Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (1075); Uniprot accession (212); PDB accession (48); 3D entries (17); cryst (1)
All (883) Archaea (90) Bacteria (628) Eukaryota (164) unclassified (1) Structure (17 - 1 cryst) Characterized (69)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellulase 12A (Cel12A) 3.2.1.4 Streptomyces sp. 11AG8 AAF91283.1
AAE59731.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
ACP76251.1
Q9KIH1 1OA4[A]
 SAMN05428941_5778   Streptomyces sp. 2114.2 SDT76171.1    
 SAMN05428941_1220   Streptomyces sp. 2114.2 SDS81576.1    
 SAMN05444521_2491   Streptomyces sp. 3214.6 SHH90108.1    
 ASR50_33355   Streptomyces sp. 4F ALV53826.1    
 ASR50_25700   Streptomyces sp. 4F ALV52474.1    
 GZL_09191 (fragment)   Streptomyces sp. 769 AJC61712.1    
 glycosyl hydrolase family 5, partial (fragment)   Streptomyces sp. AGERI-TA1 BBE15447.1    
 C2142_14235   Streptomyces sp. CB01881 AUY49888.1    
 C4J65_02545   Streptomyces sp. CB09001 AXL87313.1    
 C4J65_25330   Streptomyces sp. CB09001 AXL91258.1    
 NI25_10825   Streptomyces sp. CCM_MD2014 AIV33924.1    
 NI25_33295   Streptomyces sp. CCM_MD2014 AIV37792.1    
 AS200_04800   Streptomyces sp. CdTB01 ALV31448.1    
 AS200_13735   Streptomyces sp. CdTB01 ALV32999.1    
 CAC01_14350   Streptomyces sp. CLI2509 CLI2905 ASY33705.1    
 SAM9427_27010   Streptomyces sp. ETH9427 AXI89035.1    
 SAM9427_34610   Streptomyces sp. ETH9427 AXI90289.1    
 endo-β-1,4-glucanase (Cel;CelStrep) 3.2.1.4 Streptomyces sp. G12 CCI74016.1    
 C1703_28710 (CelS)   Streptomyces sp. Go-475 AXE89002.1    
 C1703_35895 (CeX)   Streptomyces sp. Go-475 AXE90428.1    
 DVK44_35220   Streptomyces sp. GSSD-12 AXG82121.1    
 DRB96_23030   Streptomyces sp. ICC1 AWZ14657.1    
 DRB89_22840   Streptomyces sp. ICC4 AWZ06987.1    
 CFP59_03006 (CelS)   Streptomyces sp. M56 AUA10901.1    
 C6376_01005   Streptomyces sp. P3 AVV40211.1    
 F750_0175   Streptomyces sp. PAMC 26508 AGJ52686.1    
 F750_6089   Streptomyces sp. PAMC 26508 AGJ58516.1    
 QR97_36850   Streptomyces sp. PBH53 AKN74562.1    
 QR97_26695   Streptomyces sp. PBH53 AKN72867.1    
 A4E84_29055   Streptomyces sp. S10(2016) AMW13189.1    
 CAG99_17250   Streptomyces sp. SCSIO 03032 ARQ70357.1    
 CAG99_04545   Streptomyces sp. SCSIO 03032 ARQ68208.1    
 SACTE_5809   Streptomyces sp. SirexAA-E AEN13595.1    
 B9S64_00750   Streptomyces sp. SM18 AWL36809.1    
 cellulase B (CelB)   Streptomyces sp. THW31 ADP65783.1 E5L393  
 SAMN05216371_3219   Streptomyces sp. TLI_053 SDT62471.1    
 SAMN05216371_3760   Streptomyces sp. TLI_053 SDT68960.1    
 ORF   Streptomyces sp. WAC1438 AFO53540.1    
 Strvi_2018   Streptomyces violaceusniger Tu 4113 AEM81752.1    
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 SXIM_44520   Streptomyces xiamenensis 318 AKG45836.1    
 endo-β-1,4-glucanase (Cel) 3.2.1.4 Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 DKM19_08810   Streptosporangium sp. caverna AWS41451.1    
 TERTU_0353   Teredinibacter turnerae T7901 ACR14297.1 C5BM92  
 Tbis_0352   Thermobispora bispora DSM 43833 ADG87082.1 D6Y3Q3  
 endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) 3.2.1.4 Thermotoga maritima MSB8 AGL50456.1
AAD36591.1
AHD18579.1
AKE29285.1
CAA93273.1
NP_229324.1
Q60032
Q9S5X8
3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
3VHN[A,B,C,D,E,F,G,H]
3VHO[A,B]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 Thermotoga maritima MSB8 AAD36592.1
AGL50457.1
AHD18578.1
AKE29286.1
CAA93274.1
NP_229325.1
G4FFR3
Q60033
 
 THMB_1558   Thermotoga maritima Tma100 AKE31157.1    
 THMB_1559   Thermotoga maritima Tma100 AKE31158.1    
 THMC_1558   Thermotoga maritima Tma200 AKE27413.1    
 THMC_1559   Thermotoga maritima Tma200 AKE27414.1    
 endoglucanase (N2) (fragment)   Thermotoga naphthophila CBH31132.1 D2U583  
 Tnap_1284   Thermotoga naphthophila RKU-10 ADA67369.1 D2C3R5  
 Tnap_1285   Thermotoga naphthophila RKU-10 ADA67370.1 D2C3R6  
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermotoga neapolitana AAC95059.1
CAB06783.1
O08428
P96491
 
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Thermotoga neapolitana AAC95060.1
CAB06782.1
P96492
Q798L1
 
 CTN_1106   Thermotoga neapolitana DSM 4359 ACM23282.1 B9K8J9  
 CTN_1107   Thermotoga neapolitana DSM 4359 ACM23283.1 B9K8K0  
 cellulase (TCel2;Tpet_1267) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 T2812B_05950 (fragment)   Thermotoga sp. 2812B AIY86723.1    
 T2812B_05955   Thermotoga sp. 2812B AIY86724.1    
 T2812B_05935 (fragment)   Thermotoga sp. 2812B AIY86720.1    
 CELL2_06605   Thermotoga sp. Cell2 AIY88589.1    
 CELL2_06600   Thermotoga sp. Cell2 AIY88588.1    
 TRQ2_1187   Thermotoga sp. RQ2 ACB09531.1 B1LB33  
 TRQ2_1188   Thermotoga sp. RQ2 ACB09532.1 B1LB34  
 TRQ7_07010   Thermotoga sp. RQ7 AJG41199.1    
 TRQ7_07005   Thermotoga sp. RQ7 AJG41198.1    
 GH12 protein   uncultured Bacillus sp. ALA15661.1    
 endoglucanase (RSC-EG1)   uncultured bacterium AFD36891.1    
 cellulase (Lc-CelA) 3.2.1.4 uncultured bacterium AHL27894.1   3WX5[A,B]
 cellulase (Lc-CelD) 3.2.1.4 uncultured bacterium AHL27897.1    
 cellulase (Lc-CelE) 3.2.1.4 uncultured bacterium AHL27898.1    
 Cel12E   unidentified prokaryotic organism CRL09147.1    
 CMV30_09020   Verrucomicrobia bacterium HZ-65 ATC64082.1    
 VAB18032_10320   Verrucosispora maris AB-18-032 AEB43182.1    
 BSQ33_03960   Vibrio gazogenes ATCC 43942 ASA54962.1    
 XALc_0865   Xanthomonas albilineans GPE PC73 CBA15383.1    
 AKJ12_14810   Xanthomonas arboricola pv. juglandis Xaj 417 AKU50917.1    
 XACM_3403 (CelS)   Xanthomonas axonopodis pv. citrumelo F1 AEO43650.1    
 XB05_12325   Xanthomonas campestris 17 AKC79434.1    
 AAW18_16680   Xanthomonas campestris pv. campestris 17 ALE69939.1    
 AAW18_16675   Xanthomonas campestris pv. campestris 17 ALE69938.1    
 AEA01_03880   Xanthomonas campestris pv. campestris 4013 AKS19163.1    
 AEA01_03885   Xanthomonas campestris pv. campestris 4013 AKS19164.1    
 AEA00_03850   Xanthomonas campestris pv. campestris ICMP 21080 AKS15134.1    
 AEA00_03845   Xanthomonas campestris pv. campestris ICMP 21080 AKS15133.1    
 XC_0783   Xanthomonas campestris pv. campestris str. 8004 AAY47861.1 Q4UYL2  
 XC_0784   Xanthomonas campestris pv. campestris str. 8004 AAY47862.1 Q4UYL1  
 XCC3380   Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42650.1
NP_638726.1
Q8P5G1  
 CelS   Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42651.1
NP_638727.1
Q8P5G0  
 xcc-b100_0818   Xanthomonas campestris pv. campestris str. B100 CAP50159.1 Q8P5G0  
 xcc-b100_0819   Xanthomonas campestris pv. campestris str. B100 CAP50160.1 Q8P5G1  
 XCR_3716   Xanthomonas campestris pv. raphani 756C AEL08576.1    
 XCR_3717   Xanthomonas campestris pv. raphani 756C AEL08577.1    
 XCV3634 (CelS)   Xanthomonas campestris pv. vesicatoria str. 85-10 CAJ25365.1
AOY66992.1
Q3BPE8  
 AC028_02875   Xanthomonas citri pv. aurantifolii 1566 AMV05895.1    
 TP37_03830 (fragment)   Xanthomonas citri pv. aurantifolii FDC 1559 AMV00707.1    
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