Glycoside Hydrolase Family 84

Activities in Family	[protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169); Hyaluronidase / hyaluronoglucosaminidase (EC 3.2.1.35); β-N-acetylhexosaminidase (EC 3.2.1.52);
Mechanism	Retaining e
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Asp
Note	Mechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resources	CAZypedia;
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (3338); Uniprot accession (25); PDB accession (78); 3D entries (10); cryst (0)

Summary

Download GH84 (3286) Taxonomic display Structure (10) Characterized (18)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
STSU_024235		Streptomyces tsukubensis NRRL18488	QKM69793.1
MMF93_29555		Streptomyces tubbatahanensis DSD3025	UNT00142.1
MMF93_32000		Streptomyces tubbatahanensis DSD3025	UNT00585.1
STRTU_001346		Streptomyces tubercidicus DSM 40261	WAU11170.1
STRTU_004701		Streptomyces tubercidicus DSM 40261	WAU16696.1
GCM10017668_23310		Streptomyces tuirus JCM 4255	BCL20488.1
DEJ45_23845		Streptomyces venezuelae ATCC 10595	QES15115.1
SVEN_2438		Streptomyces venezuelae ATCC 10712	CCA55724.1 QES03602.1
DEJ47_12515		Streptomyces venezuelae ATCC 14583	QES27173.1
DEJ48_25720		Streptomyces venezuelae ATCC 14584	QES36348.1
DEJ49_12110		Streptomyces venezuelae ATCC 14585	QES41658.1
DEJ46_26230		Streptomyces venezuelae ATCC 15068	QES24811.1
BN2537_6671		Streptomyces venezuelae ATCC 15439	CUM38853.1
BN2537_11271		Streptomyces venezuelae ATCC 15439	CUM41153.1
AQF52_2891		Streptomyces venezuelae ATCC 15439	ALO08485.1
AQF52_5075		Streptomyces venezuelae ATCC 15439	ALO10669.1
DEJ51_11180		Streptomyces venezuelae ATCC 21018	QES54722.1
DEJ44_11225		Streptomyces venezuelae ATCC 21113	QES06139.1
DEJ50_22225		Streptomyces venezuelae ATCC 21782	QES50138.1
U0M97_25585		Streptomyces venezuelae SvWT	WRK39094.1
U0M97_14405		Streptomyces venezuelae SvWT	WRK37040.1
B1H20_10320		Streptomyces violaceoruber S21	ARF66111.1
Strvi_5205		Streptomyces violaceusniger Tu 4113	AEM84739.1
Strvi_7941		Streptomyces violaceusniger Tu 4113	AEM87264.1
DI273_22230		Streptomyces violascens ATCC 27968	QPA01336.1
DI273_11480		Streptomyces violascens ATCC 27968	QOZ99639.1
β-N-acetylglucosaminidase		Streptomyces violascens SvNAgase2557	QXF28500.1
HWN34_11135		Streptomyces violascens YIM 100212	QLA57066.1
HWN34_21650		Streptomyces violascens YIM 100212	QLA58973.1
CP971_09685		Streptomyces viridifaciens ATCC 11989	QEV03863.1
BOQ63_016585		Streptomyces viridifaciens DSM 40239	UKZ05631.1
CP969_14450		Streptomyces viridosporus T7A ATCC 39115	QEU85779.1
IAG42_23355		Streptomyces xanthii CRXT-Y-14	QNS06225.1
IAG42_07570		Streptomyces xanthii CRXT-Y-14	QNS08579.1
V3O60_23895		Streptomyces xanthochromogenes WY144	WVT94232.1
KO717_23625		Streptomyces xanthophaeus GA114 Liu	WKD34634.1
KPP03845_102844 (NagJ)		Streptomyces xanthophaeus KPP03845	WCD86494.1
NRK68_11985		Streptomyces yangpuensis CM253	UUY47877.1
MOV08_27170		Streptomyces yunnanensis P86	WEB45932.1
MOV08_10855		Streptomyces yunnanensis P86	WEB39720.1
BXT84_12015		Sulfobacillus thermotolerans Kr	AUW94580.1
G3M56_003480		Sulfuriroseicoccus oceanibius T37	QQL45665.1
G3M56_006375		Sulfuriroseicoccus oceanibius T37	QQL46203.1
OSSY52_18200		Tepiditoga spiralis sy52	BBE31679.1
KV134_07020		Tetragenococcus halophilus CY54	QXN86017.1
C7K43_02085		Tetragenococcus koreensis KCTC 3924	AYW44822.1
Tsac_2289		Thermoanaerobacterium saccharolyticum JW/SL-YS485	AFK87293.1
Q2T46_03680		Thermoanaerobacterium sp. CMT5567-10	WKV09563.1
SAMN05660242_2297		Thermoanaerobacterium sp. RBIITD	SNX54593.1
Thethe_01898		Thermoanaerobacterium thermosaccharolyticum M0795	AGB19509.1
Thert_00287		Thermoanaerobacterium thermosaccharolyticum TG57	AST56509.1
O-glycoprotein β-N-acetylglucosaminidase (TtOGA; Tter_0116)	3.2.1.169	Thermobaculum terrenum ATCC BAA-798	ACZ41038.1	D1CDN2	5DIY[A,B]
EYR00_03915		Thomasclavelia ramosa DSM 1402	QMW73892.1
EYR00_03935		Thomasclavelia ramosa DSM 1402	QMW73896.1
I6I62_09675		Thomasclavelia ramosa FDAARGOS_1105	QQV04689.1
I6I62_09655		Thomasclavelia ramosa FDAARGOS_1105	QQV04685.1
I6I63_03785		Thomasclavelia ramosa FDAARGOS_1106	QQY28346.1
I6I63_03765		Thomasclavelia ramosa FDAARGOS_1106	QQY28342.1
I6G63_14310		Thomasclavelia ramosa FDAARGOS_906	QPS12841.1
I6G63_14290		Thomasclavelia ramosa FDAARGOS_906	QPS12837.1
NQ543_01770		Thomasclavelia spiroformis DSM 1552	UWO90001.1
NQ543_04575		Thomasclavelia spiroformis DSM 1552	UWO90526.1
NQ543_09205		Thomasclavelia spiroformis DSM 1552	UWO89135.1
NQ543_01415		Thomasclavelia spiroformis DSM 1552	UWO89931.1
NQ543_10920		Thomasclavelia spiroformis DSM 1552	UWO89447.1
NQ543_08220		Thomasclavelia spiroformis DSM 1552	UWO88976.1
NQ543_01425		Thomasclavelia spiroformis DSM 1552	UWO89933.1
CIG75_10185		Tumebacillus algifaecis THMBR28	ASS75322.1
CBW65_12910		Tumebacillus avium AR23208	ARU61830.1
CBW65_19250		Tumebacillus avium AR23208	ARU62875.1
β-N-acetylglucosaminidase (fragment)		uncultured bacterium	APO31996.1
ORF		uncultured bacterium	QEO73786.1
ORF		uncultured bacterium	QEO73622.1
GH84, Hyaluronidase		uncultured bacterium	VTZ55497.1
β-N-acetylglucosaminidase family protein		uncultured bacterium 4L05	ALB75783.1
ORF_27c		uncultured gamma proteobacterium HF0770_09E07	ADI23125.1
G7082_10700		Vagococcus hydrophili HDW17B	QIL48940.1
G314FT_10130		Vagococcus luciliae G314FT	UUV98859.1
M2901_04005		Vagococcus lutrae AT03	UQF71792.1
M2904_06950		Vagococcus lutrae AT15	UQF37859.1
M2905_06375		Vagococcus lutrae AT19	UQF18275.1
M2908_06870		Vagococcus lutrae AT32	UQF63591.1
M2909_04845		Vagococcus lutrae AT33	UQF24318.1
M2919_07110		Vagococcus lutrae AT46b	UQF11257.1
K5X77_05970		Vagococcus lutrae BN31	QZN88033.1
PML89_06055		Vagococcus lutrae K136-2	WCG04544.1
PML95_01545		Vagococcus lutrae K204-1	WCG22957.1
LVJ09_00655		Vagococcus lutrae VF20	WEB81526.1
MN187_07440		Vagococcus sp. CY52-2	UNM89122.1
FA707_04120		Vagococcus zengguangii MN-17	QCI86198.1
QNH47_00200		Virgibacillus halodenitrificans ACCC02857	WHX26309.1
QNH47_01075		Virgibacillus halodenitrificans ACCC02857	WHX26475.1
QNH47_19315		Virgibacillus halodenitrificans ACCC02857	WHX26254.1
QNH47_00195		Virgibacillus halodenitrificans ACCC02857	WHX26308.1
BME96_15585		Virgibacillus halodenitrificans PDB-F2	APC49528.1
BME96_15590		Virgibacillus halodenitrificans PDB-F2	APC49529.1
BME96_14800		Virgibacillus halodenitrificans PDB-F2	APC49382.1
CFK40_05195		Virgibacillus necropolis LMG 19488	ASN07301.1
CFK37_09225		Virgibacillus phasianinus LM2416	ASK62324.1
CFK37_08530		Virgibacillus phasianinus LM2416	ASK62202.1
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