Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (713); Uniprot accession (107); PDB accession (63); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SACE_7066   Saccharopolyspora erythraea NRRL 2338 CAM06227.1 A4FQA2  
 SELR_08510   Selenomonas ruminantium subsp. lactilytica TAM6421 BAL82559.1    
 Selsp_1425   Selenomonas sputigena ATCC 35185 AEC00383.1    
 CGQ25_17110   Sinomonas sp. R1AF57 ASN53590.1    
 KO02_20065   Sphingobacterium sp. ML3W AIM38739.1    
 BN1088_1430317   Sphingobacterium sp. PM2-P1-29 CDS91913.1    
 BN1088_1432989   Sphingobacterium sp. PM2-P1-29 CDT03377.1    
 TS85_03725   Sphingomonas hengshuiensis WHSC-8 AJP71124.1    
 BJP26_08285   Sphingomonas melonis TY AOW23572.1    
 CP552_02250   Sphingomonas melonis ZJ26 ATI54565.1    
 AV944_14970   Sphingomonas sp. LK11 APX66913.1    
 A7E77_14930   Sphingomonas sp. NIC1 ANC88070.1    
 MC45_11905   Sphingomonas taxi ATCC 55669 AIT06969.1    
 IMCC21906_02147   Spongiibacter sp. IMCC21906 AKH69814.1    
 Snas_2451   Stackebrandtia nassauensis DSM 44728 ADD42134.1 D3Q4V4  
 SZO_04490   Steptococcus equi subsp. zooepidemicus H70 CAW98371.1    
 SDSE167_1709 (HyL)   Streptococcus dysgalactiae subsp. equisimilis 167 BAN94096.1    
 SDSE_1739 (HyL)   Streptococcus dysgalactiae subsp. equisimilis AC-2713 CCI63232.1    
 SDE12394_08290   Streptococcus dysgalactiae subsp. equisimilis ATCC 12394 ADX25098.1    
 SDEG_1588 (HyL)   Streptococcus dysgalactiae subsp. equisimilis GGS_124 BAH82082.1 C5WI67  
 GGS_1455 (HyL)   Streptococcus dysgalactiae subsp. equisimilis RE378 BAM61590.1    
 SEQ_1693   Streptococcus equi subsp. equi 4047 CAW94746.1 C0MC42  
 SE071780_01724   Streptococcus equi subsp. equi ATCC 39506 ASB97311.1    
 SeseC_02032 (HyA)   Streptococcus equi subsp. zooepidemicus ATCC 35246 AEJ25853.1    
 β-N-acetylglucosaminidase (HylZ)   Streptococcus equi subsp. zooepidemicus ATCC 39920 AHJ09604.1    
 Q426_01285   Streptococcus equi subsp. zooepidemicus CY AIA67201.1    
 Sez_1507   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62840.1 B4U4C3  
 smi_1537   Streptococcus mitis B6 CBJ22777.1 D3HA79  
 AXK38_07515   Streptococcus mitis SVGS_061 AMH89096.1    
 CO686_07620   Streptococcus oralis FDAARGOS_367 ATF57309.1    
 BWR56_0605   Streptococcus oralis S.MIT/ORALIS-351 AQA08903.1    
 BWR56_0313   Streptococcus oralis S.MIT/ORALIS-351 AQA08844.1    
 SOR_1642   Streptococcus oralis Uo5 CBZ01293.1    
 STP_1214+STP_1213   Streptococcus parauberis KCTC 11537 AEF25661.1
AEF25662.1
   
 STAB904_07030   Streptococcus pyogenes 1E1 AIW12140.1    
 SP5448_03015   Streptococcus pyogenes 5448 AKK70039.1    
 STAB1101_05800   Streptococcus pyogenes 7F7 AIT77818.1    
 A20_1348c (HyL)   Streptococcus pyogenes A20 AFV38428.1    
 SPYALAB49_001292   Streptococcus pyogenes Alab49 AEQ24885.1    
 SPAP1_02925   Streptococcus pyogenes AP1 AKG27575.1    
 AUQ45_1301 (HyL)   Streptococcus pyogenes AP53 AMY97855.1    
 DP15_382   Streptococcus pyogenes ATCC 19615 AIL11961.1    
 SpyM6D471_06010   Streptococcus pyogenes D471 AKI78166.1    
 AL510_06480   Streptococcus pyogenes FDAARGOS_149 AMH03489.1    
 B2G65_03315   Streptococcus pyogenes GUR ASO73774.1    
 CFA72_03315   Streptococcus pyogenes GURSA1 ASO68058.1    
 SPYH293_01193 (HyL)   Streptococcus pyogenes H293 CDJ55441.1    
 CRD75_06595   Streptococcus pyogenes HarveyGAS ATL57227.1    
 HKU360_01353   Streptococcus pyogenes HKU360 AIW25156.1    
 HKU488_01252   Streptococcus pyogenes HKU488 AKP82181.1    
 L897_06535   Streptococcus pyogenes HSC5 AGQ27953.1    
 JMUB1235_1224   Streptococcus pyogenes JMUB1235 BAV55478.1    
 SPYJRS4_1260 (HyL)   Streptococcus pyogenes JRS4 BAR44760.1
AKI76495.1
   
 M1GAS476_1381 (HyL)   Streptococcus pyogenes M1 476 BAM30710.1    
 O-glycoprotein β-N-acetylglucosaminidase (SPy1600) 3.2.1.169 Streptococcus pyogenes M1 GAS AAK34378.1
NP_269657.1
Q99YP8  
 FE90_1013 (HyL)   Streptococcus pyogenes M23ND AIQ01776.1    
 ABO05_02690   Streptococcus pyogenes M28PF1 AKJ92195.1    
 M3B_0652 (HyL)   Streptococcus pyogenes M3-b BAU60022.1    
 AWM59_02730   Streptococcus pyogenes MEW123 AMA70173.1    
 AWM58_06365   Streptococcus pyogenes MEW427 AMA69267.1    
 MGAS10270_Spy1430 (hyl)   Streptococcus pyogenes MGAS10270 ABF34495.1 Q1JFR4  
 M6_Spy1332   Streptococcus pyogenes MGAS10394 AAT87467.1    
 MGAS10750_Spy1423 (hyl)   Streptococcus pyogenes MGAS10750 ABF38373.1 Q1J5L3  
 MGAS11027_1269   Streptococcus pyogenes MGAS11027 ANC24259.1    
 MGAS15252_1199   Streptococcus pyogenes MGAS15252 AFC66535.1    
 MGAS1882_1260   Streptococcus pyogenes MGAS1882 AFC68465.1    
 MGAS2096_Spy1335 + MGAS2096_Spy1334 (hyl) (fragment)   Streptococcus pyogenes MGAS2096 ABF36386.1
ABF36387.1
   
 MGAS23530_1178   Streptococcus pyogenes MGAS23530 ANC25854.1    
 MGAS27061_1214   Streptococcus pyogenes MGAS27061 ANC27483.1    
 Hyl   Streptococcus pyogenes MGAS315 AAM79901.1
NP_665098.1
Q8K6L2  
 M5005_Spy_1314 (HyL)   Streptococcus pyogenes MGAS5005 AAZ51932.1    
 M28_Spy1355 (HyL)   Streptococcus pyogenes MGAS6180 AAX72465.1    
 Hyl   Streptococcus pyogenes MGAS8232 AAL98163.1
NP_607664.1
Q8P022  
 MGAS9429_Spy1308 (hyl)   Streptococcus pyogenes MGAS9429 ABF32495.1 Q1JKS4  
 MTB313_1331 (HyL)   Streptococcus pyogenes MTB313 BAQ51738.1    
 MTB314_1250 (HyL)   Streptococcus pyogenes MTB314 BAQ53413.1    
 ERS445054_01436 (HyL)   Streptococcus pyogenes NCTC8198 CKH04861.1    
 SD89_02740   Streptococcus pyogenes NGAS322 AKZ50040.1    
 DK93_02705   Streptococcus pyogenes NGAS327 AKI38372.1    
 DK92_02820   Streptococcus pyogenes NGAS596 AKI36763.1    
 SD90_06060   Streptococcus pyogenes NGAS638 AKZ52495.1    
 DI45_07475   Streptococcus pyogenes NGAS743 AKI35833.1    
 A4265_05840   Streptococcus pyogenes NS53 ANC74791.1    
 Spy49_1236c (HyL)   Streptococcus pyogenes NZ131 ACI61522.1 B5XMG0  
 SPs0567   Streptococcus pyogenes SSI-1 BAC63662.1
NP_801829.1
F7IV97  
 VT08_06480   Streptococcus pyogenes STAB09014 ANP29859.1    
 B4W66_06545   Streptococcus pyogenes STAB090229 ASQ21555.1    
 VU19_06965   Streptococcus pyogenes STAB10015 AKL63572.1    
 STAB1102_06475   Streptococcus pyogenes STAB1102 AIG49217.1    
 B5D85_07215   Streptococcus pyogenes STAB120304 ASQ23430.1    
 AXK13_06415   Streptococcus pyogenes STAB13021 AND05195.1    
 AYM92_07025   Streptococcus pyogenes STAB14018 ARV01657.1    
 STAB901_06555   Streptococcus pyogenes STAB901 AIG50640.1    
 STAB902_03225   Streptococcus pyogenes STAB902 AIG46862.1    
 SpyM50541   Streptococcus pyogenes str. Manfredo CAM29879.1 A2RDF4  
 SNAG_1586 (NagH)   Streptococcus sp. NPS 308 BAV80455.1    
 AXF18_04995   Streptococcus sp. oral taxon 064 W10853 ANR75301.1    
 AXE83_07220   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97395.1    
 V470_10735   Streptococcus sp. VT 162 AJZ74457.1    
 SMD11_4482 (HyA)   Streptomyces albireticuli SMD11 ARZ70083.1    
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