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Glycoside Hydrolase Family 5

Activities in Family[retaining] arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-);
β-1,3-mannanase (EC 3.2.1.-);
β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-);
Glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Mannan exo-β-1,4-mannosidase (EC 3.2.1.-);
Steryl β-glucosidase (EC 3.2.1.104);
Endoglycosylceramidase (EC 3.2.1.123);
Chitosanase (EC 3.2.1.132);
β-D-galactofuranosidase (EC 3.2.1.146);
β-primeverosidase (EC 3.2.1.149);
Oligoxyloglucan reducing-end-specific cellobiohydrolase (EC 3.2.1.150);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168);
β-glucosidase (EC 3.2.1.21);
β-galactosidase (EC 3.2.1.23);
β-mannosidase (EC 3.2.1.25);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
Endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39);
Endo-β-1,4-glucanase (EC 3.2.1.4);
β-glucosylceramidase (EC 3.2.1.45);
β-galactosylceramidase (EC 3.2.1.46);
β-N-acetylhexosaminidase (EC 3.2.1.52);
α-L-arabinofuranosidase (EC 3.2.1.55);
Exo-β-1,3-glucanase (EC 3.2.1.58);
Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (31209); Uniprot accession (673); PDB accession (296); 3D entries (110); cryst (0)
Summary
Download GH5 (44468) Taxonomic display Structure (110) Characterized (624)
| 1 | ... | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | ... | 198 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 226292   Aspergillus minisclerotigenes v1.0 (Aspmin1)       7
 215092   Aspergillus minisclerotigenes v1.0 (Aspmin1)       22
 222420   Aspergillus minisclerotigenes v1.0 (Aspmin1)       4
 221019   Aspergillus minisclerotigenes v1.0 (Aspmin1)       16
 225022   Aspergillus minisclerotigenes v1.0 (Aspmin1)       15
 202809   Aspergillus minisclerotigenes v1.0 (Aspmin1)       49
 234146   Aspergillus minisclerotigenes v1.0 (Aspmin1)       7
 230783   Aspergillus minisclerotigenes v1.0 (Aspmin1)       27
 217482   Aspergillus minisclerotigenes v1.0 (Aspmin1)       9
 224112   Aspergillus minisclerotigenes v1.0 (Aspmin1)       9
 10573   Aspergillus minisclerotigenes v1.0 (Aspmin1)       5
 3360   Aspergillus nidulans FGSC A4 (Aspnid1)       9
 2055   Aspergillus nidulans FGSC A4 (Aspnid1)       9
 5119   Aspergillus nidulans FGSC A4 (Aspnid1)       7
 9468   Aspergillus nidulans FGSC A4 (Aspnid1)       7
 2366   Aspergillus nidulans FGSC A4 (Aspnid1)       15
 5346   Aspergillus nidulans FGSC A4 (Aspnid1)       23
 5400   Aspergillus nidulans FGSC A4 (Aspnid1)       5
 9124   Aspergillus nidulans FGSC A4 (Aspnid1)       12
 3486   Aspergillus nidulans FGSC A4 (Aspnid1)       7
 8741   Aspergillus nidulans FGSC A4 (Aspnid1)       7
 1502   Aspergillus nidulans FGSC A4 (Aspnid1)       4
 6937   Aspergillus nidulans FGSC A4 (Aspnid1)       23
 10027   Aspergillus nidulans FGSC A4 (Aspnid1)       5
 3799   Aspergillus nidulans FGSC A4 (Aspnid1)       7
 8490   Aspergillus nidulans FGSC A4 (Aspnid1)       16
 8805   Aspergillus nidulans FGSC A4 (Aspnid1)       7
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1		 Q5BDU5   5
 AN2709.2 (frameshift)   Aspergillus nidulans FGSC A4 EAA63111.1     7
 AN8068.2   Aspergillus nidulans FGSC A4 EAA59690.1     4
 AN7639.2   Aspergillus nidulans FGSC A4 EAA61825.1     7
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1		 Q1HFS8   5
 exo-β-1,3-glucanase (Anid-Bgl502;AN7533) 3.2.1.58 Aspergillus nidulans FGSC A4 EAA62113.1
ABF50886.1		 C8VBL9
Q5AVZ7		   9
 AN1332.2   Aspergillus nidulans FGSC A4 EAA65515.1     23
 AN9166.2   Aspergillus nidulans FGSC A4 EAA61999.1     16
 AN9276.2   Aspergillus nidulans FGSC A4 EAA66343.1     7
 AN4052 (Anid-Bgl501)   Aspergillus nidulans FGSC A4 EAA59523.1
XP_408189.1		     9
 AN3013.2   Aspergillus nidulans FGSC A4 EAA63584.1     12
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1		 Q5B7X2   7
 β-1,6-glucanase (Anid-Bgl503;AN3777) 3.2.1.75 Aspergillus nidulans FGSC A4 EAA59985.1
ABF50867.1		 C8V716
Q5B6Q3		   15
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1		 Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1		 Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) 3.2.1.78 Aspergillus nidulans XZ3 AGG69666.1 S4TZC3   7
 β-mannanase, partial   Aspergillus niger AKC57288.1     7
 ORF (fragment)   Aspergillus niger AMY96372.1     16
 α-L-rhamnosyl-β-D-glucosidase   Aspergillus niger QHN63926.1     23
 GH5 glucanase, partial (mitochondrion) (Glu5)   Aspergillus niger WOA03360.1     5
 291520   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       5
 165121   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       9
 278902   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       16
 215623   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       7
 317928   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       5
 253284   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       9
 298062   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       23
 279056   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       12
 12925   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       23
 314539   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       5
 302250   Aspergillus phoenicis (Corda) Thom ATCC 13157 v1.0 (Aspph1)       12
 endo-β-1,4-mannanase   Aspergillus niger 128 ADK88903.1     7
 1142884   Aspergillus niger ATCC 1015 v4 (Aspni7)       7
 1164595   Aspergillus niger ATCC 1015 v4 (Aspni7)       5
 1180495   Aspergillus niger ATCC 1015 v4 (Aspni7)       23
 1179270   Aspergillus niger ATCC 1015 v4 (Aspni7)       9
 1125014   Aspergillus niger ATCC 1015 v4 (Aspni7)       16
 1188538   Aspergillus niger ATCC 1015 v4 (Aspni7)       23
 1108924   Aspergillus niger ATCC 1015 v4 (Aspni7)       5
 1217761   Aspergillus niger ATCC 1015 v4 (Aspni7)       12
 1162736   Aspergillus niger ATCC 1015 v4 (Aspni7)       5
 1127838   Aspergillus niger ATCC 1015 v4 (Aspni7)       9
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.1     7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.2     7
 endoglucanase B (EglB) 3.2.1.4 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 endo-β-1,4-glucanase B (EglB)   Aspergillus niger CBS 120.49 / N400 AAE60102.1
AAE84292.1
CAA03653.1
CAA03658.1
CAA11965.1		     5
 An01g11670   Aspergillus niger CBS 513.88 CAK44069.1     5
 endo-β-1,6-galactanase (An03g01050) 3.2.1.164 Aspergillus niger CBS 513.88 CAK38078.1 A2QFW8   16
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 An06g02060   Aspergillus niger CBS 513.88 CAK48049.1     23
 endo-β-1,4-glucanase B (EglB;An07g08950)   Aspergillus niger CBS 513.88 CAK45103.1     5
 An08g01100   Aspergillus niger CBS 513.88 CAK39791.1     23
 An11g07660   Aspergillus niger CBS 513.88 CAK45960.1     9
 An16g02100   Aspergillus niger CBS 513.88 CAL00434.1     12
 endo-β-1,4-glucanase (EglA;An16g06800)   Aspergillus niger CBS 513.88 CAK42930.1     5
 An18g04100 (P2)   Aspergillus niger CBS 513.88 CAK43212.1     9
 160172   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       23
 167967   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       5
 167508   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       12
 158118   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       16
 156195   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       5
 161373   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       23
 163984   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       9
 159852   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       7
 161114   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       5
 168853   Aspergillus niger CBS 513.88 (Aspni_DSM_1)       9
 endo-β-1,4-glucanase (Eg1)   Aspergillus niger DL08 AHY00945.1     5
 endo-β-1,4-glucanase A (Eg-A)   Aspergillus niger DSM 26641 AUE23906.1     5
 β-mannanase   Aspergillus niger GIM3.452 AKC98250.1     7
 endo-β-1,4-glucanase (Eng1; EgI; AnCel5A) 3.2.1.4 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7		 5I77[A]
5I78[A,B]
5I79[A,B] 		5
 β-rutinosidase (AnRut) 3.2.1.168 Aspergillus niger K2     6I1A[B]
6I1A[A] 		23
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1		 G5CJA5
H2E6Y8		   7
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