| Activities in Family | endoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207) |
|---|---|
| Mechanism | Retaining |
| Clan | GH-C |
| 3D Structure Status | β-jelly roll |
| Catalytic Nucleophile/Base | Glu (experimental) |
| Catalytic Proton Donor | Glu (experimental) |
| Note | formerly known as cellulase family H. |
| External resources | CAZypedia; HOMSTRAD; |
| Commercial Enzyme Provider(s) | MEGAZYME; |
| Statistics | GenBank accession (1097); Uniprot accession (212); PDB accession (48); 3D entries (17); cryst (1) |
| Archaea | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| cellulase (TCel6;Cmaq_1621) | 3.2.1.4 | Caldivirga maquilingensis IC-167 | ABW02444.1 AEG76945.1 |
A8M9X3 | ||
| endo-β-1,4-glucanase A (EglA;EGPf;TCel1;PF0854) (Cel12) | 3.2.1.4 | Pyrococcus furiosus DSM 3638 | AAD54602.1 AAE50601.1 AAL80978.1 AAM56799.1 AAW12536.1 ABJ38334.1 ACM94275.1 ACW20099.1 AEG76943.1 NP_578583.1 |
E7FHY8 Q9V2T0 |
3VGI[A] 3WQ0[A] 3WQ1[A] 3WQ7[A,B] 3WR0[A] 3WT3[A,B] 3WXP[A] 3WY6[A] |
|
| cellulase (CelB;SSO2534) | 3.2.1.4 | Saccharolobus solfataricus P2 | CAC24331.1 AAK42663.1 NP_343873.1 |
|||
| endoglucanase / xylanase (SSO1354) | 3.2.1.4 3.2.1.8 |
Saccharolobus solfataricus P2 | AAK41590.1 NP_342800.1 |
Q97YG7 | ||
| Bacteria | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| endoglucanase (GuxA) | 3.2.1.4 | Acidothermus cellulolyticus | ABH87623.1 ABH87627.1 ABH87628.1 ABH87635.1 |
|||
| endoglucanase (GuxA;Acel_0615) | 3.2.1.4 | Acidothermus cellulolyticus 11B | ABK52388.1 | A0LSH8 | ||
| cellulase (Cel12;AcCel12B;Acel_0619) (Cel12B) | 3.2.1.4 | Acidothermus cellulolyticus 11B | ABK52392.1 | A0LSI2 | ||
| endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) | 3.2.1.151 3.2.1.4 |
Bacillus licheniformis DSM 13 = ATCC 14580 | AAU42138.1 AAU24774.1 |
Q65FM6 | 2JEM[A,B] 2JEN[A] |
|
| endo-β-1,4-glucanase (Cel12A) (Cel12A) | 3.2.1.4 | Bacillus licheniformis GXN151 | AAP44491.1 | Q7X4S4 | ||
| endo-1,4-glucanase S | 3.2.1.4 | Pectobacterium carotovorum SCC3193 | AAA24817.1 AAR63651.1 AAR67704.1 ABJ29235.1 ACP76254.1 |
P16630 | ||
| endo-1,4-glucanase B (CelB) | 3.2.1.4 | Pectobacterium carotovorum subsp. carotovorum LY34 | AAC02965.2 | O31030 | ||
| endo-β-1,4-glucanase (CMCase; W5S_2949) | 3.2.1.4 | Pectobacterium sp. SCC3193 | AFI91032.1 | P16630 | ||
| cellulase A (CelA) (Cel12A) | 3.2.1.4 | Rhodothermus marinus ITI378 | AAB65594.1 AAR63650.1 AAR67703.1 ABJ29234.1 ACP76253.1 |
O33897 | 1H0B[A,B] 2BW8[A,B] 2BWA[A,B] 2BWC[A,B] 3B7M[A,B,C,D] |
|
| STHERM_c20650 | 3.2.1.4 | Spirochaeta thermophila DSM 6192 | ADN02999.1 | E0RQU3 | ||
| endo-β-1,4-glucanase (CelA2;Cel2) | 3.2.1.4 | Streptomyces halstedii JM8 | AAC45429.1 | O08468 | ||
| endo-β-1,4-glucanase (CelB;CelB2;EGI) | 3.2.1.4 | Streptomyces lividans 1326 | AAB71950.1 AAR63649.1 AAR67702.1 ABH87634.1 ABJ29233.1 ACP76252.1 |
Q54331 | 1NLR[A] 2NLR[A] |
|
| cellulase (11AG8) | 3.2.1.4 | Streptomyces lividans TK23 | AAQ31831.1 ABH87633.1 |
|||
| endo-β-1,4-glucanase S (EglS) | 3.2.1.4 | Streptomyces rochei A2 | CAA52139.1 | Q59963 | ||
| cellulase 12A (Cel12A) | 3.2.1.4 | Streptomyces sp. 11AG8 | AAF91283.1 AAE59731.1 AAQ25310.1 AAQ31830.1 AAR63648.1 AAR67701.1 ACP76251.1 |
Q9KIH1 | 1OA4[A] | |
| endo-β-1,4-glucanase (Cel;CelStrep) | 3.2.1.4 | Streptomyces sp. G12 | CCI74016.1 | |||
| endo-β-1,4-glucanase S1 (CelS1) | 3.2.1.4 | Streptomyces viridosporus T7A | AAD25090.1 | Q9X602 | ||
| endo-β-1,4-glucanase (Cel) | 3.2.1.4 | Streptomyces xylophagus KX6 | ACN56471.1 | D2D3J0 | ||
| endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) | 3.2.1.4 | Thermotoga maritima MSB8 | AGL50456.1 AAD36591.1 AHD18579.1 AKE29285.1 CAA93273.1 NP_229324.1 |
Q60032 Q9S5X8 |
3AMH[A,B] 3AMM[A,B] 3AMN[A,B] 3AMP[A,B] 3AMQ[A,B,C,D] 3O7O[A,B] 3VHN[A,B,C,D,E,F,G,H] 3VHO[A,B] |
|
| endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) | 3.2.1.4 | Thermotoga maritima MSB8 | AAD36592.1 AGL50457.1 AHD18578.1 AKE29286.1 CAA93274.1 NP_229325.1 |
G4FFR3 Q60033 |
||
| endo-β-1,4-glucanase A (CelA) | 3.2.1.4 | Thermotoga neapolitana | AAC95059.1 CAB06783.1 |
O08428 P96491 |
||
| endo-β-1,4-glucanase B (CelB) | 3.2.1.4 | Thermotoga neapolitana | AAC95060.1 CAB06782.1 |
P96492 Q798L1 |
||
| cellulase (TCel2;Tpet_1267) | 3.2.1.4 | Thermotoga petrophila RKU-1 | ABQ47281.1 | A5IM58 | ||
| cellulase (TCel5;Tpet_1268) | 3.2.1.4 | Thermotoga petrophila RKU-1 | ABQ47282.1 | A5IM59 | ||
| cellulase (Lc-CelA) | 3.2.1.4 | uncultured bacterium | AHL27894.1 | 3WX5[A,B] | ||
| cellulase (Lc-CelD) | 3.2.1.4 | uncultured bacterium | AHL27897.1 | |||
| cellulase (Lc-CelE) | 3.2.1.4 | uncultured bacterium | AHL27898.1 | |||
| Eukaryota | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) | 3.2.1.4 | Aspergillus aculeatus F-50 | BAA00435.1 AAR63632.1 AAR67685.1 ABJ29216.1 ACP76235.1 CAA36757.1 |
P22669 | 5GM3[A,B] 5GM4[A,B,C,D,E,F,G] 5GM5[A,B,C,D,E,F,G] |
|
| endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) | 3.2.1.151 | Aspergillus aculeatus KSM 510 | AAD02275.1 | O94218 | 3VL8[A] 3VL9[A,B] 3VLB[B,D] |
|
| endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) | 3.2.1.151 | Aspergillus clavatus NRRL 1 | EAW08261.1 | A1CRJ0 | ||
| endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) | 3.2.1.4 | Aspergillus fumigatus Af293 | EAL86857.1 | |||
| endo-β-1,4-glucanase (CekA) | 3.2.1.4 | Aspergillus kawachii IFO 4308 | AAR63633.1 AAR67686.1 ABJ29217.1 ACP76236.1 BAA02297.1 |
Q12679 | ||
| endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) | 3.2.1.151 | Aspergillus nidulans FGSC A4 | EAA66551.1 ABF50842.1 |
Q5BG78 | ||
| endo-β-1,4-glucanase (EglA;AnEglA) | 3.2.1.4 | Aspergillus niger CBS 120.49 / N400 | AAE60101.1 AAE84291.1 CAA03652.1 CAA03657.1 CAA11964.1 CAG17891.1 |
O74705 | 1KS4[A] 1KS5[A] |
|
| endo-β-1,4-glucanase (EglA;An14g02760) | 3.2.1.4 | Aspergillus niger CBS 513.88 | CAK46524.1 | A2R322 | ||
| endoglucanase | 3.2.1.4 | Aspergillus niger HO | AIX97359.1 | |||
| xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) | 3.2.1.151 | Aspergillus niger N402 | ABF46829.1 | A1XP58 | ||
| endoglucanase A (EglA) (partial) | 3.2.1.4 | Aspergillus niger VTCC F-021 / VTCC-F021 | ADD12042.1 | D3YC02 | ||
| xyloglucan-specific endo-β-1,4-glucanase (XegA) | 3.2.1.151 | Aspergillus niveus PR-2 | AEV23011.1 | 4NPR[A,B] | ||
| endo-β-1,4-glucanase (CelA) | 3.2.1.4 | Aspergillus oryzae KBN616 | BAA22588.1 AAR63635.1 AAR67688.1 ABJ29219.1 ACP76238.1 |
|||
| endo-β-1,4-glucanase (CelA;AO090026000102) | 3.2.1.4 | Aspergillus oryzae RIB40 | BAE59597.1 | Q2UFR8 | ||
| endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) | 3.2.1.4 | Aspergillus terreus NIH2624 | EAU30085.1 XP_001218516.1 |
cryst | ||
| endo-β-1,4-glucanase (AuCel12A) (Cel12A) | 3.2.1.4 | Aspergillus usamii E001 | AEL12376.1 | |||
| mixed β-1,3-1,4-glucanase (Mlg2) | 3.2.1.73 | Bipolaris zeicola | AAF65311.1 | Q9P8N6 | ||
| endoglucanase (EG3; EG III) | 3.2.1.4 | Chrysosporium lucknowense | AAQ38148.1 ACH15006.1 |
|||
| endo-β-1,4-glucanase (EGIII) | 3.2.1.4 | Clonostachys rosea | AAR67695.1 AAR63642.1 ABJ29226.1 ACP76245.1 |
|||
| endoglucanase II (EG-II;Eg2;EG35) (Cel12) | 3.2.1.4 | Fomitopsis palustris FFPRI 0507 | BAF49602.1 | A4PID1 | ||
| xyloglucanase (fg05851;FGSG_05851) (6993) | 3.2.1.151 | Fusarium graminearum PH-1 | XP_386027.1 | |||
| endo-β-1,4-glucanase (Cel12g;GtCel12A) (Cel12A) | 3.2.1.4 | Gloeophyllum trabeum ATCC 11539 | AEJ35167.1 AEM23897.1 |
P84196 | ||
| endoglucanase (Cel12A) | 3.2.1.4 | Humicola grisea ATCC 22081 | AAM77714.2 AAR63636.1 AAR63637.1 AAR67689.1 AAR67690.1 ABJ29220.1 ABJ29221.1 ACP76239.1 ACP76240.1 |
Q8NJY3 | 1OLR[A] 1UU4[A] 1UU5[A] 1UU6[A] 1W2U[A] |
|
| endoglucanase (Cel12A) | 3.2.1.4 | Hypocrea schweinitzii ATCC 66965 | AAM77711.1 AAE59776.1 AAN19481.1 AAO95540.1 AAQ42102.1 AAR63631.1 AAR67684.1 ABJ29215.1 ACP76234.1 |
Q8NJY6 | 1OA3[A,B,C,D] | |
| xyloglucan endotransglycosylase (XET) | 2.4.1.207 | Macrophomina phaseolina | AAN89225.1 AAS22565.1 |
|||
| endo-β-1,3-1,4-glucanase (MoCel12A;MG00677.4) (Cel12A) | 3.2.1.73 | Magnaporthe oryzae 70-15 | XP_368567.1 | G4NAZ1 | ||
| endo-β-1,3-1,4-glucanase (MoCel12C;MG10972.4) (Cel12C) | 3.2.1.73 | Magnaporthe oryzae 70-15 | XP_361895.1 | G4NBX2 | ||
| endo-β-1,3-1,4-glucanase (MoCel12B;MG08537.4) (Cel12B) | 3.2.1.73 | Magnaporthe oryzae 70-15 | XP_362900.1 | G4N5V2 | ||
| xyloglucanase | 3.2.1.151 | Malbranchea cinnamomea | AAO95986.1 | |||
| PDE_06439 (Cel12A) | 3.2.1.4 | Penicillium oxalicum 114-2 | EPS31484.1 | |||
| acid-stable endoxyloglucanase / xyloglucan-specific endo-β-1,4-glucanase (PoXeg12A) (Xeg12A) | 3.2.1.151 | Penicillium oxalicum HP7-1 | AJA40324.1 | |||
| endoglucanase 28 (Cel12A) | 3.2.1.4 | Phanerochaete chrysosporium K3 | AAU12276.1 | Q66NB6 | ||
| xyloglucan-specific endoglucanase (EGL12-G;XEG1;PsXEG1;Ps109681;PHYSODRAFT_559651) (Cel12G) | 3.2.1.151 | Phytophthora sojae | ABB22029.1 EGZ16757.1 |
Q30BZ2 | ||
| endoglucanase (Cel3A;CMCase3a;CMCase IIIa) | 3.2.1.4 | Polyporus arcularius 69B-8 | BAD98315.1 | Q50LE3 | ||
| endo-β-1,4-glucanase (PpCel12A) (partial) (Cel12A) | 3.2.1.4 | Postia placenta Mad-698-R | ADH51731.1 | D7REW4 | ||
| xyloglucanase B (RmXEG12B) (Xeg12B) | 3.2.1.151 | Rhizomucor miehei CAU432 | AGC24033.1 | |||
| xyloglucanase A (RmXEG12A) (Xeg12A) | 3.2.1.151 | Rhizomucor miehei CAU432 | AGC24032.1 | |||
| endo-β-1,4-glucanase III (Egl3;EGIII;EG III;EG3;TrCel12A) (Cel12A) | 3.2.1.151 3.2.1.4 |
Trichoderma reesei QM9414 | AAE59774.1 AAE59775.1 AAN19479.1 AAN19480.1 AAO95538.1 AAO95539.1 AAQ24888.1 AAQ42100.1 AAQ42101.1 AAR60524.1 AAR63629.1 AAR63630.1 AAR67682.1 AAR67683.1 ABE22099.1 ABJ29213.1 ABJ29214.1 ABV71388.1 ACP76232.1 ACP76233.1 BAA20140.1 |
O00095 | 1H8V[A,B,C,D,E,F] 1OA2[A,B,C,D,E,F] 1OLQ[A,B] |
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