Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (924); Uniprot accession (212); PDB accession (46); 3D entries (16); cryst (1)
All (732) Archaea (81) Bacteria (509) Eukaryota (141) unclassified (1) Structure (16 - 1 cryst) Characterized (68)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 J113_07650 (fragment)   Mycobacterium tuberculosis CAS/NITR204 AGL26574.1    
 CCDC5079_1006 (fragment)   Mycobacterium tuberculosis CCDC5079 AGL99588.1
AEJ46196.1
   
 CCDC5180_0998 (fragment)   Mycobacterium tuberculosis CCDC5180 AEJ49835.1
AHJ54243.1
   
 MT1122 (fragment)   Mycobacterium tuberculosis CDC1551 AAK45379.1
NP_335565.1
   
 MTCTRI2_1120 (Cela2B) (fragment)   Mycobacterium tuberculosis CTRI-2 AEM99549.1    
 BTU11_05975 (fragment)   Mycobacterium tuberculosis DK9897 APR56528.1    
 M943_05745 (fragment)   Mycobacterium tuberculosis EAI5 AGQ34554.1    
 J114_05890 (fragment)   Mycobacterium tuberculosis EAI5/NITR206 AGL30551.1    
 RN03_1202 (fragment)   Mycobacterium tuberculosis F1 AMC41160.1    
 TBFG_11111 (fragment)   Mycobacterium tuberculosis F11 ABR05454.1 A1QQG5
A5WLB5
 
 RN05_1168 (fragment)   Mycobacterium tuberculosis F28 AMC45444.1    
 MRA_1101 (fragment)   Mycobacterium tuberculosis H37Ra ABQ72837.1 A5U1D7  
 Rv1090 (Cel12) (fragment)   Mycobacterium tuberculosis H37Rv CAA17206.1
AFN48988.1
CCP43843.1
NP_215606.1
O53438  
 LH57_05990 (fragment)   Mycobacterium tuberculosis H37Rv H37Rv; TMC 102 AIR13835.1    
 Y980_1090 (Cela2B) (fragment)   Mycobacterium tuberculosis H37RvSiena AJO72562.1    
 HKBS1_1157 (Cela2B) (fragment)   Mycobacterium tuberculosis HKBS1 AHJ41803.1    
 MTBK_11450 (fragment)   Mycobacterium tuberculosis K AIB47691.1    
 ER17_05820 (fragment)   Mycobacterium tuberculosis KIT87190 AID04161.1    
 TBMG_02895 (fragment)   Mycobacterium tuberculosis KZN 1435 ACT25977.1 C6DV72  
 TBSG_02910 (fragment)   Mycobacterium tuberculosis KZN 4207 AEB05039.1    
 TBXG_002874 (fragment)   Mycobacterium tuberculosis KZN 605 AFM50285.1    
 NCGM946K2_1220 (Cela2B) (fragment)   Mycobacterium tuberculosis NCGM946K2 BAW12011.1    
 K651_07900 (fragment)   Mycobacterium tuberculosis PR08 AJP79045.1    
 UZ39_07850 (fragment)   Mycobacterium tuberculosis PR10 AMP27875.1    
 MRGA327_06810 (fragment)   Mycobacterium tuberculosis RGTB327 AFE16036.1    
 MRGA423_06815 (fragment)   Mycobacterium tuberculosis RGTB423 AFE12376.1    
 AFL40_1145 (fragment)   Mycobacterium tuberculosis SCAID 187.0 ALB18245.1    
 BEE64_1138 (fragment)   Mycobacterium tuberculosis SCAID 252.0 AOE35445.1    
 BEE65_1143   Mycobacterium tuberculosis SCAID 320.0 ANZ81746.1    
 J112_05885 (fragment)   Mycobacterium tuberculosis str. Beijing/NITR203 AGJ67130.1    
 ERDMAN_1219 (Cela2B) (fragment)   Mycobacterium tuberculosis str. Erdman = ATCC 35801 BAL65022.1    
 TBHG_03961 (fragment)   Mycobacterium tuberculosis str. Haarlem EBA41557.1    
 I917_07750 (fragment)   Mycobacterium tuberculosis str. Haarlem/NITR202 AGL22806.1    
 KURONO_1230 (Cela2B) (fragment)   Mycobacterium tuberculosis str. Kurono BAQ05036.1    
 UDA_1090 (Cela2B) (fragment)   Mycobacterium tuberculosis UT205 CCE36618.1    
 TBPG_002964 (fragment)   Mycobacterium tuberculosis W-148 EGE51617.1    
 IZ84_05855 (fragment)   Mycobacterium tuberculosis ZMC13-264 AII89697.1    
 JE53_05865 (fragment)   Mycobacterium tuberculosis ZMC13-88 AII93613.1    
 BN4615_P342   Nonomuraea gerenzanensis ATCC 39727 SBO90828.1    
 BKM31_47520   Nonomuraea sp. ATCC 55076 AQZ68103.1    
 AR543_13525   Paenibacillus bovis BD3526 ANF96927.1    
 PM3016_4317   Paenibacillus mucilaginosus 3016 AFC31087.1    
 B2K_22370   Paenibacillus mucilaginosus K02 AFH63406.1
AFK65340.1
   
 KNP414_04917   Paenibacillus mucilaginosus KNP414 AEI43442.1    
 BBD42_04720   Paenibacillus sp. BIHB4019 ANY70561.1    
 endo-cellulase (Eg003)   Paenibacillus sp. EC003 BAG68846.1 B5BUQ9  
 ASL14_19825 (fragment)   Paenibacillus sp. IHB B 3084 ALP38096.1    
 ASL14_19820 (fragment)   Paenibacillus sp. IHB B 3084 ALP38095.1    
 CIC07_23005   Paenibacillus sp. RUD330 ASS68682.1    
 HPL003_27050 (fragment)   Paenibacillus terrae HPL-003 AET62122.1    
 BUPH_06693   Paraburkholderia phenoliruptrix BR3459a AFT90609.1    
 Bphy_7773   Paraburkholderia phymatum STM815 ACC76656.1 B2JYE8  
 GZ59_17320 (CelB)   Pectobacterium atrosepticum 21A AIK13553.1    
 EV46_13845   Pectobacterium atrosepticum JG10-08 AIA71644.1    
 ECA2827 (CelB)   Pectobacterium atrosepticum SCRI1043 CAG75727.1    
 SCC1_1723 (CelS)   Pectobacterium carotovorum SCC1 ASN85159.1    
 endo-1,4-glucanase S 3.2.1.4 Pectobacterium carotovorum SCC3193 AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
ACP76254.1
P16630  
 endo-1,4-glucanase B (CelB) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02965.2 O31030  
 PC1_1503   Pectobacterium carotovorum subsp. carotovorum PC1 ACT12546.1 C6DDT4  
 PCC21_015250   Pectobacterium carotovorum subsp. carotovorum PCC21 AFR02928.1    
 BCS7_07535   Pectobacterium carotovorum subsp. odoriferum BC S7 AIU88010.1    
 A8F97_03840   Pectobacterium parmentieri RNS08.42.1A AOR58038.1    
 Pecwa_2966   Pectobacterium parmentieri WPP163 ACX88712.1 D0KHY3  
 W5S_2949   Pectobacterium sp. SCC3193 AFI91032.1 P16630  
 A7983_16015   Pectobacterium wasabiae CFBP 3304 AOR64729.1    
 UC35_05460   Ramlibacter tataouinensis 5-10 AMO22450.1    
 Rmar_1627   Rhodothermus marinus DSM 4252 ACY48513.1 D0MJ55  
 cellulase A (CelA) (Cel12A) 3.2.1.4 Rhodothermus marinus ITI378 AAB65594.1
AAR63650.1
AAR67703.1
ABJ29234.1
ACP76253.1
O33897 1H0B[A,B]
2BW8[A,B]
2BWA[A,B]
2BWC[A,B]
3B7M[A,B,C,D]
 Rhom172_1176   Rhodothermus marinus SG0.5JP17-172 AEN73104.1    
 Sare_4899   Salinispora arenicola CNS-205 ABW00649.1 A8LVG0  
 Strop_4424   Salinispora tropica CNB-440 ABP56852.1 A4XD45  
 SARB121R_1 (fragment)   Sinorhizobium arboris LMG14919; HAMBI1552 ABD74851.1 D1CSP7  
 SF83666_a40330 (fragment)   Sinorhizobium fredii CCBAU 83666 ASY73621.1    
 SFHH103_04355   Sinorhizobium fredii HH103 CCE98835.1    
 type III effector NopAA   Sinorhizobium fredii USDA207 AGH09914.1    
 type III effector NopAA   Sinorhizobium fredii USDA257 AGH09926.1    
 ORF51   Sinorhizobium meliloti ABA56022.1 Q1WLH8  
 SMRU11_01365   Sinorhizobium meliloti RU11/001 ARS66095.1    
 ORF Orf70 (fragment)   Sinorhizobium meliloti SM11 ABN47076.1 A4KVH5  
 glycosyl hydrolase   Sinorhizobium meliloti USDA1963 AJT61687.1    
 SS05631_a48680 (fragment)   Sinorhizobium sp. CCBAU 05631 ASY61251.1    
 sce5731   Sorangium cellulosum So ce56 CAN95894.1 A9G7R2  
 SCE1572_06285   Sorangium cellulosum So0157-2 AGP34139.1    
 STHERM_c04060   Spirochaeta thermophila DSM 6192 ADN01378.1 E0RPR4  
 STHERM_c20650 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02999.1 E0RQU3  
 Spith_0373 (StCBM64C)   Spirochaeta thermophila DSM 6578 AEJ60658.1    
 Spith_2106   Spirochaeta thermophila DSM 6578 AEJ62362.1    
 SAM23877_5412   Streptomyces ambofaciens ATCC 23877 AKZ58457.1    
 SAM23877_1270   Streptomyces ambofaciens ATCC 23877 AKZ54319.1    
 SAML1173   Streptomyces ambofaciens ATCC 23877 CAJ90159.1 A3KKC3  
 SAM40697_1111   Streptomyces ambofaciens DSM 40697 ANB05071.1    
 SAM40697_4908   Streptomyces ambofaciens DSM 40697 ANB08865.1    
 cellulase (Cel12B)   Streptomyces argenteolus M178 BAP19008.1    
 BV401_31930   Streptomyces autolyticus CGMCC0516 AQA14333.1    
 SAV2571   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC70282.1
NP_823747.1
   
 SAV555 (CelA1)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC68265.1
NP_821730.1
   
 SAV2568 (CelA4)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC70279.1
NP_823744.1
   
 SBI_02150   Streptomyces bingchenggensis BCW-1 ADI05271.1 D7BT56  
 SBI_03420   Streptomyces bingchenggensis BCW-1 ADI06541.1 D7CAI4  
 SBI_09972   Streptomyces bingchenggensis BCW-1 ADI13090.1 D7CF74  
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