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Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (610); Uniprot accession (107); PDB accession (54); 3D entries (6); cryst (0)
Summary
All (551) Archaea (2) Bacteria (518) Eukaryota (27) unclassified (4) Structure (6) Characterized (13)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AM1_0334   Acaryochloris marina MBIC11017 ABW25393.1 B0C9V3  
 LuPra_00231 (NagJ)   Acidobacteria bacterium DSM 100886 AMY07067.1    
 TL08_13385   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS63491.1    
 UA74_14330   Actinoalloteichus sp. ADI127-7 APU14924.1    
 UA75_14920   Actinoalloteichus sp. GBA129-24 APU20994.1    
 BK816_06985   Actinomyces sp. VUL4_3 AOZ73064.1    
 SAMN04489717_2353   Actinopolymorpha singaporensis DSM 22024 SDS33076.1    
 BOQ57_07120   Aeromonas aquatica MX16A APJ14704.1    
 AH4AK4_1315   Aeromonas hydrophila 4AK4 AHE48776.1    
 VU14_15225   Aeromonas hydrophila AH10 AKA18138.1    
 TK34_14825   Aeromonas hydrophila AHNIH1 ANT68635.1    
 RY45_08040   Aeromonas hydrophila AL06-06 AJQ54030.1    
 V428_08425   Aeromonas hydrophila AL09-71 AHX32112.1    
 AhyD4_15100   Aeromonas hydrophila D4 ALZ80859.1    
 A9258_14380   Aeromonas hydrophila GYK1 ANS00756.1    
 V469_15065   Aeromonas hydrophila J-1 AJE37093.1    
 AS145_15280   Aeromonas hydrophila JBN2301 ALQ64186.1    
 AHML_08195   Aeromonas hydrophila ML09-119 AGM43421.1    
 U876_15470   Aeromonas hydrophila NJ-35 AKJ35356.1    
 V429_08430   Aeromonas hydrophila pc104A AHX68910.1    
 AHA_1474   Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK39090.1 A0KIB1  
 AI20_11820   Aeromonas hydrophila YL17 AHV35851.1    
 B224_3724   Aeromonas media WS AHX61963.1    
 ASA_2891   Aeromonas salmonicida subsp. salmonicida A449 ABO90903.1 A4SPT1  
 WL1483_3168   Aeromonas schubertii WL1483 ALP42587.1    
 O23A_p2099   Aeromonas sp. O23A ARW82842.1    
 WM43_05530   Aeromonas veronii AVNIH1 ANB52160.1    
 B565_2712   Aeromonas veronii B565 AEB50747.1    
 AMS64_16320   Aeromonas veronii TH0426 AMQ43796.1    
 PYTT_0357   Akkermansia glycaniphila SEH73907.1    
 Amuc_0052   Akkermansia muciniphila ATCC BAA-835 ACD03898.1 B2ULA9  
 A4V05_09275   Akkermansia muciniphila YL44 ANU61601.1
ASB35092.1		    
 A4V05_07355   Akkermansia muciniphila YL44 ANU61257.1
ASB34749.1		    
 SAMN04489726_0657   Allokutzneria albata DSM 44149 SDM26279.1    
 AJAP_22360   Amycolatopsis japonica MG417-CF17 AIG77328.1    
 SAMN04489733_2442   Amycolatopsis keratiniphila FH 1893 SDU25424.1    
 SD37_17520   Amycolatopsis orientalis B-37 ANN21840.1    
 AORI_3373 (HyA)   Amycolatopsis orientalis HCCB10007 AGM05958.1    
 Apre_0148   Anaerococcus prevotii DSM 20548 ACV28200.1 C7RFD9  
 AUT26_00055   Arthrobacter sp. ATCC 21022 AMB38803.1    
 UM93_02995   Arthrobacter sp. IHBB 11108 AJT42837.1    
 ARZXY2_3886 (HyA)   Arthrobacter sp. ZXY-2 AOY73389.1    
 Astex_2731   Asticcacaulis excentricus CB 48 ADU14370.1 C5SHP0  
 ABI39_10530   Bacteroides dorei CL03T12C01 AND19781.1    
 EL88_03340   Bacteroides dorei HS1_L1_B_010 AII62258.1    
 GV66_10670   Bacteroides dorei HS1_L3_B_079 AII68140.1    
 IY41_10920   Bacteroides dorei HS2_L_2_B_045b ALA73909.1    
 BF638R_3871   Bacteroides fragilis 638R CBW24319.1 E1WNE3  
 MB0529_03756   Bacteroides fragilis BE1 CUA20357.1    
 VU15_18105   Bacteroides fragilis BOB25 AKA53424.1    
 BF3796   Bacteroides fragilis NCTC 9343 CAH09476.1 Q5L8V6  
 AE940_14650   Bacteroides fragilis S14 ANQ61933.1    
 BF4022   Bacteroides fragilis YCH46 BAD50764.1 Q64P18  
 Bache_2906   Bacteroides helcogenes P 36-108 ADV44841.1    
 Bache_1389   Bacteroides helcogenes P 36-108 ADV43394.1    
 Btheta7330_03705   Bacteroides thetaiotaomicron 7330 ALJ43235.1    
 β-N-acetylglucosaminidase (BtOGA;BtGH84;BT4395;BT_4395) 3.2.1.169 Bacteroides thetaiotaomicron VPI-5482 AAO79500.1
NP_813306.1		 Q89ZI2 2CHN[A,B]
2CHO[A,B]
2J47[A]
2J4G[A,B]
2JIW[A,B]
2VVN[A,B]
2VVS[A]
2W4X[A]
2W66[A,B]
2W67[A,B]
2WCA[A]
2WZH[A]
2WZI[A,B]
2X0H[A,B]
2XJ7[A,B]
2XM1[A,B]
2XM2[A,B]
4AIS[A,B]
4AIU[A]
4UR9[A,B]
5ABE[A,B]
5ABF[A,B]
5ABG[A,B]
5ABH[A,B]
5FKY[A,B]
5FL0[A,B]
5FL1[A,B]
 BVU_2069   Bacteroides vulgatus ATCC 8482 ABR39734.1 A6L220  
 BvMPK_1310   Bacteroides vulgatus mpk ALK83919.1    
 BARVI_02830   Barnesiella viscericola DSM 18177 AHF11939.1    
 BARVI_06650   Barnesiella viscericola DSM 18177 AHF13792.1    
 BARVI_04265   Barnesiella viscericola DSM 18177 AHF13697.1    
 BBBF_1509   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ98716.1    
 BBBF_1623   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ98830.1    
 RY70_1661   Bifidobacterium bifidum BF3 ALE11990.1    
 RY70_1784   Bifidobacterium bifidum BF3 ALE12108.1    
 BBB_1496 (NagH)   Bifidobacterium bifidum BGN4 AFL05087.1    
 BBB_1610   Bifidobacterium bifidum BGN4 AFL05200.1    
 BBPR_1514   Bifidobacterium bifidum PRL2010 ADP36543.1 E4NYU1  
 BBPR_1635   Bifidobacterium bifidum PRL2010 ADP36658.1 E4NZK7  
 BBIF_1576   Bifidobacterium bifidum S17 ADO53781.1 E3EMP2  
 BBIF_1461   Bifidobacterium bifidum S17 ADO53666.1 E3ER91  
 BH708_12545   Brachybacterium sp. P6-10-X1 APX33409.1    
 BBR47_17990   Brevibacillus brevis NBRC 100599 NBRC 100599 (= 47) BAH42776.1 C0ZAG7  
 EX87_00210   Brevibacillus laterosporus B9 AKF92268.1    
 BRLA_c012190   Brevibacillus laterosporus LMG 15441 AIG25559.1    
 SAMN05216534_0106   Candidatus Aquiluna sp. UB-MaderosW2red SCX03314.1    
 SAR116_2153   Candidatus Puniceispirillum marinum IMCC1322 ADE40396.1 D5BNW2  
 Ccan_17870   Capnocytophaga canimorsus Cc5 AEK23903.1    
 BN424_3212   Carnobacterium maltaromaticum LMA28 CCO12633.1
CCO12451.2		    
 NY10_1498   Carnobacterium sp. CP1 ALV22103.1    
 ZP_03681730.1   Catenibacterium mitsuokai DSM 15897 ZP_03681730.1 E2NP60  
 CJA_1347 (Hyl84)   Cellvibrio japonicus Ueda107 ACE83103.1 B3PCY4  
 CBR65_07415   Cellvibrio sp. PSBB006 ARU27280.1    
 B0D95_01855   Cellvibrio sp. PSBB023 AQT58976.1    
 Cpin_5708   Chitinophaga pinensis DSM 2588 ACU63130.1 C7PBR6  
 U729_414   Clostridium baratii str. Sullivan AIY84741.1    
 ORF (fragment)   Clostridium chauvoei ATCC 10092 ARO85866.1    
 CCH01_05680   Clostridium chauvoei JF4335 SLK13973.1    
 CCH01_04350   Clostridium chauvoei JF4335 SLK13108.1    
 β-N-acetylglucosaminidase (Nag84A) 3.2.1.52 Clostridium paraputrificum M-21 BAC99989.1 Q76D19  
 exo-β-N-acetylglucosaminidase (NagH;CpGH84A;CPF_0184) (GH84A)   Clostridium perfringens ATCC 13124 ABG83307.1 Q0TUP2  
 CPF_0875   Clostridium perfringens ATCC 13124 ABG84510.1 Q0TSR6  
 hyaluronidase (NagJ;CpNagJ;CpOGA;CPF_1442) 3.2.1.52 Clostridium perfringens ATCC 13124 ABG84519.1 Q0TR53 2J62[A,B]
2V5C[A,B]
2V5D[A]
2VUR[A,B]
2WB5[A,B]
2X0Y[A,B]
2YDQ[A]
2YDR[A]
2YDS[A]
4ZXL[A]
 CPF_1487   Clostridium perfringens ATCC 13124 ABG84775.1 Q0TR10  
 BXT91_07960   Clostridium perfringens CP15 AQW23854.1    
 BXT91_09180   Clostridium perfringens CP15 AQW24088.1    
 BXT91_07755   Clostridium perfringens CP15 AQW23813.1    
 BXT91_04855   Clostridium perfringens CP15 AQW23263.1    
 BXT91_01220   Clostridium perfringens CP15 AQW22579.1    
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