Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (713); Uniprot accession (107); PDB accession (63); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SAR116_2153   Candidatus Puniceispirillum marinum IMCC1322 ADE40396.1 D5BNW2  
 CGC47_04655   Capnocytophaga canimorsus 7120 ATA78068.1    
 Ccan_17870   Capnocytophaga canimorsus Cc5 AEK23903.1    
 CGC54_04470   Capnocytophaga canimorsus H3936 ATA94859.1    
 CGC56_04450   Capnocytophaga canimorsus H5594 ATA91483.1    
 CGC48_11185   Capnocytophaga cynodegmi G7591 ATA69132.1    
 CGC52_00045   Capnocytophaga sp. H2931 ATA75918.1    
 CGC49_00045   Capnocytophaga sp. H4358 ATA73768.1    
 CGC58_12095   Capnocytophaga stomatis H2177 ATA90410.1    
 BN424_3212   Carnobacterium maltaromaticum LMA28 CCO12633.1
CCO12451.2
   
 NY10_1498   Carnobacterium sp. CP1 ALV22103.1    
 ZP_03681730.1   Catenibacterium mitsuokai DSM 15897 ZP_03681730.1 E2NP60  
 CJA_1347 (Hyl84)   Cellvibrio japonicus Ueda107 ACE83103.1 B3PCY4  
 CBR65_07415   Cellvibrio sp. PSBB006 ARU27280.1    
 B0D95_01855   Cellvibrio sp. PSBB023 AQT58976.1    
 Cpin_5708   Chitinophaga pinensis DSM 2588 ACU63130.1 C7PBR6  
 U729_414   Clostridium baratii str. Sullivan AIY84741.1    
 BTM20_03575   Clostridium chauvoei 12S0467 ATD54361.1    
 BTM20_02905   Clostridium chauvoei 12S0467 ATD54239.1    
 ORF (fragment)   Clostridium chauvoei ATCC 10092 ARO85866.1    
 BTM21_09485   Clostridium chauvoei DSM 7528 ATD57955.1    
 BTM21_10175   Clostridium chauvoei DSM 7528 ATD58081.1    
 CCH01_05680   Clostridium chauvoei JF4335 SLK13973.1    
 CCH01_04350   Clostridium chauvoei JF4335 SLK13108.1    
 β-N-acetylglucosaminidase (Nag84A) 3.2.1.52 Clostridium paraputrificum M-21 BAC99989.1 Q76D19  
 exo-β-N-acetylglucosaminidase (NagH;CpGH84A;CPF_0184) (GH84A)   Clostridium perfringens ATCC 13124 ABG83307.1 Q0TUP2  
 CPF_0875   Clostridium perfringens ATCC 13124 ABG84510.1 Q0TSR6  
 hyaluronidase (NagJ;CpNagJ;CpOGA;CPF_1442) 3.2.1.52 Clostridium perfringens ATCC 13124 ABG84519.1 Q0TR53 2J62[A,B]
2V5C[A,B]
2V5D[A]
2VUR[A,B]
2WB5[A,B]
2X0Y[A,B]
2YDQ[A]
2YDR[A]
2YDS[A]
4ZXL[A]
 CPF_1487   Clostridium perfringens ATCC 13124 ABG84775.1 Q0TR10  
 BXT91_07960   Clostridium perfringens CP15 AQW23854.1    
 BXT91_09180   Clostridium perfringens CP15 AQW24088.1    
 BXT91_07755   Clostridium perfringens CP15 AQW23813.1    
 BXT91_04855   Clostridium perfringens CP15 AQW23263.1    
 BXT91_01220   Clostridium perfringens CP15 AQW22579.1    
 hyaluronidase (NagH) 3.2.1.35 Clostridium perfringens CPN50 AAA23259.1 P26831  
 BXT94_05065   Clostridium perfringens Del1 AQW26168.1    
 BXT94_09995   Clostridium perfringens Del1 AQW27091.1    
 BXT94_08590   Clostridium perfringens Del1 AQW26821.1    
 BXT94_01245   Clostridium perfringens Del1 AQW25488.1    
 BG908_09150   Clostridium perfringens EHE-NE18 ASY51816.1    
 BG908_00960   Clostridium perfringens EHE-NE18 ASY50288.1    
 BG908_07510   Clostridium perfringens EHE-NE18 ASY51512.1    
 BG908_04900   Clostridium perfringens EHE-NE18 ASY51023.1    
 BG908_07720   Clostridium perfringens EHE-NE18 ASY51551.1    
 FORC3_1464   Clostridium perfringens FORC_003 ALG48841.1    
 FORC3_1405   Clostridium perfringens FORC_003 ALG48782.1    
 FORC3_0878   Clostridium perfringens FORC_003 ALG48255.1    
 FORC3_0197   Clostridium perfringens FORC_003 ALG47574.1    
 FORC25_1876   Clostridium perfringens FORC_025 AOY54289.1    
 FORC25_0195   Clostridium perfringens FORC_025 AOY52617.1    
 FORC25_1634   Clostridium perfringens FORC_025 AOY54048.1    
 FORC25_1579   Clostridium perfringens FORC_025 AOY53993.1    
 JFP55_09025   Clostridium perfringens JP55 AMN33043.1    
 JFP55_07655   Clostridium perfringens JP55 AMN32783.1    
 JFP55_05255   Clostridium perfringens JP55 AMN32340.1    
 JFP55_01035   Clostridium perfringens JP55 AMN31574.1    
 ORF   Clostridium perfringens JP718 AKF16618.1    
 JFP838_08600   Clostridium perfringens JP838 AMN35805.1    
 JFP838_04820   Clostridium perfringens JP838 AMN35102.1    
 JFP838_08335   Clostridium perfringens JP838 AMN35753.1    
 JFP838_09815   Clostridium perfringens JP838 AMN36040.1    
 JFP838_01120   Clostridium perfringens JP838 AMN34415.1    
 CMR01_07300   Clostridium perfringens LLY_N11 ATD48581.1    
 CMR01_14245   Clostridium perfringens LLY_N11 ATD49893.1    
 CMR01_10490   Clostridium perfringens LLY_N11 ATD49188.1    
 CMR01_07555   Clostridium perfringens LLY_N11 ATD48631.1    
 CMR01_06090   Clostridium perfringens LLY_N11 ATD48347.1    
 hyaluronidase / ?-toxin (NagH;CPE0191) (GH84A) 3.2.1.35 Clostridium perfringens str. 13 BAB79897.1
NP_561107.1
P26831  
 CPE0881 (NagI) (GH84B)   Clostridium perfringens str. 13 BAB80587.1
NP_561797.1
Q8XM09  
 β-N-acetylglucosaminidase (NagJ;CpNagJ;CPE1234) (GH84C) 3.2.1.52 Clostridium perfringens str. 13 BAB80940.1
NP_562150.1
Q8XL08 2CBI[A,B]
2CBJ[A,B]
2XPK[A,B]
 CPE1279 (NagK) (GH84D)   Clostridium perfringens str. 13 BAB80985.1
NP_562195.1
Q8XKW3  
 CPE1523 (NagL) (GH84E)   Clostridium perfringens str. 13 BAB81229.1
NP_562439.1
Q8XK80  
 ZP_02866700.1   Clostridium spiroforme DSM 1552 ZP_02866700.1 B1BZX3  
 ZP_02866764.1   Clostridium spiroforme DSM 1552 ZP_02866764.1 B1C037  
 ZP_02867242.1   Clostridium spiroforme DSM 1552 ZP_02867242.1 B1C1G5  
 ZP_02867840.1   Clostridium spiroforme DSM 1552 ZP_02867840.1 B1C363  
 ZP_02868223.1   Clostridium spiroforme DSM 1552 ZP_02868223.1 B1C496  
 ZP_02868276.1   Clostridium spiroforme DSM 1552 ZP_02868276.1 B1C4U9  
 ZP_02868278.1   Clostridium spiroforme DSM 1552 ZP_02868278.1 B1C4V1  
 RN83_03935   Cutibacterium acnes KCOM 1861 (= ChDC B594) ALD69353.1    
 DTL3_1494   Defluviitoga tunisiensis CEP78785.1    
 DEHRE_01505   Dehalobacter restrictus DSM 9455 PER-K23 AHF08960.1    
 DCF50_p2023   Dehalobacter sp. CF AFV06026.1    
 DHBDCA_p2011   Dehalobacter sp. DCA AFV03038.1    
 Deipe_0025   Deinococcus peraridilitoris DSM 19664 AFZ65635.1    
 Deipe_0032   Deinococcus peraridilitoris DSM 19664 AFZ65641.1    
 B4W81_15750   Enterococcus faecium AQY33418.1    
 B4W80_15630   Enterococcus faecium AQY30317.1    
 Hyl / HylEfm   Enterococcus faecium CV133 AAN34803.1
ADI24170.1
ADI24171.1
ADI24172.1
ADI24173.1
ADI24174.1
ADO66963.1
Q8GMZ8  
 HMPREF0351_12988 (HyL)   Enterococcus faecium DO AFK60612.1    
 EfmE745_02894 (NagJ)   Enterococcus faecium E745 AOT80102.1    
 AL015_14870   Enterococcus faecium ISMMS_VRE_2 AOM20586.1    
 CNX66_14775   Enterococcus faecium K60-39 ATD79796.1    
 hyaluronidase (fragment)   Enterococcus faecium LMT ADO16337.1 E2IY99  
 BVA20_200024 (NagJ)   Enterococcus faecium VREF AQT58374.1    
 hyaluronidase (HyL)   Enterococcus faecium VRE_5 ASS34091.1    
 IMCC3135_00340 (NagJ)   Granulosicoccus antarcticus IMCC3135 ASJ70194.1    
 AEM38_12230   Hyphomonadaceae bacterium UKL13-1 AMS30046.1    
 SAMN04515669_1993   Jiangella sp. DSM 45060 SDS81322.1    
 SAMN04515669_5996   Jiangella sp. DSM 45060 SDT69268.1    
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