Activities in Family	N-acetyl β-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169)
Mechanism	Retaining
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Asp
Note	Mechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resources	CAZypedia;
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (610); Uniprot accession (107); PDB accession (54); 3D entries (6); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-N-acetylglucosaminidase (BtOGA;BtGH84;BT4395;BT_4395)	3.2.1.169	Bacteroides thetaiotaomicron VPI-5482	AAO79500.1 NP_813306.1	Q89ZI2	2CHN[A,B] 2CHO[A,B] 2J47[A] 2J4G[A,B] 2JIW[A,B] 2VVN[A,B] 2VVS[A] 2W4X[A] 2W66[A,B] 2W67[A,B] 2WCA[A] 2WZH[A] 2WZI[A,B] 2X0H[A,B] 2XJ7[A,B] 2XM1[A,B] 2XM2[A,B] 4AIS[A,B] 4AIU[A] 4UR9[A,B] 5ABE[A,B] 5ABF[A,B] 5ABG[A,B] 5ABH[A,B] 5FKY[A,B] 5FL0[A,B] 5FL1[A,B]
β-N-acetylglucosaminidase (Nag84A)	3.2.1.52	Clostridium paraputrificum M-21	BAC99989.1	Q76D19
hyaluronidase (NagJ;CpNagJ;CpOGA;CPF_1442)	3.2.1.52	Clostridium perfringens ATCC 13124	ABG84519.1	Q0TR53	2J62[A,B] 2V5C[A,B] 2V5D[A] 2VUR[A,B] 2WB5[A,B] 2X0Y[A,B] 2YDQ[A] 2YDR[A] 2YDS[A] 4ZXL[A]
hyaluronidase (NagH)	3.2.1.35	Clostridium perfringens CPN50	AAA23259.1	P26831
hyaluronidase / ?-toxin (NagH;CPE0191) (GH84A)	3.2.1.35	Clostridium perfringens str. 13	BAB79897.1 NP_561107.1	P26831
β-N-acetylglucosaminidase (NagJ;CpNagJ;CPE1234) (GH84C)	3.2.1.52	Clostridium perfringens str. 13	BAB80940.1 NP_562150.1	Q8XL08	2CBI[A,B] 2CBJ[A,B] 2XPK[A,B]
O-glycoprotein β-N-acetylglucosaminidase (SPy1600)	3.2.1.169	Streptococcus pyogenes M1 GAS	AAK34378.1 NP_269657.1	Q99YP8
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
O-glycoprotein β-N-acetylglucosaminidase / O-GlcNAcase (OGA;hOGA;Mea5;Mgea5;NCOAT)	3.2.1.169	Homo sapiens	AAD05385.2 AAG21428.1 AAH39583.2 AAH47877.1 BAA31654.2 BAA31654.3 BAG63869.1 NP_036347.1	D3DR79 O60502 O75166 Q86WV0 Q9HAR0	5M7R[A,B] 5M7S[A,B] 5M7T[A,A,B,B] 5M7U[A,B] 5TKE[A,B] 5UHK[A,C] 5UHL[A,C] 5UHO[A,C] 5UHP[A,B,C,D] 5UN8[A,B,C,D] 5UN9[A,B]
O-GlcNAcase (Mgea5;NCOAT)	3.2.1.169	Mus musculus	AAG43273.2 AAH20093.1 AAH41109.1 AAH54821.1 BAB28416.1 BAB31029.1 BAC40564.1 BAC97998.1 BAE26311.1 NP_076288.1	Q8BTT2 Q8CFX2 Q9CSJ4 Q9CU60 Q9EQQ9
β-N-acetylglucosaminidase (Pc12g08730)	3.2.1.52	Penicillium rubens Wisconsin 54-1255	CAP80500.1	B6GYK2
O-GlcNAcase (Mgea5;NCOAT)	3.2.1.169	Rattus norvegicus	AAK72103.1 NP_571979.1	Q8VIJ5
short O-GlcNAcase (TaOGA53)	3.2.1.169	Trichoplax adhaerens	AKA09673.1
O-GlcNAcase (TaOGA54)	3.2.1.169	Trichoplax adhaerens	AKA09674.1
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