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Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-β-glucosidase (EC 3.2.1.58); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (17231); Uniprot accession (2560); PDB accession (105); 3D entries (33); cryst (4)
Summary
All (16380) Archaea (94) Bacteria (15236) Eukaryota (949) Viruses (1) unclassified (100) Structure (33 - 4 cryst) Characterized (293)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (Bgl) 3.2.1.21 Chaetomium thermophilum CT2 ABR57325.2
ABI63598.1
ABR57325.1		 A6YRT4  
 β-glucosidase / β-xylosidase (Bxl5) 3.2.1.21 Chrysosporium lucknowense VKM F-3500-D / C1 AEN99939.1    
 β-glucosidase/ exo-β-1,3-glucosidase (Bgl2) 3.2.1.21
3.2.1.58		 Coccidioides posadasii AAF21242.1    
 β-glucosidase (Bgl1) 3.2.1.21 Coccidioides posadasii C735 AAB67972.1 O14424  
 β-glucosidase 3.2.1.21 Dictyostelium discoideum AX3 AAA74233.1 Q23892  
 β-xylosidase (Xyl1) 3.2.1.37 Fragaria x ananassa AAS17751.2
CAW96536.1
CAW96699.1
CAX01913.1
CAX07267.1
CBD30903.1		 Q6RXY3  
 avenacinase I 3.2.1.- Gaeumannomyces graminis AAB09777.1 Q00903  
 avenacinase II (fragment) 3.2.1.- Gaeumannomyces graminis AAA63146.1 Q00902  
 β-glucosidase (Bgl;GmBGL) 3.2.1.21 Glycine max AIO11756.1    
 β-xylosidase (XYL) 3.2.1.37 Hordeum vulgare AAK38482.1
CAW52643.1
CAW96538.1
CAW96701.1
CAX01915.1
CAX07269.1
CBC23916.1
CBD30905.1		 Q8W011  
 α-L-arabinofuranosidase / β-xylosidase (ARA-I) 3.2.1.37
3.2.1.55		 Hordeum vulgare subsp. vulgare AAK38481.1
BAJ89945.1
CAW52644.1
CAW96539.1
CAW96702.1
CAX01916.1
CAX07270.1
CBC23918.1
CBD30906.1		 Q8W012  
 exo-β-1,3-1,4-glucanase (ExoI) 3.2.1.- Hordeum vulgare subsp. vulgare AAD23382.1
BAK05680.1		 Q9XEI3 1EX1[A]
1IEQ[A]
1IEV[A]
1IEW[A]
1IEX[A]
1J8V[A]
1LQ2[A]
1X38[A]
1X39[A]
3WLH[A]
3WLI[A]
3WLJ[A]
3WLK[X]
3WLL[A]
3WLM[A]
3WLN[A]
3WLO[A]
3WLP[A]
3WLQ[A]
3WLR[A]
3WLS[A]
3WLT[A]
 exo-β-1,3,1,4-glucanase II (ExoII) 3.2.1.- Hordeum vulgare subsp. vulgare AAC49170.1 Q42835  
 β-xylosidase (Xyl3A) 3.2.1.37 Humicola insolens Y1 / GCMCC 4573 AJK31203.1    
 β-glucosidase I (Bgl1) 3.2.1.21 Hypocrea orientalis EU7-22 AFM77966.1    
 β-glucosidase I (Bgl;KmBglI) 3.2.1.21 Kluyveromyces marxianus NBRC1777 ACY95404.1 D1GCC6 3ABZ[A,B,C,D]
3AC0[A,B,C,D]
 β-glucosidase (BglN) 3.2.1.21 Kuraishia capsulata 35M5N AAA91297.1 Q12653  
 β-xylosidase / β-glucosidase (Lxyl-p1-1) 3.2.1.21
3.2.1.37		 Lentinula edodes M95.33 AET31457.1
AET31458.1		    
 β-xylosidase / β-glucosidase (Lxyl-p1-2) (7-β-xylosyltaxane-active) 3.2.1.21
3.2.1.37		 Lentinula edodes M95.33 AET31459.1
AET31460.1		    
 β-glucosidase 3.2.1.21 Magnaporthe grisea Y34 AAX07690.1 Q5EMW3  
 β-glucosidase (MoCel3B;MG03508.4) (Cel3B) 3.2.1.21 Magnaporthe oryzae 70-15 XP_360965.1 G4N7Z0  
 β-glucosidase (MoCel3A;MG09353.4) (Cel3A) 3.2.1.21 Magnaporthe oryzae 70-15 XP_364573.1 G4NI45  
 β-xylosidase / α-L-arabinosidase (Xyl1) 3.2.1.37
3.2.1.55		 Medicago sativa subsp. x varia ABQ45227.1 A5JTQ2  
 β-glucosidase (HMPREF1544_06945) 3.2.1.21 Mucor circinelloides f. circinelloides 1006PhL EPB86303.1    
 β-glucosidase 1 (Bgl1) 3.2.1.21 Mucor javanicus NBRC 4572 BAO00904.1    
 β-glucosidase 2 (Bgl2) (partial) 3.2.1.21 Mucor javanicus NBRC 4572 BAO00905.1    
 β-glucanase (W5-16143) 3.2.1.21 Neocallimastix patriciarum W5 AEX92706.1    
 β-glucosidase (Bgs;NpaBGS) 3.2.1.21 Neocallimastix patriciarum W5 AFI47447.1    
 β-glucosidase (Bgl6;Gh3-3;NcGH3-3;NcCel3A;Ncrα-Bgl101;NCU08755) (Cel3A) 3.2.1.21 Neurospora crassa OR74A EAA26868.1
XP_330872.1
XP_956104.1		    
 β-glucosidase (Bgl2;Gh3-4;NCU04952) 3.2.1.21 Neurospora crassa OR74A EAA30164.1
XP_324309.1		    
 β-xylosidase (Gh3-7;NCU09923) 3.2.1.37 Neurospora crassa OR74A CAB91343.2
CAW52623.1
CAW52647.1
CBC23874.1
CBC23924.1
XP_329671.1		 Q9P627  
 β-glucosidase 3.2.1.21 Nicotiana tabacum BAA33065.1 O82151  
 β-glucosidase (Bgl3;PtBglu3) 3.2.1.21 Paecilomyces sp. J18 ADM47481.1    
 β-glucosidase (Bgl1) 3.2.1.21 Penicillium brasilianum IBT 20888 ABP88968.1 A5A4M8  
 β-glucosidase I (Bgl1;BglI) 3.2.1.21 Penicillium decumbens 114-2 / JU-A10 ACD86466.1 B3GK87  
 β-glucosidase I (Bgl1;Dbgl1) 3.2.1.21 Penicillium decumbens CICC 40361 ADB82653.1 D3JUX2  
 β-glucosidase (BGL I) 3.2.1.21 Periconia sp. BCC 2871 ABX84365.1
AFH41575.1		 A9UIG0  
 β-glucosidase (Bgl1) 3.2.1.21 Phaeosphaeria avenaria WAC1293 CAB82861.1 Q9P879  
 glucan β-1,3-glucosidase (Bgl) 3.2.1.21
3.2.1.58		 Phanerochaete chrysosporium K-3 BAB85988.1 Q8TGC6  
 glucan β-1,3-glucosidase (CbgL;Cbgl-1;Cbgl-2) (Bgl1A) 3.2.1.21
3.2.1.58		 Phanerochaete chrysosporium OGC101 AAC26489.1
AAC26490.1		 O74203
Q9URP5		  
 β-glucosidase I (Bgl1;BGLI) 3.2.1.21 Pichia etchellsii ACF93471.1 B5B423  
 β-glucosidase (Cel3A) (Cel3A) 3.2.1.21 Piromyces sp. E2 AAO41704.1 Q875K3  
 β-1,4-xylosidase (PtaBXL1;Bxl2) 3.2.1.37 Populus tremula x Populus alba CAJ41429.1
CAW52631.1
CBC23891.1		 Q333M3  
 α-L-arabinofuranosidase / β-xylosidase (Arf2) 3.2.1.55 Pyrus pyrifolia BAD98523.1
BAF79669.1
CAW52634.1
CBC23897.1		 Q4W7I3  
 α-L-arabinofuranosidase / β-1,4-xylosidase (RsAraf1) 3.2.1.55 Raphanus sativus BAE44362.1
CAW52632.1
CBC23893.1		 Q3V5Q1  
 β-xylosidase (Bxl1) 3.2.1.37 Rasamsonia emersonii CBS 814.70 AAL32053.2 Q8X212  
 avenacinase (Aven1;Aven) 3.2.1.- Rasamsonia emersonii CBS 814.70 AAM94393.3 Q8J261  
 β-glucosidase (ReCel3A) (Cel3A) 3.2.1.21 Rasamsonia emersonii IMI 392299 AAL69548.3
AAL69548.2		 Q8TGI8 4D0J[A,B,C,D]
5JU6[A,B,C,D]
 β-N-acetylglucosaminidase (Nag;RmNag) 3.2.1.52 Rhizomucor miehei CAU432 AGC24356.1   4ZM6[A,B]
 β-glucosidase (RmBglu3) (Bglu3B) 3.2.1.21 Rhizomucor miehei CAU432 AIY32164.1    
 β-glucosidase (Bgl) 3.2.1.21 Rhizomucor miehei NRRL 5282 CAP58431.2
CAP58431.1		 B0JE65  
 β-glucosidase 2 (Bgl2) 3.2.1.21 Saccharomycopsis fibuligera AAA34315.1 P22507  
 β-glucosidase 1 (Bgl1) 3.2.1.21 Saccharomycopsis fibuligera ATCC 36309 AAA34314.1 P22506  
 β-glucosidase (Bgl1;SfBGL1) (partial) 3.2.1.21 Saccharomycopsis fibuligera CGMCC:2.1626 AEV40916.1    
 β-glucosidase (fragment) 3.2.1.21 Schizophyllum commune AAA33925.1 P29091  
 β-glucosidase (SPBC1683.04) 3.2.1.21 Schizosaccharomyces pombe 972h- CAB91166.1
NP_595060.1		 Q9P6J6  
 β-glucosidase (tomatinase;B2Tom) 3.2.1.21 Septoria lycopersici AAB08445.1
AAB08446.1		 Q99324 cryst
 β-glucosidase (Bgl3;BglG;SmBGL3) 3.2.1.21 Stachybotrys microspora A19 AFC40275.1    
 β-glucosidase 3.2.1.21 Talaromyces aculeatus ATCC 10409 AGA96121.1    
 β-xylosidase (Bxy3A) 3.2.1.37 Talaromyces cellulolyticus CF-2612 / FERM BP-5826 BAK96214.1    
 β-glucosidase 3A (TCE0_039f12945) (Bgl3A) 3.2.1.21 Talaromyces cellulolyticus Y-94 GAM40530.1    
 β-glucosidase (Bgl3) (Bgl3A) 3.2.1.21 Talaromyces funiculosus NCL1 AFU91382.1    
 β-glucosidase (Bgl3A) 3.2.1.21 Talaromyces leycettanus JCM12802 AMR94085.1    
 β-glucosidase (Bgl3;Bgl) 3.2.1.21 Talaromyces purpureogenus KJS506 (KACC 93053P) ACV87737.1 C9E9M9  
 β-glucosidase (Bgl2;BGLII;Bg2;BGII) 3.2.1.21 Thermoascus aurantiacus IFO 9748 AAY33982.1
AAY33983.1		 Q4U4W7  
 β-glucosidase (Bgl1;Bg1;TaBgl1) 3.2.1.21 Thermoascus aurantiacus IFO 9748 AAZ95587.1
AAZ95588.1		 Q0ZUL0  
 β-glucosidase (MYCTH_80304) 3.2.1.21
3.2.1.58
3.2.1.-		 Thermothelomyces thermophila ATCC 42464 AEO58175.1    
 β-glucosidase (MtBgl3a;MYCTH_66804) (Bgl3A) 3.2.1.21 Thermothelomyces thermophila ATCC 42464 AEO58343.1    
 β-glucosidase (TkBgl3A) (Bgl3A) 3.2.1.21 Trichoderma koningiopsis FCD3-1 AIB10099.1    
 β-xylosidase (Bxl1) (Xyl3A) 3.2.1.37 Trichoderma reesei CAA93248.1
CAW52645.1
CBC23920.1		 Q92458 5A7M[A,B]
5AE6[A,B]
 β-glucosidase 1 (Bgl1;Bgl-1;TrBGL1) (Cel3A) 3.2.1.21 Trichoderma reesei QM9414 AAA18473.1 Q12715 3ZYZ[A]
4I8D[A,B]
 β-glucosidase (epB-BGL) 3.2.1.21 Trichoderma sp. W63 / CGMCC 5209 AJC01624.1    
 β-glucosidase I (Bgl1;BGL1;VbglI) 3.2.1.21 Trichoderma viride AS 3.3711 ACS93768.1 C6GGC9  
 β-glucosidase 3.2.1.21 Tropaeolum majus CAA07070.1 O82074  
 β-glucosidase (Bgl1) 3.2.1.21 Uromyces viciae-fabae CAE01320.1 Q70KQ7  
 β-glucosidase (UeBgl3A) (Bgl3A) 3.2.1.21 Ustilago esculenta NBRC 9887 BAK61808.1    
 β-glucosidase (Bgl;BGL-II) 3.2.1.21 Volvariella volvacea V14 AAG59831.1 Q9C3Z9  
 β-glucosidase 3.2.1.21 Wickerhamomyces anomalus VAR. ACETAETHERIUS CAA26662.1 P06835  
 exoglucanase (Exg1) 3.2.1.- Zea mays AAF79936.1
CAC21961.1		 Q9LLB8  
 β-xylosidase 3.2.1.37 Zea mays BZ3 CAW52613.1
ACL54109.1
CAW96523.1
CAW96686.1
CAX01900.1
CAX07254.1
CBC23853.1
CBD30890.1		    
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (JMB19063) 3.2.1.21 compost metagenome     3U48[B]
3U4A[A,B]
3U48[A]
 broad-specificity β-glucosidase/β-xylosidase (GlyA1) (partial) 3.2.1.21
3.2.1.37		 metagenome     5K6M[A]
5K6N[A]
5K6O[A]
5K6L[A]
 β-glucosidase (Unglu135B12;TY-135-138) 3.2.1.21 uncultured microorganism AFX98011.1    
 β-glucosidase (UmCel3G) 3.2.1.21 uncultured microorganism ABU68675.1 A7Y421  
 β-xylosidase (G06-24) 3.2.1.- uncultured organism ACY24766.1 D8VMY1  
 β-glucanase 3.2.1.- uncultured organism ADD62001.1 D9ZF97  
 SARM_0077 / 0_03232 / TW-71 (fragment; probable frameshift) 3.2.1.- uncultured organism ADX05759.1    
 c53_8 3.2.1.37 uncultured organism AGU11176.1    
 c84_2 3.2.1.21
3.2.1.37		 uncultured organism AGU12029.1    
 β-xylosidase / xylanase E2 3.2.1.37 unidentified AEF56854.1    
 β-glucosidase A3 3.2.1.21 unidentified AEF56853.1    
 β-glucosidase (UmCelC7;Cb1) 3.2.1.21 unidentified microorganism ABX76049.1 A9UGW5  
 β-glucosidase (UmCelS19;Sb1) 3.2.1.21 unidentified microorganism ABX76051.1 A9UID4  
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