Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (1897); Uniprot accession (87); PDB accession (52); 3D entries (19); cryst (1)
Archaea
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 cellulase (TCel6;Cmaq_1621) 3.2.1.4 pubmed
Caldivirga maquilingensis IC-167 ABW02444.1
AEG76945.1
A8M9X3  
 endo-β-1,4-glucanase A (EglA;EGPf;TCel1;PF0854) (Cel12) 3.2.1.4 pubmed
Pyrococcus furiosus DSM 3638 NP_578583.1
AAD54602.1
AAE50601.1
AAL80978.1
AAM56799.1
AAW12536.1
ABJ38334.1
ACM94275.1
ACW20099.1
AEG76943.1
E7FHY8
Q9V2T0
3VGI[A]
3WQ0[A]
3WQ1[A]
3WQ7[A,B]
3WR0[A]
3WT3[A,B]
3WXP[A]
3WY6[A]
 cellulase (CelB;SSO2534) 3.2.1.4 pubmed
Saccharolobus solfataricus P2 CAC24331.1
AAK42663.1
NP_343873.1
Q97VS7  
 endoglucanase (SSO1354) 3.2.1.4 pubmed
Saccharolobus solfataricus P2 AAK41590.1
NP_342800.1
Q97YG7  
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 endoglucanase (GuxA;Acel_0615) 3.2.1.4 doi
Acidothermus cellulolyticus 11B ABK52388.1 A0LSH8  
 cellulase (Cel12;AcCel12B;Acel_0619) (Cel12B) 3.2.1.4 pubmed
Acidothermus cellulolyticus 11B ABK52392.1 A0LSI2  
 endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) 3.2.1.151
3.2.1.4
pubmed
pubmed
Bacillus licheniformis DSM 13 = ATCC 14580 AAU42138.1
AAU24774.1
Q65FM6
Q7X4S4
2JEM[A,B]
2JEN[A]
 endo-β-1,4-glucanase (Cel12A) (Cel12A) 3.2.1.4 pubmed
Bacillus licheniformis GXN151 AAP44491.1 Q7X4S4  
 Rv1090 (Cel12) (possible fragment) 3.2.1.4 pubmed
Mycobacterium tuberculosis H37Rv CAA17206.1
AFN48988.1
CCP43843.1
NP_215606.1
O53438  
 endo-1,4-glucanase S 3.2.1.4 pubmed
Pectobacterium carotovorum SCC3193 AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
ACP76254.1
P16630  
 endo-1,4-glucanase B (CelB) 3.2.1.4 pubmed
Pectobacterium carotovorum subsp. carotovorum LY34 AAC02965.2 O31030  
 endo-β-1,4-glucanase (CMCase; W5S_2949) 3.2.1.4 doi
Pectobacterium sp. SCC3193 AFI91032.1 P16630  
 cellulase A (CelA) (Cel12A) 3.2.1.4 pubmed
Rhodothermus marinus ITI378 AAB65594.1
AAR63650.1
AAR67703.1
ABJ29234.1
ACP76253.1
O33897 1H0B[A,B]
2BW8[A,B]
2BWA[A,B]
2BWC[A,B]
3B7M[A,B,C,D]
 type III effector NopAA 3.2.1.151 pubmed
Sinorhizobium fredii USDA257 AGH09926.1 A0A0T6ZV48
M4PUR5
6SDU[A,B,C,D]
 STHERM_c20650 3.2.1.4 pubmed
Spirochaeta thermophila DSM 6192 ADN02999.1 E0RQU3  
 endo-β-1,4-glucanase (CelA2;Cel2) 3.2.1.4 pubmed
Streptomyces halstedii JM8 AAC45429.1 O08468  
 endo-β-1,4-glucanase (CelB;CelB2;EGI) 3.2.1.4 pubmed
Streptomyces lividans 1326 AAB71950.1
AAR63649.1
AAR67702.1
ABH87634.1
ABJ29233.1
ACP76252.1
Q54331 1NLR[A]
2NLR[A]
 endo-β-1,4-glucanase S (EglS) 3.2.1.4 pubmed
Streptomyces rochei A2 CAA52139.1 Q59963  
 cellulase 12A (Cel12A) 3.2.1.4 pubmed
Streptomyces sp. 11AG8 AAF91283.1
AAE59731.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
ACP76251.1
Q9KIH1 1OA4[A]
 endo-β-1,4-glucanase (Cel;CelStrep) 3.2.1.4 pubmed
Streptomyces sp. G12 CCI74016.1 I7L8N7  
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 doi
Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 endo-β-1,4-glucanase (Cel) 3.2.1.4 URL
Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) 3.2.1.4 pubmed
Thermotoga maritima MSB8 AGL50456.1
AAD36591.1
AHD18579.1
AKE29285.1
CAA93273.1
NP_229324.1
G4FFR2
Q60032
Q9S5X8
B[nd]
3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
3VHN[A,B,C,D,E,F,G,H]
3VHO[A,B]
3VHP[A]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 pubmed
Thermotoga maritima MSB8 AAD36592.1
AGL50457.1
AHD18578.1
AKE29286.1
CAA93274.1
NP_229325.1
G4FFR3
Q60033
Q7DF96
 
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 pubmed
Thermotoga neapolitana AAC95059.1
CAB06783.1
O08428
P96491
 
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 pubmed
Thermotoga neapolitana AAC95060.1
CAB06782.1
P96492
Q798L1
 
 cellulase (TCel2;Tpet_1267) 3.2.1.4 pubmed
Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 pubmed
Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 endoglucanase (RSC-EG1) 3.2.1.4 pubmed
uncultured bacterium AFD36891.1 H9BVK4  
 cellulase (Lc-CelA) 3.2.1.4 pubmed
uncultured bacterium AHL27894.1 W8PWF3 3WX5[A,B]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) 3.2.1.4 pubmed
Aspergillus aculeatus F-50 BAA00435.1
AAR63632.1
AAR67685.1
ABJ29216.1
ACP76235.1
CAA36757.1
P22669 5GM3[A,B]
5GM4[A,B,C,D,E,F,G]
5GM5[A,B,C,D,E,F,G]
 endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) 3.2.1.151 pubmed
Aspergillus aculeatus KSM 510 AAD02275.1 O94218 3VL8[A]
3VL9[A,B]
3VLB[B,D]
 endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) 3.2.1.151 pubmed
Aspergillus clavatus NRRL 1 EAW08261.1 A1CRJ0  
 endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) 3.2.1.151
3.2.1.4
pubmed
pubmed
Aspergillus fumigatus Af293 EAL86857.1 Q4WGT4  
 endoglucanase (Cel12B) 3.2.1.4 pubmed
Aspergillus kawachii IFO 4308 AAM77715.1
AAR63634.1
AAR67687.1
ABJ29218.1
ACP76237.1
Q8NJY2  
 endo-β-1,4-glucanase (CekA) 3.2.1.4 pubmed
Aspergillus kawachii IFO 4308 AAR63633.1
AAR67686.1
ABJ29217.1
ACP76236.1
BAA02297.1
Q12679  
 endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) 3.2.1.151 pubmed
Aspergillus nidulans FGSC A4 EAA66551.1
ABF50842.1
Q5BG78  
 endo-β-1,4-glucanase (EglA;AnEglA) 3.2.1.4 pubmed
Aspergillus niger CBS 120.49 / N400 AAE60101.1
AAE84291.1
CAA03652.1
CAA03657.1
CAA11964.1
CAG17891.1
O74705 1KS4[A]
1KS5[A]
 endo-β-1,4-glucanase (EglA;An14g02760) 3.2.1.4 pubmed
Aspergillus niger CBS 513.88 CAK46524.1 A2R322  
 endoglucanase 3.2.1.4 pubmed
Aspergillus niger HO AIX97359.1 O74705  
 xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) 3.2.1.151 pubmed
Aspergillus niger N402 ABF46829.1 A1XP58  
 endoglucanase A (EglA) (partial) 3.2.1.4 pubmed
Aspergillus niger VTCC F-021 / VTCC-F021 ADD12042.1 D3YC02  
 xyloglucan-specific endo-β-1,4-glucanase (XegA) 3.2.1.151 pubmed
Aspergillus niveus PR-2 AEV23011.1 H6TQN1 4NPR[A,B]
 endo-β-1,4-glucanase (CelA) 3.2.1.4 pubmed
Aspergillus oryzae KBN616 BAA22588.1
AAR63635.1
AAR67688.1
ABJ29219.1
ACP76238.1
O13454  
 endo-β-1,4-glucanase (CelA;AO090026000102) 3.2.1.4 pubmed
Aspergillus oryzae RIB40 BAE59597.1 Q2UFR8  
 endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) 3.2.1.4 pubmed
Aspergillus terreus NIH2624 EAU30085.1
XP_001218516.1
Q0C8U0 cryst
 endo-β-1,4-glucanase (AuCel12A) (Cel12A) 3.2.1.4 pubmed
Aspergillus usamii E001 AEL12376.1 G1ETN1  
 mixed β-1,3-1,4-glucanase (Mlg2) 3.2.1.4
3.2.1.73
pubmed
pubmed
Bipolaris zeicola AAF65311.1 Q9P8N6  
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Chaetomium brasiliense CBS 140.50 AAM77701.1
AAR63638.1
AAR67691.1
ABJ29222.1
ACP76241.1
Q8NJZ6  
 endoglucanase (EG3; EG III) 3.2.1.4 pubmed
Chrysosporium lucknowense AAQ38148.1
ACH15006.1
   
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Clonostachys rosea 1003 AAM77706.1 Q8NJZ1  
 endoglucanase (Cel12B) 3.2.1.4 pubmed
Clonostachys rosea 1003 AAM77707.1
AAR63643.1
AAR67696.1
ABJ29227.1
ACP76246.1
Q8NJZ0  
 endoglucanase (Cel12C) 3.2.1.4 pubmed
Clonostachys rosea 1003 AAM77708.1
AAR63644.1
AAR67697.1
ABJ29228.1
ACP76247.1
Q8NJY9  
 endoglucanase (Cel12D) 3.2.1.4 pubmed
Clonostachys rosea 1003 AAM77709.1
AAR63645.1
AAR67698.1
ABJ29229.1
ACP76248.1
Q8NJY8  
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Emericella desertorum CBS 653.73 AAM77702.1
AAR63647.1
AAR67700.1
ABJ29231.1
ACP76250.1
Q8NJZ5  
 endoglucanase II (EG-II;Eg2;EG35) (Cel12) 3.2.1.4 pubmed
Fomitopsis palustris FFPRI 0507 BAF49602.1 A4PID1  
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Fusarium equiseti CBS 185.34 AAM77703.1
AAR63639.1
AAR67692.1
ABJ29223.1
ACP76242.1
Q8NJZ4  
 xyloglucanase (fg05851;FGSG_05851) (6993) 3.2.1.151 pubmed
Fusarium graminearum PH-1 XP_386027.1    
 broad specificity endo-β-glucanase (fg11037;FGSG_11037) (7138) 3.2.1.4 pubmed
Fusarium graminearum PH-1 XP_391213.1    
 broad specificity endo-β-glucanase (FGRAMPH1_01T25915; fg07892;FGSG_07892) (7048) 3.2.1.4 pubmed
Fusarium graminearum PH-1 SCB65334.1
XP_388068.1
I1RUJ7  
 broad specificity endo-β-glucanase (fgd146-200;FGSG_16349) (7213) 3.2.1.4 pubmed
Fusarium graminearum PH-1 XP_383205.1    
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Fusarium striatum CBS 203.32 AAM77704.1
AAR63640.1
AAR67693.1
ABJ29224.1
ACP76243.1
Q8NJZ3  
 endoglucanase (Cel12B) 3.2.1.4 pubmed
Fusarium striatum CBS 203.32 AAM77705.1
AAR63641.1
AAR67694.1
ABJ29225.1
ACP76244.1
Q8NJZ2  
 endo-β-1,4-glucanase (Cel12g;GtCel12A) (Cel12A) 3.2.1.4 pubmed
Gloeophyllum trabeum ATCC 11539 AEJ35167.1
AEM23897.1
F8T946
P84196
 
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Humicola grisea ATCC 22081 AAM77714.2
AAR63636.1
AAR63637.1
AAR67689.1
AAR67690.1
ABJ29220.1
ABJ29221.1
ACP76239.1
ACP76240.1
Q8NJY3 1OLR[A]
1UU4[A]
1UU5[A]
1UU6[A]
1W2U[A]
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Hypocrea schweinitzii ATCC 66965 AAM77711.1
AAE59776.1
AAN19481.1
AAO95540.1
AAQ42102.1
AAR63631.1
AAR67684.1
ABJ29215.1
ACP76234.1
Q8NJY6 1OA3[A,B,C,D]
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Memnoniella echinata CBS 304.54 AAM77710.1
AAR63646.1
AAR67699.1
ABJ29230.1
ACP76249.1
Q8NJY7  
 PDE_06439 (Cel12A) 3.2.1.4 pubmed
Penicillium oxalicum 114-2 EPS31484.1 S7ZMB4  
 acid-stable endoxyloglucanase / xyloglucan-specific endo-β-1,4-glucanase (PoXeg12A) (Xeg12A) 3.2.1.151 pubmed
Penicillium oxalicum HP7-1 AJA40324.1 A0A0A7RRF2  
 endoglucanase 28 (Cel12A) 3.2.1.4 pubmed
Phanerochaete chrysosporium K3 AAU12276.1 Q66NB6  
 xyloglucan-specific endoglucanase (EGL12-G;XEG1;PsXEG1;Ps109681;PHYSODRAFT_559651) (Cel12G) 3.2.1.151 pubmed
Phytophthora sojae ABB22029.1
EGZ16757.1
G4ZHR2
Q30BZ2
 
 endoglucanase (Cel3A;CMCase3a;CMCase IIIa) 3.2.1.4 doi
Polyporus arcularius 69B-8 BAD98315.1 Q50LE3  
 endo-β-1,4-glucanase (PpCel12A) (partial) (Cel12A) 3.2.1.4 pubmed
Postia placenta Mad-698-R ADH51731.1 D7REW4  
 endo-β-1,3-1,4-glucanase (MoCel12A;MG00677.4) (Cel12A) 3.2.1.73 pubmed
Pyricularia oryzae 70-15 XP_368567.1 G4NAZ1  
 endo-xyloglucanase (MoCel12C;MG10972.4) (Cel12C) 3.2.1.151 pubmed
Pyricularia oryzae 70-15 XP_361895.1 G4NBX2  
 endo-β-1,3-1,4-glucanase (MoCel12B;MG08537.4) (Cel12B) 3.2.1.73 pubmed
Pyricularia oryzae 70-15 XP_362900.1 G4N5V2  
 xyloglucanase B (RmXEG12B) (Xeg12B) 3.2.1.151 pubmed
Rhizomucor miehei CAU432 AGC24033.1 M9PK16  
 xyloglucanase A (RmXEG12A) (Xeg12A) 3.2.1.151 pubmed
Rhizomucor miehei CAU432 AGC24032.1 M9PJT0  
 β-glucanase (lichenase-like) (Cel12A) 3.2.1.4 pubmed
Stachybotrys chartarum CECT 20565 / Stachybotrys atra BP-A CAL48345.1 Q08HM8  
 endo-β-1,4-glucanase 3 / III (Egl3;EG3;EGIII;ThEG3;ThEGIII) (Cel12A) 3.2.1.4 pubmed
Trichoderma harzianum IOC-3844 AFK32784.1 I3RY46 4H7M[A,B]
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Trichoderma koningii ATCC 2613 AAM77712.1 Q8NJY5  
 endo-β-1,4-glucanase III (Egl3;EGIII;EG III;EG3;TrCel12A) (Cel12A) 3.2.1.4 pubmed
Trichoderma reesei QM9414 AAE59774.1
AAE59775.1
AAN19479.1
AAN19480.1
AAO95538.1
AAO95539.1
AAQ24888.1
AAQ42100.1
AAQ42101.1
AAR60524.1
AAR63629.1
AAR63630.1
AAR67682.1
AAR67683.1
ABE22099.1
ABJ29213.1
ABJ29214.1
ABV71388.1
ACP76232.1
ACP76233.1
BAA20140.1
O00095 1H8V[A,B,C,D,E,F]
1OA2[A,B,C,D,E,F]
1OLQ[A,B]
 endoglucanase (Cel12A) 3.2.1.4 pubmed
Trichoderma viride ATCC 26802 AAM77713.1 Q8NJY4  
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