Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (929); Uniprot accession (212); PDB accession (46); 3D entries (16); cryst (1)
All (737) Archaea (81) Bacteria (514) Eukaryota (141) unclassified (1) Structure (16 - 1 cryst) Characterized (68)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endoglucanase (GuxA) 3.2.1.4 Acidothermus cellulolyticus ABH87623.1
ABH87627.1
ABH87628.1
ABH87635.1
   
 endoglucanase (GuxA;Acel_0615) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52388.1 A0LSH8  
 cellulase (Cel12;AcCel12B;Acel_0619) (Cel12B) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52392.1 A0LSI2  
 Sequence 21 from patent US 7094588   Actinomycetales ABJ29232.1    
 SAMN04489716_5736   Actinoplanes derwentensis DSM 43941 SDT69193.1    
 SAMN04489716_3523   Actinoplanes derwentensis DSM 43941 SDT37787.1    
 SAMN04489716_4668   Actinoplanes derwentensis DSM 43941 SDT58383.1    
 AFR_34770   Actinoplanes friuliensis DSM 7358 AGZ45210.1    
 sugar hydrolase (possible fragment)   Actinoplanes garbadinensis ATCC 31049 ACR33037.1 C4NFG5  
 AMIS_9720   Actinoplanes missouriensis 431 BAL86192.1    
 L083_4927 (CelD)   Actinoplanes sp. N902-109 AGL18437.1    
 ACPL_1196 (CelB)   Actinoplanes sp. SE50/110 AEV82093.1
SLL97899.1
   
 ACPL_4925 (CelD)   Actinoplanes sp. SE50/110 AEV85816.1
SLM01620.1
   
 CDG81_11320   Actinopolyspora erythraea YIM 90600 ASU78771.1    
 CDG81_10540   Actinopolyspora erythraea YIM 90600 ASU81030.1    
 Amir_3027   Actinosynnema mirum DSM 43827 ACU36946.1 C6WRV4  
 Amir_3987   Actinosynnema mirum DSM 43827 ACU37852.1 C6WFR6  
 CNX65_19970   Actinosynnema pretiosum X47 ATE55280.1    
 CNX65_15280   Actinosynnema pretiosum X47 ATE54484.1    
 SAMN04489733_2479   Amycolatopsis keratiniphila FH 1893 SDU25836.1    
 BB31_29280   Amycolatopsis lurida NRRL 2430 AJK57257.1    
 B737_3042   Amycolatopsis mediterranei RB AGT83706.1    
 B737_3253   Amycolatopsis mediterranei RB AGT83917.1    
 B737_0877 (fragment)   Amycolatopsis mediterranei RB AGT81541.1    
 RAM_16730   Amycolatopsis mediterranei S699 AEK41834.1
AFO76789.1
   
 RAM_15640   Amycolatopsis mediterranei S699 AEK41616.1
AFO76577.1
   
 RAM_04485 (fragment)   Amycolatopsis mediterranei S699 AEK39389.1
AFO74412.1
   
 AMED_3075   Amycolatopsis mediterranei U32 ADJ44866.1 D8I2N0  
 AMED_3289   Amycolatopsis mediterranei U32 ADJ45078.1 D8I5I9  
 AMED_0879 (fragment)   Amycolatopsis mediterranei U32 ADJ42698.1 D8I297  
 AMETH_3794   Amycolatopsis methanolica 239 AIJ23886.1    
 SD37_23480   Amycolatopsis orientalis B-37 ANN18307.1    
 SD37_11275   Amycolatopsis orientalis B-37 ANN21711.1    
 AA314_02187   Archangium gephyra DSM 2261 AKJ00561.1    
 ABAZ39_31220   Azospirillum brasilense Az39 AIB16326.1    
 AMK58_27045   Azospirillum brasilense Sp 7 ALJ39133.1    
 AZOBR_p440082   Azospirillum brasilense Sp245 CCD03369.1    
 BGLY_3695 (Cel12A)   Bacillus glycinifermentans SCA87518.1    
 COP00_10275   Bacillus glycinifermentans KBN06P03352 ATH95484.1    
 CPQ91_16850   Bacillus licheniformis ATCC 9789 ATI77402.1    
 BL1202_03592   Bacillus licheniformis BL1202 AOP16513.1    
 endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) 3.2.1.151
3.2.1.4
Bacillus licheniformis DSM 13 = ATCC 14580 AAU42138.1
AAU24774.1
Q65FM6 2JEM[A,B]
2JEN[A]
 endo-β-1,4-glucanase (Cel12A) (Cel12A) 3.2.1.4 Bacillus licheniformis GXN151 AAP44491.1 Q7X4S4  
 AB684_16890   Bacillus licheniformis HRBL-15TDI7 AMR11758.1    
 cellulase 12A (Cel12A)   Bacillus licheniformis MK7 AKI23605.1    
 endo-β-1,4-glucanase (Cel12A)   Bacillus licheniformis MTCC 429 AFM31225.1    
 B37_02912 (CelS)   Bacillus licheniformis SCCB 37 ARC74937.1    
 B14_01155 (CelS)   Bacillus licheniformis SCDB 14 ARC64180.1    
 B34_01939 (CelS)   Bacillus licheniformis SCDB 34 ARC69355.1    
 BaDB11_01500 (CelS)   Bacillus licheniformis SCK B11 ARC60142.1    
 S100141_02791   Bacillus licheniformis SRCM100141 ARW44086.1    
 endoglucanase (Gh12A)   Bacillus licheniformis SVD1 BAL45508.1    
 MUY_003433 (Cel12A)   Bacillus licheniformis WX-02 AKQ74565.1    
 BaLi_c33850 (Cel12A)   Bacillus paralicheniformis ATCC 9945a AGN37700.1    
 SC10_B2orf05071   Bacillus paralicheniformis BL-09 AJO19726.1    
 BLMD_16830   Bacillus paralicheniformis MDJK30 ARA86997.1    
 S101395_04029   Bacillus sonorensis SRCM101395 ASB90531.1    
 CJO35_16465   Bacillus sp. 1s-1 ASV16655.1    
 BSZ43_16355   Bacillus sp. H15-1 APJ28225.1    
 AXW83_18545   Bosea sp. PAMC 26642 AMJ62031.1    
 NK6_2875 (fragment)   Bradyrhizobium diazoefficiens NK6 BAR56055.1    
 AAV28_06690   Bradyrhizobium diazoefficiens USDA 110 AND87528.1    
 blr1656   Bradyrhizobium diazoefficiens USDA 110 NP_768296.1
BAC46921.1
Q89TW7  
 blr1964   Bradyrhizobium diazoefficiens USDA 110 AAG60937.1
BAC47229.1
NP_768604.1
H7C6J8
Q9AN41
 
 BD122_08510   Bradyrhizobium diazoefficiens USDA 122 APO50271.1    
 BD122_10095   Bradyrhizobium diazoefficiens USDA 122 APO50597.1    
 RN69_38260   Bradyrhizobium japonicum E109 AJA65482.1    
 RN69_39665   Bradyrhizobium japonicum E109 AJA65701.1    
 BKD09_RS41420   Bradyrhizobium japonicum J5 APG14830.1    
 BKD09_RS44345   Bradyrhizobium japonicum J5 APG15344.1    
 BJS_08173 (fragment)   Bradyrhizobium japonicum SEMIA 5079 AHY48600.1    
 BJS_08633 (fragment)   Bradyrhizobium japonicum SEMIA 5079 AHY56931.1    
 BJ6T_81680   Bradyrhizobium japonicum USDA 6 BAL13413.1
AGH09952.1
   
 BJ6T_78820   Bradyrhizobium japonicum USDA 6 BAL13128.1    
 type III effector NopAA   Bradyrhizobium japonicum USDA122 AGH09984.1    
 type III effector NopAA   Bradyrhizobium japonicum USDA123 AGH10014.1    
 type III effector NopAA   Bradyrhizobium japonicum USDA124 AGH10046.1    
 BM43_5605   Burkholderia gladioli ATCC 10248 AJW94672.1    
 bgla_2g18810   Burkholderia gladioli BSR3 AEA64317.1    
 CO712_23895   Burkholderia gladioli pv. gladioli FDAARGOS_389 ATF88101.1    
 CEJ98_21995   Burkholderia gladioli pv. gladioli KACC 11889 ASD81684.1    
 bglu_2g11820   Burkholderia glumae BGR1 ACR31570.1 C5AI40  
 KS03_4742   Burkholderia glumae LMG 2196 = ATCC 33617 AJY63069.1    
 BGL_1c19080   Burkholderia glumae PG1 AJK46417.1    
 bpln_1p0970   Burkholderia plantarii ATCC 43733 ALK35238.1    
 BC1001_PA6467 (XgeA)   Burkholderia sp. CCGE1001 AMD29415.1    
 BC1002_6861   Burkholderia sp. CCGE1002 ADG20670.1 D5WP47  
 Caci_3603   Catenulispora acidiphila DSM 44928 ACU72507.1 C7QAK8  
 Caci_4913   Catenulispora acidiphila DSM 44928 ACU73773.1 C7Q337  
 CBP52_03445   Cellulomonas sp. PSBB021 ASR54350.1    
 CSACC_24690 (CelS)   Clostridium saccharobutylicum BAS/B3/SW/136 AQS00645.1    
 CLSA_c24690   Clostridium saccharobutylicum DSM 13864 AGX43443.1    
 CLOSACC_24690 (CelS)   Clostridium saccharobutylicum NCP 195 AQS14628.1    
 CLOSC_24620 (CelS)   Clostridium saccharobutylicum NCP 200 AQR90741.1    
 CLOBY_24460 (CelS)   Clostridium saccharobutylicum NCP 258 AQS10303.1    
 Cspa_c25190   Clostridium saccharoperbutylacetonicum N1-4(HMT) AGF56284.1    
 CLSAP_23380 (CelS)   Clostridium saccharoperbutylacetonicum N1-504 AQR95024.1    
 pRALTA_0250   Cupriavidus taiwanensis LMG 19424 CAP63926.1 B2AK99  
 DICTH_0465   Dictyoglomus thermophilum H-6-12 ACI19111.1
AAE50602.1
B5YCT9  
 Dtur_0628   Dictyoglomus turgidum DSM 6724 ACK41916.1 B8DZI3  
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