Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (1030); Uniprot accession (212); PDB accession (48); 3D entries (17); cryst (1)
All (838) Archaea (88) Bacteria (586) Eukaryota (163) unclassified (1) Structure (17 - 1 cryst) Characterized (69)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 IQ48_13775 (fragment)   Mycobacterium tuberculosis 0B218DS AIH43180.1    
 IQ42_13915 (fragment)   Mycobacterium tuberculosis 0B222DS AIH39811.1    
 IQ47_13705 (fragment)   Mycobacterium tuberculosis 0B228DS AIH36473.1    
 IQ45_13730 (fragment)   Mycobacterium tuberculosis 0B229DS AIH32996.1    
 T209_13685 (fragment)   Mycobacterium tuberculosis 0B235DS AIH29531.1    
 IQ46_13575 (fragment)   Mycobacterium tuberculosis 0B259XDR AIH25860.1    
 IQ43_13560 (fragment)   Mycobacterium tuberculosis 0B329XDR AIH22066.1    
 BTB1458_1215 (Cela2B) (fragment)   Mycobacterium tuberculosis 1458 AOZ42219.1    
 MT18B_1443 (fragment)   Mycobacterium tuberculosis 18b AJK61120.1    
 RN14_1174 (fragment)   Mycobacterium tuberculosis 22103 AMC85222.1    
 RN12_1176 (fragment)   Mycobacterium tuberculosis 22115 AMC76785.1    
 RN10_1251 (fragment)   Mycobacterium tuberculosis 2242 AMC67797.1    
 RN11_1283 (fragment)   Mycobacterium tuberculosis 2279 AMC72293.1    
 RN15_1175 (fragment)   Mycobacterium tuberculosis 26105 AMC89407.1    
 RN13_1176 (fragment)   Mycobacterium tuberculosis 37004 AMC80995.1    
 MT49_1188 (Cela2B) (fragment)   Mycobacterium tuberculosis 49-02 CDM09351.1    
 IQ44_13650 (fragment)   Mycobacterium tuberculosis 6A024XDR AIH18280.1    
 MT7199_1117 (fragment)   Mycobacterium tuberculosis 7199-99 CCG10966.1    
 LJ70_05940 (fragment)   Mycobacterium tuberculosis 96075 AIQ03728.1    
 LJ80_05950 (fragment)   Mycobacterium tuberculosis 96121 AIQ07719.1    
 TM57_09960 (fragment)   Mycobacterium tuberculosis Beijing AOT75068.1    
 UB21_05830 (fragment)   Mycobacterium tuberculosis Beijing-like AJW48658.1    
 HKBT1_1155 (Cela2B) (fragment)   Mycobacterium tuberculosis BT1 AHJ50101.1    
 HKBT2_1160 (Cela2B) (fragment)   Mycobacterium tuberculosis BT2 AHJ45957.1    
 J113_07650 (fragment)   Mycobacterium tuberculosis CAS/NITR204 AGL26574.1    
 CCDC5079_1006 (fragment)   Mycobacterium tuberculosis CCDC5079 AGL99588.1
AEJ46196.1
   
 CCDC5180_0998 (fragment)   Mycobacterium tuberculosis CCDC5180 AEJ49835.1
AHJ54243.1
   
 MT1122 (fragment)   Mycobacterium tuberculosis CDC1551 AAK45379.1
NP_335565.1
   
 MTCTRI2_1120 (Cela2B) (fragment)   Mycobacterium tuberculosis CTRI-2 AEM99549.1    
 BTU11_05975 (fragment)   Mycobacterium tuberculosis DK9897 APR56528.1    
 M943_05745 (fragment)   Mycobacterium tuberculosis EAI5 AGQ34554.1    
 J114_05890 (fragment)   Mycobacterium tuberculosis EAI5/NITR206 AGL30551.1    
 RN03_1202 (fragment)   Mycobacterium tuberculosis F1 AMC41160.1    
 TBFG_11111 (fragment)   Mycobacterium tuberculosis F11 ABR05454.1 A1QQG5
A5WLB5
 
 RN05_1168 (fragment)   Mycobacterium tuberculosis F28 AMC45444.1    
 MRA_1101 (fragment)   Mycobacterium tuberculosis H37Ra ABQ72837.1 A5U1D7  
 Rv1090 (Cel12) (fragment)   Mycobacterium tuberculosis H37Rv CAA17206.1
AFN48988.1
CCP43843.1
NP_215606.1
O53438  
 LH57_05990 (fragment)   Mycobacterium tuberculosis H37Rv H37Rv; TMC 102 AIR13835.1    
 Y980_1090 (Cela2B) (fragment)   Mycobacterium tuberculosis H37RvSiena AJO72562.1    
 HKBS1_1157 (Cela2B) (fragment)   Mycobacterium tuberculosis HKBS1 AHJ41803.1    
 MTBK_11450 (fragment)   Mycobacterium tuberculosis K AIB47691.1    
 ER17_05820 (fragment)   Mycobacterium tuberculosis KIT87190 AID04161.1    
 TBMG_02895 (fragment)   Mycobacterium tuberculosis KZN 1435 ACT25977.1 C6DV72  
 TBSG_02910 (fragment)   Mycobacterium tuberculosis KZN 4207 AEB05039.1    
 TBXG_002874 (fragment)   Mycobacterium tuberculosis KZN 605 AFM50285.1    
 NCGM946K2_1220 (Cela2B) (fragment)   Mycobacterium tuberculosis NCGM946K2 BAW12011.1    
 K651_07900 (fragment)   Mycobacterium tuberculosis PR08 AJP79045.1    
 UZ39_07850 (fragment)   Mycobacterium tuberculosis PR10 AMP27875.1    
 MRGA327_06810 (fragment)   Mycobacterium tuberculosis RGTB327 AFE16036.1    
 MRGA423_06815 (fragment)   Mycobacterium tuberculosis RGTB423 AFE12376.1    
 AFL40_1145 (fragment)   Mycobacterium tuberculosis SCAID 187.0 ALB18245.1    
 BEE64_1138 (fragment)   Mycobacterium tuberculosis SCAID 252.0 AOE35445.1    
 BEE65_1143   Mycobacterium tuberculosis SCAID 320.0 ANZ81746.1    
 J112_05885 (fragment)   Mycobacterium tuberculosis str. Beijing/NITR203 AGJ67130.1    
 ERDMAN_1219 (Cela2B) (fragment)   Mycobacterium tuberculosis str. Erdman = ATCC 35801 BAL65022.1    
 TBHG_03961 (fragment)   Mycobacterium tuberculosis str. Haarlem EBA41557.1    
 I917_07750 (fragment)   Mycobacterium tuberculosis str. Haarlem/NITR202 AGL22806.1    
 KURONO_1230 (Cela2B) (fragment)   Mycobacterium tuberculosis str. Kurono BAQ05036.1    
 UDA_1090 (Cela2B) (fragment)   Mycobacterium tuberculosis UT205 CCE36618.1    
 TBPG_002964 (fragment)   Mycobacterium tuberculosis W-148 EGE51617.1    
 IZ84_05855 (fragment)   Mycobacterium tuberculosis ZMC13-264 AII89697.1    
 JE53_05865 (fragment)   Mycobacterium tuberculosis ZMC13-88 AII93613.1    
 BN4615_P342   Nonomuraea gerenzanensis ATCC 39727 SBO90828.1    
 BKM31_47520   Nonomuraea sp. ATCC 55076 AQZ68103.1    
 AR543_13525   Paenibacillus bovis BD3526 ANF96927.1    
 PM3016_4317   Paenibacillus mucilaginosus 3016 AFC31087.1    
 B2K_22370   Paenibacillus mucilaginosus K02 AFH63406.1
AFK65340.1
   
 KNP414_04917   Paenibacillus mucilaginosus KNP414 AEI43442.1    
 BBD42_04720   Paenibacillus sp. BIHB4019 ANY70561.1    
 endo-cellulase (Eg003)   Paenibacillus sp. EC003 BAG68846.1 B5BUQ9  
 ASL14_19825 (fragment)   Paenibacillus sp. IHB B 3084 ALP38096.1    
 ASL14_19820 (fragment)   Paenibacillus sp. IHB B 3084 ALP38095.1    
 CIC07_23005   Paenibacillus sp. RUD330 ASS68682.1    
 HPL003_27050 (fragment)   Paenibacillus terrae HPL-003 AET62122.1    
 BUPH_06693   Paraburkholderia phenoliruptrix BR3459a AFT90609.1    
 Bphy_7773   Paraburkholderia phymatum STM815 ACC76656.1 B2JYE8  
 GZ59_17320 (CelB)   Pectobacterium atrosepticum 21A AIK13553.1    
 CVS35_08805   Pectobacterium atrosepticum 36A ATY90439.1    
 EV46_13845   Pectobacterium atrosepticum JG10-08 AIA71644.1    
 ECA2827 (CelB)   Pectobacterium atrosepticum SCRI1043 CAG75727.1    
 OA04_27600 (CelS)   Pectobacterium carotovorum 3-2 AVT59300.1    
 SCC1_1723 (CelS)   Pectobacterium carotovorum SCC1 ASN85159.1    
 endo-1,4-glucanase S 3.2.1.4 Pectobacterium carotovorum SCC3193 AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
ACP76254.1
P16630  
 CTV95_06760   Pectobacterium carotovorum subsp. brasiliense BZA12 ATV43178.1    
 endo-1,4-glucanase B (CelB) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02965.2 O31030  
 PC1_1503   Pectobacterium carotovorum subsp. carotovorum PC1 ACT12546.1 C6DDT4  
 PCC21_015250   Pectobacterium carotovorum subsp. carotovorum PCC21 AFR02928.1    
 BCS7_07535   Pectobacterium carotovorum subsp. odoriferum BC S7 AIU88010.1    
 A8F97_03840   Pectobacterium parmentieri RNS08.42.1A AOR58038.1    
 Pecwa_2966   Pectobacterium parmentieri WPP163 ACX88712.1 D0KHY3  
 endo-β-1,4-glucanase (CMCase; W5S_2949) 3.2.1.4 Pectobacterium sp. SCC3193 AFI91032.1 P16630  
 A7983_16015   Pectobacterium wasabiae CFBP 3304 AOR64729.1    
 C6W10_16715   Plantactinospora sp. BB1 AVT41531.1    
 C6W10_28830   Plantactinospora sp. BB1 AVT39792.1    
 C6W10_12250   Plantactinospora sp. BB1 AVT37103.1    
 C6361_21755   Plantactinospora sp. BC1 AVT31668.1    
 C6361_19140   Plantactinospora sp. BC1 AVT31245.1    
 C6361_13155   Plantactinospora sp. BC1 AVT30285.1    
 UC35_05460   Ramlibacter tataouinensis 5-10 AMO22450.1    
 Rmar_1627   Rhodothermus marinus DSM 4252 ACY48513.1 D0MJ55  
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