Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); amino acid transporter; [retaining] sucrose 6(F)-phosphate phosphorylase (EC 2.4.1.329); [retaining] glucosylglycerol phosphorylase (EC 2.4.1.359); ; Glucosylglycerate phosphorylase (EC 2.4.1.352); [retaining] sucrose α-glucosidase (EC 3.2.1.48); oligosaccharide α-4-glucosyltransferase (EC 2.4.1.161); [retaining] α-amylase (EC 3.2.1.1)
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (117346); Uniprot accession (7841); PDB accession (587); 3D entries (139); cryst (2)
All (112273) Archaea (638) Bacteria (106893) Eukaryota (4608) Viruses (3) unclassified (131) Structure (139 - 2 cryst) Characterized (826)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 SULO_14340 (TreZ)   Saccharolobus solfataricus SARC-O AZF82411.1     10
 SULO_14345 (GlgX)   Saccharolobus solfataricus SARC-O AZF82412.1     11
 SULZ_14420 (TreZ)   Saccharolobus solfataricus SUL120 AZF85017.1     10
 SULZ_14425 (GlgX)   Saccharolobus solfataricus SUL120 AZF85018.1     11
 SULZ_14430   Saccharolobus solfataricus SUL120 AZF85019.1     26
 SULA_2829   Saccharolobus solfataricus SULA AKA80272.1     26
 SULA_2828   Saccharolobus solfataricus SULA AKA80271.1     11
 SULA_2827   Saccharolobus solfataricus SULA AKA80270.1     10
 SULB_2828   Saccharolobus solfataricus SULB AKA74884.1     10
 SULB_2829   Saccharolobus solfataricus SULB AKA74885.1     11
 SULB_2830   Saccharolobus solfataricus SULB AKA74886.1     26
 SULG_14400 (TreZ)   Saccharolobus solfataricus SULG AZF69349.1     10
 SULG_14405 (GlgX)   Saccharolobus solfataricus SULG AZF69350.1     11
 SULG_14410   Saccharolobus solfataricus SULG AZF69351.1     26
 SULM_14340   Saccharolobus solfataricus SULM AZF77202.1     26
 SULM_14335 (GlgX)   Saccharolobus solfataricus SULM AZF77201.1     11
 SULM_14330 (TreZ)   Saccharolobus solfataricus SULM AZF77200.1     10
 C2R22_10880   Salinigranum rubrum GX10 AUV82090.1    
 C2R22_03185   Salinigranum rubrum GX10 AUV80780.1     31
 C2R22_06620   Salinigranum rubrum GX10 AUV81372.1     31
 C2R22_04915   Salinigranum rubrum GX10 AUV81080.1     16
 C2R22_03170   Salinigranum rubrum GX10 AUV80777.1     31
 C2R22_06615   Salinigranum rubrum GX10 AUV81371.1     31
 Shell_0233   Staphylothermus hellenicus DSM 12710 ADI31372.1 D7DB25   20
 maltogenic α-amylase / cyclomaltodextrinase (MA;SmMA;Smar_0613) 3.2.1.133
3.2.1.54
Staphylothermus marinus F1 ABN69720.1 A3DM60 4AEE[A,B] 20
 D1868_04840 (TreZ)   Stygiolobus azoricus FC6 QGR19372.1     10
 D1868_04835 (GlgX)   Stygiolobus azoricus FC6 QGR19371.1     11
 D1868_04830   Stygiolobus azoricus FC6 QGR19370.1     26
 α-amylase/maltooligosyltrehalose trehalohydrolase (TreZ) 3.2.1.1
3.2.1.141
Sulfolobus acidocaldarius BAA11011.1
BAA11863.1
Q53641   10
 maltooligosyltrehalose synthase (TreY;MTSase) 5.4.99.15 Sulfolobus acidocaldarius BAA11009.1
BAA11865.1
Q53688 1IV8[A] 26
 isoamylase (TreX) 3.2.1.68 Sulfolobus acidocaldarius ATCC33909 BAA11864.1 O05152   11
 Saci_1439   Sulfolobus acidocaldarius DSM 639 AAY80765.1 F2Z6B6   11
 Saci_1440 (TreZ)   Sulfolobus acidocaldarius DSM 639 AAY80766.1 F2Z6C5   10
 ATY89_10840   Sulfolobus acidocaldarius GG12-C01-09 ALU30387.1     26
 ATY89_10830   Sulfolobus acidocaldarius GG12-C01-09 ALU30385.1     10
 ATY89_10835   Sulfolobus acidocaldarius GG12-C01-09 ALU30386.1     11
 SacN8_06985   Sulfolobus acidocaldarius N8 AGE71361.1     26
 SacN8_06995   Sulfolobus acidocaldarius N8 AGE71363.1     10
 SacN8_06990   Sulfolobus acidocaldarius N8 AGE71362.1     11
 ATZ20_02385   Sulfolobus acidocaldarius NG05B_CO5_07 ALU31106.1     10
 ATZ20_02390   Sulfolobus acidocaldarius NG05B_CO5_07 ALU31107.1     11
 ATZ20_02395   Sulfolobus acidocaldarius NG05B_CO5_07 ALU31108.1     26
 SacRon12I_06985   Sulfolobus acidocaldarius Ron12/I AGE73632.1     26
 SacRon12I_06990   Sulfolobus acidocaldarius Ron12/I AGE73633.1     11
 SacRon12I_06995   Sulfolobus acidocaldarius Ron12/I AGE73634.1     10
 SUSAZ_06870   Sulfolobus acidocaldarius SUSAZ AHC51689.1     26
 SUSAZ_06880   Sulfolobus acidocaldarius SUSAZ AHC51691.1     10
 SUSAZ_06875   Sulfolobus acidocaldarius SUSAZ AHC51690.1     11
 TreX (fragment)   Sulfolobus islandicus B9B AAP93396.1 Q6X9I6  
 TreX (fragment)   Sulfolobus islandicus D4 AAP93395.1 Q6X9I7  
 SiH_0855   Sulfolobus islandicus HVE10/4 ADX82208.1     26
 SiH_0856   Sulfolobus islandicus HVE10/4 ADX82209.1     11
 SiH_0857   Sulfolobus islandicus HVE10/4 ADX82210.1     10
 TreX (fragment)   Sulfolobus islandicus I7 AAP93398.1 Q6X9I9  
 TreX (fragment)   Sulfolobus islandicus K10B AAP93394.1 Q6X9I9  
 LD85_0438   Sulfolobus islandicus L.D.8.5 ADB86216.1 D2PG22   10
 LD85_0437   Sulfolobus islandicus L.D.8.5 ADB86215.1 D2PG21   11
 LD85_0436   Sulfolobus islandicus L.D.8.5 ADB86214.1 D2PG20   26
 LS215_0444   Sulfolobus islandicus L.S.2.15 ACP34570.1 C3MLH2   11
 LS215_0445   Sulfolobus islandicus L.S.2.15 ACP34571.1 C3MLH3   10
 LS215_0443   Sulfolobus islandicus L.S.2.15 ACP34569.1 C3MLH1   26
 SiL_0517   Sulfolobus islandicus LAL14/1 AGJ61988.1     10
 SiL_0518   Sulfolobus islandicus LAL14/1 AGJ61989.1     11
 SiL_0519   Sulfolobus islandicus LAL14/1 AGJ61990.1     26
 M1425_0478   Sulfolobus islandicus M.14.25 ACP37333.1 C3MUX0   11
 M1425_0477   Sulfolobus islandicus M.14.25 ACP37332.1 C3MUW9   10
 M1425_0479   Sulfolobus islandicus M.14.25 ACP37334.1 C3MUX1   26
 M1627_0491   Sulfolobus islandicus M.16.27 ACP54489.1 C3N2K1   11
 M1627_0490   Sulfolobus islandicus M.16.27 ACP54488.1 C3N2K0   10
 M1627_0492   Sulfolobus islandicus M.16.27 ACP54490.1 C3N2K2   26
 M164_0513   Sulfolobus islandicus M.16.4 ACR41144.1 C4KE21   11
 M164_0514   Sulfolobus islandicus M.16.4 ACR41145.1 C4KE22   26
 M164_0512   Sulfolobus islandicus M.16.4 ACR41143.1 C4KE20   10
 TreX (fragment)   Sulfolobus islandicus N15B AAP93399.1 Q6X9I9  
 TreX (fragment)   Sulfolobus islandicus N23A AAP93391.1 Q6X9I9  
 TreX (fragment)   Sulfolobus islandicus N38D AAP93400.1 Q6X9I2  
 TreX (fragment)   Sulfolobus islandicus REN1H1 AAP93397.1 Q6X9I5  
 SiRe_0490   Sulfolobus islandicus REY15A ADX84576.1     26
 SiRe_0486   Sulfolobus islandicus REY15A ADX84572.1     10
 SiRe_0487+SiRe_0489   Sulfolobus islandicus REY15A ADX84575.1     11
 TreX (fragment)   Sulfolobus islandicus U3C AAP93392.1 Q6X9J0  
 TreX (fragment)   Sulfolobus islandicus V8 AAP93393.1 Q6X9I9  
 YG5714_0403   Sulfolobus islandicus Y.G.57.14 ACP44695.1 C3NA11   11
 YG5714_0404   Sulfolobus islandicus Y.G.57.14 ACP44696.1 C3NA12   10
 YG5714_0402   Sulfolobus islandicus Y.G.57.14 ACP44694.1 C3NA10   26
 YN1551_2617   Sulfolobus islandicus Y.N.15.51 ACP49544.1 C3NLJ1   11
 YN1551_2616   Sulfolobus islandicus Y.N.15.51 ACP49543.1 C3NLJ0   10
 YN1551_2618   Sulfolobus islandicus Y.N.15.51 ACP49545.1 C3NLJ2   26
 BFU36_08340   Sulfolobus sp. A20 AOL17761.1     11
 BFU36_08335   Sulfolobus sp. A20 AOL16710.1     26
 BFU36_11610   Sulfolobus sp. A20 AOL17246.1     10
 GFS33_11355 (TreZ)   Sulfolobus sp. E11-6 QGA69219.1     10
 GFS33_11360 (GlgX)   Sulfolobus sp. E11-6 QGA69220.1     11
 GFS33_11365   Sulfolobus sp. E11-6 QGA69221.1     26
 GFS03_06080 (GlgX)   Sulfolobus sp. E5-1-F QGA54169.1     11
 GFS03_06085   Sulfolobus sp. E5-1-F QGA54170.1     26
 GFS03_06075 (TreZ)   Sulfolobus sp. E5-1-F QGA54168.1     10
 IC007_0222   Sulfolobus sp. JCM 16834 IC-007 BBG25717.1     26
 IC007_0221   Sulfolobus sp. JCM 16834 IC-007 BBG25716.1     11
 EWF20_07910   Sulfolobus sp. S-194 QIW25344.1     26
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