Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (924); Uniprot accession (212); PDB accession (46); 3D entries (16); cryst (1)
All (732) Archaea (81) Bacteria (509) Eukaryota (141) unclassified (1) Structure (16 - 1 cryst) Characterized (68)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SCO1187 (CelB;SCG11A.18)   Streptomyces coelicolor A3(2) CAB61599.1
AHA82090.1
NP_625477.1
Q9RJY3  
 SCO5691 or SC5H4.15   Streptomyces coelicolor A3(2) CAB91127.1
AHA82092.1
NP_629819.1
Q9KYS4  
 TU94_24000   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP04081.1    
 TU94_04665   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP00870.1    
 BN159_2113 (Cela1)   Streptomyces davawensis JCM 4913 CCK26492.1    
 SGLAU_26650   Streptomyces glaucescens GLA.O AIS01268.1    
 SGLAU_24490   Streptomyces glaucescens GLA.O AIS00840.1    
 AVL59_24080   Streptomyces griseochromogenes ATCC 14511 ANP52219.1    
 endo-β-1,4-glucanase (CelA2;Cel2) 3.2.1.4 Streptomyces halstedii JM8 AAC45429.1 O08468  
 SHJG_1894   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY87169.1    
 SHJGH_1659   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF61325.1    
 SHL15_0383   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO91588.1    
 SHXM_07212   Streptomyces hygroscopicus XM201 AQW53749.1    
 ABB07_10530   Streptomyces incarnatus NRRL 8089 AKJ10438.1    
 SIRAN3033   Streptomyces iranensis CDR06119.1    
 SLA_6235   Streptomyces laurentii ATCC 31255 BAU87104.1    
 Sle_19910   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR61452.1    
 Sle_59080   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR65364.1    
 SLINC_6733   Streptomyces lincolnensis NRRL 2936 ANS68957.1    
 SLINC_6107   Streptomyces lincolnensis NRRL 2936 ANS68331.1    
 SLINC_8275   Streptomyces lincolnensis NRRL 2936 ANS70499.1    
 SLINC_0625   Streptomyces lincolnensis NRRL 2936 ANS62849.1    
 endo-β-1,4-glucanase (CelB;CelB2;EGI) 3.2.1.4 Streptomyces lividans 1326 AAB71950.1
AAR63649.1
AAR67702.1
ABH87634.1
ABJ29233.1
ACP76252.1
Q54331 1NLR[A]
2NLR[A]
 cellulase (11AG8) 3.2.1.4 Streptomyces lividans TK23 AAQ31831.1
ABH87633.1
   
 SLIV_31860   Streptomyces lividans TK24 AIJ17260.1    
 SLIV_10170   Streptomyces lividans TK24 AIJ13034.1    
 SNOD_25355   Streptomyces nodosus ATCC 14899 AJE42988.1    
 SNOD_24165   Streptomyces nodosus ATCC 14899 AJE42792.1    
 B1H29_10270   Streptomyces pactum ACT12 AQS67261.1    
 B1H29_31990   Streptomyces pactum ACT12 AQS70901.1    
 Spa2297_04285   Streptomyces parvulus 2297 ANJ06270.1    
 Sfla_6354   Streptomyces pratensis ATCC 33331 ADW07712.1 C9N590  
 Sfla_0771   Streptomyces pratensis ATCC 33331 ADW02233.1 C9NF61  
 SPRI_6750   Streptomyces pristinaespiralis HCCB 10218 ALC25056.1    
 SPRI_6625   Streptomyces pristinaespiralis HCCB 10218 ALC24931.1    
 BFF78_11660   Streptomyces puniciscabiei TW1S1 AOR31621.1    
 M271_15500   Streptomyces rapamycinicus NRRL 5491 AGP54676.1    
 TUE45_06190 (CelS)   Streptomyces reticuli CUW31447.1    
 TUE45_pSRTUE45c_0481 (CeX)   Streptomyces reticuli CUW33113.1    
 endo-β-1,4-glucanase S (EglS) 3.2.1.4 Streptomyces rochei A2 CAA52139.1 Q59963  
 SCAB_5981 (CelB)   Streptomyces scabiei 87.22 CBG67793.1 C9YVP5  
 SCAB_25571   Streptomyces scabiei 87.22 CBG69663.1 C9Z271  
 SCAB_90081   Streptomyces scabiei 87.22 CBG75942.1 C9Z9L5  
 CGL27_33255   Streptomyces sp. 11-1-2 ASQ97258.1    
 cellulase 12A (Cel12A) 3.2.1.4 Streptomyces sp. 11AG8 AAF91283.1
AAE59731.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
ACP76251.1
Q9KIH1 1OA4[A]
 SAMN05428941_5778   Streptomyces sp. 2114.2 SDT76171.1    
 SAMN05428941_1220   Streptomyces sp. 2114.2 SDS81576.1    
 SAMN05444521_2491   Streptomyces sp. 3124.6 SHH90108.1    
 ASR50_33355   Streptomyces sp. 4F ALV53826.1    
 ASR50_25700   Streptomyces sp. 4F ALV52474.1    
 GZL_09191 (fragment)   Streptomyces sp. 769 AJC61712.1    
 NI25_10825   Streptomyces sp. CCM_MD2014 AIV33924.1    
 NI25_33295   Streptomyces sp. CCM_MD2014 AIV37792.1    
 AS200_04800   Streptomyces sp. CdTB01 ALV31448.1    
 AS200_13735   Streptomyces sp. CdTB01 ALV32999.1    
 CAC01_14350   Streptomyces sp. CLI2509 CLI2905 ASY33705.1    
 endo-β-1,4-glucanase (Cel;CelStrep) 3.2.1.4 Streptomyces sp. G12 CCI74016.1    
 F750_0175   Streptomyces sp. PAMC 26508 AGJ52686.1    
 F750_6089   Streptomyces sp. PAMC 26508 AGJ58516.1    
 QR97_36850   Streptomyces sp. PBH53 AKN74562.1    
 QR97_26695   Streptomyces sp. PBH53 AKN72867.1    
 A4E84_29055   Streptomyces sp. S10(2016) AMW13189.1    
 CAG99_17250   Streptomyces sp. SCSIO 03032 ARQ70357.1    
 CAG99_04545   Streptomyces sp. SCSIO 03032 ARQ68208.1    
 SACTE_5809   Streptomyces sp. SirexAA-E AEN13595.1    
 cellulase B (CelB)   Streptomyces sp. THW31 ADP65783.1 E5L393  
 SAMN05216371_3219   Streptomyces sp. TLI_053 SDT62471.1    
 SAMN05216371_3760   Streptomyces sp. TLI_053 SDT68960.1    
 ORF   Streptomyces sp. WAC1438 AFO53540.1    
 Strvi_2018   Streptomyces violaceusniger Tu 4113 AEM81752.1    
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 SXIM_44520   Streptomyces xiamenensis 318 AKG45836.1    
 endo-β-1,4-glucanase (Cel) 3.2.1.4 Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 TERTU_0353   Teredinibacter turnerae T7901 ACR14297.1 C5BM92  
 Tbis_0352   Thermobispora bispora DSM 43833 ADG87082.1 D6Y3Q3  
 endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) 3.2.1.4 Thermotoga maritima MSB8 AGL50456.1
AAD36591.1
AHD18579.1
AKE29285.1
CAA93273.1
NP_229324.1
Q60032
Q9S5X8
3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
3VHN[A,B,C,D,E,F,G,H]
3VHO[A,B]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 Thermotoga maritima MSB8 AAD36592.1
AGL50457.1
AHD18578.1
AKE29286.1
CAA93274.1
NP_229325.1
G4FFR3
Q60033
 
 THMB_1558   Thermotoga maritima Tma100 AKE31157.1    
 THMB_1559   Thermotoga maritima Tma100 AKE31158.1    
 THMC_1558   Thermotoga maritima Tma200 AKE27413.1    
 THMC_1559   Thermotoga maritima Tma200 AKE27414.1    
 endoglucanase (N2) (fragment)   Thermotoga naphthophila CBH31132.1 D2U583  
 Tnap_1284   Thermotoga naphthophila RKU-10 ADA67369.1 D2C3R5  
 Tnap_1285   Thermotoga naphthophila RKU-10 ADA67370.1 D2C3R6  
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermotoga neapolitana AAC95059.1
CAB06783.1
O08428
P96491
 
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Thermotoga neapolitana AAC95060.1
CAB06782.1
P96492
Q798L1
 
 CTN_1106   Thermotoga neapolitana DSM 4359 ACM23282.1 B9K8J9  
 CTN_1107   Thermotoga neapolitana DSM 4359 ACM23283.1 B9K8K0  
 cellulase (TCel2;Tpet_1267) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 T2812B_05950 (fragment)   Thermotoga sp. 2812B AIY86723.1    
 T2812B_05955   Thermotoga sp. 2812B AIY86724.1    
 T2812B_05935 (fragment)   Thermotoga sp. 2812B AIY86720.1    
 CELL2_06605   Thermotoga sp. Cell2 AIY88589.1    
 CELL2_06600   Thermotoga sp. Cell2 AIY88588.1    
 TRQ2_1187   Thermotoga sp. RQ2 ACB09531.1 B1LB33  
 TRQ2_1188   Thermotoga sp. RQ2 ACB09532.1 B1LB34  
 TRQ7_07010   Thermotoga sp. RQ7 AJG41199.1    
 TRQ7_07005   Thermotoga sp. RQ7 AJG41198.1    
 GH12 protein   uncultured Bacillus sp. ALA15661.1    
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