Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (55939); Uniprot accession (7858); PDB accession (467); 3D entries (111); cryst (2)
All (51170) Archaea (370) Bacteria (47636) Eukaryota (3034) unclassified (130) Structure (111 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 Memar_1265   Methanoculleus marisnigri JR1 ABN57195.1 A3CUZ5   9
 MMAB1_3002   Methanoculleus sp. MAB1 CVK34215.1     9
 Metho_1364   Methanomethylovorans hollandica DSM 15978 AGB49579.1     5
 Mhar_1650   Methanosaeta harundinacea 6Ac AET65010.1    
 Mzhil_0346   Methanosalsum zhilinae DSM 4017 AEH60222.1     5
 MA1641   Methanosarcina acetivorans C2A AAM05050.1
NP_616570.1
Q8TQA8   16
 MA_2000 (TreX)   Methanosarcina acetivorans C2A AAM05403.1
NP_616923.1
Q8TPB3   11
 MA3032   Methanosarcina acetivorans C2A AAM06405.1
NP_617925.1
Q8TLK4  
 MSBR2_0702 (fragment)   Methanosarcina barkeri 227 AKB57218.1     11
 MSBR2_1700   Methanosarcina barkeri 227 AKB58216.1    
 MCM1_0563 (fragment)   Methanosarcina barkeri CM1 AKJ37661.1    
 MCM1_0690 (fragment)   Methanosarcina barkeri CM1 AKJ37779.1     11
 MCM1_1975   Methanosarcina barkeri CM1 AKJ38997.1    
 MSBRM_0676   Methanosarcina barkeri MS AKB53674.1    
 MSBRM_1705 (fragment)   Methanosarcina barkeri MS AKB54703.1     11
 Mbar_A1790   Methanosarcina barkeri str. Fusaro AAZ70731.1 Q46BL1  
 Mbar_A2517   Methanosarcina barkeri str. Fusaro AAZ71430.1 Q469L2   11
 MSBRW_2208   Methanosarcina barkeri str. Wiesmoor AKB51461.1     11
 MSBRW_2946   Methanosarcina barkeri str. Wiesmoor AKB52199.1    
 MSLAZ_2149   Methanosarcina lacustris Z-7289 AKB75410.1     11
 MSMAS_1146   Methanosarcina mazei S-6 AKB64342.1     16
 MSMAW_1124   Methanosarcina mazei WWM610 AKB40115.1     16
 MSSAC_3006   Methanosarcina siciliae C2J AKB37596.1    
 MSSAC_0894   Methanosarcina siciliae C2J AKB35484.1     11
 MSSAC_0246   Methanosarcina siciliae C2J AKB34836.1     16
 MSSIH_0835   Methanosarcina siciliae HI350 AKB31525.1     11
 MSSIH_2645 (fragment)   Methanosarcina siciliae HI350 AKB33335.1    
 MSSIT_2684   Methanosarcina siciliae T4/M AKB29403.1    
 MSSIT_0864   Methanosarcina siciliae T4/M AKB27583.1     11
 AAY43_06875   Methanosarcina sp. 795 ALK05475.1    
 MSKOL_2442 (fragment)   Methanosarcina sp. Kolksee AKB48219.1     11
 MSKOL_2443 (fragment)   Methanosarcina sp. Kolksee AKB48220.1     11
 MSKOL_2659   Methanosarcina sp. Kolksee AKB48436.1    
 MSMTP_2247   Methanosarcina sp. MTP4 AKB25716.1    
 MSTHC_0746   Methanosarcina thermophila CHTI-55 AKB15064.1    
 MESMT1_1427   Methanosarcina thermophila MT-1 BAW29357.1    
 MSTHT_2537   Methanosarcina thermophila TM-1 AKB14295.1    
 MSVAZ_2430 (fragment)   Methanosarcina vacuolata Z-761 AKB44699.1    
 MSVAZ_2431 (fragment)   Methanosarcina vacuolata Z-761 AKB44700.1     11
 MSVAZ_2654   Methanosarcina vacuolata Z-761 AKB44923.1    
 MCON_0285   Methanothrix soehngenii GP6 AEB67166.1    
 AQV86_02860 (fragment)   Nanohaloarchaea archaeon SG9 AOV94842.1    
 Nmag_1154   Natrialba magadii ATCC 43099 ADD04738.1 D3SRN3  
 maltotriose-forming α-amylase 3.2.1.1
3.2.1.116
Natronococcus sp. Ah-36 BAA05516.1 Q60224  
 PAP_00275   Palaeococcus pacificus DY20341 AIF68502.1     7
 PAP_01075   Palaeococcus pacificus DY20341 AIF68657.1     2
 PAP_09095   Palaeococcus pacificus DY20341 AIF70199.1    
 PAP_04995   Palaeococcus pacificus DY20341 AIF69410.1     20
 PTO0068   Picrophilus torridus DSM 9790 AAT42653.1 Q6L2Z8   3
 PTO0067   Picrophilus torridus DSM 9790 AAT42652.1 Q6L2Z9   9
 trehalose synthase (PTO0069) 5.4.99.16 Picrophilus torridus DSM 9790 AAT42654.1
CBF79071.1
Q6L2Z7   16
 PAE0318   Pyrobaculum aerophilum str. IM2 AAL62712.1
NP_558530.1
Q8ZZC9  
 Pars_2149   Pyrobaculum arsenaticum DSM 13514 ABP51695.1 A4WMS8  
 Pcal_0222   Pyrobaculum calidifontis JCM 11548 ABO07659.1 A3MSP2  
 P186_1084   Pyrobaculum ferrireducens 1860 AET32520.1    
 Pisl_1967   Pyrobaculum islandicum DSM 4184 ABL89114.1 A1RVY2  
 Pogu_2740   Pyrobaculum oguniense TE7 AFA40767.1    
 Pogu_1977 (fragment)   Pyrobaculum oguniense TE7 AFA40004.1     10
 PYWP30_02089   Pyrobaculum sp. WP30 AKT35703.1    
 PFC_01500   Pyrococcus furiosus COM1 AFN03271.1     7
 PFC_01505   Pyrococcus furiosus COM1 AFN03272.1     2
 PFC_08890   Pyrococcus furiosus COM1 AFN04701.1     20
 α-amylase / cyclomaltodextrinase (PFTA;PF1939) (Amy13) 3.2.1.1
3.2.1.54
Pyrococcus furiosus DSM 3638 AAL82063.1
CAZ78721.1
NP_579668.1
Q8TZP8 4AEF[A,B] 20
 β-cyclodextrin glucanotransferase (PfCgt;PF0478;PF0478*) 2.4.1.19 Pyrococcus furiosus DSM 3638 ABA33720.1
AAL80602.1
ABA30024.1
ABA30025.1
NP_578207.1
Q3HUR2
Q8U3I8
  2
 α-amylase (AmyA;PF0477) 3.2.1.1 Pyrococcus furiosus DSM 3638 AAL80601.1
AAB67705.1
AAC45663.1
NP_578206.1
O08452
Q8U3I9
  7
 TQ32_06200   Pyrococcus kukulkanii NCB100 AMM54113.1     20
 α-amylase (thermostable)   Pyrococcus woesei     3QGV[A] 7
 α-amylase (AmyA) 3.2.1.1 Pyrococcus woesei AAD54338.1
AAF44693.1
ACH26211.1
Q7LYT7
Q9P9L0
1MWO[A]
1MXD[A]
1MXG[A]
7
 PYCH_18550   Pyrococcus yayanosii CH1 AEH25510.1     7
 PYCH_18540   Pyrococcus yayanosii CH1 AEH25509.1     2
 PYCH_17070   Pyrococcus yayanosii CH1 AEH25366.1     20
 Shell_0233   Staphylothermus hellenicus DSM 12710 ADI31372.1 D7DB25   20
 maltogenic α-amylase / cyclomaltodextrinase (MA;SmMA;Smar_0613) 3.2.1.133
3.2.1.54
Staphylothermus marinus F1 ABN69720.1 A3DM60 4AEE[A,B] 20
 α-amylase/maltooligosyltrehalose trehalohydrolase (TreZ) 3.2.1.1
3.2.1.141
Sulfolobus acidocaldarius BAA11011.1
BAA11863.1
Q53641   10
 maltooligosyltrehalose synthase (TreY;MTSase) 5.4.99.15 Sulfolobus acidocaldarius BAA11009.1
BAA11865.1
Q53688 1IV8[A] 26
 isoamylase (TreX) 3.2.1.68 Sulfolobus acidocaldarius ATCC33909 BAA11864.1 O05152   11
 Saci_1439   Sulfolobus acidocaldarius DSM 639 AAY80765.1 F2Z6B6   11
 Saci_1440 (TreZ)   Sulfolobus acidocaldarius DSM 639 AAY80766.1 F2Z6C5   10
 ATY89_10840   Sulfolobus acidocaldarius GG12-C01-09 ALU30387.1     26
 ATY89_10830   Sulfolobus acidocaldarius GG12-C01-09 ALU30385.1     10
 ATY89_10835   Sulfolobus acidocaldarius GG12-C01-09 ALU30386.1     11
 SacN8_06985   Sulfolobus acidocaldarius N8 AGE71361.1     26
 SacN8_06995   Sulfolobus acidocaldarius N8 AGE71363.1     10
 SacN8_06990   Sulfolobus acidocaldarius N8 AGE71362.1     11
 ATZ20_02385   Sulfolobus acidocaldarius NG05B_CO5_07 ALU31106.1     10
 ATZ20_02390   Sulfolobus acidocaldarius NG05B_CO5_07 ALU31107.1     11
 ATZ20_02395   Sulfolobus acidocaldarius NG05B_CO5_07 ALU31108.1     26
 SacRon12I_06985   Sulfolobus acidocaldarius Ron12/I AGE73632.1     26
 SacRon12I_06990   Sulfolobus acidocaldarius Ron12/I AGE73633.1     11
 SacRon12I_06995   Sulfolobus acidocaldarius Ron12/I AGE73634.1     10
 SUSAZ_06870   Sulfolobus acidocaldarius SUSAZ AHC51689.1     26
 SUSAZ_06880   Sulfolobus acidocaldarius SUSAZ AHC51691.1     10
 SUSAZ_06875   Sulfolobus acidocaldarius SUSAZ AHC51690.1     11
 TreX (fragment)   Sulfolobus islandicus B9B AAP93396.1 Q6X9I6  
 TreX (fragment)   Sulfolobus islandicus D4 AAP93395.1 Q6X9I7  
 SiH_0855   Sulfolobus islandicus HVE10/4 ADX82208.1     26
 SiH_0856   Sulfolobus islandicus HVE10/4 ADX82209.1     11
 SiH_0857   Sulfolobus islandicus HVE10/4 ADX82210.1     10
 TreX (fragment)   Sulfolobus islandicus I7 AAP93398.1 Q6X9I9  
 TreX (fragment)   Sulfolobus islandicus K10B AAP93394.1 Q6X9I9  
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