Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (763); Uniprot accession (107); PDB accession (63); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 M5005_Spy_1314 (HyL)   Streptococcus pyogenes MGAS5005 AAZ51932.1    
 M28_Spy1355 (HyL)   Streptococcus pyogenes MGAS6180 AAX72465.1    
 Hyl   Streptococcus pyogenes MGAS8232 AAL98163.1
NP_607664.1
Q8P022  
 MGAS9429_Spy1308 (hyl)   Streptococcus pyogenes MGAS9429 ABF32495.1 Q1JKS4  
 MTB313_1331 (HyL)   Streptococcus pyogenes MTB313 BAQ51738.1    
 MTB314_1250 (HyL)   Streptococcus pyogenes MTB314 BAQ53413.1    
 ERS445054_01436 (HyL)   Streptococcus pyogenes NCTC8198 CKH04861.1    
 SD89_02740   Streptococcus pyogenes NGAS322 AKZ50040.1    
 DK93_02705   Streptococcus pyogenes NGAS327 AKI38372.1    
 DK92_02820   Streptococcus pyogenes NGAS596 AKI36763.1    
 SD90_06060   Streptococcus pyogenes NGAS638 AKZ52495.1    
 DI45_07475   Streptococcus pyogenes NGAS743 AKI35833.1    
 A4265_05840   Streptococcus pyogenes NS53 ANC74791.1    
 Spy49_1236c (HyL)   Streptococcus pyogenes NZ131 ACI61522.1 B5XMG0  
 SPs0567   Streptococcus pyogenes SSI-1 BAC63662.1
NP_801829.1
F7IV97  
 VT08_06480   Streptococcus pyogenes STAB09014 ANP29859.1    
 B4W66_06545   Streptococcus pyogenes STAB090229 ASQ21555.1    
 VU19_06965   Streptococcus pyogenes STAB10015 AKL63572.1    
 STAB1102_06475   Streptococcus pyogenes STAB1102 AIG49217.1    
 B5D85_07215   Streptococcus pyogenes STAB120304 ASQ23430.1    
 AXK13_06415   Streptococcus pyogenes STAB13021 AND05195.1    
 AYM92_07025   Streptococcus pyogenes STAB14018 ARV01657.1    
 STAB901_06555   Streptococcus pyogenes STAB901 AIG50640.1    
 STAB902_03225   Streptococcus pyogenes STAB902 AIG46862.1    
 SpyM50541   Streptococcus pyogenes str. Manfredo CAM29879.1 A2RDF4  
 SNAG_1586 (NagH)   Streptococcus sp. NPS 308 BAV80455.1    
 AXF18_04995   Streptococcus sp. oral taxon 064 W10853 ANR75301.1    
 AXE83_07220   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97395.1    
 V470_10735   Streptococcus sp. VT 162 AJZ74457.1    
 SMD11_4482 (HyA)   Streptomyces albireticuli SMD11 ARZ70083.1    
 DC74_3168   Streptomyces albulus NK660 AIA03668.1    
 DC74_6418   Streptomyces albulus NK660 AIA06855.1    
 DC74_7083   Streptomyces albulus NK660 AIA07511.1    
 SAZ_32240   Streptomyces albulus ZPM AKA06592.1    
 SAZ_16910   Streptomyces albulus ZPM AKA03945.1    
 SAZ_36730   Streptomyces albulus ZPM AKA07330.1    
 SLNHY_7224   Streptomyces albus BK3-25 AOU81915.1    
 SLNWT_7238   Streptomyces albus DSM 41398 AJE87614.1    
 XNR_2089   Streptomyces albus J1074 AGI88465.1    
 XNR_4292   Streptomyces albus J1074 AGI90623.1    
 Salbus254_4525   Streptomyces albus SM254 AMM10985.1    
 Salbus254_2354   Streptomyces albus SM254 AMM08865.1    
 SAM23877_2700   Streptomyces ambofaciens ATCC 23877 AKZ55749.1    
 SAM23877_1062   Streptomyces ambofaciens ATCC 23877 AKZ54111.1    
 SAML0971   Streptomyces ambofaciens ATCC 23877 CAJ89957.1 A3KJS2  
 SAM40697_2476   Streptomyces ambofaciens DSM 40697 ANB06435.1    
 SAM40697_0930   Streptomyces ambofaciens DSM 40697 ANB04891.1    
 BV401_16825   Streptomyces autolyticus CGMCC0516 AQA11885.1    
 BV401_05140   Streptomyces autolyticus CGMCC0516 AQA09972.1    
 SBI_00159   Streptomyces bingchenggensis BCW-1 ADI03280.1 D7BUT9  
 SBI_07080   Streptomyces bingchenggensis BCW-1 ADI10200.1 D7C3H5  
 TU94_11620   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP02049.1    
 KY5_2790   Streptomyces formicae KY5 ATL27808.1    
 SFUL_2231   Streptomyces fulvissimus DSM 40593 AGK77186.1    
 B1H19_15215   Streptomyces gilvosporeus F607 ARF55359.1    
 SGLAU_12155   Streptomyces glaucescens GLA.O AIR98428.1    
 WQO_11075   Streptomyces globisporus C-1027 ALU93848.1    
 SGR_4877   Streptomyces griseus subsp. griseus NBRC 13350 BAG21706.1 B1VX60  
 SHXM_04285   Streptomyces hygroscopicus XM201 AQW50822.1    
 SHXM_00809   Streptomyces hygroscopicus XM201 AQW47346.1    
 SHXM_09497   Streptomyces hygroscopicus XM201 AQW56034.1    
 SIRAN9180   Streptomyces iranensis CDR16919.1    
 SIRAN6412   Streptomyces iranensis CDR09818.1    
 SLA_2333   Streptomyces laurentii ATCC 31255 BAU83261.1    
 SLAV_24290   Streptomyces lavendulae subsp. lavendulae CCM 3239 ATZ26660.1    
 Sle_45640   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR64022.1    
 SLINC_6481   Streptomyces lincolnensis NRRL 2936 ANS68705.1    
 SL103_05840   Streptomyces lydicus 103 AOP45824.1    
 SL103_25090   Streptomyces lydicus 103 AOP49085.1    
 SMALA_0277   Streptomyces malaysiensis DSM 4137 ATL80523.1    
 SMALA_2653   Streptomyces malaysiensis DSM 4137 ATL82887.1    
 BBN63_23315   Streptomyces niveus SCSIO 3406 AQU68689.1    
 SNOUR_11055   Streptomyces noursei ATCC 11455 ANZ15525.1    
 SNOUR_27095   Streptomyces noursei ATCC 11455 ANZ18673.1    
 B1H29_24135   Streptomyces pactum ACT12 AQS72201.1    
 CGZ69_12140   Streptomyces peucetius subsp. caesius ATCC 27952 ATW48560.1    
 Sfla_1448   Streptomyces pratensis ATCC 33331 ADW02888.1 C9ND52  
 Sfla_4228   Streptomyces pratensis ATCC 33331 ADW05636.1 C9NFQ2  
 SPRI_4862   Streptomyces pristinaespiralis HCCB 10218 ALC23168.1    
 SPRI_1498   Streptomyces pristinaespiralis HCCB 10218 ALC19804.1    
 M271_31960   Streptomyces rapamycinicus NRRL 5491 AGP57818.1    
 M271_46640   Streptomyces rapamycinicus NRRL 5491 AGP60691.1    
 A4G23_01727 (NagJ)   Streptomyces rubrolavendulae MJM4426 AOT58904.1    
 A7J05_23755   Streptomyces silaceus ACCC40021 APY88300.1    
 CGL27_17860   Streptomyces sp. 11-1-2 ASQ94684.1    
 CGL27_04195   Streptomyces sp. 11-1-2 ASQ92465.1    
 SAMN06272775_1257   Streptomyces sp. 2323.1 SOE10206.1    
 SAMN06272775_0353   Streptomyces sp. 2323.1 SOE09262.1    
 SAMN06272775_4687   Streptomyces sp. 2323.1 SOE13712.1    
 ASR50_12850   Streptomyces sp. 4F ALV50208.1    
 GZL_01022   Streptomyces sp. 769 AJC53626.1    
 GZL_02592   Streptomyces sp. 769 AJC55181.1    
 GZL_05761   Streptomyces sp. 769 AJC58336.1    
 T261_5410   Streptomyces sp. A02 AJT67035.3
AJT67035.1
AJT67035.2
   
 T261_1828   Streptomyces sp. A02 AJT63513.1    
 C2142_11665   Streptomyces sp. CB01881 AUY49489.1    
 NI25_36120   Streptomyces sp. CCM_MD2014 AIV38295.1    
 ABE83_24825   Streptomyces sp. CFMR 7 ALC29914.1    
 CXR04_05305   Streptomyces sp. CMB-StM0423 AUH39737.1    
 CXR04_24860   Streptomyces sp. CMB-StM0423 AUH42975.1    
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