2.4.1.183 Cryptococcus neoformans var. neoformans JEC21 AAW44814.1
AAR97368.1
Q5KDD1   22
 CNH03660   Cryptococcus neoformans var. neoformans JEC21 AAW45221.1 Q5K924   1
 CNA01120   Cryptococcus neoformans var. neoformans JEC21 AAW41268.1 Q5KPY6   1
 CNE03480   Cryptococcus neoformans var. neoformans JEC21 AAW43607.1 Q5KGI6   1
 α-amylase (Amy-CS2) 3.2.1.1 Cryptococcus sp. S-2 BAA12010.1
BAA12011.1
Q92394   1
 1MB.26   Cryptosporidium parvum CAD98636.1 Q7YY51   25
 cgd6_3280 (1MB.422)   Cryptosporidium parvum CAD98370.1
EAK89954.1
Q7YYW0   9
 1MB.513   Cryptosporidium parvum CAD98416.1 Q7YYR4  
 α-amylase (Amy2A)   Ctenopharyngodon idella ACX35465.1 D0EM61   24
 pancreatic amylase (AmY) (fragment)   Ctenopharyngodon idella ACV04936.1 D4HNE8   24
 α-amylase (fragment)   Ctenopharyngodon idella ADY39424.1     24
 starch branching enzyme   Cucumis melo subsp. melo ADN33992.1 E5GBZ3   8
 cytosolic α-amylase   Cucumis melo subsp. melo ADN34132.1 E5GCD3   6
 starch branching enzyme I (CS_SBa_056C11) (fragment)   Cucumis sativus ACA35282.1 B3U2B7   8
 starch branching enzyme I (CS_SBa_075L23)   Cucumis sativus ACA35286.1 B3U2C1   8
 SbeII (fragment)   Cucurbita moschata AEV91543.1     8
 starch debranching enzyme, partial (IsaI) (fragment)   Cucurbita moschata AEV91544.1     11
 α-glucosidase / maltase 1 (Cpm1) (binary toxin-binding) 3.2.1.20 Culex pipiens AAL05443.1 Q95WY5   17
 maltase 1 (Cpm1) (fragment)   Culex pipiens BP ABN64095.1 A4KVA0   17
 maltase 1 (Cpm1) (possible frameshift)   Culex pipiens BP ABN64096.1 A4KVA1   17
 ORF   Culex pipiens pallens AAZ15878.1 Q4F8A2   8
 maltase 1 (Cpm1)   Culex pipiens S-LAB ABN64094.1 A4KV99   17
 binary toxin receptor protein   Culex quinquefasciatus ASO96882.1     17
 binary toxin receptor protein   Culex quinquefasciatus ASO96881.1     17
 α-glucosidase / maltase 1 (Cqm1) (mid-gut)   Culex quinquefasciatus ABC59609.1 Q1PQK2   17
 salivary α-glucosidase   Culex tarsalis ACJ64288.1 B8RIZ0   17
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