Activities in Family	[protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169); Hyaluronidase / hyaluronoglucosaminidase (EC 3.2.1.35); β-N-acetylhexosaminidase (EC 3.2.1.52);
Mechanism	Retaining e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Asp
Note	Mechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resources	CAZypedia;
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (3337); Uniprot accession (25); PDB accession (78); 3D entries (10); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
β-N-acetylglucosaminidase (BtOGA;BtGH84;BT4395;BT_4395)	3.2.1.169	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79500.1 NP_813306.1	Q89ZI2	2CHN[A,B] 2CHO[A,B] 2J47[A] 2J4G[A,B] 2JIW[A,B] 2VVN[A,B] 2VVS[A] 2W4X[A] 2W66[A,B] 2W67[A,B] 2WCA[A] 2WZH[A] 2WZI[A,B] 2X0H[A,B] 2XJ7[A,B] 2XM1[A,B] 2XM2[A,B] 4AIS[A,B] 4AIU[A] 4UR9[A,B] 5ABE[A,B] 5ABF[A,B] 5ABG[A,B] 5ABH[A,B] 5FKY[A,B] 5FL0[A,B] 5FL1[A,B] 5MI4[A] 5MI5[A] 5MI6[A] 5MI7[A] 7K41[A] 7OU8[A,B]
β-N-acetylglucosaminidase (Nag84A)	3.2.1.52	pubmed	Clostridium paraputrificum M-21	BAC99989.1	Q76D19
exo-β-N-acetylglucosaminidase (NagH; CpGH84A; CPF_0184) (GH84A)	3.2.1.52	pubmed	Clostridium perfringens ATCC 13124	ABG83307.1	A0A0H2YRL1 P26831 Q0TUP2	6PV4[A,B,C,D]
β-N-acetylglucosaminidase 84B (CpGH84B; CPF_0875)	3.2.1.52	pubmed	Clostridium perfringens ATCC 13124	ABG84510.1		6PV5[A]
hyaluronidase / β-N-acetylglucosaminidase 84C (NagJ; CpNagJ; CpOGA; CpGH84C; CPF_1442)	3.2.1.52 3.2.1.169	pubmed pubmed	Clostridium perfringens ATCC 13124	ABG84519.1	Q0TR53	2J62[A,B] 2V5C[A,B] 2V5D[A] 2VUR[A,B] 2WB5[A,B] 2X0Y[A,B] 2YDQ[A] 2YDR[A] 2YDS[A] 4ZXL[A] 5OXD[A] 6RHE[A] 7KHV[A,B,C,D,E,F]
β-N-acetylglucosaminidase 84D (CpGH84D / CPF_1487)	3.2.1.52	pubmed	Clostridium perfringens ATCC 13124	ABG84775.1		6PWI[A,B]
hyaluronidase (NagH)	3.2.1.35	pubmed	Clostridium perfringens CPN50	AAA23259.1	P26831
hyaluronidase / ?-toxin (NagH;CPE0191) (GH84A)	3.2.1.35	pubmed	Clostridium perfringens str. 13	BAB79897.1 NP_561107.1	P26831
β-N-acetylglucosaminidase (NagJ;CpNagJ;CPE1234) (GH84C)	3.2.1.52	pubmed	Clostridium perfringens str. 13	BAB80940.1 NP_562150.1	Q0TR53 Q8XL08	2CBI[A,B] 2CBJ[A,B] 2XPK[A,B]
O-glycoprotein β-N-acetylglucosaminidase (SpOGA; SPy1600)	3.2.1.169	pubmed	Streptococcus pyogenes M1 GAS SF370	AAK34378.1 NP_269657.1	Q99YP8
O-glycoprotein β-N-acetylglucosaminidase (TtOGA; Tter_0116)	3.2.1.169	pubmed	Thermobaculum terrenum ATCC BAA-798	ACZ41038.1	D1CDN2	5DIY[A,B]
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
O-glycoprotein β-N-acetylglucosaminidase / O-GlcNAcase (OGA;hOGA;Mea5;Mgea5;NCOAT)	3.2.1.169	pubmed	Homo sapiens	AAD05385.2 AAG21428.1 AAH39583.2 AAH47877.1 BAA31654.2 BAA31654.3 BAG63869.1 NP_036347.1	B4DYV7 D3DR79 O60502 O75166 Q86WV0 Q9HAR0	5M7R[A,B] 5M7S[A,B] 5M7T[A,B] 5M7U[A,B] 5TKE[A,B] 5UHK[A,C] 5UHL[A,C] 5UHO[A,C] 5UHP[A,B,C,D] 5UN8[A,B,C,D] 5UN9[A,B] 5VVO[A,B] 5VVT[A,C] 5VVU[A,C] 5VVV[A,C] 5VVX[A,C] 6HKI[A,B] 6PM9[A,B,C,D] 7OU6[A,B] 7YEH[C,D] 8P0L[A,B]
O-GlcNAcase (Mgea5;NCOAT)	3.2.1.169	pubmed	Mus musculus	AAG43273.2 AAH20093.1 AAH41109.1 AAH54821.1 BAB28416.1 BAB31029.1 BAC40564.1 BAC97998.1 BAE26311.1 NP_076288.1	Q05CX1 Q8BTT2 Q8CFX2 Q9CSJ4 Q9CU60 Q9EQQ9
β-N-acetylglucosaminidase (Pc12g08730)	3.2.1.52	pubmed	Penicillium rubens Wisconsin 54-1255	CAP80500.1	B6GYK2
O-GlcNAcase (Mgea5;NCOAT)	3.2.1.169	pubmed	Rattus norvegicus	AAK72103.1 NP_571979.1	Q8VIJ5
short O-GlcNAcase (TaOGA53)	3.2.1.169	pubmed	Trichoplax adhaerens	AKA09673.1	A0A0D5X1V2
O-GlcNAcase (TaOGA54)	3.2.1.169	pubmed	Trichoplax adhaerens	AKA09674.1	A0A0D5X2Y8
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
β-N-acetylglucosaminidase (c92_2)	3.2.1.52	pubmed	uncultured organism	AGU12251.1
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