Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (929); Uniprot accession (212); PDB accession (46); 3D entries (16); cryst (1)
All (737) Archaea (81) Bacteria (514) Eukaryota (141) unclassified (1) Structure (16 - 1 cryst) Characterized (68)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellulase (TCel6;Cmaq_1621) 3.2.1.4 Caldivirga maquilingensis IC-167 ABW02444.1
AEG76945.1
A8M9X3  
 endo-β-1,4-glucanase A (EglA;EGPf;TCel1;PF0854) (Cel12) 3.2.1.4 Pyrococcus furiosus DSM 3638 AAD54602.1
AAE50601.1
AAL80978.1
AAM56799.1
AAW12536.1
ABJ38334.1
ACM94275.1
ACW20099.1
AEG76943.1
NP_578583.1
E7FHY8
Q9V2T0
3VGI[A]
3WQ0[A]
3WQ1[A]
3WQ7[A,B]
3WR0[A]
3WT3[A,B]
3WXP[A]
3WY6[A]
 cellulase (CelB;SSO2534) 3.2.1.4 Sulfolobus solfataricus P2 CAC24331.1
AAK42663.1
NP_343873.1
   
 endoglucanase / xylanase (SSO1354) 3.2.1.4
3.2.1.8
Sulfolobus solfataricus P2 AAK41590.1
NP_342800.1
Q97YG7  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endoglucanase (GuxA) 3.2.1.4 Acidothermus cellulolyticus ABH87623.1
ABH87627.1
ABH87628.1
ABH87635.1
   
 endoglucanase (GuxA;Acel_0615) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52388.1 A0LSH8  
 cellulase (Cel12;AcCel12B;Acel_0619) (Cel12B) 3.2.1.4 Acidothermus cellulolyticus 11B ABK52392.1 A0LSI2  
 endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) 3.2.1.151
3.2.1.4
Bacillus licheniformis DSM 13 = ATCC 14580 AAU42138.1
AAU24774.1
Q65FM6 2JEM[A,B]
2JEN[A]
 endo-β-1,4-glucanase (Cel12A) (Cel12A) 3.2.1.4 Bacillus licheniformis GXN151 AAP44491.1 Q7X4S4  
 endo-1,4-glucanase S 3.2.1.4 Pectobacterium carotovorum SCC3193 AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
ACP76254.1
P16630  
 endo-1,4-glucanase B (CelB) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02965.2 O31030  
 cellulase A (CelA) (Cel12A) 3.2.1.4 Rhodothermus marinus ITI378 AAB65594.1
AAR63650.1
AAR67703.1
ABJ29234.1
ACP76253.1
O33897 1H0B[A,B]
2BW8[A,B]
2BWA[A,B]
2BWC[A,B]
3B7M[A,B,C,D]
 STHERM_c20650 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02999.1 E0RQU3  
 endo-β-1,4-glucanase (CelA2;Cel2) 3.2.1.4 Streptomyces halstedii JM8 AAC45429.1 O08468  
 endo-β-1,4-glucanase (CelB;CelB2;EGI) 3.2.1.4 Streptomyces lividans 1326 AAB71950.1
AAR63649.1
AAR67702.1
ABH87634.1
ABJ29233.1
ACP76252.1
Q54331 1NLR[A]
2NLR[A]
 cellulase (11AG8) 3.2.1.4 Streptomyces lividans TK23 AAQ31831.1
ABH87633.1
   
 endo-β-1,4-glucanase S (EglS) 3.2.1.4 Streptomyces rochei A2 CAA52139.1 Q59963  
 cellulase 12A (Cel12A) 3.2.1.4 Streptomyces sp. 11AG8 AAF91283.1
AAE59731.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
ACP76251.1
Q9KIH1 1OA4[A]
 endo-β-1,4-glucanase (Cel;CelStrep) 3.2.1.4 Streptomyces sp. G12 CCI74016.1    
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 endo-β-1,4-glucanase (Cel) 3.2.1.4 Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) 3.2.1.4 Thermotoga maritima MSB8 AGL50456.1
AAD36591.1
AHD18579.1
AKE29285.1
CAA93273.1
NP_229324.1
Q60032
Q9S5X8
3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
3VHN[A,B,C,D,E,F,G,H]
3VHO[A,B]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 Thermotoga maritima MSB8 AAD36592.1
AGL50457.1
AHD18578.1
AKE29286.1
CAA93274.1
NP_229325.1
G4FFR3
Q60033
 
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermotoga neapolitana AAC95059.1
CAB06783.1
O08428
P96491
 
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Thermotoga neapolitana AAC95060.1
CAB06782.1
P96492
Q798L1
 
 cellulase (TCel2;Tpet_1267) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 cellulase (Lc-CelA) 3.2.1.4 uncultured bacterium AHL27894.1   3WX5[A,B]
 cellulase (Lc-CelD) 3.2.1.4 uncultured bacterium AHL27897.1    
 cellulase (Lc-CelE) 3.2.1.4 uncultured bacterium AHL27898.1    
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) 3.2.1.4 Aspergillus aculeatus F-50 BAA00435.1
AAR63632.1
AAR67685.1
ABJ29216.1
ACP76235.1
CAA36757.1
P22669 5GM3[A,B]
5GM4[A,B,C,D,E,F,G]
5GM5[A,B,C,D,E,F,G]
 endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) 3.2.1.151 Aspergillus aculeatus KSM 510 AAD02275.1 O94218 3VL8[A]
3VL9[A,B]
3VLB[B,D]
 endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) 3.2.1.151 Aspergillus clavatus NRRL 1 EAW08261.1 A1CRJ0  
 endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) 3.2.1.4 Aspergillus fumigatus Af293 EAL86857.1    
 endo-β-1,4-glucanase (CekA) 3.2.1.4 Aspergillus kawachii IFO 4308 AAR63633.1
AAR67686.1
ABJ29217.1
ACP76236.1
BAA02297.1
Q12679  
 endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) 3.2.1.151 Aspergillus nidulans FGSC A4 EAA66551.1
ABF50842.1
Q5BG78  
 endo-β-1,4-glucanase (EglA;AnEglA) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60101.1
AAE84291.1
CAA03652.1
CAA03657.1
CAA11964.1
CAG17891.1
O74705 1KS4[A]
1KS5[A]
 endo-β-1,4-glucanase (EglA;An14g02760) 3.2.1.4 Aspergillus niger CBS 513.88 CAK46524.1 A2R322  
 endoglucanase 3.2.1.4 Aspergillus niger HO AIX97359.1    
 xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) 3.2.1.151 Aspergillus niger N402 ABF46829.1 A1XP58  
 endoglucanase A (EglA) (partial) 3.2.1.4 Aspergillus niger VTCC F-021 / VTCC-F021 ADD12042.1 D3YC02  
 xyloglucan-specific endo-β-1,4-glucanase (XegA) 3.2.1.151 Aspergillus niveus PR-2 AEV23011.1   4NPR[A,B]
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Aspergillus oryzae KBN616 BAA22588.1
AAR63635.1
AAR67688.1
ABJ29219.1
ACP76238.1
   
 endo-β-1,4-glucanase (CelA;AO090026000102) 3.2.1.4 Aspergillus oryzae RIB40 BAE59597.1 Q2UFR8  
 endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) 3.2.1.4 Aspergillus terreus NIH2624 EAU30085.1
XP_001218516.1
  cryst
 endo-β-1,4-glucanase (AuCel12A) (Cel12A) 3.2.1.4 Aspergillus usamii E001 AEL12376.1    
 mixed β-1,3-1,4-glucanase (Mlg2) 3.2.1.73 Bipolaris zeicola AAF65311.1 Q9P8N6  
 endoglucanase (EG3; EG III) 3.2.1.4 Chrysosporium lucknowense AAQ38148.1
ACH15006.1
   
 endo-β-1,4-glucanase (EGIII) 3.2.1.4 Clonostachys rosea AAR67695.1
AAR63642.1
ABJ29226.1
ACP76245.1
   
 endoglucanase II (EG-II;Eg2;EG35) (Cel12) 3.2.1.4 Fomitopsis palustris FFPRI 0507 BAF49602.1 A4PID1  
 xyloglucanase (fg05851;FGSG_05851) (6993) 3.2.1.151 Fusarium graminearum PH-1 XP_386027.1    
 endo-β-1,4-glucanase (Cel12g;GtCel12A) (Cel12A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 AEJ35167.1
AEM23897.1
P84196  
 endoglucanase (Cel12A) 3.2.1.4 Humicola grisea ATCC 22081 AAM77714.2
AAR63636.1
AAR63637.1
AAR67689.1
AAR67690.1
ABJ29220.1
ABJ29221.1
ACP76239.1
ACP76240.1
Q8NJY3 1OLR[A]
1UU4[A]
1UU5[A]
1UU6[A]
1W2U[A]
 endoglucanase (Cel12A) 3.2.1.4 Hypocrea schweinitzii ATCC 66965 AAM77711.1
AAE59776.1
AAN19481.1
AAO95540.1
AAQ42102.1
AAR63631.1
AAR67684.1
ABJ29215.1
ACP76234.1
Q8NJY6 1OA3[A,B,C,D]
 xyloglucan endotransglycosylase (XET) 2.4.1.207 Macrophomina phaseolina AAN89225.1
AAS22565.1
   
 endo-β-1,3-1,4-glucanase (MoCel12A;MG00677.4) (Cel12A) 3.2.1.73 Magnaporthe oryzae 70-15 XP_368567.1 G4NAZ1  
 endo-β-1,3-1,4-glucanase (MoCel12C;MG10972.4) (Cel12C) 3.2.1.73 Magnaporthe oryzae 70-15 XP_361895.1 G4NBX2  
 endo-β-1,3-1,4-glucanase (MoCel12B;MG08537.4) (Cel12B) 3.2.1.73 Magnaporthe oryzae 70-15 XP_362900.1 G4N5V2  
 xyloglucanase 3.2.1.151 Malbranchea cinnamomea AAO95986.1    
 PDE_06439 (Cel12A) 3.2.1.4 Penicillium oxalicum 114-2 EPS31484.1    
 acid-stable endoxyloglucanase / xyloglucan-specific endo-β-1,4-glucanase (PoXeg12A) (Xeg12A) 3.2.1.151 Penicillium oxalicum HP7-1 AJA40324.1    
 endoglucanase 28 (Cel12A) 3.2.1.4 Phanerochaete chrysosporium K3 AAU12276.1 Q66NB6  
 xyloglucan-specific endoglucanase (EGL12-G;XEG1;PsXEG1;Ps109681;PHYSODRAFT_559651) (Cel12G) 3.2.1.151 Phytophthora sojae ABB22029.1
EGZ16757.1
Q30BZ2  
 endoglucanase (Cel3A;CMCase3a;CMCase IIIa) 3.2.1.4 Polyporus arcularius 69B-8 BAD98315.1 Q50LE3  
 endo-β-1,4-glucanase (PpCel12A) (partial) (Cel12A) 3.2.1.4 Postia placenta Mad-698-R ADH51731.1 D7REW4  
 xyloglucanase B (RmXEG12B) (Xeg12B) 3.2.1.151 Rhizomucor miehei CAU432 AGC24033.1    
 xyloglucanase A (RmXEG12A) (Xeg12A) 3.2.1.151 Rhizomucor miehei CAU432 AGC24032.1    
 endo-β-1,4-glucanase III (Egl3;EGIII;EG III;EG3;TrCel12A) (Cel12A) 3.2.1.151
3.2.1.4
Trichoderma reesei QM9414 AAE59774.1
AAE59775.1
AAN19479.1
AAN19480.1
AAO95538.1
AAO95539.1
AAQ24888.1
AAQ42100.1
AAQ42101.1
AAR60524.1
AAR63629.1
AAR63630.1
AAR67682.1
AAR67683.1
ABE22099.1
ABJ29213.1
ABJ29214.1
ABV71388.1
ACP76232.1
ACP76233.1
BAA20140.1
O00095 1H8V[A,B,C,D,E,F]
1OA2[A,B,C,D,E,F]
1OLQ[A,B]
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