Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (866); Uniprot accession (107); PDB accession (64); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CPE1523 (NagL) (GH84E)   Clostridium perfringens str. 13 BAB81229.1
NP_562439.1
Q8XK80  
 ZP_02866700.1   Clostridium spiroforme DSM 1552 ZP_02866700.1 B1BZX3  
 ZP_02866764.1   Clostridium spiroforme DSM 1552 ZP_02866764.1 B1C037  
 ZP_02867242.1   Clostridium spiroforme DSM 1552 ZP_02867242.1 B1C1G5  
 ZP_02867840.1   Clostridium spiroforme DSM 1552 ZP_02867840.1 B1C363  
 ZP_02868223.1   Clostridium spiroforme DSM 1552 ZP_02868223.1 B1C496  
 ZP_02868276.1   Clostridium spiroforme DSM 1552 ZP_02868276.1 B1C4U9  
 ZP_02868278.1   Clostridium spiroforme DSM 1552 ZP_02868278.1 B1C4V1  
 RN83_03935   Cutibacterium acnes KCOM 1861 (= ChDC B594) ALD69353.1    
 TIIST44_11080   Cutibacterium acnes subsp. defendens ATCC 11828 AER06669.1    
 DTL3_1494   Defluviitoga tunisiensis CEP78785.1    
 DEHRE_01505   Dehalobacter restrictus DSM 9455 PER-K23 AHF08960.1    
 DCF50_p2023   Dehalobacter sp. CF AFV06026.1    
 DHBDCA_p2011   Dehalobacter sp. DCA AFV03038.1    
 Deipe_0025   Deinococcus peraridilitoris DSM 19664 AFZ65635.1    
 Deipe_0032   Deinococcus peraridilitoris DSM 19664 AFZ65641.1    
 Hyl / HylEfm   Enterococcus faecium CV133 AAN34803.1
ADI24170.1
ADI24171.1
ADI24172.1
ADI24173.1
ADI24174.1
ADO66963.1
Q8GMZ8  
 HMPREF0351_12988 (HyL)   Enterococcus faecium DO AFK60612.1    
 EfmE745_02894 (NagJ)   Enterococcus faecium E745 AOT80102.1    
 AL015_14870   Enterococcus faecium ISMMS_VRE_2 AOM20586.1    
 B4W81_15750   Enterococcus faecium isolate 2014-VREF-268 AQY33418.1    
 B4W80_15630   Enterococcus faecium isolate 2014-VREF-63 AQY30317.1    
 CNX66_14775   Enterococcus faecium K60-39 ATD79796.1    
 hyaluronidase (fragment)   Enterococcus faecium LMT ADO16337.1 E2IY99  
 BVA20_200024 (NagJ)   Enterococcus faecium VREF AQT58374.1    
 hyaluronidase (HyL)   Enterococcus faecium VRE_5 ASS34091.1    
 C5Q98_04560   Fastidiosipila sanguinis CCUG 47711 AVM42533.1    
 C5Q98_07220   Fastidiosipila sanguinis CCUG 47711 AVM43011.1    
 IMCC3135_00340 (NagJ)   Granulosicoccus antarcticus IMCC3135 ASJ70194.1    
 AEM38_12230   Hyphomonadaceae bacterium UKL13-1 AMS30046.1    
 SAMN04515669_1993   Jiangella sp. DSM 45060 SDS81322.1    
 SAMN04515669_5996   Jiangella sp. DSM 45060 SDT69268.1    
 SAMN04515669_4129   Jiangella sp. DSM 45060 SDT45345.1    
 AOZ06_30485   Kibdelosporangium phytohabitans KLBMP1111 ALG10651.1    
 ORF   Kibdelosporangium sp. MJ126-NF4 CTQ98152.1    
 B7C62_10000   Kitasatospora albolonga YIM 101047 ARF72566.1    
 B6264_04765   Kitasatospora aureofaciens DM-1 ARF82628.1    
 KSE_54890   Kitasatospora setae KM-6054 BAJ31264.1 E4NID4  
 CFP65_5355   Kitasatospora sp. MMS16-BH015 AUG80063.1    
 Kole_1175   Kosmotoga olearia TBF 19.5.1 ACR79875.1 C5CIL3  
 IX53_06900   Kosmotoga pacifica SLHLJ1 AKI97589.1    
 Kfla_3229   Kribbella flavida DSM 17836 ADB32291.1 D2Q4H7  
 KALB_2454   Kutzneria albida DSM 43870 AHH95822.1    
 LA20249_05340   Lactobacillus alimentarius DSM 20249 AUI71637.1    
 BI355_1875   Lactobacillus crustorum MN047 APU72174.1    
 SAMN04515683_3013   Leifsonia sp. 157MF SDK30261.1    
 SAMN04515690_0031   Leifsonia sp. 197AMF SDG96065.1    
 SAMN04515684_3752   Leifsonia sp. 466MF SDJ45408.1    
 SAMN04515685_2996   Leifsonia sp. 467MF SEN42862.1    
 SAMN04515686_1939   Leifsonia sp. 509MF SDN65779.1    
 SAMN04515691_3986   Leifsonia sp. 98AMF SFM91757.1    
 A0130_10705   Leifsonia xyli SE134 ANF32080.1    
 LIP_0414   Limnochorda pilosa HC45 BAS26271.1    
 LIP_2435   Limnochorda pilosa HC45 BAS28276.1    
 VV02_00325   Luteipulveratus mongoliensis MN07-A0370 AKU14678.1    
 HP15_3245   Marinobacter adhaerens HP15 ADP99009.1 E4PQV2  
 MARHY3369   Marinobacter hydrocarbonoclasticus ATCC 49840 CCG96824.1    
 Maqu_3474   Marinobacter hydrocarbonoclasticus VT8 ABM20545.1 A1U6C6  
 ABA45_16460   Marinobacter psychrophilus 20041 AKO53824.1    
 AU15_02470   Marinobacter salarius R9SW1 AHI30650.1    
 MARSALSMR5_00692 (NagJ)   Marinobacter salarius SMR5 ARM82790.1    
 BKP64_17465   Marinobacter salinus Hb8 AOY89812.1    
 AU14_08640   Marinobacter similis A3d10 AHI28656.1    
 MRBBS_3509   Marinobacter sp. BSs20148 AFP32445.1    
 ACP86_06760   Marinobacter sp. CP1 AKV95873.1    
 SAMN04487880_3400   Marinobacter sp. es.042 SNB59103.1    
 ASQ50_08380   Marinobacter sp. LQ44 AMQ88714.1    
 SAMN04488490_3601   Marinobacter sp. LV10R510-11A SOB77775.1    
 MESINF_2633   Mesotoga infera SSC14073.1    
 Theba_0994   Mesotoga prima MesG1.Ag.4.2 AFK06700.1    
 GA0070618_5078   Micromonospora echinospora DSM 43816 SCF30737.1    
 GA0070618_6292   Micromonospora echinospora DSM 43816 SCF40132.1    
 BN938_1905   Mucinivorans hirudinis M3 CDN31984.1    
 ADH68_08645   Muribaculum intestinale YL27 ASB38050.1    
 hyaluronidase (NagH)   Mycoplasma alligatoris A21JP2 AAR98795.1
AAR98795.2
Q6R3F5  
 DP067_01440   Mycoplasma anatis NCTC 10156 AWX70028.1    
 CO229_00395   Mycoplasma bovirhinis GS01 ATO30597.1    
 MBVR141_0256   Mycoplasma bovirhinis HAZ141_2 BBA22202.1    
 AAW50_02380   Mycoplasma canis LV AKF41258.1    
 AAW50_03220   Mycoplasma canis LV AKF41400.1    
 AXW82_03135   Mycoplasma canis PG 14 AMD81521.1    
 AXW82_02315   Mycoplasma canis PG 14 AMD81372.1    
 MCRO_0688   Mycoplasma crocodyli MP145 ADE19509.1 D5E696  
 MCYN_0715 (Mcyn0715)   Mycoplasma cynos C142 CCP24447.1    
 BN4615_P8322   Nonomuraea gerenzanensis ATCC 39727 SBO98806.1    
 BKM31_02665   Nonomuraea sp. ATCC 55076 AQZ60561.1    
 B0W44_11820   Novibacillus thermophilus SG-1 AQS56348.1    
 BST96_16375   Oceanicoccus sagamiensis NBRC 107125 ARN75545.1    
 OG2516_04129   Oceanicola granulosus HTCC2516 EAR51054.1 Q2CEE3 2XSA[A]
2XSB[A]
 Ornrh_0573   Ornithobacterium rhinotracheale DSM 15997 AFL96774.1    
 Q785_06875   Ornithobacterium rhinotracheale ORT-UMN 88 AIP99456.1    
 B9T62_02240   Paenibacillus donghaensis KCTC 13049 ASA19732.1    
 B4V02_23295   Paenibacillus kribbensis AM49 ASR49395.1    
 ERIC2_c20510 (NagJ)   Paenibacillus larvae subsp. larvae DSM 25430 AHD05842.1    
 ERICII_02011 (NagJ)   Paenibacillus larvae subsp. larvae DSM 25430 DSM 25430; ERIC_II AVG12381.1    
 ERICI_02607 (NagJ)   Paenibacillus larvae subsp. larvae ERIC_I AVF22424.1    
 ERICIII_02624 (NagJ)   Paenibacillus larvae subsp. larvae Eric_III AVF26760.1    
 ERICIV_02613 (NagJ)   Paenibacillus larvae subsp. larvae Eric_IV AVF31507.1    
 B1222_02630   Paenibacillus larvae subsp. pulvifaciens ATCC 13537 AQT83576.1    
 B5S25_21010   Paenibacillus larvae subsp. pulvifaciens CCM 38 AQZ48679.1    
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