Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC; pullulanase (EC; cyclomaltodextrin glucanotransferase (EC; cyclomaltodextrinase (EC; trehalose-6-phosphate hydrolase (EC; oligo-α-glucosidase (EC; maltogenic amylase (EC; neopullulanase (EC; α-glucosidase (EC; maltotetraose-forming α-amylase (EC; isoamylase (EC; glucodextranase (EC; maltohexaose-forming α-amylase (EC; maltotriose-forming α-amylase (EC; branching enzyme (EC; trehalose synthase (EC; 4-α-glucanotransferase (EC; maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC ; sucrose phosphorylase (EC; malto-oligosyltrehalose trehalohydrolase (EC; isomaltulose synthase (EC; malto-oligosyltrehalose synthase (EC; amylo-α-1,6-glucosidase (EC; α-1,4-glucan: phosphate α-maltosyltransferase (EC; amino acid transporter; [retaining] sucrose 6(F)-phosphate phosphorylase (EC; [retaining] glucosylglycerol phosphorylase (EC; ; Glucosylglycerate phosphorylase (EC; [retaining] sucrose α-glucosidase (EC; oligosaccharide α-4-glucosyltransferase (EC; [retaining] α-amylase (EC
Mechanism Retaining
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (117346); Uniprot accession (7841); PDB accession (587); 3D entries (139); cryst (2)
All (112273) Archaea (638) Bacteria (106893) Eukaryota (4608) Viruses (3) unclassified (131) Structure (139 - 2 cryst) Characterized (826)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 EWF20_07915 (GlgX)   Sulfolobus sp. S-194 QIW24075.1     11
 EWF20_07920 (TreZ)   Sulfolobus sp. S-194 QIW24076.1     10
 IC006_0241   Sulfuracidifex tepidarius IC-006 BBG22957.1     26
 IC006_0240   Sulfuracidifex tepidarius IC-006 BBG22956.1     11
 D1869_06685 (GlgX)   Sulfurisphaera ohwakuensis TA-1 QGR16896.1     11
 D1869_06680   Sulfurisphaera ohwakuensis TA-1 QGR18446.1     26
 D1869_06690 (TreZ)   Sulfurisphaera ohwakuensis TA-1 QGR16897.1     10
 ST0926 + ST0927   Sulfurisphaera tokodaii str. 7 BAB65938.1
 ST0928   Sulfurisphaera tokodaii str. 7 BAB65940.1
Q973H3   11
 ST0929   Sulfurisphaera tokodaii str. 7 BAB65941.1
Q973H2 3HJE[A] 26
 pullulanase type III (PulhA;Pul-Ta) Thermococcus aggregans CAB94218.1
Q9P9A0   20
 TBCH5v1_1707   Thermococcus barophilus CH5 ALM75617.1     2
 TBCH5v1_1915   Thermococcus barophilus CH5 ALM75820.1     20
 TERMP_01455   Thermococcus barophilus MP ADT84430.1     2
 TERMP_01653   Thermococcus barophilus MP ADT84628.1     20
 A3L01_09160   Thermococcus barossii SHCK-94 ASJ05521.1     7
 A3L01_10085   Thermococcus barossii SHCK-94 ASJ05693.1     20
 A3L01_08030   Thermococcus barossii SHCK-94 ASJ05313.1     2
 A3L02_07325 (fragment)   Thermococcus celer Vu 13 ASI99378.1     7
 A3L02_06140   Thermococcus celer Vu 13 ASI99171.1     2
 A3L02_08135   Thermococcus celer Vu 13 ASI99531.1     20
 A3L02_04155   Thermococcus celer Vu 13 ASI99919.1     20
 CL1_1040   Thermococcus cleftensis AFL95243.1     7
 cyclomaltodextrinase (CD;TcCD;CL1_0884) Thermococcus cleftensis AFL95089.1     20
 CL1_1275   Thermococcus cleftensis AFL95474.1     2
 CL1_0091   Thermococcus cleftensis AFL94306.1     20
 TEU_02420   Thermococcus eurythermalis A501 AIU69287.1     7
 TEU_01265   Thermococcus eurythermalis A501 AIU69076.1     2
 TEU_03500   Thermococcus eurythermalis A501 AIU69487.1     20
 TGAM_0222 (AmyA-1)   Thermococcus gammatolerans EJ3 ACS32724.1 C5A3B2   7
 TGAM_0599   Thermococcus gammatolerans EJ3 ACS33101.1 C5A4D9   20
 TGAM_1752   Thermococcus gammatolerans EJ3 ACS34254.1 C5A1I5   20
 A3K92_06290   Thermococcus gorgonarius W-12 ASJ01118.1     20
 A3K92_00110   Thermococcus gorgonarius W-12 ASI99994.1     2
 A3K92_02180   Thermococcus gorgonarius W-12 ASJ00372.1     20
 A3K92_00920   Thermococcus gorgonarius W-12 ASJ00148.1    
 X802_03495 (fragment)   Thermococcus guaymasensis DSM 11113 AJC72690.1     7
 X802_01660   Thermococcus guaymasensis DSM 11113 AJC71037.1     20
 X802_07225   Thermococcus guaymasensis DSM 11113 AJC71972.1     20
 α-amylase (Amy) Thermococcus hydrothermalis AL662 AAC97877.1
 FH039_07515   Thermococcus indicus IOH1 QDA31473.1     20
 FH039_11610   Thermococcus indicus IOH1 QDA32566.1     2
 FH039_01575   Thermococcus indicus IOH1 QDA30565.1     20
 β-cyclodextrin glucanotransferase (Cgt;TK-cgt;TK2172) Thermococcus kodakarensis KOD1 BAB78538.1
Q8X268   2
 cyclodextrinase (CDase-Tk;TK1770) Thermococcus kodakarensis KOD1 BAD85959.1
Q5JJ59   20
 amylopullulanase / pullulanase type III (Pul-Tk;TK-PUL;TK0977)
Thermococcus kodakarensis KOD1 BAD85166.1
Q5JID9 5OT1[A] 20
 α-amylase (ApkA;TK1884) Thermococcus kodakarensis KOD1 BAA21130.1
 OCC_06841   Thermococcus litoralis DSM 5473 EHR78983.1    
 OCC_09349   Thermococcus litoralis DSM 5473 EHR79590.1     20
 TON_1451   Thermococcus onnurineus NA1 ACJ16941.1 B6YXX8   2
 cyclomaltodextrinase (Tocd;TON_1796) Thermococcus onnurineus NA1 ACJ17286.1 B6YV58   20
 α-amylase (TO_Amyl;TON_1660) Thermococcus onnurineus NA1 ABA26948.1
B6YUG5   7
 A3L08_01160   Thermococcus pacificus P-4 ASJ07607.1     2
 A3L08_07175   Thermococcus pacificus P-4 ASJ07670.1     20
 A3L08_02825   Thermococcus pacificus P-4 ASJ06341.1     20
 TES1_1436   Thermococcus paralvinellae ES1 AHF80814.1     2
 TES1_1658   Thermococcus paralvinellae ES1 AHF81034.1     20
 A0127_05805   Thermococcus peptonophilus OG-1 AMQ18717.1     7
 A0127_04445   Thermococcus peptonophilus OG-1 AMQ18471.1     2
 A0127_00260   Thermococcus peptonophilus OG-1 AMQ17709.1     20
 A7C91_03825 (fragment)   Thermococcus piezophilus CDGS ANF22396.1     7
 A3L09_02000   Thermococcus profundus DT 5432 ASJ02127.1     2
 A3L09_07315   Thermococcus profundus DT 5432 ASJ03075.1     20
 A3L09_01615   Thermococcus profundus DT 5432 ASJ02053.1     7
 A3L10_09460   Thermococcus radiotolerans EJ2 ASJ15344.1     20
 A3L10_07420   Thermococcus radiotolerans EJ2 ASJ14969.1     2
 A3L11_07945   Thermococcus siculi RG-20 ASJ09163.1     20
 A3L11_03375   Thermococcus siculi RG-20 ASJ08321.1     20
 A3L11_02635   Thermococcus siculi RG-20 ASJ08179.1     7
 A3L11_01395   Thermococcus siculi RG-20 ASJ07951.1     2
 ADU37_CDS00170   Thermococcus sp. 2319x1 ALV61716.1    
 ADU37_CDS21030   Thermococcus sp. 2319x1 ALV63800.1     7
 ADU37_CDS18980   Thermococcus sp. 2319x1 ALV63597.1     20
 ADU37_CDS20530   Thermococcus sp. 2319x1 ALV63752.1     20
 GQS_07090   Thermococcus sp. 4557 AEK73316.1     7
 GQS_08270   Thermococcus sp. 4557 AEK73548.1     2
 GQS_06205 (fragment)   Thermococcus sp. 4557 AEK73139.1     20
 CDI07_07550   Thermococcus sp. 5-4 ASA78160.1     2
 CDI07_03875   Thermococcus sp. 5-4 ASA77467.1     20
 CDI07_09920   Thermococcus sp. 5-4 ASA78605.1     20
 α-amylase (BD5031) Thermococcus sp. AEPII 1a AAM48113.1
Q8NKR4   7
 TAM4_475   Thermococcus sp. AM4 EEB74530.1     20
 TAM4_1203   Thermococcus sp. AM4 EEB73455.2     7
 TAM4_1607   Thermococcus sp. AM4 EEB74240.2     20
 α-cyclodextrin glucanotransferase (CgtA) Thermococcus sp. B1001 BAA88217.1
Q9UWN2   2
 cyclomaltodextrinase (CdnA)
Thermococcus sp. B1001 BAB18100.1
Q9HHC8   20
 α-amylase (BD5064) Thermococcus sp. GU5L5 AAM48112.1
Q8NKR5   7
 α-amylase (THJA) Thermococcus sp. HJ21 ABU98335.1 B4X9V8   7
 TIRI35C_2170   Thermococcus sp. IRI35c CAD5245324.1     7
 TIRI35C_0125 (fragment)   Thermococcus sp. IRI35c CAD5243279.1     20
 TIRI35C_1035   Thermococcus sp. IRI35c CAD5244189.1     20
 TIRI35C_1925   Thermococcus sp. IRI35c CAD5245079.1     2
 A3L12_00010   Thermococcus sp. P6 ASJ09798.1     7
 A3L12_05090   Thermococcus sp. P6 ASJ10715.1     20
 α-amylase Thermococcus sp. Rt3 AAB87860.1
O50200   7
 FPV09_08980   Thermococcus sp. SY113 QEK15204.1     7
 FPV09_09900   Thermococcus sp. SY113 QEK15349.1     2
 FPV09_07855 (fragment)   Thermococcus sp. SY113 QEK15905.1     20
 α-amylase (Amy) Thermococcus thioreducens AAT11125.1 Q66SB4   7
 A3L14_00190   Thermococcus thioreducens OGL-20P ASJ11397.1     7

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