Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (60437); Uniprot accession (7858); PDB accession (485); 3D entries (113); cryst (2)
All (55616) Archaea (381) Bacteria (51891) Eukaryota (3214) unclassified (130) Structure (113 - 2 cryst) Characterized (813)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 33 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 CNL03660   Cryptococcus neoformans var. neoformans JEC21 AAW46412.1 Q5K924   1
 CNK02760   Cryptococcus neoformans var. neoformans JEC21 AAW46356.1 Q5K993   1
 CNF00610   Cryptococcus neoformans var. neoformans JEC21 AAW43932.1 Q5KFT6   30
 CNJ03090   Cryptococcus neoformans var. neoformans JEC21 AAW45872.1 Q5KA48   25
 α-1,3-glucan synthase (Ags1;CNG04420) 2.4.1.183 Cryptococcus neoformans var. neoformans JEC21 AAW44814.1
AAR97368.1
Q5KDD1   22
 CNH03660   Cryptococcus neoformans var. neoformans JEC21 AAW45221.1 Q5K924   1
 CNA01120   Cryptococcus neoformans var. neoformans JEC21 AAW41268.1 Q5KPY6   1
 CNE03480   Cryptococcus neoformans var. neoformans JEC21 AAW43607.1 Q5KGI6   1
 α-amylase (Amy-CS2) 3.2.1.1 Cryptococcus sp. S-2 BAA12010.1
BAA12011.1
Q92394   1
 1MB.26   Cryptosporidium parvum CAD98636.1 Q7YY51   25
 cgd6_3280 (1MB.422)   Cryptosporidium parvum CAD98370.1
EAK89954.1
Q7YYW0   9
 1MB.513   Cryptosporidium parvum CAD98416.1 Q7YYR4  
 α-amylase (Amy2A)   Ctenopharyngodon idella ACX35465.1 D0EM61   24
 pancreatic amylase (AmY) (fragment)   Ctenopharyngodon idella ACV04936.1 D4HNE8   24
 α-amylase (fragment)   Ctenopharyngodon idella ADY39424.1     24
 starch branching enzyme   Cucumis melo subsp. melo ADN33992.1 E5GBZ3   8
 cytosolic α-amylase   Cucumis melo subsp. melo ADN34132.1 E5GCD3   6
 starch branching enzyme I (CS_SBa_056C11) (fragment)   Cucumis sativus ACA35282.1 B3U2B7   8
 starch branching enzyme I (CS_SBa_075L23)   Cucumis sativus ACA35286.1 B3U2C1   8
 SbeII (fragment)   Cucurbita moschata AEV91543.1     8
 starch debranching enzyme, partial (IsaI) (fragment)   Cucurbita moschata AEV91544.1     11
 α-glucosidase / maltase 1 (Cpm1) (binary toxin-binding) 3.2.1.20 Culex pipiens AAL05443.1 Q95WY5   17
 maltase 1 (Cpm1) (fragment)   Culex pipiens BP ABN64095.1 A4KVA0   17
 maltase 1 (Cpm1) (possible frameshift)   Culex pipiens BP ABN64096.1 A4KVA1   17
 ORF   Culex pipiens pallens AAZ15878.1 Q4F8A2   8
 maltase 1 (Cpm1)   Culex pipiens S-LAB ABN64094.1 A4KV99   17
 binary toxin receptor protein   Culex quinquefasciatus ASO96882.1     17
 binary toxin receptor protein   Culex quinquefasciatus ASO96881.1     17
 α-glucosidase / maltase 1 (Cqm1) (mid-gut)   Culex quinquefasciatus ABC59609.1 Q1PQK2   17
 salivary α-glucosidase   Culex tarsalis ACJ64288.1 B8RIZ0   17
 starch branching enzyme (fragment)   Culex tarsalis ACJ64305.1 B8RJ07   8
 α-glucosidase (fragment)   Culex tarsalis ACJ64310.1 C4N154   17
 α-amylase (fragment)   Culex tarsalis ACJ64321.1 B8RJ22  
 α-amylase (fragment)   Culex tarsalis ACJ64402.1 B8RJA3   15
 α-amylase (fragment)   Culex tarsalis ACJ64479.1 B8RJI0  
 α-amylase 3.2.1.1 Culex tarsalis AAA03350.1 Q23767   15
 maltase   Culicoides nubeculosus ACM40914.1 B9URL7   17
 maltase / allergen (Cul n 8)   Culicoides nubeculosus ADJ67272.1 D9IL18   17
 maltase / allergen (Cul o 1)   Culicoides obsoletus AGI16774.1     17
 α-amylase (Amy1;CsAMY1) (fragment)   Culicoides sonorensis AAU06472.1 Q66UE3  
 maltase / allergen (Mal1;CsMAL1;Cul s 1)   Culicoides sonorensis AAU06480.1 Q66UC5   17
 ORF (fragment)   Culicoides sonorensis AAV84200.1 Q5QBM4   17
 α-amylase (fragment)   Culter alburnus ADY39430.1     24
 α-amylase (Amy) (fragment)   Curtonotidae sp. FM-2005a AAY88835.1 Q3SCB3   15
 α-amylase (Amy) (fragment)   Curtonotidae sp. FM-2005b AAY88836.1 Q3SCB2   15
 α-amylase 3.2.1.1 Cuscuta reflexa AAA16513.1 Q42678   6
 CYME_CMB158C   Cyanidioschyzon merolae strain 10D BAM78952.1    
 CYME_CMD033C   Cyanidioschyzon merolae strain 10D BAM79124.1    
 CYME_CMH144C   Cyanidioschyzon merolae strain 10D BAM79815.1     8
 CYME_CMI294C   Cyanidioschyzon merolae strain 10D BAM80148.1     11
 CYME_CMP300C   Cyanidioschyzon merolae strain 10D BAM81898.1     14
 CYME_CMS197C   Cyanidioschyzon merolae strain 10D BAM82814.1     11
 CYFA0S_03e04170g   Cyberlindnera fabianii YJS4271 CDR39508.1     40
 CYFA0S_03e05952g   Cyberlindnera fabianii YJS4271 CDR39670.1     40
 CYFA0S_03e05974g   Cyberlindnera fabianii YJS4271 CDR39674.1     40
 CYFA0S_03e06634g   Cyberlindnera fabianii YJS4271 CDR39735.1     25
 CYFA0S_07e01398g   Cyberlindnera fabianii YJS4271 CDR41381.1     8
 starch branching enzyme I, partial (SbeI) (fragment)   Cydonia oblonga AMX81604.1     8
 α-amylase   Cynoglossus semilaevis AGT37610.1     24
 rBAT protein (RbaT)   Cyprinus carpio AEX13745.1     17
 RbaT (fragment)   Cyprinus carpio ABY57295.1 B0FGW1   35
 α-amylase (fragment)   Cyprinus carpio jian AFB76589.1     24
 α-amylase (Amy) (fragment)   Cypselidae sp. FM-2005 AAY88837.1 Q3SCB1   15
 α-amylase   Dactylis glomerata ACY38052.1 D0VEB9   6
 α-amylase   Dactylis glomerata ACZ72923.1 D2K7Z9   6
 DKEY-202M23.2-001 (partial)   Danio rerio CAX14245.1 B8JJX3   17
 ORF   Danio rerio AAH44497.1
AAH63982.1
Q803G1   34
 Unknown (protein for MGC:66313)   Danio rerio AAH54681.1
AAI65756.1
NP_956722.1
Q7SYK9   24
 α-amylase 3 (Amy2A) (pancreatic)   Danio rerio AAH54669.1
AAH62867.1
CAQ15469.1
Q7SYL6   24
 Unknown (protein for MGC:92137)   Danio rerio AAH75900.1 Q6DHR7   24
 Unknown (protein for MGC:158423)   Danio rerio AAI28866.1 A1A5Y9   34
 solute carrier (Slc3a2)   Danio rerio AAH53236.1
AAG37838.1
AAI59203.1
NP_571676.1
Q7T2P3
Q9DDS9
  34
 DEHA0A14300g   Debaryomyces hansenii CBS767 CAG84911.1 Q6BXY6   40
 DEHA0B01650g   Debaryomyces hansenii CBS767 CAG85024.1 Q6BXN1   8
 DEHA0E00627g   Debaryomyces hansenii CBS767 CAG87533.1 Q6BR20   40
 DEHA2C06864g   Debaryomyces hansenii CBS767 CAG86039.2     25
 α-amylase (Amy) (fragment)   Delia radicum AAY88825.1 Q3SCC3   15
 α-amylase (Amy) (fragment)   Delia radicum AAY88826.1 Q3SCC2   15
 α-amylase (Amy) (fragment)   Delia radicum AAY88827.1 Q3SCC1   15
 unknown   Dendroctonus ponderosae AEE61654.1     15
 unknown   Dendroctonus ponderosae AEE62033.1     8
 unknown (fragment)   Dendroctonus ponderosae AEE61835.1     17
 allergen (Der f 4)   Dermatophagoides farinae AHX03180.1     24
 Der f 4 allergen (Der_f_4.0107)   Dermatophagoides farinae AIP86945.1     24
 Der f 4 allergen (Der_f_4.0101)   Dermatophagoides farinae AIP86939.1     24
 Der f 4 allergen (Der_f_4.0104)   Dermatophagoides farinae AIP86942.1     24
 Der f 4 allergen (Der_f_4.0106)   Dermatophagoides farinae AIP86944.1     24
 Der f 4 allergen (Der_f_4.0105)   Dermatophagoides farinae AIP86943.1     24
 Der f 4 allergen (Der_f_4.0103)   Dermatophagoides farinae AIP86941.1     24
 Der f 4 allergen (Der_f_4.0108)   Dermatophagoides farinae AIP86946.1     24
 Der f 4 allergen (Der_f_4.0102)   Dermatophagoides farinae AIP86940.1     24
 Der f 4 allergen   Dermatophagoides farinae AJF93907.1     24
 α-amylase (Der p 4;Derp4) (allergen) 3.2.1.1 Dermatophagoides pteronyssinus AAD38942.1 P49274
Q9Y197
  24
 α-amylase 3.2.1.1 Diabrotica virgifera virgifera AAF20998.1 Q9U406   15
 Amy1   Diatraea saccharalis AAP92665.1 Q7YXU5   15
 Amy3   Diatraea saccharalis AAP97394.1 Q7YXJ3   15
 Amy2   Diatraea saccharalis AAP97393.1 Q7YXJ4   15
 α-amylase (Amy2) (fragment)   Dicentrarchus labrax CAC33515.1 Q98TR6  
 starch branching enzyme I, partial (SbeI) (fragment)   Dichotomanthes tristaniicarpa AMX81605.1     8
 alpha amylase 2 (Amy2)   Dictyosoma burgeri AMQ67310.1     24
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