Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (81895); Uniprot accession (7842); PDB accession (519); 3D entries (121); cryst (2)
All (76925) Archaea (468) Bacteria (72801) Eukaryota (3524) Viruses (1) unclassified (131) Structure (121 - 2 cryst) Characterized (823)
| 1 | 2 | 3 | 4 | 5 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 TreY (fragment)   Acidianus ambivalens DSM 3772 CBY66041.1     26
 DFR85_11605 (TreY)   Acidianus brierleyi DSM 1651 AWR95146.1     26
 DFR85_11615 (TreZ)   Acidianus brierleyi DSM 1651 AWR95148.1     10
 DFR85_11610 (GlgX)   Acidianus brierleyi DSM 1651 AWR95147.1     11
 Ahos_1028   Acidianus hospitalis W1 AEE93914.1     11
 Ahos_1027   Acidianus hospitalis W1 AEE93913.1     26
 Ahos_1029   Acidianus hospitalis W1 AEE93915.1     10
 B6F84_09245   Acidianus manzaensis YN-25 ARM76187.1     10
 B6F84_09240   Acidianus manzaensis YN-25 ARM76186.1     11
 B6F84_09235   Acidianus manzaensis YN-25 ARM76185.1     26
 DFR86_07945 (GlgX)   Acidianus sulfidivorans JP7 AWR98289.1     11
 DFR86_07950 (TreZ)   Acidianus sulfidivorans JP7 AWR97488.1     10
 DFR86_07940 (TreY)   Acidianus sulfidivorans JP7 AWR97487.1     26
 ASAC_1074   Acidilobus saccharovorans 345-15 ADL19479.1 D9Q2E1   20
 SE86_06510   Acidilobus sp. 7A AMD30973.1    
 Arcve_0957   Archaeoglobus veneficus SNP6 AEA46968.1    
 AArcSl_2639 (TreS)   archaeon AArc-Sl AUX10258.1     16
 AArcSl_1341   archaeon AArc-Sl AUX08972.1     31
 AArcSl_1398   archaeon AArc-Sl AUX09029.1     20
 AArcSl_1393 (AmyA)   archaeon AArc-Sl AUX09024.1    
 AArcSl_2638 (Amya2)   archaeon AArc-Sl AUX10257.1    
 CPM_1881   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85657.1     3
 CPM_0719   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84576.1     10
 CPM_1882   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85658.1     9
 CPM_0178   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84072.1     11
 CPM_0718   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK84575.1     26
 CPM_1880   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85656.1     16
 CPM_1614   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85401.1     20
 CSP5_1944   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM87483.1     9
 CSP5_0721   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM52961.1     10
 CSP5_1943   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM87453.1     3
 CSP5_0720   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM52923.1     26
 CSP5_1645   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM79844.1     20
 CSP5_1942   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM87424.1     16
 CSP5_0212   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM34926.1     11
 DKAM_0273   Desulfurococcus amylolyticus 1221n ACL10599.1 B8D2L1   20
 Desfe_0644   Desulfurococcus amylolyticus DSM 16532 AFL66545.1     20
 Desmu_0336   Desulfurococcus mucosus DSM 2162 ADV64655.1     20
 pullulanase (ApuA;Pul-Dm;Desmu_0653) 3.2.1.41 Desulfurococcus mucosus DSM 2162 AAG31033.1
ADV64961.1
E8R8Y5
Q9HHB0
  20
 HacjB3_03370   Halalkalicoccus jeotgali B3 ADJ14067.1 D8J7H2   31
 DV733_14390   Halapricum salinum CBA1105 QCC52347.1    
 DV733_15085   Halapricum salinum CBA1105 QCC52475.1     31
 DV733_13565   Halapricum salinum CBA1105 QCC52193.1    
 DV733_04110   Halapricum salinum CBA1105 QCC50471.1    
 DV733_10555   Halapricum salinum CBA1105 QCC51650.1     31
 DV733_13560   Halapricum salinum CBA1105 QCC52192.1    
 DV733_03790   Halapricum salinum CBA1105 QCC50410.1    
 DV733_13220   Halapricum salinum CBA1105 QCC52127.1    
 DV733_10535   Halapricum salinum CBA1105 QCC51646.1     16
 DV733_15055   Halapricum salinum CBA1105 QCC52469.1    
 DV733_03055   Halapricum salinum CBA1105 QCC50274.1    
 DV733_14385   Halapricum salinum CBA1105 QCC52346.1    
 DV733_08025   Halapricum salinum CBA1105 QCC51192.1    
 DV733_08980   Halapricum salinum CBA1105 QCC52913.1    
 DV733_11125   Halapricum salinum CBA1105 QCC51754.1    
 DV733_11110   Halapricum salinum CBA1105 QCC51751.1    
 DV733_06220   Halapricum salinum CBA1105 QCC50864.1    
 DV733_14395 (fragment)   Halapricum salinum CBA1105 QCC52348.1    
 DV733_05720   Halapricum salinum CBA1105 QCC50772.1     31
 DV733_05665   Halapricum salinum CBA1105 QCC50762.1    
 DV733_14380   Halapricum salinum CBA1105 QCC52345.1    
 DV733_12095 (fragment)   Halapricum salinum CBA1105 QCC51923.1    
 DV733_10530   Halapricum salinum CBA1105 QCC51645.1     4
 α-amylase (AmyH) 3.2.1.1 Haloarcula hispanica CAI64586.1 Q4A3E0  
 HAH_0971 (Agla1)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM56589.1     31
 HAH_2473 (MalA)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM58060.1    
 HAH_2792 (Amy2)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM58372.1    
 HAH_1360 (fragment)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM56974.1    
 HISP_14190   Haloarcula hispanica N601 AHB67104.1    
 HISP_04995   Haloarcula hispanica N601 AHB65391.1     31
 HISP_06960   Haloarcula hispanica N601 AHB65764.1    
 HISP_12590   Haloarcula hispanica N601 AHB66804.1    
 α-amylase (MalA) 3.2.1.1 Haloarcula japonica TR-1 BAM75337.1    
 rrnAC2350 (Amy)   Haloarcula marismortui ATCC 43049 AAV47170.1
QCP91873.1
Q5UZY3  
 rrnAC0224 (AglA1)   Haloarcula marismortui ATCC 43049 AAV45283.1
CBF79161.1
QCP93063.1
Q5V5B9   31
 rrnAC1962 (MalA)   Haloarcula marismortui ATCC 43049 AAV46830.1
QCP91538.1
Q5V0X3  
 SG26_06460   Haloarcula sp. CBA1115 AJF25395.1    
 SG26_04895   Haloarcula sp. CBA1115 AJF25106.1    
 SG26_12670   Haloarcula sp. CBA1115 AJF26520.1     31
 SG26_14800   Haloarcula sp. CBA1115 AJF26906.1    
 BVU17_12030   Haloarcula taiwanensis AUG48216.1    
 BVU17_11455   Haloarcula taiwanensis AUG48107.1     16
 BVU17_13580   Haloarcula taiwanensis AUG48503.1    
 BVU17_04730   Haloarcula taiwanensis AUG46856.1     31
 BVU17_04725   Haloarcula taiwanensis AUG46855.1     31
 HARCEL1_05000   Haloarculaceae archaeon HArcel1 AWB27109.1    
 DV707_09090   Halobellus limi CGMCC 1.10331 QCC47800.1    
 DV707_13520   Halobellus limi CGMCC 1.10331 QCC48595.1     31
 DV707_12370   Halobellus limi CGMCC 1.10331 QCC48393.1     31
 DV707_08085   Halobellus limi CGMCC 1.10331 QCC48907.1     31
 DV707_07410   Halobellus limi CGMCC 1.10331 QCC47500.1    
 CHINAEXTREME_10100   Halobiforma lacisalsi AJ5 APW98117.1    
 CHINAEXTREME_12360   Halobiforma lacisalsi AJ5 APW98517.1     31
 ABY42_09415   Haloferax gibbonsii ARA6 AKU07947.1     31
 ABY42_02600   Haloferax gibbonsii ARA6 AKU06683.1    
 ABY42_09420   Haloferax gibbonsii ARA6 AKU07948.1     31
 ABY42_08360   Haloferax gibbonsii ARA6 AKU07761.1    
 α-cyclomaltodextrin glucanotransferase (Cgt) 2.4.1.19 Haloferax mediterranei CAI46245.1 Q53I75   2
 BM92_03985   Haloferax mediterranei ATCC 33500 AHZ21871.1     31
 BM92_06595   Haloferax mediterranei ATCC 33500 AHZ22338.1    
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