Activities in Family	Trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-); Kdo hydrolase (EC 3.2.1.124); Exo-α-sialidase (EC 3.2.1.18); Anhydrosialidase (EC 4.2.2.15);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (11188); Uniprot accession (128); PDB accession (186); 3D entries (29); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase		Neorhizobium galegae bv. orientalis str. HAMBI 540	CDN52351.1
LZK73_26350		Neorhizobium galegae VafX2	UIY32292.1
QEO92_18650		Neorhizobium petrolearium OS53	WGI67016.1
QTA58_08630		Rhizobium sp. CSC1952	WJR68796.1
NCHU2750_32650		Neorhizobium sp. NCHU2750	AYD02650.1
JO391_17195		Neotabrizicola shimadae N10	QYZ72018.1
A8C56_04405		Niabella ginsenosidivorans BS26	ANH80320.1
A8C56_20450		Niabella ginsenosidivorans BS26	ANH83039.1
NIASO_04175		Niabella soli DSM 19437	AHF14599.1
NIASO_04220		Niabella soli DSM 19437	AHF14608.1
NIASO_17320 (probable fragment)		Niabella soli DSM 19437	AHF16453.1
NIASO_17345		Niabella soli DSM 19437	AHF16457.1
neuraminidase		Niabella soli DSM 19437	AHF16870.1
NIASO_17335		Niabella soli DSM 19437	AHF16456.1
U0035_02385		Niabella yanshanensis HAMBI_3031	WQD38993.1
U0035_00215		Niabella yanshanensis HAMBI_3031	WQD38569.1
U0035_02370		Niabella yanshanensis HAMBI_3031	WQD38990.1
U0035_02380		Niabella yanshanensis HAMBI_3031	WQD38992.1
U0035_02325		Niabella yanshanensis HAMBI_3031	WQD38981.1
U0035_03780		Niabella yanshanensis HAMBI_3031	WQD39270.1
U0035_03565		Niabella yanshanensis HAMBI_3031	WQD39227.1
L8T27_011030		Niallia sp. Man26	UPO86156.1
Niako_0563		Niastella koreensis GR20-10	AEV96958.1
Niako_2799		Niastella koreensis GR20-10	AEV99133.1
Niako_3601		Niastella koreensis GR20-10	AEV99901.1
Niako_5013		Niastella koreensis GR20-10	AEW01252.1
MU582_13840		Nocardioidaceae bacterium SCSIO 66511	UPK73517.1
Nocox_19560 (NedA) (fragment)		Nonomuraea coxensis DSM 45129	QYC41521.1
OIE67_33010		Nonomuraea fuscirosea NBC 01801	WSA48890.1
OIE67_45600		Nonomuraea fuscirosea NBC 01801	WSA51254.1
OIE67_14730		Nonomuraea fuscirosea NBC 01801	WSA55808.1
OIE67_33005		Nonomuraea fuscirosea NBC 01801	WSA48889.1
OIE67_32515		Nonomuraea fuscirosea NBC 01801	WSA48793.1
BN4615_P137		Nonomuraea gerenzanensis ATCC 39727	SBO90623.1
BN4615_P334		Nonomuraea gerenzanensis ATCC 39727	SBO90820.1
BN4615_P3463		Nonomuraea gerenzanensis ATCC 39727	SBO93947.1
LCN96_54555		Nonomuraea gerenzanensis L70	UBU13173.1
LCN96_53565		Nonomuraea gerenzanensis L70	UBU12984.1
LCN96_14335		Nonomuraea gerenzanensis L70	UBU16140.1
GBF35_12860		Nonomuraea nitratireducens WYY166	QFY07456.1
GBF35_12865		Nonomuraea nitratireducens WYY166	QFY07457.1
GBF35_40500		Nonomuraea nitratireducens WYY166	QFY12024.1
WBK31_24460		Nonomuraea sp. N2-4H	WXK61931.1
WBK31_24455		Nonomuraea sp. N2-4H	WXK61930.1
U9J33_11990		Novosphingobium sp. RL4	WRT91931.1
FEZ18_00905		Oceanihabitans sp. IOP_32	QFZ55957.1
NP439_23560		Oceanobacillus jeddahense QA-1986 374	UUI02969.1
exo-α-sialidase		Oerskovia paurometabola O129	WBR35090.1
FFI11_015855		Oerskovia sp. KBS0722	QDW63780.1
FFI11_014185		Oerskovia sp. KBS0722	QDW63506.1
FKG96_06435		Olivibacter sp. LS-1	QEL04300.1
FKG96_08600		Olivibacter sp. LS-1	QEL04322.1
FKG96_20880		Olivibacter sp. LS-1	QEL04423.1
FKG96_20870		Olivibacter sp. LS-1	QEL03173.1
FKG96_23440		Olivibacter sp. LS-1	QEL03661.1
FKG96_18945		Olivibacter sp. LS-1	QEL02804.1
H8S90_08990		Olivibacter sp. SDN3	QNL51687.1
H8S90_10850		Olivibacter sp. SDN3	QNL52022.1
H8S90_08975		Olivibacter sp. SDN3	QNL51684.1
H8S90_17350		Olivibacter sp. SDN3	QNL52574.1
H8S90_12185		Olivibacter sp. SDN3	QNL52257.1
OPIT5_09180		Opitutaceae bacterium TAV5	AHF90349.1
OPIT5_15740		Opitutaceae bacterium TAV5	AHF91454.1
OPIT5_15785		Opitutaceae bacterium TAV5	AHF91462.1
OPIT5_17805		Opitutaceae bacterium TAV5	AHF91798.1
OPIT5_20450		Opitutaceae bacterium TAV5	AHF92263.1
OPIT5_22710		Opitutaceae bacterium TAV5	AHF92617.1
neuraminidase		Opitutaceae bacterium TAV5	AHF93787.1
OPIT5_30165		Opitutaceae bacterium TAV5	AHF93797.1
OPIT5_23730		Opitutaceae bacterium TAV5	AHF92758.1
F7C95_07490		Opitutae bacterium ISCC 51	QXD25722.1
F7C95_09865		Opitutae bacterium ISCC 51	QXD26332.1
F7C95_09760		Opitutae bacterium ISCC 51	QXD26134.1
F7C95_15325		Opitutae bacterium ISCC 51	QXD23284.1
F7C95_09380		Opitutae bacterium ISCC 51	QXD26061.1
GA003_09810		Opitutae bacterium ISCC 52	QXD30397.1
GA003_15230		Opitutae bacterium ISCC 52	QXD27357.1
GA003_09325		Opitutae bacterium ISCC 52	QXD30129.1
GA003_09705		Opitutae bacterium ISCC 52	QXD30202.1
GA003_07450		Opitutae bacterium ISCC 52	QXD29790.1
ASA1KI_38020		Opitutales bacterium ASA1	BET68884.1
SAMN05444173_3051		Opitutus sp. GAS368	SDS49230.1
SAMN05444173_3052		Opitutus sp. GAS368	SDS49269.1
DV701_06145		Ornithinimicrobium avium AMA3305	AXH95765.1
MT999_02690		Ornithobacterium rhinotracheale 97	UOH66335.1
MT993_00140		Ornithobacterium rhinotracheale A171	UOH63657.1
neuraminidase		Ornithobacterium rhinotracheale DKC_170	AFP58790.1
neuraminidase		Ornithobacterium rhinotracheale DK_1818	AFP58789.1
Ornrh_1957		Ornithobacterium rhinotracheale DSM 15997	AFL98101.1
EQP59_07395		Ornithobacterium rhinotracheale FARPER-174b	QAR31170.1
neuraminidase		Ornithobacterium rhinotracheale HU_10	AFP58784.1
NV236_09260		Ornithobacterium rhinotracheale IRI-Sh	UVD86848.1
MT996_05280		Ornithobacterium rhinotracheale K223	UOH78881.1
Q785_09650		Ornithobacterium rhinotracheale ORT-UMN 88	AIQ00673.1
neuraminidase		Ornithobacterium rhinotracheale RSA_340	AFP58788.1
neuraminidase		Ornithobacterium rhinotracheale SC_1121	AFP58783.1 AFP58781.1 AFP58785.1 AFP58786.1 AFP58787.1
neuraminidase		Ornithobacterium rhinotracheale SC_1144	AFP58782.1
neuraminidase		Ornithobacterium rhinotracheale UL-PI_99	AFP58780.1
OTERR_02380 (fragment)		Oryzomicrobium terrae TPP412	QEL63714.1
OBV_34470		Oscillibacter valericigenes Sjm18-20	BAL00646.1
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