Glycoside Hydrolase Family 84

Activities in FamilyN-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorAsp
NoteMechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resourcesCAZypedia;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (691); Uniprot accession (107); PDB accession (63); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-N-acetylglucosaminidase (BtOGA;BtGH84;BT4395;BT_4395) 3.2.1.169 Bacteroides thetaiotaomicron VPI-5482 AAO79500.1
NP_813306.1
Q89ZI2 2CHN[A,B]
2CHO[A,B]
2J47[A]
2J4G[A,B]
2JIW[A,B]
2VVN[A,B]
2VVS[A]
2W4X[A]
2W66[A,B]
2W67[A,B]
2WCA[A]
2WZH[A]
2WZI[A,B]
2X0H[A,B]
2XJ7[A,B]
2XM1[A,B]
2XM2[A,B]
4AIS[A,B]
4AIU[A]
4UR9[A,B]
5ABE[A,B]
5ABF[A,B]
5ABG[A,B]
5ABH[A,B]
5FKY[A,B]
5FL0[A,B]
5FL1[A,B]
5MI4[A]
5MI5[A]
5MI6[A]
5MI7[A]
 β-N-acetylglucosaminidase (Nag84A) 3.2.1.52 Clostridium paraputrificum M-21 BAC99989.1 Q76D19  
 hyaluronidase (NagJ;CpNagJ;CpOGA;CPF_1442) 3.2.1.52 Clostridium perfringens ATCC 13124 ABG84519.1 Q0TR53 2J62[A,B]
2V5C[A,B]
2V5D[A]
2VUR[A,B]
2WB5[A,B]
2X0Y[A,B]
2YDQ[A]
2YDR[A]
2YDS[A]
4ZXL[A]
 hyaluronidase (NagH) 3.2.1.35 Clostridium perfringens CPN50 AAA23259.1 P26831  
 hyaluronidase / ?-toxin (NagH;CPE0191) (GH84A) 3.2.1.35 Clostridium perfringens str. 13 BAB79897.1
NP_561107.1
P26831  
 β-N-acetylglucosaminidase (NagJ;CpNagJ;CPE1234) (GH84C) 3.2.1.52 Clostridium perfringens str. 13 BAB80940.1
NP_562150.1
Q8XL08 2CBI[A,B]
2CBJ[A,B]
2XPK[A,B]
 O-glycoprotein β-N-acetylglucosaminidase (SPy1600) 3.2.1.169 Streptococcus pyogenes M1 GAS AAK34378.1
NP_269657.1
Q99YP8  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 O-glycoprotein β-N-acetylglucosaminidase / O-GlcNAcase (OGA;hOGA;Mea5;Mgea5;NCOAT) 3.2.1.169 Homo sapiens AAD05385.2
AAG21428.1
AAH39583.2
AAH47877.1
BAA31654.2
BAA31654.3
BAG63869.1
NP_036347.1
D3DR79
O60502
O75166
Q86WV0
Q9HAR0
5M7R[A,B]
5M7S[A,B]
5M7T[A,A,B,B]
5M7U[A,B]
5TKE[A,B]
5UHK[A,C]
5UHL[A,C]
5UHO[A,C]
5UHP[A,B,C,D]
5UN8[A,B,C,D]
5UN9[A,B]
5VVO[A,B]
5VVT[A,C]
5VVU[A,C]
5VVV[A,C]
5VVX[A,C]
 O-GlcNAcase (Mgea5;NCOAT) 3.2.1.169 Mus musculus AAG43273.2
AAH20093.1
AAH41109.1
AAH54821.1
BAB28416.1
BAB31029.1
BAC40564.1
BAC97998.1
BAE26311.1
NP_076288.1
Q8BTT2
Q8CFX2
Q9CSJ4
Q9CU60
Q9EQQ9
 
 β-N-acetylglucosaminidase (Pc12g08730) 3.2.1.52 Penicillium rubens Wisconsin 54-1255 CAP80500.1 B6GYK2  
 O-GlcNAcase (Mgea5;NCOAT) 3.2.1.169 Rattus norvegicus AAK72103.1
NP_571979.1
Q8VIJ5  
 short O-GlcNAcase (TaOGA53) 3.2.1.169 Trichoplax adhaerens AKA09673.1    
 O-GlcNAcase (TaOGA54) 3.2.1.169 Trichoplax adhaerens AKA09674.1    
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