Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (6329); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (6088) Archaea (1) Bacteria (5613) Eukaryota (431) Viruses (37) unclassified (6) Structure (21) Characterized (97)
| 1 | ... | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BW733_14130 (fragment)   Tessaracoccus flavescens SST-39T AQP51794.1    
 RPIT_12385   Tessaracoccus flavus RP1T AQP45501.1    
 BKM78_13850   Tessaracoccus sp. T2.5-30 AQX16876.1    
 THTE_2055   Thermogutta terrifontis R1 ASV74657.1    
 THTE_2789   Thermogutta terrifontis R1 ASV75391.1    
 THTE_1431   Thermogutta terrifontis R1 ASV74033.1    
 exo-neuraminidase (TdNeu;TDE0471) 3.2.1.18 Treponema denticola ATCC 35405 AAS10966.1
NP_971085.1
Q73QH2  
 TPE_0275   Treponema pedis str. T A4 AGT42771.1    
 TPE_2363   Treponema pedis str. T A4 AGT44837.1    
 FUT84_11840   Treponema phagedenis B31.4 QEK01776.1    
 FUT82_13880   Treponema phagedenis B36.5 QEJ98971.1    
 FUT79_12915   Treponema phagedenis B43.1 QEJ96011.1    
 FUT81_12310   Treponema phagedenis S11.1 QEK10134.1    
 FUT83_12180   Treponema phagedenis S2.3 QEK04479.1    
 FUT80_09325   Treponema phagedenis S8.5 QEK06889.1    
 GWP43_06145   Treponema sp. OMZ 804 QHX44502.1    
 NCTC13354_01304 (NedA)   Trueperella bialowiezensis NCTC13354 VEI13587.1    
 NCTC13354_01448 (NanA)   Trueperella bialowiezensis NCTC13354 VEI13727.1    
 neuraminidase   Trueperella bonasi DSM 17163 AGI95981.1    
 NanP   Trueperella pyogenes AAK98800.1 Q8VPE8  
 sialidase (NanH) 3.2.1.18 Trueperella pyogenes AAK15462.1 Q9AHP2  
 DBV13_04120 (fragment)   Trueperella pyogenes Arash114 AWA43258.1    
 DBV13_04125 (fragment)   Trueperella pyogenes Arash114 AWA43259.1    
 neuraminidase (NanP) (fragment)   Trueperella pyogenes FL-1 ARA90381.1    
 neuraminidase (NanH)   Trueperella pyogenes FL-1 ARA90380.1    
 DDE06_09730   Trueperella pyogenes TP-2849 AWG17066.1    
 DDE06_06825   Trueperella pyogenes TP-2849 AWG16543.1    
 EB776_07725   Trueperella pyogenes TP1 AZR01201.1    
 EB776_05110   Trueperella pyogenes TP1 AZR00725.1    
 EB775_03470   Trueperella pyogenes TP2 AZR02452.1    
 EB775_00845   Trueperella pyogenes TP2 AZR01983.1    
 EBQ11_01545   Trueperella pyogenes TP3 AZR04057.1    
 EBQ11_09420   Trueperella pyogenes TP3 AZR05421.1    
 EBQ10_06315   Trueperella pyogenes TP4 AZR06946.1    
 EBQ10_03405   Trueperella pyogenes TP4 AZR06434.1    
 DC090_07800   Trueperella pyogenes TP4479 AWG04339.1    
 DC090_04895   Trueperella pyogenes TP4479 AWG03812.1    
 X956_00875 (fragment)   Trueperella pyogenes TP8 AJC68877.1    
 X956_03635   Trueperella pyogenes TP8 AJC69304.1    
 GMBLW1_06220   Tuwongella immobilis VTS04048.1    
 GMBLW1_20260   Tuwongella immobilis VTR99890.1    
 GMBLW1_44930   Tuwongella immobilis VTS06759.1    
 GMBLW1_20260   Tuwongella immobilis MBLW1 VIP01934.1    
 GMBLW1_44930   Tuwongella immobilis MBLW1 VIP04700.1    
 GMBLW1_06220   Tuwongella immobilis MBLW1 VIP03338.1    
 HGMM_F10C03C23   uncultured Acidobacteria bacterium BAL53855.1    
 ORF (fragment)   uncultured bacterium APO34972.1    
 ORF (fragment)   uncultured bacterium APO32020.1    
 GH33, Sialidase   uncultured bacterium VDS02392.1    
 ORF (fragment)   uncultured bacterium fosmid pJB148G3 AIF26887.1    
 sialidase   uncultured bacterium Rlip1 ACM91104.1 C0K074  
 Sialidase26   unidentified bacterium     6MRV[A,B]
6MRX[A,B,C,D]
6MYV[A,B,C,D]
6MRV[B]
 CMV30_05015   Verrucomicrobia bacterium HZ-65 ATC63364.1    
 CMV30_08310   Verrucomicrobia bacterium HZ-65 ATC63952.1    
 IMCC26134_04605   Verrucomicrobia bacterium IMCC26134 AKC83918.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 DYL72_11630   Vibrio anguillarum J360 AZS25596.1    
 DYL72_11630   Vibrio anguillarum J360 AZS25596.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 NanH   Vibrio cholerae 17674 QBJ27574.1    
 NanH   Vibrio cholerae 17674 QBJ27574.1    
 NanH   Vibrio cholerae 18470 QBJ27573.1    
 NanH   Vibrio cholerae 18470 QBJ27573.1    
 EZZ25_09390   Vibrio cholerae 20000 QBJ29517.1    
 EZZ25_09390   Vibrio cholerae 20000 QBJ29517.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 A1552VC_01566 (NanH)   Vibrio cholerae A1552 AWB74302.1    
 A1552VC_01566 (NanH)   Vibrio cholerae A1552 AWB74302.1    
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2 Q5IB64
Q5IB64
 
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2
AAW31751.1
Q5IB64
Q5IB64
 
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 ASZ81_01775   Vibrio cholerae CRC1106 APF56916.1    
 ASZ81_01775   Vibrio cholerae CRC1106 APF56916.1    
 neuraminidase   Vibrio cholerae CRC711 APF53177.1    
 neuraminidase   Vibrio cholerae CRC711 APF53177.1    
 ASZ88_01723 (NanH)   Vibrio cholerae E1320 APF68105.1    
 ASZ88_01723 (NanH)   Vibrio cholerae E1320 APF68105.1    
 EEL44_12020   Vibrio cholerae E4 AYV09698.1    
 EEL44_12020   Vibrio cholerae E4 AYV09698.1    
 neuraminidase   Vibrio cholerae E506 APF60361.1    
 neuraminidase   Vibrio cholerae E506 APF60361.1    
 CSW01_08950   Vibrio cholerae E7946 ATQ46817.1    
 CSW01_08950   Vibrio cholerae E7946 ATQ46817.1    
 neuraminidase   Vibrio cholerae E9120 APF71815.1    
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