Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (1681); Uniprot accession (212); PDB accession (55); 3D entries (20); cryst (1)
All (1484) Archaea (126) Bacteria (1075) Eukaryota (278) unclassified (5) Structure (20 - 1 cryst) Characterized (83)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellulase (TCel6;Cmaq_1621) 3.2.1.4 Caldivirga maquilingensis IC-167 ABW02444.1
AEG76945.1
A8M9X3  
 endo-β-1,4-glucanase A (EglA;EGPf;TCel1;PF0854) (Cel12) 3.2.1.4 Pyrococcus furiosus DSM 3638 NP_578583.1
AAD54602.1
AAE50601.1
AAL80978.1
AAM56799.1
AAW12536.1
ABJ38334.1
ACM94275.1
ACW20099.1
AEG76943.1
E7FHY8
Q9V2T0
3VGI[A]
3WQ0[A]
3WQ1[A]
3WQ7[A,B]
3WR0[A]
3WT3[A,B]
3WXP[A]
3WY6[A]
 cellulase (CelB;SSO2534) 3.2.1.4 Saccharolobus solfataricus P2 CAC24331.1
AAK42663.1
NP_343873.1
   
 endoglucanase (SSO1354) 3.2.1.4 Saccharolobus solfataricus P2 AAK41590.1
NP_342800.1
Q97YG7  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endoglucanase (GuxA;Acel_0615) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52388.1 A0LSH8  
 cellulase (Cel12;AcCel12B;Acel_0619) (Cel12B) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52392.1 A0LSI2  
 endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) 3.2.1.151
3.2.1.4
Bacillus licheniformis DSM 13 = ATCC 14580 AAU42138.1
AAU24774.1
Q65FM6 2JEM[A,B]
2JEN[A]
 endo-β-1,4-glucanase (Cel12A) (Cel12A) 3.2.1.4 Bacillus licheniformis GXN151 AAP44491.1 Q7X4S4  
 Rv1090 (Cel12) (possible fragment) 3.2.1.4 Mycobacterium tuberculosis H37Rv CAA17206.1
AFN48988.1
CCP43843.1
NP_215606.1
O53438  
 endo-1,4-glucanase S 3.2.1.4 Pectobacterium carotovorum SCC3193 AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
ACP76254.1
P16630  
 endo-1,4-glucanase B (CelB) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02965.2 O31030  
 endo-β-1,4-glucanase (CMCase; W5S_2949) 3.2.1.4 Pectobacterium sp. SCC3193 AFI91032.1 P16630  
 cellulase A (CelA) (Cel12A) 3.2.1.4 Rhodothermus marinus ITI378 AAB65594.1
AAR63650.1
AAR67703.1
ABJ29234.1
ACP76253.1
O33897 1H0B[A,B]
2BW8[A,B]
2BWA[A,B]
2BWC[A,B]
3B7M[A,B,C,D]
 type III effector NopAA 3.2.1.151 Sinorhizobium fredii USDA257 AGH09926.1   6SDU[A,B,C,D]
 STHERM_c20650 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02999.1 E0RQU3  
 endo-β-1,4-glucanase (CelA2;Cel2) 3.2.1.4 Streptomyces halstedii JM8 AAC45429.1 O08468  
 endo-β-1,4-glucanase (CelB;CelB2;EGI) 3.2.1.4 Streptomyces lividans 1326 AAB71950.1
AAR63649.1
AAR67702.1
ABH87634.1
ABJ29233.1
ACP76252.1
Q54331 1NLR[A]
2NLR[A]
 endo-β-1,4-glucanase S (EglS) 3.2.1.4 Streptomyces rochei A2 CAA52139.1 Q59963  
 cellulase 12A (Cel12A) 3.2.1.4 Streptomyces sp. 11AG8 AAF91283.1
AAE59731.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
ACP76251.1
Q9KIH1 1OA4[A]
 endo-β-1,4-glucanase (Cel;CelStrep) 3.2.1.4 Streptomyces sp. G12 CCI74016.1    
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 endo-β-1,4-glucanase (Cel) 3.2.1.4 Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) 3.2.1.4 Thermotoga maritima MSB8 AGL50456.1
AAD36591.1
AHD18579.1
AKE29285.1
CAA93273.1
NP_229324.1
Q60032
Q9S5X8
B[nd]
3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
3VHN[A,B,C,D,E,F,G,H]
3VHO[A,B]
3VHP[A]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 Thermotoga maritima MSB8 AAD36592.1
AGL50457.1
AHD18578.1
AKE29286.1
CAA93274.1
NP_229325.1
G4FFR3
Q60033
 
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermotoga neapolitana AAC95059.1
CAB06783.1
O08428
P96491
 
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Thermotoga neapolitana AAC95060.1
CAB06782.1
P96492
Q798L1
 
 cellulase (TCel2;Tpet_1267) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 endoglucanase (RSC-EG1) 3.2.1.4 uncultured bacterium AFD36891.1    
 cellulase (Lc-CelA) 3.2.1.4 uncultured bacterium AHL27894.1   3WX5[A,B]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) 3.2.1.4 Aspergillus aculeatus F-50 BAA00435.1
AAR63632.1
AAR67685.1
ABJ29216.1
ACP76235.1
CAA36757.1
P22669 5GM3[A,B]
5GM4[A,B,C,D,E,F,G]
5GM5[A,B,C,D,E,F,G]
 endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) 3.2.1.151 Aspergillus aculeatus KSM 510 AAD02275.1 O94218 3VL8[A]
3VL9[A,B]
3VLB[B,D]
 endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) 3.2.1.151 Aspergillus clavatus NRRL 1 EAW08261.1 A1CRJ0  
 endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) 3.2.1.151
3.2.1.4
Aspergillus fumigatus Af293 EAL86857.1    
 endoglucanase (Cel12B) 3.2.1.4 Aspergillus kawachii IFO 4308 AAM77715.1
AAR63634.1
AAR67687.1
ABJ29218.1
ACP76237.1
Q8NJY2  
 endo-β-1,4-glucanase (CekA) 3.2.1.4 Aspergillus kawachii IFO 4308 AAR63633.1
AAR67686.1
ABJ29217.1
ACP76236.1
BAA02297.1
Q12679  
 endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) 3.2.1.151 Aspergillus nidulans FGSC A4 EAA66551.1
ABF50842.1
Q5BG78  
 endo-β-1,4-glucanase (EglA;AnEglA) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60101.1
AAE84291.1
CAA03652.1
CAA03657.1
CAA11964.1
CAG17891.1
O74705 1KS4[A]
1KS5[A]
 endo-β-1,4-glucanase (EglA;An14g02760) 3.2.1.4 Aspergillus niger CBS 513.88 CAK46524.1 A2R322  
 endoglucanase 3.2.1.4 Aspergillus niger HO AIX97359.1    
 xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) 3.2.1.151 Aspergillus niger N402 ABF46829.1 A1XP58  
 endoglucanase A (EglA) (partial) 3.2.1.4 Aspergillus niger VTCC F-021 / VTCC-F021 ADD12042.1 D3YC02  
 xyloglucan-specific endo-β-1,4-glucanase (XegA) 3.2.1.151 Aspergillus niveus PR-2 AEV23011.1   4NPR[A,B]
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Aspergillus oryzae KBN616 BAA22588.1
AAR63635.1
AAR67688.1
ABJ29219.1
ACP76238.1
   
 endo-β-1,4-glucanase (CelA;AO090026000102) 3.2.1.4 Aspergillus oryzae RIB40 BAE59597.1 Q2UFR8  
 endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) 3.2.1.4 Aspergillus terreus NIH2624 EAU30085.1
XP_001218516.1
  cryst
 endo-β-1,4-glucanase (AuCel12A) (Cel12A) 3.2.1.4 Aspergillus usamii E001 AEL12376.1    
 mixed β-1,3-1,4-glucanase (Mlg2) 3.2.1.4
3.2.1.73
Bipolaris zeicola AAF65311.1 Q9P8N6  
 endoglucanase (Cel12A) 3.2.1.4 Chaetomium brasiliense CBS 140.50 AAM77701.1
AAR63638.1
AAR67691.1
ABJ29222.1
ACP76241.1
Q8NJZ6  
 endoglucanase (EG3; EG III) 3.2.1.4 Chrysosporium lucknowense AAQ38148.1
ACH15006.1
   
 endoglucanase (Cel12A) 3.2.1.4 Clonostachys rosea 1003 AAM77706.1 Q8NJZ1  
 endoglucanase (Cel12B) 3.2.1.4 Clonostachys rosea 1003 AAM77707.1
AAR63643.1
AAR67696.1
ABJ29227.1
ACP76246.1
Q8NJZ0  
 endoglucanase (Cel12C) 3.2.1.4 Clonostachys rosea 1003 AAM77708.1
AAR63644.1
AAR67697.1
ABJ29228.1
ACP76247.1
Q8NJY9  
 endoglucanase (Cel12D) 3.2.1.4 Clonostachys rosea 1003 AAM77709.1
AAR63645.1
AAR67698.1
ABJ29229.1
ACP76248.1
Q8NJY8  
 endoglucanase (Cel12A) 3.2.1.4 Emericella desertorum CBS 653.73 AAM77702.1
AAR63647.1
AAR67700.1
ABJ29231.1
ACP76250.1
Q8NJZ5  
 endoglucanase II (EG-II;Eg2;EG35) (Cel12) 3.2.1.4 Fomitopsis palustris FFPRI 0507 BAF49602.1 A4PID1  
 endoglucanase (Cel12A) 3.2.1.4 Fusarium equiseti CBS 185.34 AAM77703.1
AAR63639.1
AAR67692.1
ABJ29223.1
ACP76242.1
Q8NJZ4  
 xyloglucanase (fg05851;FGSG_05851) (6993) 3.2.1.151 Fusarium graminearum PH-1 XP_386027.1    
 broad specificity endo-β-glucanase (fg11037;FGSG_11037) (7138) 3.2.1.4 Fusarium graminearum PH-1 XP_391213.1    
 broad specificity endo-β-glucanase (FGRAMPH1_01T25915; fg07892;FGSG_07892) (7048) 3.2.1.4 Fusarium graminearum PH-1 SCB65334.1
XP_388068.1
   
 broad specificity endo-β-glucanase (fgd146-200;FGSG_16349) (7213) 3.2.1.4 Fusarium graminearum PH-1 XP_383205.1    
 endoglucanase (Cel12A) 3.2.1.4 Fusarium striatum CBS 203.32 AAM77704.1
AAR63640.1
AAR67693.1
ABJ29224.1
ACP76243.1
Q8NJZ3  
 endoglucanase (Cel12B) 3.2.1.4 Fusarium striatum CBS 203.32 AAM77705.1
AAR63641.1
AAR67694.1
ABJ29225.1
ACP76244.1
Q8NJZ2  
 endo-β-1,4-glucanase (Cel12g;GtCel12A) (Cel12A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 AEJ35167.1
AEM23897.1
P84196  
 endoglucanase (Cel12A) 3.2.1.4 Humicola grisea ATCC 22081 AAM77714.2
AAR63636.1
AAR63637.1
AAR67689.1
AAR67690.1
ABJ29220.1
ABJ29221.1
ACP76239.1
ACP76240.1
Q8NJY3 1OLR[A]
1UU4[A]
1UU5[A]
1UU6[A]
1W2U[A]
 endoglucanase (Cel12A) 3.2.1.4 Hypocrea schweinitzii ATCC 66965 AAM77711.1
AAE59776.1
AAN19481.1
AAO95540.1
AAQ42102.1
AAR63631.1
AAR67684.1
ABJ29215.1
ACP76234.1
Q8NJY6 1OA3[A,B,C,D]
 endoglucanase (Cel12A) 3.2.1.4 Memnoniella echinata CBS 304.54 AAM77710.1
AAR63646.1
AAR67699.1
ABJ29230.1
ACP76249.1
Q8NJY7  
 PDE_06439 (Cel12A) 3.2.1.4 Penicillium oxalicum 114-2 EPS31484.1    
 acid-stable endoxyloglucanase / xyloglucan-specific endo-β-1,4-glucanase (PoXeg12A) (Xeg12A) 3.2.1.151 Penicillium oxalicum HP7-1 AJA40324.1    
 endoglucanase 28 (Cel12A) 3.2.1.4 Phanerochaete chrysosporium K3 AAU12276.1 Q66NB6  
 xyloglucan-specific endoglucanase (EGL12-G;XEG1;PsXEG1;Ps109681;PHYSODRAFT_559651) (Cel12G) 3.2.1.151 Phytophthora sojae ABB22029.1
EGZ16757.1
Q30BZ2  
 endoglucanase (Cel3A;CMCase3a;CMCase IIIa) 3.2.1.4 Polyporus arcularius 69B-8 BAD98315.1 Q50LE3  
 endo-β-1,4-glucanase (PpCel12A) (partial) (Cel12A) 3.2.1.4 Postia placenta Mad-698-R ADH51731.1 D7REW4  
 endo-β-1,3-1,4-glucanase (MoCel12A;MG00677.4) (Cel12A) 3.2.1.73 Pyricularia oryzae 70-15 XP_368567.1 G4NAZ1  
 endo-β-1,3-1,4-glucanase (MoCel12C;MG10972.4) (Cel12C) 3.2.1.73 Pyricularia oryzae 70-15 XP_361895.1 G4NBX2  
 endo-β-1,3-1,4-glucanase (MoCel12B;MG08537.4) (Cel12B) 3.2.1.73 Pyricularia oryzae 70-15 XP_362900.1 G4N5V2  
 xyloglucanase B (RmXEG12B) (Xeg12B) 3.2.1.151 Rhizomucor miehei CAU432 AGC24033.1    
 xyloglucanase A (RmXEG12A) (Xeg12A) 3.2.1.151 Rhizomucor miehei CAU432 AGC24032.1    
 β-glucanase (lichenase-like) (Cel12A) 3.2.1.4 Stachybotrys chartarum CECT 20565 / Stachybotrys atra BP-A CAL48345.1 Q08HM8  
 endo-β-1,4-glucanase 3 / III (Egl3;EG3;EGIII;ThEG3;ThEGIII) (Cel12A) 3.2.1.4 Trichoderma harzianum IOC-3844 AFK32784.1   4H7M[A,B]
 endoglucanase (Cel12A) 3.2.1.4 Trichoderma koningii ATCC 2613 AAM77712.1 Q8NJY5  
 endo-β-1,4-glucanase III (Egl3;EGIII;EG III;EG3;TrCel12A) (Cel12A) 3.2.1.151
3.2.1.4
Trichoderma reesei QM9414 AAE59774.1
AAE59775.1
AAN19479.1
AAN19480.1
AAO95538.1
AAO95539.1
AAQ24888.1
AAQ42100.1
AAQ42101.1
AAR60524.1
AAR63629.1
AAR63630.1
AAR67682.1
AAR67683.1
ABE22099.1
ABJ29213.1
ABJ29214.1
ABV71388.1
ACP76232.1
ACP76233.1
BAA20140.1
O00095 1H8V[A,B,C,D,E,F]
1OA2[A,B,C,D,E,F]
1OLQ[A,B]
 endoglucanase (Cel12A) 3.2.1.4 Trichoderma viride ATCC 26802 AAM77713.1 Q8NJY4  
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