Activities in Family	[protein]-3-O-(GlcNAc)-L-Ser/Thr β-N-acetylglucosaminidase (EC 3.2.1.169); Hyaluronidase / hyaluronoglucosaminidase (EC 3.2.1.35); β-N-acetylhexosaminidase (EC 3.2.1.52);
Mechanism	Retaining e
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Asp
Note	Mechanism shown in Macauley et al. (2005) JBC 280:25313-25322
External resources	CAZypedia;
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (3338); Uniprot accession (25); PDB accession (78); 3D entries (10); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
HUT08_10445		Streptomyces sp. NA00687	QKW49894.1
HUT14_11890		Streptomyces sp. NA02536	QKW00523.1
HUT19_03345		Streptomyces sp. NA02950	QKV97375.1
HUT19_27055		Streptomyces sp. NA02950	QKV94952.1
HUT18_04520		Streptomyces sp. NA04227	QKW05749.1
HUT18_08850		Streptomyces sp. NA04227	QKW06494.1
QFW82_30000		Streptomyces sp. NA07423	WHX24294.1
QFW82_41560		Streptomyces sp. NA07423	WHX23062.1
OSU72_18960		Streptomyces sp. NA13	WAC98097.1
OSU72_08265		Streptomyces sp. NA13	WAC96129.1
JIW86_26145		Streptomyces sp. NBC00162	UUU41987.1
OG428_03410		Streptomyces sp. NBC_01422	WUY01466.1
OG428_11550		Streptomyces sp. NBC_01422	WUX97114.1
OG290_10960		Streptomyces sp. NBC_01423	WUX90248.1
OG290_32220		Streptomyces sp. NBC_01423	WUX94170.1
OG906_01690		Streptomyces sp. NBC_01426	WUX80191.1
OG906_22315		Streptomyces sp. NBC_01426	WUX83885.1
OG406_26080		Streptomyces sp. NBC_01428	WUX76943.1
OG627_23545		Streptomyces sp. NBC_01429	WUX69607.1
OG574_07820		Streptomyces sp. NBC_01445	WSE03307.1
OG574_29845		Streptomyces sp. NBC_01445	WSE07165.1
OIU81_06910		Streptomyces sp. NBC_01454	WUW69579.1
OIU81_24595		Streptomyces sp. NBC_01454	WUW72726.1
OG875_21290		Streptomyces sp. NBC_01498	WTL26874.1
L2I08_03910		Streptomyces sp. NBU3104	UKL02116.1
L2I08_24010		Streptomyces sp. NBU3104	UKL05797.1
DKG71_33705		Streptomyces sp. NEAU-S7GS2	AWN30438.1
DKG71_15055		Streptomyces sp. NEAU-S7GS2	AWN27276.1
DEH18_05855		Streptomyces sp. NHF165	QHF93476.1
QTO28_25170		Streptomyces sp. P9-2B-1	WJY34104.1
QTO28_11345		Streptomyces sp. P9-2B-1	WJY31563.1
QT196_13925		Streptomyces sp. P9-2B-2	WJY42831.1
QT196_31860		Streptomyces sp. P9-2B-2	WJY41497.1
F750_5429		Streptomyces sp. PAMC 26508	AGJ57858.1
F750_2484		Streptomyces sp. PAMC 26508	AGJ54970.1
AW27_021890		Streptomyces sp. PCS3-D2	WKV73922.1
MTP06_16830		Streptomyces sp. PLM4	BDH68234.1
MTP06_38940		Streptomyces sp. PLM4	BDH70445.1
V2W30_13885		Streptomyces sp. Q6	WWQ64326.1
V2W30_35290		Streptomyces sp. Q6	WWQ68079.1
GPZ77_11710		Streptomyces sp. QHH-9511	QGZ48959.1
LZ559_11200		Streptomyces sp. R527F	UIZ12948.1
HYQ63_37385		Streptomyces sp. Rer75	QLH25584.1
HYQ63_15140		Streptomyces sp. Rer75	QLH21788.1
HEP86_32055		Streptomyces sp. RPA4-5	QIY58291.1
SJI45_18305		Streptomyces sp. S399	WPR52706.1
SSPS47_10445		Streptomyces sp. S4.7	QHY95537.1
D7Y56_11295		Streptomyces sp. S501	QBR06459.1
D7Y56_25530		Streptomyces sp. S501	QBR08995.1
A6E92_21715		Streptomyces sp. S8	ARI54491.1
VM636_20310		Streptomyces sp. SCSIO 75703	WVW69662.1
H0E86_11220		Streptomyces sp. SCSIO-PteL053	WDT91650.1
GQS52_18250		Streptomyces sp. SCUT-3	QMV25192.1
B6R96_23165		Streptomyces sp. Sge12	ARE76488.1
QFA72_10655		Streptomyces sp. SH5	WGP10110.1
SACTE_2080		Streptomyces sp. SirexAA-E	AEN09981.1
B9S66_19285		Streptomyces sp. SM17	AWL34185.1
B9S66_08445		Streptomyces sp. SM17	AWL32202.1
HBB06_19035		Streptomyces sp. SNU607	WKV80077.1
HBB06_04685		Streptomyces sp. SNU607	WKV77480.1
U5072_09325		Streptomyces sp. SS162	WVS77801.1
A7X85_05910		Streptomyces sp. ST1015	QZZ25845.1
A7X85_40335		Streptomyces sp. ST1015	QZZ31638.1
GEV49_36515		Streptomyces sp. SYP-A7193	QFX85835.1
PBV52_37650		Streptomyces sp. T12	WDF44861.1
SAMN05216371_2596		Streptomyces sp. TLI_053	SDT50703.1
BSL84_11585		Streptomyces sp. TN58	APU40312.1
GLX30_23390		Streptomyces sp. Tu 2975	QIP86473.1
TK78_23700		Streptomyces sp. Tue 6075 Tue6075	APS21586.1
MCU78_21695		Streptomyces sp. TYQ1024	UKW31397.1
OH133_25700		Streptomyces sp. VB1	UZI31221.1
Q3V23_12735 (fragment)		Streptomyces sp. VNUA116	WKU44870.1
D1J60_12450		Streptomyces sp. W1SF4	AZM89199.1
LH646_03950		Streptomyces sp. WA1-19	UDF06768.1
LH646_23795		Streptomyces sp. WA1-19	UDF10354.1
LEL86_07245		Streptomyces sp. WA6-1-16	UCA49084.1
DLM49_24560		Streptomyces sp. WAC 01438	AZM62276.1
DMA15_12300		Streptomyces sp. WAC 01529	AZM53278.1
DMB38_09890		Streptomyces sp. WAC 06738	AZM46090.1
DMB38_30245		Streptomyces sp. WAC 06738	AZM49493.1
C5L38_22450		Streptomyces sp. WAC00288	AVH97474.1
MWG59_11465		Streptomyces sp. WAC00303	UPT41996.1
O7599_06415		Streptomyces sp. WMMC500	WBB62162.1
O7599_27520		Streptomyces sp. WMMC500	WBB59299.1
KV381_11275		Streptomyces sp. WY228	QXQ96886.1
Q3Y56_10810		Streptomyces sp. XD-27	WKX70345.1
C9F11_14935 (NagJ)		Streptomyces sp. YIM 121038	QCX76656.1
KME66_23525		Streptomyces sp. YPW6	QWQ43618.1
CP982_16105		Streptomyces spectabilis ATCC 27465	QEV60069.1
FH965_14340		Streptomyces spectabilis NRRL 2792	QDQ11607.1
DDQ41_06880		Streptomyces spongiicola HNM0071	AWK08695.1
SSPO_092090		Streptomyces sporoclivatus NBRC 100767	BBJ46491.1
SSPO_064950		Streptomyces sporoclivatus NBRC 100767	BBJ43777.1
LDH80_26000		Streptomyces tanashiensis Kala	UZX23946.1
F3L20_26690		Streptomyces tendae 139	QER88973.1
F3L20_13615		Streptomyces tendae 139	QER86802.1
AY578_11115		Streptomyces thermocarboxydus K155	UVT09795.1
DDW44_08545		Streptomyces tirandamycinicus HNM0039	AWI32955.1
GBW32_00725		Streptomyces tsukubensis AT3	QFR91839.1
B7R87_09575		Streptomyces tsukubensis NRRL 18488	AZK94096.1
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