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Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-β-glucosidase (EC 3.2.1.58); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (20155); Uniprot accession (2560); PDB accession (117); 3D entries (40); cryst (4)
Summary
All (19268) Archaea (102) Bacteria (18008) Eukaryota (1056) Viruses (1) unclassified (101) Structure (40 - 4 cryst) Characterized (300)
| 1 | 2 | 3 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (BglX;STM2166) 3.2.1.21 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL21070.1
BAA13102.1
NP_461111.1		 Q56078  
 β-glucosidase (BglSk;Sked_04360) 3.2.1.21 Sanguibacter keddieii DSM 10542 ACZ20402.1 D1BKC5  
 β-glucosidase (BglA49) 3.2.1.21 Serratia sp. TN49 ADK91094.1    
 STHERM_c13940 (possible fragment) 3.2.1.- Spirochaeta thermophila DSM 6192 ADN02334.1 E0RUB3  
 STHERM_c14620 3.2.1.- Spirochaeta thermophila DSM 6192 ADN02402.1 E0RTA6  
 STHERM_c14600 3.2.1.- Spirochaeta thermophila DSM 6192 ADN02400.1 E0RTA4  
 oleandomycin β-glycosidase (OleR) 3.2.1.- Streptomyces antibioticus ATCC 11891 AAC12650.1 O68843  
 β-glucosidase (SCO0458) 3.2.1.21 Streptomyces coelicolor A3(2) CAB56688.1
NP_624778.1		 Q9RL29  
 β-N-acetylhexosaminidase (NagA;SCO2758) 3.2.1.52 Streptomyces coelicolor A3(2) CAB66297.1
NP_626989.1		 Q9RDG9  
 β-N-acetylglucosaminidase (DasD;SCO5235) 3.2.1.52 Streptomyces coelicolor A3(2) CAB94620.1
NP_629382.1		 Q9K488  
 β-xylosidase (BxlA) 3.2.1.37 Streptomyces lividans 1326 AAC99628.1 Q9ZI15  
 β-xylosidase (Bxl2) 3.2.1.37 Streptomyces sp. CH7 AAO42605.1 Q7X508  
 β-N-acetylglucosaminidase II (NagA) 3.2.1.52 Streptomyces thermoviolaceus OPC-520 BAA32403.1 O82840  
 β-xylosidase (BxlA) 3.2.1.37 Streptomyces thermoviolaceus OPC-520 BAB61064.1
BAD02389.1		 Q76BU6 cryst
 macrolide β-glycosidase / β-glucosidase (DesR) 3.2.1.21
3.2.1.-		 Streptomyces venezuelae ACR54627.1
AAC68679.1
AAO96653.1
AAO98875.1
AAY77317.1		 C5IXN7
Q9ZGH5		 4I3G[A,B]
 β-N-acetylhexosaminidase (NahA; STH300) 3.2.1.52 Symbiobacterium thermophilum IAM 14863 BAD39285.1    
 3-O-β-glucopyranosyl-specific ginsenosidase type III / β-glycosidase (BgpA;Bgl-gyp 3082) 3.2.1.21
3.2.1.38
3.2.1.-		 Terrabacter ginsenosidimutans ACZ66247.2
ACZ66247.1		 D2KAT1  
 β-glucosidase / β-xylosidase (XglS) (fragment) 3.2.1.21
3.2.1.37		 Thermoanaerobacter brockii ATCC 53556 / DSM 1457 CAA91219.1 P96090  
 β-xylosidase / α-L-arabinofuranosidase (XarB) 3.2.1.37
3.2.1.55		 Thermoanaerobacter ethanolicus JW 200 AAF43783.1
AAB23220.1		 Q9JRQ1  
 cellodextrinase D (BglA;Ggh-A) 3.2.1.74 Thermobispora bispora NRRL 15568 AAB36835.1 Q59506  
 β-glucosidase B (BglB;TM0025) (Cel3) 3.2.1.21 Thermotoga maritima MSB8 AAD35119.1
AAM56786.1
AGL48948.1
AHD18204.1
AKE27834.1
CAH68687.1
CAT81443.1
NP_227841.1		 Q9WXN2  
 β-xylosidase (XloA;TM0076) (Xyl3) 3.2.1.37 Thermotoga maritima MSB8 AAD35170.1
AGL48999.1
AHD18154.1
AKE27884.1
NP_227892.1		 Q9WXT1 cryst
 β-N-acetylglucosaminidase (NagA;TM0809) 3.2.1.52 Thermotoga maritima MSB8 AAD35891.1
AGL49735.1
AHD17438.1
AKE28590.1
NP_228618.1		 B6DVV2
Q9WZR6		 3WO8[A,B]
 β-glucosidase B (BglB;TnBgl3B;CTN_0670) (Bgl3B) 3.2.1.21 Thermotoga neapolitana DSM 4359 ABI29899.1
ACM22846.1		 Q0GC07 2WT3[A]
2WT5[A]
2WT6[A]
2X40[A]
2X41[A]
2X42[A]
 β-N-acetylglucosaminidase (CbsA) 3.2.1.52 Thermotoga neapolitana KCCM41025 AAK16587.1 Q9AG27 5BZA[A,B,C,D]
5C0Q[A,B,C,D]
 β-glucosidase B / laminaribiase (BglB) 3.2.1.21
3.2.1.58		 Thermotoga neapolitana Z2706-MC24 CAB01407.1 Q60038 cryst
 β-glucosidase (BG-B;TCel11;TpBlg3;Tpet_0898) 3.2.1.21 Thermotoga petrophila RKU-1 ABQ46916.1 A5IL43  
 exo-chitosanase (Cho) 3.2.1.132 Trichormus fertilissimus RPAN1 ACV53814.1 C9D7S2  
 β-glucoside phosphorylase BglP 2.4.1.- uncultured bacterium AUG44408.1
AUG44422.1		   5VQD[A]
5VQE[A]
 β-glucosidase (Bgl2;BGL4A6-ORF17) 3.2.1.21 uncultured bacterium AEV59721.1    
 β-glucosidase (Bgl1;BGL02B4-ORF21) 3.2.1.21 uncultured bacterium AEV59720.1    
 β-glucosidase (UmBgl3A) 3.2.1.21 uncultured bacterium AAZ32298.1 Q461Q3  
 β-glucosidase (UmBgl3B;RG2) 3.2.1.21 uncultured bacterium ABA42186.1 Q3HXC2  
 β-glucosidase (UmBgl3C;RG3) 3.2.1.21 uncultured bacterium ABA42187.1 Q3HXC1  
 β-glucosidase (BGL5;Bgl7O16) 3.2.1.21 uncultured bacterium AFH08277.1    
 β-glucosidase (BGL7;Bgl9) 3.2.1.21 uncultured bacterium AFH08279.1    
 β-glucosidase (BGL9;Bgl11) 3.2.1.21 uncultured bacterium AFH08281.1    
 β-glucosidase (UmBgl3D) 3.2.1.21 uncultured bacterium ABE60716.1 Q1PDD6  
 β-glucosidase (RG11) 3.2.1.21 uncultured bacterium ABI94087.1 Q06B36  
 β-glucosidase (RG12) 3.2.1.21 uncultured bacterium ABI94088.1 Q06B35  
 β-glucosidase (RG14) 3.2.1.21 uncultured bacterium ABI94089.1 Q06B34  
 β-glucosidase (RG20) 3.2.1.21 uncultured bacterium ABI94090.1 Q06B33  
 β-glucosidase (RG25) 3.2.1.21 uncultured bacterium ABI94091.1 Q06B32  
 β-glucosidase (AS-Esc6) 3.2.1.21 uncultured bacterium AHG23300.1    
 β-glucosidase (AmBGL17) 3.2.1.21 uncultured bacterium AHI85741.1    
 β-glucosidase (A1_GH3) 3.2.1.21 uncultured bacterium A1_9 AEW47937.1    
 β-glucosidase 3.2.1.21 uncultured bacterium Contig178 AHF25279.1    
 β-glucosidase (D1_GH3) 3.2.1.21 uncultured bacterium D1_14 AEW47953.1    
 β-glucosidase (H1_GH3) 3.2.1.21 uncultured bacterium H1_5 AEW47970.1    
 β-glucosidase (LAB20g4) 3.2.1.21 uncultured bacterium LAB20 AGH13484.1    
 glucan β-1,4-glucosidase (LAB25g2) 3.2.1.21 uncultured bacterium LAB25 AGH13451.1    
 glucan 1,4-β-glucosidase (SRF2g18) 3.2.1.21 uncultured bacterium SRF2 AGH13475.1    
 β-glucosidase/β-xylosidase (Bgx1;RuBGX1) 3.2.1.21
3.2.1.37		 uncultured rumen bacterium ADD17009.1 D3VYD8  
 β-glucosidase (RuBg3A;BgX2;RubgX2;16C12) 3.2.1.21 uncultured rumen bacterium ADM89625.1    
 β-xylosidase (XynA;R13) (Xyl3A) 3.2.1.37 uncultured rumen bacterium CAP07659.1 A8E1A9  
 β-glucosidase (CelB) 3.2.1.21 unidentified bacterium AAA91967.1 Q60055  
 β-N-acetylhexosaminidase (NagZ;VC0692) 3.2.1.52 Vibrio cholerae O1 biovar El Tor str. N16961 AAF93857.1
NP_230341.1		 Q9KU37 1TR9[A]
1Y65[A]
2OXN[A]
3GS6[A]
3GSM[A]
  β-N-acetylglucosaminidase II (EXoII) 3.2.1.52 Vibrio furnissii AAC44686.2
AAE36541.1		 P96157  
 [N-glycan] β-1,2-xylosidase (NixI;XCC2892) 3.2.1.37 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42164.1
NP_638240.1		 Q8P6S3  
 β-hexosaminidase (NagZ;YPO1615) 3.2.1.52 Yersinia pestis CO92 CAC90437.1
CAL20260.1
NP_405196.1		 Q8ZFS3  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-L-arabinofuranosidase / β-1,4-xylosidase (Xyl3;AtBX3;At5g09730) 3.2.1.37
3.2.1.55		 Arabidopsis thaliana CAB89357.1
AAK96639.1
AED91439.1
BAB09531.1
CAL81217.1
CAW52616.1
CBC23860.1
NP_196535.1		 Q9LXD6  
 α-L-arabinofuranosidase / β-D-xylosidase (Xyl1;BXL1;AtBXL1;At5g49360) 3.2.1.37
3.2.1.55		 Arabidopsis thaliana BAB09906.1
AAM53325.1
AED95802.1
BAF00595.1
CAW52618.1
CAW96520.1
CAW96683.1
CAX01897.1
CAX07251.1
CBC23864.1
CBD30887.1
NP_199747.1		 Q9FGY1  
 β-xylosidase (Xyl4;AtBXL4;At5g64570) 3.2.1.37 Arabidopsis thaliana BAB11424.1
AED97922.1
ANM70278.1
ANM70279.1
BAD94481.1
CAW52619.1
CBC23866.1
NP_201262.1		 Q9FLG1  
 β-glucosidase 1 (Bgl1;AaBGL1;AaBg1;Aa?G) 3.2.1.21 Aspergillus aculeatus F-50 BAA10968.1
AER93027.1		 P48825 4IIB[A,B]
4IIC[A,B]
4IID[A,B]
4IIE[A,B]
4IIF[A,B]
4IIG[A,B]
4IIH[A,B]
 β-xylosidase (Xyl) 3.2.1.37 Aspergillus awamori K4 BAE19756.1
CAW52633.1
CBC23895.1		 Q4AEG8  
 β-xylosidase (Xylx100) 3.2.1.37 Aspergillus awamori X-100 ACF61038.1 B5AK91
Q4AEG8		  
 β-glucosidase (Bgl1;NfBGL1) 3.2.1.21 Aspergillus fischeri P1 / CGMCC 3.15369 AIM56897.1    
 β-1,4-xylosidase (Xld) 3.2.1.37 Aspergillus fumigatus ABA40420.1 Q0H905
Q4WRB0		  
 β-glucosidase (AfG;AFUA_8G02100) 3.2.1.21 Aspergillus fumigatus Af293 EAL84958.1    
 β-glucosidase (AfBG;AFUA_1G17410;Afu1g17410) 3.2.1.21 Aspergillus fumigatus Af293 EAL91070.1 Q4WR62  
 β-glucosidase 1 (Afum-Bgl101;Af?G;AFUA_1G05770;Afu1g05770) 3.2.1.21 Aspergillus fumigatus Af293 EAL88289.1
ABU35789.1
ACE10248.1
ACH05254.1
ACJ91428.1		 Q4WJJ3 5FJI[A,B]
 β-glucosidase / cellulase (Bgl3) 3.2.1.21 Aspergillus fumigatus Z5 ADX78143.1    
 β-1,4-xylosidase (XylA) 3.2.1.37 Aspergillus japonicus MU-2 BAG82824.1 B6EY09  
 β-glucosidase A (BglA) 3.2.1.21 Aspergillus kawachii IFO4308 BAA19913.1 P87076  
 β-xylosidase (XlnD) 3.2.1.37 Aspergillus nidulans CAA73902.1 O42810
Q5BAS1		  
 β-glucosidase (AN1804.2) 3.2.1.21 Aspergillus nidulans FGSC A4 EAA64969.1 Q5BCC6  
 β-xylosidase / α-L-arabinofuranosidase (BxlB;AnXA;AN8401.2) 3.2.1.37
3.2.1.55		 Aspergillus nidulans FGSC A4 EAA67023.1 Q5ATH9  
 β-xylosidase (BxlA;XlnD;AN2359.2) 3.2.1.37 Aspergillus nidulans FGSC A4 EAA64470.1 Q5BAS1  
 β-glucosidase (AN0712.2) 3.2.1.21 Aspergillus nidulans FGSC A4 EAA65189.1
ABF50843.1		 Q5BFG8  
 β-glucosidase (AN2828) 3.2.1.21 Aspergillus nidulans FGSC A4 EAA63399.1 C8VJG1
Q5B9F2		  
 β-glucosidase (SP188;AnBgl1;AnCel3A) (peptide fragment) (Cel3A) 3.2.1.21 Aspergillus niger AAB27405.1    
 β-xylosidase (XlnD;AnXlnD;Asp n 14;P1.1) 3.2.1.37 Aspergillus niger 90196 AAD13106.1
CAW52630.1
CBC23888.1		 O00089
O93933		  
 β-glucosidase (P1.2) (partial) 3.2.1.21 Aspergillus niger ASKU28 AFW98805.1    
 β-glucosidase (Bgl1;BG3;BGs) 3.2.1.21 Aspergillus niger B1 CAB75696.1 Q9P8F4  
 β-xylosidase (XlnD;AnXln3D) (Xln3D) 3.2.1.37 Aspergillus niger BE-2 AIC36733.1    
 β-xylosidase (XlnD;Asp n 14;AnXlnD) 3.2.1.37 Aspergillus niger CBS 120.49 / NW147 AAQ80268.1
CAB06417.1
CAB59162.1
CAW52627.1
CBC23882.1		 O00089  
 β-xylosidase (XlnD;An01g09960) 3.2.1.37 Aspergillus niger CBS 513.88 CAK37179.1 A2QA27  
 β-glucosidase (Bgl1;An18g03570) 3.2.1.21 Aspergillus niger CBS 513.88 CAK48740.1 A2RAL4  
 β-glucosidase (Bgl1) 3.2.1.21 Aspergillus niger CGMCC 3.316 AFJ19133.1    
 β-xylosidase (XlnD) 3.2.1.37 Aspergillus niger GS1 ADD69953.1    
 β-glucosidase (Cel3) 3.2.1.21 Aspergillus oryzae CAD67686.1
AJI43741.1		    
 β-xylosidase (XylA;Xyl-1) 3.2.1.37 Aspergillus oryzae KBN616 BAA28267.1
BAA24107.1
CAW52628.1
CAW52629.1
CBC23884.1
CBC23886.1		 O42698
O59862
Q2UR38		  
 β-glucosidase (B7;BglA;Bgl1;Ao?G;BGHG1;BglC;AO090009000356) (Cel3A) 3.2.1.21 Aspergillus oryzae RIB40 BAE54829.1 Q2UUD6 5FJJ[A,B,C,D]
 β-xylosidase (XylA;Xyl-1;AO090005000986) 3.2.1.37 Aspergillus oryzae RIB40 BAE55977.1 Q2UR38  
 β-glucosidase 5 (Bgl5;BglG;AO090001000544) 3.2.1.21 Aspergillus oryzae RIB40 BAE57053.1 Q2UN12  
 β-glucosidase 1 / aryl β-glucosidase (Bgl1;BglJ;AO090003001511) 3.2.1.21 Aspergillus oryzae RIB40 BAE58551.1 Q2UIR4  
 aryl β-glucosidase (BglA;AO090038000223) 3.2.1.21 Aspergillus oryzae RIB40 BAE64040.1 Q2U325  
 β-1,6-glucosidase (BglH;AO090038000425) 3.2.1.21 Aspergillus oryzae RIB40 BAE64214.1 Q2U2K1  
 aryl β-glucosidase (BglF;AO090103000127) 3.2.1.21 Aspergillus oryzae RIB40 BAE65597.1 Q2TYS6  
 β-glucosidase (Bgl;BGL1) 3.2.1.21 Aspergillus saccharolyticus CBS 127449 AEL79685.1    
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