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Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-); β-1,2-glucosidase (EC 3.2.1.-); β-1,3-glucosidase (EC 3.2.1.-); xyloglucan-specific exo-β-1,4-glucanase / exo-xyloglucanase (EC 3.2.1.155); stevioside-β-1,2-glucosidase (EC 3.2.1.-); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); protodioscin 26-O-β-D-glucosidase (EC 3.2.1.186); β-glucuronidase (EC 3.2.1.31); avenacinase (EC 3.2.1.-); tomatinase β-1,2-glucosidase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that some enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (48397); Uniprot accession (325); PDB accession (181); 3D entries (54); cryst (4)
Summary
Download GH3 (47394) Taxonomic display Structure (54 - 4 cryst) Characterized (339)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-glucosidase (AN2828) 3.2.1.21 pubmed
 Aspergillus nidulans FGSC A4 EAA63399.1 C8VJG1
Q5B9F2		  
 β-glucosidase (SP188;AnBgl1;AnCel3A) (peptide fragment) (Cel3A) 3.2.1.21 pubmed
 Aspergillus niger AAB27405.1    
 β-xylosidase (XlnD;AnXlnD;Asp n 14;P1.1) 3.2.1.37 pubmed
 Aspergillus niger 90196 AAD13106.1
CAW52630.1
CBC23888.1		 O00089
O93933		  
 β-glucosidase (P1.2) 3.2.1.21 pubmed
 Aspergillus niger ASKU28 AFW98805.1 K7WQK7  
 β-glucosidase 3.2.1.21 URL
 Aspergillus niger ATCC 10574 ANT73245.1    
 β-glucosidase (Bgl1;BG3;BGs) 3.2.1.21 pubmed
 Aspergillus niger B1 CAB75696.1 Q9P8F4  
 β-xylosidase (XlnD;AnXln3D) (Xln3D) 3.2.1.37 doi
 Aspergillus niger BE-2 AIC36733.1 A0A060IKI3  
 β-xylosidase (XlnD;Asp n 14;AnXlnD) 3.2.1.37 pubmed
 Aspergillus niger CBS 120.49 / NW147 AAQ80268.1
CAB06417.1
CAB59162.1
CAW52627.1
CBC23882.1		 O00089  
 β-xylosidase (XlnD;An01g09960) 3.2.1.37 pubmed
 Aspergillus niger CBS 513.88 CAK37179.1 A2QA27  
 β-glucosidase (Bgl1;An18g03570) 3.2.1.21 pubmed
 Aspergillus niger CBS 513.88 CAK48740.1 A2RAL4  
 β-glucosidase (Bgl1) 3.2.1.21 pubmed
 Aspergillus niger CGMCC 3.316 AFJ19133.1 I1Z9C3  
 β-xylosidase (XlnD) 3.2.1.37 doi
 Aspergillus niger GS1 ADD69953.1    
 β-glucosidase (Bgl1) 3.2.1.21   Aspergillus niger zju-2 ACJ02084.1    
 β-glucosidase 1 (Bgl1) 3.2.1.21 pubmed
 Aspergillus niger ZJUBE-1 QAV54755.1    
 β-glucosidase 2 (Bgl2) 3.2.1.21 pubmed
 Aspergillus niger ZJUBE-1 QAV54756.1    
 β-glucosidase (Cel3) 3.2.1.21 pubmed
 Aspergillus oryzae CAD67686.1
AJI43741.1		 A0A1L1X0X9  
 β-xylosidase (XylA;Xyl-1) 3.2.1.37 pubmed
 Aspergillus oryzae KBN616 BAA28267.1
BAA24107.1
CAW52628.1
CAW52629.1
CBC23884.1
CBC23886.1		 O42698
O59862
Q2UR38		  
 β-glucosidase (B7;BglA;Bgl1;AobG;BGHG1;BglC;AO090009000356) (Cel3A) 3.2.1.21 pubmed
 Aspergillus oryzae RIB40 BAE54829.1 Q2UUD6 5FJJ[A,B,C,D]
 β-xylosidase (XylA;Xyl-1;AO090005000986) 3.2.1.37 pubmed
 Aspergillus oryzae RIB40 BAE55977.1 Q2UR38  
 β-glucosidase 5 (Bgl5;BglG;AO090001000544) 3.2.1.21 pubmed
 Aspergillus oryzae RIB40 BAE57053.1 Q2UN12  
 β-glucosidase 1 / aryl β-glucosidase (Bgl1;BglJ;AO090003001511) 3.2.1.21 pubmed
 Aspergillus oryzae RIB40 BAE58551.1 Q2UIR4  
 isoprimeverose-producing oligoxyloglucan hydrolase (AO090701000274; IpeA; BglD) 3.2.1.120 pubmed
 Aspergillus oryzae RIB40 BAE62006.1   5YOT[A,B]
5YQS[A,B]
7EAP[A]
 aryl β-glucosidase (BglA;AO090038000223) 3.2.1.21 pubmed
 Aspergillus oryzae RIB40 BAE64040.1 Q2U325  
 β-1,6-glucosidase (BglH;AO090038000425) 3.2.1.- pubmed
 Aspergillus oryzae RIB40 BAE64214.1 Q2U2K1  
 aryl β-glucosidase (BglF;AO090103000127) 3.2.1.21 pubmed
 Aspergillus oryzae RIB40 BAE65597.1 Q2TYS6  
 β-glucosidase (Bgl;BGL1) 3.2.1.21 pubmed
 Aspergillus saccharolyticus CBS 127449 AEL79685.1 G0X2F9  
 β-xylosidase (XlnD) 3.2.1.8 pubmed
 Aspergillus sp. BCC125 AGB57183.1 L0L918  
 β-glucosidase (BglS;ATEG_07931) 3.2.1.21 pubmed
 Aspergillus terreus NIH2624 EAU32193.1 Q0CEF3  
 β-glucosidase 3 (fragment) 3.2.1.21 pubmed
 Aspergillus wentii   P29090  
 β-1,4-xylosidase (XylI) 3.2.1.37 pubmed
 Aureobasidium melanogenum ATCC 20524 BAI82526.1 D4AHT5  
 β-glucosidase / avenacinase (Sap1) 3.2.1.21
3.2.1.-		 doi
doi
 Botrytis cinerea SAS56 CAB61489.1 Q9UVJ6  
 β-glucosidase 1 (GH3BG1;CsGH3BG1) 3.2.1.21 pubmed
 Camellia sinensis ARU79079.1 A0A1Y0K2D5  
 β-glucosidase (D2-BGL) 3.2.1.21 pubmed
 Chaetomella raphigera 737 AID68373.1 A0A068FT77 6JXG[A]
 β-glucosidase (Cel3B; CEL3b) 3.2.1.21 pubmed
 Chaetomium atrobrunneum ANR02040.1    
 β-glucosidase (Cel3A; CEL3a) 3.2.1.21 pubmed
 Chaetomium atrobrunneum ANR02039.1    
 β-glucosidase (CHGG_03421) 3.2.1.21 pubmed
 Chaetomium globosum CBS 148.51 EAQ91486.1 Q2H8N3  
 β-glucosidase / β-xylosidase (Bxl5) 3.2.1.21 pubmed
 Chrysosporium lucknowense VKM F-3500-D / C1 AEN99939.1 G3FAQ7  
 β-glucosidase/ exo-β-1,3-glucosidase (Bgl2) 3.2.1.21
3.2.1.-		 pubmed
pubmed
 Coccidioides posadasii AAF21242.1 Q9UVC8  
 β-glucosidase (Bgl1) 3.2.1.21 pubmed
 Coccidioides posadasii C735 AAB67972.1 O14424  
 β-glucosidase 3.2.1.21 pubmed
 Dictyostelium discoideum AX3 AAA74233.1 Q23892  
 β-glucosidase (Bgl3A) 3.2.1.21 pubmed
 Evansstolkia leycettana JCM12802 AMR94085.1 A0A1B0VFN7  
 β-xylosidase (Xyl1) 3.2.1.37 pubmed
 Fragaria x ananassa AAS17751.2
CAW96536.1
CAW96699.1
CAX01913.1
CAX07267.1
CBD30903.1		 Q6RXY3  
 avenacinase I 3.2.1.21
3.2.1.-		 pubmed
pubmed
 Gaeumannomyces graminis AAB09777.1 Q00903  
 β-1,6/1,3-glucosidase (GtGen3A) 3.2.1.-
3.2.1.-		 pubmed
pubmed
pubmed
pubmed
 Gentiana triflora BBB05245.1    
 β-glucosidase (Bgl;GmBGL) 3.2.1.21 pubmed
 Glycine max AIO11756.1 A0A0B4PJM3  
 β-xylosidase (XYL) 3.2.1.37 pubmed
 Hordeum vulgare AAK38482.1
CAW52643.1
CAW96538.1
CAW96701.1
CAX01915.1
CAX07269.1
CBC23916.1
CBD30905.1		 Q8W011  
 α-L-arabinofuranosidase / β-xylosidase (ARA-I) 3.2.1.37
3.2.1.55		 pubmed
pubmed
 Hordeum vulgare subsp. vulgare AAK38481.1
BAJ89945.1
CAW52644.1
CAW96539.1
CAW96702.1
CAX01916.1
CAX07270.1
CBC23918.1
CBD30906.1		 F2D4C4
Q8W012		  
 exo-β-1,3-1,4-glucanase (ExoI) 3.2.1.- pubmed
 Hordeum vulgare subsp. vulgare AAD23382.1
BAK05680.1		 F2EEA8
Q9XEI3		 1EX1[A]
1IEQ[A]
1IEV[A]
1IEW[A]
1IEX[A]
1J8V[A]
1LQ2[A]
1X38[A]
1X39[A]
3WLH[A]
3WLI[A]
3WLJ[A]
3WLK[X]
3WLL[A]
3WLM[A]
3WLN[A]
3WLO[A]
3WLP[A]
3WLQ[A]
3WLR[A]
3WLS[A]
3WLT[A]
6JG1[A]
6JG2[A]
6JG6[A]
6JG7[A]
6JGA[A]
6JGB[A]
6JGC[A]
6JGD[A]
6JGE[A]
6JGG[A]
6JGK[A]
6JGL[A]
6JGN[A]
6JGO[A]
6JGP[A]
6JGQ[A]
6JGR[A]
6JGS[A]
6JGT[A]
6K6V[A]
6KUF[A]
6L1J[A]
6LBB[A]
6LBV[A]
6LC5[A]
6MD6[A]
6MI1[A]
 exo-β-1,3,1,4-glucanase II (ExoII) 3.2.1.- pubmed
 Hordeum vulgare subsp. vulgare AAC49170.1 Q42835  
 β-xylosidase (Xyl3A) 3.2.1.37 pubmed
 Humicola insolens Y1 / GCMCC 4573 AJK31203.1 A0A0C5AKM5  
 β-glucosidase I (Bgl1) 3.2.1.21 pubmed
 Hypocrea orientalis EU7-22 AFM77966.1 I6SJL7  
 β-glucosidase I (Bgl;KmBglI) 3.2.1.21 pubmed
 Kluyveromyces marxianus NBRC1777 ACY95404.1 D1GCC6 3ABZ[A,B,C,D]
3AC0[A,B,C,D]
 β-glucosidase (BglN) 3.2.1.21 pubmed
 Kuraishia capsulata 35M5N AAA91297.1 Q12653  
 β-xylosidase / β-glucosidase (Lxyl-p1-1) 3.2.1.21
3.2.1.37		 pubmed
pubmed
 Lentinula edodes M95.33 AET31457.1
AET31458.1		 G8GLN9  
 β-xylosidase / β-glucosidase (Lxyl-p1-2) (7-β-xylosyltaxane-active) 3.2.1.21
3.2.1.37		 pubmed
pubmed
 Lentinula edodes M95.33 AET31459.1
AET31460.1		 G8GLP2 6JBS[A,B,C,D]
6KJ0[A,B]
7EY1[A,B,C,D]
7EY2[A,B,C,D,E,F]
 β-xylosidase / α-L-arabinosidase (Xyl1) 3.2.1.37
3.2.1.55		 pubmed
pubmed
 Medicago sativa subsp. x varia ABQ45227.1 A5JTQ2  
 β-glucosidase (HMPREF1544_06945) 3.2.1.21 pubmed
 Mucor circinelloides 1006PhL EPB86303.1 S2JU28  
 β-glucosidase 1 (Bgl1) 3.2.1.21 pubmed
 Mucor javanicus NBRC 4572 BAO00904.1 U3U8W9  
 β-glucosidase 2 (Bgl2) 3.2.1.21 pubmed
 Mucor javanicus NBRC 4572 BAO00905.1 U3U793  
 β-glucanase (W5-16143) 3.2.1.21 pubmed
 Neocallimastix patriciarum W5 AEX92706.1 H2BPT0  
 β-glucosidase (Bgs;NpaBGS) 3.2.1.21 pubmed
 Neocallimastix patriciarum W5 AFI47447.1 I6PFJ4  
 β-glucosidase (Bgl6; Gh3-3; NcGH3-3; NcCel3A; Ncrα-Bgl101; NCU08755) (Cel3A) 3.2.1.21 pubmed
 Neurospora crassa OR74A EAA26868.1
XP_330872.1
XP_956104.1		 Q7RWP2 5NBS[A,B]
 β-glucosidase (Bgl2;Gh3-4;NCU04952) 3.2.1.21 pubmed
 Neurospora crassa OR74A EAA30164.1
XP_324309.1		 Q7S3R5  
 β-xylosidase (Gh3-7;NCU09923) 3.2.1.37 pubmed
 Neurospora crassa OR74A CAB91343.2
CAW52623.1
CAW52647.1
CBC23874.1
CBC23924.1
XP_329671.1		 Q9P627  
 β-glucosidase (Bgl3; PtBglu3) 3.2.1.21 pubmed
 Paecilomyces sp. thermophila ADM47481.1 J9PDC5  
 β-glucosidase (Bgl1) 3.2.1.21 pubmed
 Penicillium brasilianum IBT 20888 ABP88968.1 A5A4M8  
 β-glucosidase I (Bgl1;BglI) 3.2.1.21 pubmed
 Penicillium decumbens 114-2 / JU-A10 ACD86466.1 B3GK87  
 β-glucosidase I (Bgl1;Dbgl1) 3.2.1.21 doi
 Penicillium decumbens CICC 40361 ADB82653.1 D3JUX2  
 β-glucosidase (Bgl4;PDE_01565) 3.2.1.21 pubmed
 Penicillium oxalicum 114-2 EPS26627.1    
 β-glucosidase (BGL I) 3.2.1.21 pubmed
 Periconia sp. BCC 2871 ABX84365.1
AFH41575.1		 A9UIG0
H9ZXX1		  
 β-glucosidase (Bgl1) 3.2.1.21 pubmed
 Phaeosphaeria avenaria WAC1293 CAB82861.1 Q9P879  
 xylan 1,4-β-xylosidase (PcBxl3) 3.2.1.37 pubmed
 Phanerochaete chrysosporium     7VC6[A]
7VC7[A]
 glucan β-1,3-glucosidase (Bgl) 3.2.1.21
3.2.1.-		 pubmed
pubmed
 Phanerochaete chrysosporium K-3 BAB85988.1 Q8TGC6  
 glucan β-1,3-glucosidase (CbgL;Cbgl-1;Cbgl-2) (Bgl1A) 3.2.1.21
3.2.1.-		 pubmed
doi
 Phanerochaete chrysosporium OGC101 AAC26489.1
AAC26490.1		 O74203
Q9URP5		  
 β-glucosidase I (Bgl1;BGLI) 3.2.1.21 pubmed
 Pichia etchellsii ACF93471.1 B5B423  
 β-glucosidase (Cel3A) (Cel3A) 3.2.1.21 pubmed
 Piromyces sp. E2 AAO41704.1 Q875K3  
 β-1,4-xylosidase (PtaBXL1;Bxl2) 3.2.1.37 doi
 Populus tremula x Populus alba CAJ41429.1
CAW52631.1
CBC23891.1		 Q333M3  
 β-glucosidase 3.2.1.21 pubmed
 Pyricularia grisea Y34 AAX07690.1 Q5EMW3  
 β-glucosidase (MoCel3B;MG03508.4) (Cel3B) 3.2.1.21 pubmed
 Pyricularia oryzae 70-15 XP_360965.1 G4N7Z0  
 β-glucosidase (MoCel3A;MG09353.4) (Cel3A) 3.2.1.21 pubmed
 Pyricularia oryzae 70-15 XP_364573.1 G4NI45  
 α-L-arabinofuranosidase / β-xylosidase (Arf2) 3.2.1.37
3.2.1.55		 pubmed
pubmed
 Pyrus pyrifolia BAD98523.1
BAF79669.1
CAW52634.1
CBC23897.1		 A7VJC6
Q4W7I3		  
 α-L-arabinofuranosidase / β-1,4-xylosidase (RsAraf1) 3.2.1.37
3.2.1.55		 pubmed
pubmed
 Raphanus sativus BAE44362.1
CAW52632.1
CBC23893.1		 Q3V5Q1  
 acid β-glucosidase (fragment) (Bgl3B) 3.2.1.21   Rasamsonia emersonii / Talaromyces leycettanus JM12802 ASU50140.1    
 β-xylosidase (Bxl1) 3.2.1.37 pubmed
 Rasamsonia emersonii CBS 814.70 AAL32053.2 Q8X212  
 avenacinase (Aven1;Aven) 3.2.1.- pubmed
 Rasamsonia emersonii CBS 814.70 AAM94393.3 Q8J261  
 β-glucosidase (ReCel3A) (Cel3A) 3.2.1.21 pubmed
 Rasamsonia emersonii IMI 392299 AAL69548.3
AAL69548.2		 Q8TGI8 4D0J[A,B,C,D]
5JU6[A,B,C,D]
 β-N-acetylglucosaminidase (Nag;RmNag) 3.2.1.52 pubmed
 Rhizomucor miehei CAU432 AGC24356.1 V9M3A9 4ZM6[A,B]
 β-glucosidase (RmBglu3) (Bglu3B) 3.2.1.21 pubmed
 Rhizomucor miehei CAU432 AIY32164.1 A0A0B4RUW2  
 β-glucosidase (Bgl) 3.2.1.21 pubmed
 Rhizomucor miehei NRRL 5282 CAP58431.2
CAP58431.1		 B0JE65  
 RO3G_04558.1 (Rory-Bgl104) (13377) 3.2.1.21 pubmed
 Rhizopus delemar RA 99-880 EIE79853.1 I1BUH3  
 β-glucosidase 2 (Bgl2) 3.2.1.21 pubmed
 Saccharomycopsis fibuligera AAA34315.1 P22507  
 β-glucosidase 1 (Bgl1) 3.2.1.21 pubmed
 Saccharomycopsis fibuligera ATCC 36309 AAA34314.1 P22506  
 β-glucosidase (Bgl1;SfBGL1) 3.2.1.21 pubmed
 Saccharomycopsis fibuligera CGMCC:2.1626 AEV40916.1 G9C7I6  
 β-glucosidase (fragment) 3.2.1.21 pubmed
 Schizophyllum commune AAA33925.1 P29091  
 β-glucosidase (tomatinase;B2Tom) 3.2.1.- pubmed
 Septoria lycopersici AAB08445.1
AAB08446.1		 Q99324 cryst
 β-xylosidase (LeXyl2;Xyl2) (fragment) 3.2.1.37 pubmed
 Solanum lycopersicum BAC98299.1 Q76MS4  
 β-xylosidase (LeXyl1;Xyl1) 3.2.1.37 pubmed
 Solanum lycopersicum BAC98298.1
CAW52640.1
CAW96537.1
CAW96700.1
CAX01914.1
CAX07268.1
CBC23909.1
CBD30904.1		 Q76MS5  
 β-glucosidase (Bgl3;BglG;SmBGL3) 3.2.1.21 doi
 Stachybotrys microspora A19 AFC40275.1 H9CWR4  
 β-glucosidase 3.2.1.21 pubmed
 Talaromyces aculeatus ATCC 10409 AGA96121.1 L0H8J8  
 β-xylosidase 1 (BxTW1) 3.2.1.37 pubmed
 Talaromyces amestolkiae CIB AKJ79184.1    
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