Glycoside Hydrolase Family 12

Known Activitiesendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesHOMSTRAD; InterPro; PFAM;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (446); Uniprot accession (198); PDB accession (27); 3D entries (10); cryst (1)
All (283) Archaea (46) Bacteria (141) Eukaryota (96) Structure (10 - 1 cryst) Characterized (66)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 endoglucanase (GuxA) 3.2.1.4 Acidothermus cellulolyticus ABH87623.1
ABH87627.1
ABH87628.1
ABH87635.1
   
 endoglucanase (GuxA;Acel_0615) 3.2.1.4 Acidothermus cellulolyticus 11B ATCC 43068 ABK52388.1 A0LSH8  
 cellulase (Cel12;Acel_0619) 3.2.1.4 Acidothermus cellulolyticus 11B ATCC 43068 ABK52392.1 A0LSI2  
 Sequence 21 from patent US 7094588   Actinomycetales ABJ29232.1    
 sugar hydrolase (possible fragment)   Actinoplanes garbadinensis ATCC 31049 ACR33037.1 C4NFG5  
 ACPL_1196 (CelB)   Actinoplanes sp. SE50/110 AEV82093.1    
 ACPL_4925 (CelD)   Actinoplanes sp. SE50/110 AEV85816.1    
 Amir_3027   Actinosynnema mirum DSM 43827 ACU36946.1 C6WRV4  
 Amir_3987   Actinosynnema mirum DSM 43827 ACU37852.1 C6WFR6  
 RAM_16730   Amycolatopsis mediterranei S699 AEK41834.1    
 RAM_15640   Amycolatopsis mediterranei S699 AEK41616.1    
 RAM_04485 (fragment)   Amycolatopsis mediterranei S699 AEK39389.1    
 AMED_3075   Amycolatopsis mediterranei U32 ADJ44866.1 D8I2N0  
 AMED_3289   Amycolatopsis mediterranei U32 ADJ45078.1 D8I5I9  
 AMED_0879 (fragment)   Amycolatopsis mediterranei U32 ADJ42698.1 D8I297  
 AZOBR_p440082   Azospirillum brasilense Sp245 CCD03369.1    
 endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) 3.2.1.151
3.2.1.4
Bacillus licheniformis ATCC 14580 / DSM13 AAU24774.1
AAU42138.1
Q65FM6 2JEM[A,B]
2JEN[A]
 endo-β-1,4-glucanase (Cel12A) (Cel12A) 3.2.1.4 Bacillus licheniformis GXN151 AAP44491.1 Q7X4S4  
 endoglucanase (Gh12A)   Bacillus licheniformis SVD1 BAL45508.1    
 blr1656   Bradyrhizobium japonicum USDA 110 BAC46921.1
NP_768296.1
Q89TW7  
 blr1964   Bradyrhizobium japonicum USDA 110 AAG60937.1
BAC47229.1
NP_768604.1
Q9AN41  
 BJ6T_81680   Bradyrhizobium japonicum USDA 6 BAL13413.1    
 BJ6T_78820   Bradyrhizobium japonicum USDA 6 BAL13128.1    
 bgla_2g18810   Burkholderia gladioli BSR3 AEA64317.1    
 bglu_2g11820   Burkholderia glumae BGR1 ACR31570.1 C5AI40  
 Bphy_7773   Burkholderia phymatum STM815 ACC76656.1 B2JYE8  
 BC1002_6861   Burkholderia sp. CCGE1002 ADG20670.1 D5WP47  
 Caci_3603   Catenulispora acidiphila DSM 44928 ACU72507.1 C7QAK8  
 Caci_4913   Catenulispora acidiphila DSM 44928 ACU73773.1 C7Q337  
 Cphy_1640   Clostridium phytofermentans ISDg ABX42012.1 A9KRD8  
 pRALTA_0250   Cupriavidus taiwanensis LMG 19424 CAP63926.1 B2AK99  
 cellulase   Dictyoglomus AAE50602.1    
 DICTH_0465   Dictyoglomus thermophilum H-6-12 ATCC 35947 ACI19111.1 B5YCT9  
 Dtur_0628   Dictyoglomus turgidum DSM 6724 ACK41916.1 B8DZI3  
 AciX8_3578   Granulicella mallensis MP5ACTX8 AEU37871.1    
 Kfla_1833   Kribbella flavida DSM 17836 ADB30927.1 D2PPG5  
 Micau_1146   Micromonospora aurantiaca ATCC 27029 ADL44708.1 D9TD70  
 ML5_1409   Micromonospora sp. L5 ADU06947.1 D3CAR1  
 glycoside hydrolase family GH12 protein (Cel12) (fragment)   Mycobacterium africanum ADG63154.1 D6MNR4  
 MAF_11050 (Cela2B) (fragment)   Mycobacterium africanum GM041182 CCC26177.1    
 Mb1120 (CelA2b) (fragment)   Mycobacterium bovis AF2122/97 CAD93981.1
NP_854776.1
   
 BCGMEX_1122 (fragment)   Mycobacterium bovis BCG str. Mexico AET18405.1    
 BCGM_1116 (Cela2B) (fragment)   Mycobacterium bovis BCG str. Moreau RDJ CCC63709.1    
 BCG_1150 (fragment)   Mycobacterium bovis BCG str. Pasteur 1173P2 CAL71137.1 A1KHN0  
 JTY_1123 (Cela2B) (fragment)   Mycobacterium bovis BCG str. Tokyo 172 BAH25413.1 C1AM84  
 glycoside hydrolase family GH12 protein (Cel12) (fragment)   Mycobacterium canettii ADG63155.1 D6MNR5  
 MCAN_10991 (Cela2B) (fragment)   Mycobacterium canettii CIPT 140010059 CCC43435.1    
 glycoside hydrolase family GH12 protein (Cel12) (fragment)   Mycobacterium caprae ADG63157.1 D6MNR7  
 glycoside hydrolase family GH12 protein (Cel12) (fragment)   Mycobacterium microti ADG63156.1 D6MNR6  
 glycoside hydrolase family GH12 protein (Cel12) (fragment)   Mycobacterium pinnipedii ADG63158.1 D6MNR8  
 CCDC5079_1006 (fragment)   Mycobacterium tuberculosis CCDC5079 AEJ46196.1    
 CCDC5180_0998 (fragment)   Mycobacterium tuberculosis CCDC5180 AEJ49835.1    
 MT1122 (fragment)   Mycobacterium tuberculosis CDC1551 AAK45379.1
NP_335565.1
   
 MTCTRI2_1120 (Cela2B) (fragment)   Mycobacterium tuberculosis CTRI-2 AEM99549.1    
 TBFG_11111 (fragment)   Mycobacterium tuberculosis F11 ABR05454.1 A1QQG5
A5WLB5
 
 MRA_1101 (fragment)   Mycobacterium tuberculosis H37Ra ATCC 25177 ABQ72837.1 A5U1D7  
 Rv1090 (Cel12) (fragment) 3.2.1.73 Mycobacterium tuberculosis H37Rv CAA17206.1
NP_215606.1
O53438  
 TBMG_02895 (fragment)   Mycobacterium tuberculosis KZN 1435 ACT25977.1 C6DV72  
 TBSG_02910 (fragment)   Mycobacterium tuberculosis KZN 4207 AEB05039.1    
 KNP414_04917   Paenibacillus mucilaginosus KNP414 AEI43442.1    
 endo-cellulase (Eg003)   Paenibacillus sp. EC003 BAG68846.1 B5BUQ9  
 HPL003_27050 (fragment)   Paenibacillus terrae HPL-003 AET62122.1    
 ECA2827 (CelB)   Pectobacterium atrosepticum SCRI1043 CAG75727.1    
 endo-1,4-glucanase S 3.2.1.4 Pectobacterium carotovorum SCC3193 AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
ACP76254.1
P16630.1  
 endo-1,4-glucanase B (CelB) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02965.2 O31030  
 PC1_1503   Pectobacterium carotovorum subsp. carotovorum PC1 ACT12546.1 C6DDT4  
 Pecwa_2966   Pectobacterium wasabiae WPP163 ACX88712.1 D0KHY3  
 Rmar_1627   Rhodothermus marinus DSM 4252 ACY48513.1 D0MJ55  
 cellulase A (CelA) (Cel12A) 3.2.1.4 Rhodothermus marinus ITI378 AAB65594.1
AAR63650.1
AAR67703.1
ABJ29234.1
ACP76253.1
O33897 1H0B[A,B]
2BW8[A,B]
2BWA[A,B]
2BWC[A,B]
3B7M[A,B,C,D]
 Rhom172_1176   Rhodothermus marinus SG0.5JP17-172 AEN73104.1    
 Sare_4899   Salinispora arenicola CNS-205 ABW00649.1 A8LVG0  
 Strop_4424   Salinispora tropica CNB-440 ABP56852.1 A4XD45  
 SARB121R_1 (fragment)   Sinorhizobium arboris LMG14919; HAMBI1552 ABD74851.1 D1CSP7  
 SFHH103_04355   Sinorhizobium fredii HH103 CCE98835.1    
 ORF51   Sinorhizobium meliloti ABA56022.1 Q1WLH8  
 ORF Orf70 (fragment)   Sinorhizobium meliloti SM11 ABN47076.1 A4KVH5  
 sce5731   Sorangium cellulosum 'So ce 56' CAN95894.1 A9G7R2  
 STHERM_c04060   Spirochaeta thermophila DSM 6192 ADN01378.1 E0RPR4  
 STHERM_c20650   Spirochaeta thermophila DSM 6192 ADN02999.1 E0RQU3  
 Spith_0373   Spirochaeta thermophila DSM 6578 AEJ60658.1    
 Spith_2106   Spirochaeta thermophila DSM 6578 AEJ62362.1    
 SAML1173   Streptomyces ambofaciens ATCC 23877 CAJ90159.1 A3KKC3  
 SAV2571   Streptomyces avermitilis MA-4680 BAC70282.1
NP_823747.1
   
 SAV555 (CelA1)   Streptomyces avermitilis MA-4680 BAC68265.1
NP_821730.1
   
 SAV2568 (CelA4)   Streptomyces avermitilis MA-4680 BAC70279.1
NP_823744.1
   
 SBI_02150   Streptomyces bingchenggensis BCW-1 ADI05271.1 D7BT56  
 SBI_03420   Streptomyces bingchenggensis BCW-1 ADI06541.1 D7CAI4  
 SBI_09972   Streptomyces bingchenggensis BCW-1 ADI13090.1 D7CF74  
 SCO1187 (CelB;SCG11A.18)   Streptomyces coelicolor A3(2) CAB61599.1
NP_625477.1
Q9RJY3  
 SCO5691 or SC5H4.15   Streptomyces coelicolor A3(2) CAB91127.1
NP_629819.1
Q9KYS4  
 Sfla_6354   Streptomyces flavogriseus ATCC 33331 ADW07712.1 C9N590  
 Sfla_0771   Streptomyces flavogriseus ATCC 33331 ADW02233.1 C9NF61  
 endo-β-1,4-glucanase (CelA2;Cel2) 3.2.1.4 Streptomyces halstedii JM8 AAC45429.1 O08468  
 SHJG_1894   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY87169.1    
 endo-β-1,4-glucanase (CelB;CelB2;EGI) 3.2.1.4 Streptomyces lividans 1326 AAB71950.1
AAR63649.1
AAR67702.1
ABH87634.1
ABJ29233.1
ACP76252.1
Q54331 1NLR[A]
2NLR[A]
 cellulase (11AG8) 3.2.1.4 Streptomyces lividans TK23 AAQ31831.1
ABH87633.1
   
 endo-β-1,4-glucanase S (EglS) 3.2.1.4 Streptomyces rochei A2 CAA52139.1 Q59963  
 SCAB_5981 (CelB)   Streptomyces scabiei 87.22 CBG67793.1 C9YVP5  
 SCAB_25571   Streptomyces scabiei 87.22 CBG69663.1 C9Z271  
 SCAB_90081   Streptomyces scabiei 87.22 CBG75942.1 C9Z9L5  
 cellulase 12A (Cel12A) 3.2.1.4 Streptomyces sp. 11AG8 AAE59731.1
AAF91283.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
ACP76251.1
Q9KIH1 1OA4[A]
 SACTE_5809   Streptomyces sp. SirexAA-E AEN13595.1    
 cellulase B (CelB)   Streptomyces sp. THW31 ADP65783.1 E5L393  
 Strvi_2018   Streptomyces violaceusniger Tu 4113 AEM81752.1    
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 endo-β-1,4-glucanase (Cel) 3.2.1.4 Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 TERTU_0353   Teredinibacter turnerae T7901 ACR14297.1 C5BM92  
 Tbis_0352   Thermobispora bispora DSM 43833 ADG87082.1 D6Y3Q3  
 endo-β-1,4-glucanase A (CelA;TM1524;TM_1524) (Cel12A) 3.2.1.4 Thermotoga maritima MSB8 AAD36591.1
CAA93273.1
NP_229324.1
Q60032
Q9S5X8
3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 Thermotoga maritima MSB8 AAD36592.1
CAA93274.1
NP_229325.1
Q60033  
 endoglucanase (N2) (fragment)   Thermotoga naphthophila CBH31132.1 D2U583  
 Tnap_1284   Thermotoga naphthophila RKU-10 ADA67369.1 D2C3R5  
 Tnap_1285   Thermotoga naphthophila RKU-10 ADA67370.1 D2C3R6  
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermotoga neapolitana AAC95059.1
CAB06783.1
O08428
P96491
 
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Thermotoga neapolitana AAC95060.1
CAB06782.1
P96492
Q798L1
 
 CTN_1106   Thermotoga neapolitana DSM 4359 ACM23282.1 B9K8J9  
 CTN_1107   Thermotoga neapolitana DSM 4359 ACM23283.1 B9K8K0  
 cellulase (TCel2;Tpet_1267) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 TRQ2_1187   Thermotoga sp. RQ2 ACB09531.1 B1LB33  
 TRQ2_1188   Thermotoga sp. RQ2 ACB09532.1 B1LB34  
 VAB18032_10320   Verrucosispora maris AB-18-032 AEB43182.1    
 XALc_0865   Xanthomonas albilineans GPE PC73 CBA15383.1    
 XAC3507 + XAC3506 (CelS) (two fragments)   Xanthomonas axonopodis pv. citri str. 306 AAM38349.1
AAM38350.1
NP_643813.1
NP_643814.1
   
 XACM_3403 (CelS)   Xanthomonas axonopodis pv. citrumelo F1 AEO43650.1    
 cellulase S (fragment)   Xanthomonas axonopodis pv. phaseoli LMG 7455 AEB26740.1    
 xcc-b100_0818   Xanthomonas campestris pv. campestris B100 CAP50159.1 Q8P5G0  
 xcc-b100_0819   Xanthomonas campestris pv. campestris B100 CAP50160.1 Q8P5G1  
 XC_0783   Xanthomonas campestris pv. campestris str. 8004 AAY47861.1 Q4UYL2  
 XC_0784   Xanthomonas campestris pv. campestris str. 8004 AAY47862.1 Q4UYL1  
 XCC3380   Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42650.1
NP_638726.1
   
 CelS   Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42651.1
NP_638727.1
   
 XCR_3716   Xanthomonas campestris pv. raphani 756C AEL08576.1    
 XCR_3717   Xanthomonas campestris pv. raphani 756C AEL08577.1    
 XCV3634 (CelS)   Xanthomonas campestris pv. vesicatoria str. 85-10 CAJ25365.1 Q3BPE8  
 XOO1076 (CelS;BglXoA) (possible fragment)   Xanthomonas oryzae pv. oryzae KACC10331 AAW74330.1    
 XOO1077 (BglXoB)   Xanthomonas oryzae pv. oryzae KACC10331 AAW74331.1    
 XOO0976 (possible fragment)   Xanthomonas oryzae pv. oryzae MAFF 311018 BAE67731.1 Q2P6U6  
 XOO0977   Xanthomonas oryzae pv. oryzae MAFF 311018 BAE67732.1 Q2P6U5  
 PXO_02431   Xanthomonas oryzae pv. oryzae PXO99A ACD60719.1 B2SLS0  
 PXO_02432 (probable fragment)   Xanthomonas oryzae pv. oryzae PXO99A ACD60720.1 B2SLS1  




Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II