Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (54780); Uniprot accession (7858); PDB accession (467); 3D entries (111); cryst (2)
All (50004) Archaea (367) Bacteria (46504) Eukaryota (3003) unclassified (130) Structure (111 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 TreY (fragment)   Acidianus ambivalens DSM 3772 CBY66041.1     26
 Ahos_1028   Acidianus hospitalis W1 AEE93914.1     11
 Ahos_1027   Acidianus hospitalis W1 AEE93913.1     26
 Ahos_1029   Acidianus hospitalis W1 AEE93915.1     10
 B6F84_09245   Acidianus manzaensis YN-25 ARM76187.1     10
 B6F84_09240   Acidianus manzaensis YN-25 ARM76186.1     11
 B6F84_09235   Acidianus manzaensis YN-25 ARM76185.1     26
 ASAC_1074   Acidilobus saccharovorans 345-15 ADL19479.1 D9Q2E1   20
 SE86_06510   Acidilobus sp. 7A AMD30973.1    
 Arcve_0957   Archaeoglobus veneficus SNP6 AEA46968.1    
 CPM_1881   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85657.1     3
 CPM_0719   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84576.1     10
 CPM_1882   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85658.1     9
 CPM_0178   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84072.1     11
 CPM_0718   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84575.1     26
 CPM_1880   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85656.1     16
 CPM_1614   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85401.1     20
 CSP5_1944   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM87483.1     9
 CSP5_0721   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM52961.1     10
 CSP5_1943   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM87453.1     3
 CSP5_0720   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM52923.1     26
 CSP5_1645   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM79844.1     20
 CSP5_1942   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM87424.1     16
 CSP5_0212   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM34926.1     11
 DKAM_0273   Desulfurococcus amylolyticus 1221n ACL10599.1 B8D2L1   20
 Desfe_0644   Desulfurococcus amylolyticus DSM 16532 AFL66545.1     20
 Desmu_0336   Desulfurococcus mucosus DSM 2162 ADV64655.1     20
 pullulanase (ApuA;Pul-Dm;Desmu_0653) 3.2.1.41 Desulfurococcus mucosus DSM 2162 AAG31033.1
ADV64961.1
E8R8Y5
Q9HHB0
  20
 HacjB3_03370   Halalkalicoccus jeotgali B3 ADJ14067.1 D8J7H2   31
 α-amylase (AmyH) 3.2.1.1 Haloarcula hispanica CAI64586.1 Q4A3E0  
 HAH_0971 (Agla1)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM56589.1     31
 HAH_2473 (MalA)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM58060.1    
 HAH_2792 (Amy2)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM58372.1    
 HAH_1360 (fragment)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM56974.1    
 HISP_14190   Haloarcula hispanica N601 AHB67104.1    
 HISP_04995   Haloarcula hispanica N601 AHB65391.1     31
 HISP_06960   Haloarcula hispanica N601 AHB65764.1    
 HISP_12590   Haloarcula hispanica N601 AHB66804.1    
 α-amylase (MalA) 3.2.1.1 Haloarcula japonica TR-1 BAM75337.1    
 rrnAC2350 (Amy)   Haloarcula marismortui ATCC 43049 AAV47170.1 Q5UZY3  
 rrnAC0224 (AglA1)   Haloarcula marismortui ATCC 43049 AAV45283.1
CBF79161.1
Q5V5B9   31
 rrnAC1962 (MalA)   Haloarcula marismortui ATCC 43049 AAV46830.1 Q5V0X3  
 SG26_06460   Haloarcula sp. CBA1115 AJF25395.1    
 SG26_04895   Haloarcula sp. CBA1115 AJF25106.1    
 SG26_12670   Haloarcula sp. CBA1115 AJF26520.1     31
 SG26_14800   Haloarcula sp. CBA1115 AJF26906.1    
 CHINAEXTREME_10100   Halobiforma lacisalsi AJ5 APW98117.1    
 CHINAEXTREME_12360   Halobiforma lacisalsi AJ5 APW98517.1     31
 ABY42_09415   Haloferax gibbonsii ARA6 AKU07947.1     31
 ABY42_02600   Haloferax gibbonsii ARA6 AKU06683.1    
 ABY42_09420   Haloferax gibbonsii ARA6 AKU07948.1     31
 ABY42_08360   Haloferax gibbonsii ARA6 AKU07761.1    
 α-cyclomaltodextrin glucanotransferase (Cgt) 2.4.1.19 Haloferax mediterranei CAI46245.1 Q53I75   2
 BM92_03985   Haloferax mediterranei ATCC 33500 AHZ21871.1     31
 BM92_06595   Haloferax mediterranei ATCC 33500 AHZ22338.1    
 BM92_00090   Haloferax mediterranei ATCC 33500 AHZ21153.1    
 BM92_06580   Haloferax mediterranei ATCC 33500 AHZ22336.1     2
 HFX_0535 (Amyp1)   Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK18262.1     2
 HFX_0533 (Amy1)   Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK18260.1    
 HFX_1044 (Amy3)   Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK18760.1     31
 HFX_1802 (Amy4)   Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK19506.1
AFK19506.2
   
 HVO_0567   Haloferax volcanii DS2 ADE03517.1 D4GSG2  
 HVO_1710   Haloferax volcanii DS2 ADE04704.1 D4H055  
 Hbor_26440   Halogeometricum borinquense DSM 11551 ADQ68196.1 E4NT99  
 Hmuk_0209   Halomicrobium mukohataei DSM 12286 ACV46346.1 C7NWY1   20
 Hmuk_2260   Halomicrobium mukohataei DSM 12286 ACV48372.1 C7NXD8   31
 Hmuk_0052   Halomicrobium mukohataei DSM 12286 ACV46203.1 C7NVT8   31
 Hmuk_0051   Halomicrobium mukohataei DSM 12286 ACV46202.1 C7NVT7   31
 Hmuk_0210   Halomicrobium mukohataei DSM 12286 ACV46347.1 C7NWY2   2
 Halxa_4124   Halopiger xanaduensis SH-6 AEH38729.1     20
 Hqrw_2193 (Amya1)   Haloquadratum walsbyi C23 CCC40085.1    
 Hqrw_2840 (Amya2)   Haloquadratum walsbyi C23 CCC40652.1    
 HQ2031A   Haloquadratum walsbyi DSM 16790 CAJ52158.1 Q18IL2  
 HQ2540A   Haloquadratum walsbyi DSM 16790 CAJ52652.1 Q18H91  
 HTIA_0919   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33058.1    
 HTIA_0920   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33059.1    
 HTIA_0927   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33066.1     31
 HTIA_0928   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33067.1     31
 HTIA_0925   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33064.1     4
 HTIA_0926   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33065.1     16
 HTIA_2290 (fragment)   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34399.1    
 Huta_1052   Halorhabdus utahensis DSM 12940 ACV11235.1 C7NVF1  
 Hlac_0544   Halorubrum lacusprofundi ATCC 49239 ACM56146.1 B9LTL2  
 Hlac_0587   Halorubrum lacusprofundi ATCC 49239 ACM56189.1 B9LTQ5   16
 Hlac_1504   Halorubrum lacusprofundi ATCC 49239 ACM57092.1 B9LP04  
 HALLA_17420   Halostagnicola larsenii XH-48 AHG01126.1    
 Htur_2652   Haloterrigena turkmenica DSM 5511 ADB61528.1 D2RWM7  
 Htur_2110 (possible fragment)   Haloterrigena turkmenica DSM 5511 ADB60993.1 D2RTP2  
 Mcup_1211   Metallosphaera cuprina Ar-4 AEB95316.1     11
 Mcup_1210   Metallosphaera cuprina Ar-4 AEB95315.1     10
 Mcup_1212   Metallosphaera cuprina Ar-4 AEB95317.1     26
 maltooligosyltrehalose trehalohydrolase (TreZ;MTH) 3.2.1.141 Metallosphaera hakonensis JCM 8857 AAR18372.1 Q6SZP6   10
 maltooligosyltrehalose synthase (TreY;MTS) 5.4.99.15 Metallosphaera hakonensis JCM 8857 AAR18371.1 Q6SZP7   26
 glycogen debranching enzyme (TreX)   Metallosphaera hakonensis JCM 8857 AAS00512.1 Q6R5P1   11
 MBBA_1452 (GlgB)   Methanoculleus bourgensis SAI88306.1     9
 BN140_2271 (GlgB)   Methanoculleus bourgensis MS2 type strain:MS2 CCJ37194.1     9
 Memar_0386   Methanoculleus marisnigri JR1 ABN56319.1 A3CSG9  
 Memar_1265   Methanoculleus marisnigri JR1 ABN57195.1 A3CUZ5   9
 MMAB1_3002   Methanoculleus sp. MAB1 CVK34215.1     9
 Metho_1364   Methanomethylovorans hollandica DSM 15978 AGB49579.1     5
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