Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); amino acid transporter; [retaining] sucrose 6(F)-phosphate phosphorylase (EC 2.4.1.329); [retaining] glucosylglycerol phosphorylase (EC 2.4.1.359); ; Glucosylglycerate phosphorylase (EC 2.4.1.352); [retaining] sucrose α-glucosidase (EC 3.2.1.48); oligosaccharide α-4-glucosyltransferase (EC 2.4.1.161); [retaining] α-amylase (EC 3.2.1.1)
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (117346); Uniprot accession (7841); PDB accession (587); 3D entries (139); cryst (2)
All (112273) Archaea (638) Bacteria (106893) Eukaryota (4608) Viruses (3) unclassified (131) Structure (139 - 2 cryst) Characterized (826)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 Hmuk_0051   Halomicrobium mukohataei DSM 12286 ACV46202.1 C7NVT7   31
 Hmuk_0210   Halomicrobium mukohataei DSM 12286 ACV46347.1 C7NWY2   2
 GBQ70_04335   Halomicrobium mukohataei ZPS1 QFR19708.1     20
 GBQ70_03575   Halomicrobium mukohataei ZPS1 QFR19574.1     31
 GBQ70_04340   Halomicrobium mukohataei ZPS1 QFR21889.1     2
 GBQ70_03580   Halomicrobium mukohataei ZPS1 QFR19575.1     31
 GBQ70_14460   Halomicrobium mukohataei ZPS1 QFR21592.1     31
 LC1Hm_2615 (Amya2)   Halomicrobium sp. LC1Hm QGA83648.1     31
 LC1Hm_1562 (MalL)   Halomicrobium sp. LC1Hm QGA82609.1     31
 LC1Hm_2614 (AmyA)   Halomicrobium sp. LC1Hm QGA83647.1     31
 E5139_03580   Halomicrobium sp. ZP60 QCD64768.1     31
 E5139_04340   Halomicrobium sp. ZP60 QCD64902.1     20
 E5139_14445   Halomicrobium sp. ZP60 QCD66783.1     31
 E5139_03575   Halomicrobium sp. ZP60 QCD64767.1     31
 E5139_04345   Halomicrobium sp. ZP60 QCD67080.1     2
 halTADL_2973   halophilic archaeon True-ADL ATW89676.1     31
 halTADL_1688   halophilic archaeon True-ADL ATW88443.1    
 halTADL_0142   halophilic archaeon True-ADL ATW86964.1    
 Halxa_4124   Halopiger xanaduensis SH-6 AEH38729.1     20
 FCF25_00085   Haloprofundus sp. MHR1 QCJ45623.1    
 FCF25_09565   Haloprofundus sp. MHR1 QCJ47346.1    
 FCF25_12120   Haloprofundus sp. MHR1 QCJ47818.1     31
 Hqrw_2193 (Amya1)   Haloquadratum walsbyi C23 CCC40085.1    
 Hqrw_2840 (Amya2)   Haloquadratum walsbyi C23 CCC40652.1    
 HQ2031A   Haloquadratum walsbyi DSM 16790 CAJ52158.1 Q18IL2  
 HQ2540A   Haloquadratum walsbyi DSM 16790 CAJ52652.1 Q18H91  
 Hrd1104_08090   Halorhabdus sp. CBA1104 QGN07266.1    
 Hrd1104_10170   Halorhabdus sp. CBA1104 QGN08248.1    
 Hrd1104_10105   Halorhabdus sp. CBA1104 QGN08246.1    
 Hrd1104_10155   Halorhabdus sp. CBA1104 QGN07625.1     4
 Hrd1104_10160   Halorhabdus sp. CBA1104 QGN07626.1    
 Hrd1104_12340   Halorhabdus sp. CBA1104 QGN08006.1     31
 Hrd1104_12335   Halorhabdus sp. CBA1104 QGN08005.1     31
 Hrd1104_10110 (fragment)   Halorhabdus sp. CBA1104 QGN07617.1     16
 HTIA_0919   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33058.1    
 HTIA_0920   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33059.1    
 HTIA_0927   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33066.1     31
 HTIA_0928   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33067.1     31
 HTIA_0925   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33064.1     4
 HTIA_0926   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33065.1     16
 HTIA_2290 (fragment)   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34399.1     43
 Huta_1052   Halorhabdus utahensis DSM 12940 ACV11235.1 C7NVF1  
 EO776_06625   Halorubrum ezzemoulense Fb21 QAY19711.1     31
 EO776_08825   Halorubrum ezzemoulense Fb21 QAY20110.1    
 EO776_03740   Halorubrum ezzemoulense Fb21 QAY19160.1    
 Hlac_0544   Halorubrum lacusprofundi ATCC 49239 ACM56146.1 B9LTL2  
 Hlac_0587   Halorubrum lacusprofundi ATCC 49239 ACM56189.1 B9LTQ5   16
 Hlac_1504   Halorubrum lacusprofundi ATCC 49239 ACM57092.1 B9LP04  
 EKH57_02550   Halorubrum sp. BOL3-1 QAU11730.1    
 EKH57_08180   Halorubrum sp. BOL3-1 QAU12702.1    
 EKH57_05850   Halorubrum sp. BOL3-1 QAU12278.1     31
 Hrr1229_003705   Halorubrum sp. CBA1229 QKY16027.1    
 Hrr1229_004130   Halorubrum sp. CBA1229 QKY16107.1     16
 Hrr1229_014235   Halorubrum sp. CBA1229 QKY17979.1    
 DOS48_02585   Halorubrum sp. PV6 AZQ13798.1    
 DOS48_12565   Halorubrum sp. PV6 AZQ15605.1     31
 DOS48_07230   Halorubrum sp. PV6 AZQ14641.1    
 HPS36_03420   Halorubrum sp. RHB-C QKG91944.1    
 HPS36_12965   Halorubrum sp. RHB-C QKG93725.1    
 I7X12_01675   Halosimplex litoreum YGH94 QPV63371.1     31
 I7X12_17565   Halosimplex litoreum YGH94 QPV62517.1    
 I7X12_01670   Halosimplex litoreum YGH94 QPV63370.1     31
 HZS54_21685   Halosimplex pelagicum R2 QLH84088.1    
 HZS54_16210   Halosimplex pelagicum R2 QLH83071.1     31
 HZS54_16215   Halosimplex pelagicum R2 QLH83072.1     31
 HZS55_18135   Halosimplex rubrum R27 QLH79096.1    
 HZS55_12365   Halosimplex rubrum R27 QLH78043.1     31
 HZS55_12370   Halosimplex rubrum R27 QLH78044.1     31
 HALLA_17420   Halostagnicola larsenii XH-48 AHG01126.1     43
 J0X25_01050   Haloterrigena sp. KZCA68 QSW99578.1    
 HYG82_04595   Haloterrigena sp. YPL8 QLG48175.1    
 HYG82_05350 (fragment)   Haloterrigena sp. YPL8 QLG48315.1     43
 HYG82_13775   Haloterrigena sp. YPL8 QLG49849.1    
 Htur_2652   Haloterrigena turkmenica DSM 5511 ADB61528.1 D2RWM7  
 Htur_2110 (possible fragment)   Haloterrigena turkmenica DSM 5511 ADB60993.1 D2RTP2   43
 Mcup_1211   Metallosphaera cuprina Ar-4 AEB95316.1     11
 Mcup_1210   Metallosphaera cuprina Ar-4 AEB95315.1     10
 Mcup_1212   Metallosphaera cuprina Ar-4 AEB95317.1     26
 DFR87_00645   Metallosphaera hakonensis HO1-1 AWR98466.1     26
 DFR87_00650 (GlgX)   Metallosphaera hakonensis HO1-1 AWR98467.1     11
 DFR87_00665 (TreZ)   Metallosphaera hakonensis HO1-1 AWR98470.1     10
 maltooligosyltrehalose trehalohydrolase (TreZ;MTH) 3.2.1.141 Metallosphaera hakonensis JCM 8857 AAR18372.1 Q6SZP6   10
 maltooligosyltrehalose synthase (TreY;MTS) 5.4.99.15 Metallosphaera hakonensis JCM 8857 AAR18371.1 Q6SZP7   26
 glycogen debranching enzyme (TreX)   Metallosphaera hakonensis JCM 8857 AAS00512.1 Q6R5P1   11
 GWK48_00055 (TreZ)   Metallosphaera tengchongensis Ric-A QKQ98999.1     10
 GWK48_00045 (GlgX)   Metallosphaera tengchongensis Ric-A QKQ98997.1     11
 GWK48_00040   Metallosphaera tengchongensis Ric-A QKR00902.1     26
 MBBA_1452 (GlgB)   Methanoculleus bourgensis SAI88306.1     9
 BN140_2271 (GlgB)   Methanoculleus bourgensis MS2 type strain:MS2 CCJ37194.1     9
 Memar_0386   Methanoculleus marisnigri JR1 ABN56319.1 A3CSG9  
 Memar_1265   Methanoculleus marisnigri JR1 ABN57195.1 A3CUZ5   9
 MMAB1_3002   Methanoculleus sp. MAB1 CVK34215.1     9
 Metho_1364   Methanomethylovorans hollandica DSM 15978 AGB49579.1     5
 Mhar_1650   Methanosaeta harundinacea 6Ac AET65010.1    
 Mzhil_0346   Methanosalsum zhilinae DSM 4017 AEH60222.1     5
 MA1641   Methanosarcina acetivorans C2A AAM05050.1
NP_616570.1
Q8TQA8   16
 MA_2000 (TreX)   Methanosarcina acetivorans C2A AAM05403.1
NP_616923.1
Q8TPB3   11
 MA3032   Methanosarcina acetivorans C2A AAM06405.1
NP_617925.1
Q8TLK4  
 MSBR2_0702 (fragment)   Methanosarcina barkeri 227 AKB57218.1     11
 MSBR2_1700   Methanosarcina barkeri 227 AKB58216.1    
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