Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (54252); Uniprot accession (7858); PDB accession (465); 3D entries (110); cryst (2)
All (49476) Archaea (367) Bacteria (45982) Eukaryota (2997) unclassified (130) Structure (110 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 LS215_0444   Sulfolobus islandicus L.S.2.15 ACP34570.1 C3MLH2   11
 LS215_0445   Sulfolobus islandicus L.S.2.15 ACP34571.1 C3MLH3   10
 LS215_0443   Sulfolobus islandicus L.S.2.15 ACP34569.1 C3MLH1   26
 SiL_0517   Sulfolobus islandicus LAL14/1 AGJ61988.1     10
 SiL_0518   Sulfolobus islandicus LAL14/1 AGJ61989.1     11
 SiL_0519   Sulfolobus islandicus LAL14/1 AGJ61990.1     26
 M1425_0478   Sulfolobus islandicus M.14.25 ACP37333.1 C3MUX0   11
 M1425_0477   Sulfolobus islandicus M.14.25 ACP37332.1 C3MUW9   10
 M1425_0479   Sulfolobus islandicus M.14.25 ACP37334.1 C3MUX1   26
 M1627_0491   Sulfolobus islandicus M.16.27 ACP54489.1 C3N2K1   11
 M1627_0490   Sulfolobus islandicus M.16.27 ACP54488.1 C3N2K0   10
 M1627_0492   Sulfolobus islandicus M.16.27 ACP54490.1 C3N2K2   26
 M164_0513   Sulfolobus islandicus M.16.4 ACR41144.1 C4KE21   11
 M164_0514   Sulfolobus islandicus M.16.4 ACR41145.1 C4KE22   26
 M164_0512   Sulfolobus islandicus M.16.4 ACR41143.1 C4KE20   10
 TreX (fragment)   Sulfolobus islandicus N15B AAP93399.1 Q6X9I9  
 TreX (fragment)   Sulfolobus islandicus N23A AAP93391.1 Q6X9I9  
 TreX (fragment)   Sulfolobus islandicus N38D AAP93400.1 Q6X9I2  
 TreX (fragment)   Sulfolobus islandicus REN1H1 AAP93397.1 Q6X9I5  
 SiRe_0490   Sulfolobus islandicus REY15A ADX84576.1     26
 SiRe_0486   Sulfolobus islandicus REY15A ADX84572.1     10
 SiRe_0487+SiRe_0489   Sulfolobus islandicus REY15A ADX84575.1     11
 TreX (fragment)   Sulfolobus islandicus U3C AAP93392.1 Q6X9J0  
 TreX (fragment)   Sulfolobus islandicus V8 AAP93393.1 Q6X9I9  
 YG5714_0403   Sulfolobus islandicus Y.G.57.14 ACP44695.1 C3NA11   11
 YG5714_0404   Sulfolobus islandicus Y.G.57.14 ACP44696.1 C3NA12   10
 YG5714_0402   Sulfolobus islandicus Y.G.57.14 ACP44694.1 C3NA10   26
 YN1551_2617   Sulfolobus islandicus Y.N.15.51 ACP49544.1 C3NLJ1   11
 YN1551_2616   Sulfolobus islandicus Y.N.15.51 ACP49543.1 C3NLJ0   10
 YN1551_2618   Sulfolobus islandicus Y.N.15.51 ACP49545.1 C3NLJ2   26
 maltooligosyltrehalose synthase (TreY) 5.4.99.15 Sulfolobus shibatae AAF17554.1
AAM81591.1
Q9UWN8   26
 maltooligosyl trehalose trehalohydrolase (TreZ) 3.2.1.141 Sulfolobus shibatae AAF17553.1
AAM81589.1
Q9UWN9   10
 glycogen debranching enzyme (TreX) 2.4.1.25
3.2.1.68
Sulfolobus shibatae B12 AAM81590.1 Q8NKQ3   11
 Ssol_2807   Sulfolobus solfataricus 98/2 ACX92889.1 D0KPY5   26
 Ssol_2806   Sulfolobus solfataricus 98/2 ACX92888.1 D0KPY4   11
 Ssol_2805   Sulfolobus solfataricus 98/2 ACX92887.1 D0KPY3   10
 SULC_2826   Sulfolobus solfataricus 98/2 SULC AKA77581.1     11
 SULC_2825   Sulfolobus solfataricus 98/2 SULC AKA77580.1     10
 SULC_2827   Sulfolobus solfataricus 98/2 SULC AKA77582.1     26
 α-amylase / maltooligosyltrehalose trehalohydrolase (GTHase) 3.2.1.1
3.2.1.141
Sulfolobus solfataricus KM1 AAR46454.1
BAA11010.1
Q55088 1EH9[A]
1EHA[A]
3VGB[A]
3VGD[A]
3VGE[A]
3VGF[A]
3VGG[A]
3VGH[A]
10
 glycosyltrehalose-producing enzyme 5.4.99.15 Sulfolobus solfataricus KM1 BAA11008.1 Q55262   26
 SSOP1_2225   Sulfolobus solfataricus P1 SAI85779.1     11
 SSOP1_2226   Sulfolobus solfataricus P1 SAI85780.1     26
 SSOP1_2224   Sulfolobus solfataricus P1 SAI85778.1     10
 maltooligosyltrehalose synthase (TreY;SSO2095) 5.4.99.15 Sulfolobus solfataricus P2 AAK42274.1
CAA69505.1
NP_343484.1
P95869
Q7LX98
  26
 maltooligosyltrehalose trehalohydrolase (TreZ;MTHase;SSO2093;c06020) 3.2.1.141 Sulfolobus solfataricus P2 AAK42272.1
CAA69503.1
CAC23737.1
NP_343482.1
P95867   10
 isoamylase / 4-α-glucanotransferase (TreX;SSO2094;GlgX;ORF-c06_004;c06021) 2.4.1.25
3.2.1.68
Sulfolobus solfataricus P2 AAK42273.1
CAA69504.1
CAC23738.1
NP_343483.1
P95868
Q7LX99
2VNC[A,B]
2VR5[A,B]
2VUY[A,B]
11
 SULA_2829   Sulfolobus solfataricus SULA AKA80272.1     26
 SULA_2828   Sulfolobus solfataricus SULA AKA80271.1     11
 SULA_2827   Sulfolobus solfataricus SULA AKA80270.1     10
 SULB_2828   Sulfolobus solfataricus SULB AKA74884.1     10
 SULB_2829   Sulfolobus solfataricus SULB AKA74885.1     11
 SULB_2830   Sulfolobus solfataricus SULB AKA74886.1     26
 BFU36_08340   Sulfolobus sp. A20 AOL17761.1     11
 BFU36_08335   Sulfolobus sp. A20 AOL16710.1     26
 BFU36_11610   Sulfolobus sp. A20 AOL17246.1     10
 ST0926 + ST0927   Sulfolobus tokodaii str. 7 BAB65938.1
BAB65939.1
NP_376829.1
NP_376830.1
Q973H4
Q973H5
  10
 ST0928   Sulfolobus tokodaii str. 7 BAB65940.1
NP_376831.1
Q973H3   11
 ST0929   Sulfolobus tokodaii str. 7 BAB65941.1
NP_376832.1
Q973H2 3HJE[A] 26
 pullulanase type III (PulhA;Pul-Ta) 3.2.1.41 Thermococcus aggregans CAB94218.1
CAZ78888.1
Q9P9A0   20
 TBCH5v1_1707   Thermococcus barophilus CH5 ALM75617.1     2
 TBCH5v1_1915   Thermococcus barophilus CH5 ALM75820.1     20
 TERMP_01455   Thermococcus barophilus MP ADT84430.1     2
 TERMP_01653   Thermococcus barophilus MP ADT84628.1     20
 A3L01_09160   Thermococcus barossii SHCK-94 ASJ05521.1     7
 A3L01_10085   Thermococcus barossii SHCK-94 ASJ05693.1     20
 A3L01_08030   Thermococcus barossii SHCK-94 ASJ05313.1     2
 A3L02_07325 (fragment)   Thermococcus celer Vu 13 ASI99378.1     7
 A3L02_06140   Thermococcus celer Vu 13 ASI99171.1     2
 A3L02_08135   Thermococcus celer Vu 13 ASI99531.1     20
 A3L02_04155   Thermococcus celer Vu 13 ASI99919.1     20
 CL1_1040   Thermococcus cleftensis AFL95243.1     7
 cyclomaltodextrinase (CD;TcCD;CL1_0884) 3.2.1.54 Thermococcus cleftensis AFL95089.1     20
 CL1_1275   Thermococcus cleftensis AFL95474.1     2
 CL1_0091   Thermococcus cleftensis AFL94306.1     20
 TEU_02420   Thermococcus eurythermalis A501 AIU69287.1     7
 TEU_01265   Thermococcus eurythermalis A501 AIU69076.1     2
 TEU_03500   Thermococcus eurythermalis A501 AIU69487.1     20
 TGAM_0222 (AmyA-1)   Thermococcus gammatolerans EJ3 ACS32724.1 C5A3B2   7
 TGAM_0599   Thermococcus gammatolerans EJ3 ACS33101.1 C5A4D9   20
 TGAM_1752   Thermococcus gammatolerans EJ3 ACS34254.1 C5A1I5   20
 A3K92_06290   Thermococcus gorgonarius W-12 ASJ01118.1     20
 A3K92_00110   Thermococcus gorgonarius W-12 ASI99994.1     2
 A3K92_02180   Thermococcus gorgonarius W-12 ASJ00372.1     20
 A3K92_00920   Thermococcus gorgonarius W-12 ASJ00148.1    
 X802_03495 (fragment)   Thermococcus guaymasensis DSM 11113 AJC72690.1     7
 X802_01660   Thermococcus guaymasensis DSM 11113 AJC71037.1     20
 X802_07225   Thermococcus guaymasensis DSM 11113 AJC71972.1     20
 α-amylase (Amy) 3.2.1.1 Thermococcus hydrothermalis AL662 AAC97877.1
AAC97878.1
ACH26213.1
O93647
O93648
  7
 β-cyclodextrin glucanotransferase (Cgt;TK-cgt;TK2172) 2.4.1.19 Thermococcus kodakarensis KOD1 BAB78538.1
BAD86361.1
CAT70763.1
Q8X268   2
 cyclodextrinase (CDase-Tk;TK1770) 3.2.1.54 Thermococcus kodakarensis KOD1 BAD85959.1
CAT70564.1
Q5JJ59   20
 amylopullulanase / pullulanase type III (Pul-Tk;TK-PUL;TK0977) 3.2.1.1
3.2.1.41
Thermococcus kodakarensis KOD1 BAD85166.1
CAT69621.1
CAZ78793.1
Q5JID9   20
 α-amylase (ApkA;TK1884) 3.2.1.1 Thermococcus kodakarensis KOD1 BAA21130.1
ACH26210.1
BAD86073.1
CAT70635.1
O33476
Q5JER7
  7
 OCC_06841   Thermococcus litoralis DSM 5473 EHR78983.1    
 OCC_09349   Thermococcus litoralis DSM 5473 EHR79590.1     20
 TON_1451   Thermococcus onnurineus NA1 ACJ16941.1 B6YXX8   2
 cyclomaltodextrinase (Tocd;TON_1796) 3.2.1.54 Thermococcus onnurineus NA1 ACJ17286.1 B6YV58   20
 α-amylase (TO_Amyl;TON_1660) 3.2.1.1 Thermococcus onnurineus NA1 ABA26948.1
ACJ17150.1
B6YUG5   7
 A3L08_01160   Thermococcus pacificus P-4 ASJ07607.1     2
 A3L08_07175   Thermococcus pacificus P-4 ASJ07670.1     20
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