Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13513); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (12129) Archaea (93) Bacteria (9771) Eukaryota (2138) Viruses (7) unclassified (120) Structure (76) Characterized (549)
| 1 | ... | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 endo-β-1,4-mannanase (Man5A)   Trichoderma viride WL 0422 AFP95336.1     7
 88n22   Trifolium repens ADD09589.1 D3YBD8   14
 CAMPLR22A2D_LOCUS770 (fragment)   Triticum aestivum SPT16176.1     14
 Sequence 108383 from patent US 7214786   Triticum aestivum ABT20913.1     7
 ORF (fragment)   Ulocladium sp. 0729-007 1 C PDA/MF07-034 CDL74345.1     5
 Type 1-7.1 (partial)   uncultured bovine rumen ciliate AEQ16450.1     4
 CMC5 (fragment)   uncultured equine caecal ciliate CDG46722.1     4
 CMC6 (fragment)   uncultured equine caecal ciliate CDG46723.1     4
 CMC9 (fragment)   uncultured equine caecal ciliate CDG46724.1     4
 CMC9 (fragment)   uncultured equine caecal ciliate CDG46724.1     4
 AAA17YJ10FL   uncultured eukaryote CCA94935.1     7
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18706.1    
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18715.1    
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18717.1    
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18719.1    
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18720.1    
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18721.1    
 GH45 endoglucanase, partial (fragment)   uncultured fungus CCC18722.1    
 ORF (fragment)   uncultured fungus CCC18707.1     5
 ORF (fragment)   uncultured fungus CCC18708.1     5
 ORF (fragment)   uncultured fungus CCC18709.1     5
 ORF (fragment)   uncultured fungus CCC18710.1     5
 ORF (fragment)   uncultured fungus CCC18711.1     5
 ORF (fragment)   uncultured fungus CCC18712.1     5
 ORF (fragment)   uncultured fungus CCC18713.1     5
 ORF (fragment)   uncultured fungus CCC18714.1     5
 ORF (fragment)   uncultured fungus CCC18716.1     5
 ORF (fragment)   uncultured fungus CCC18718.1     5
 endo-β-1,4-D-glucanase, partial (fragment)   uncultured Neocallimastigomycetes ANI24562.1
ANI24564.1
    4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24575.1
ANI24572.1
    4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24568.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24567.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24574.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24577.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24576.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24563.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24573.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24570.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24566.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24571.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24560.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24569.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24565.1     4
 endo-β-1,4-D-glucanase, partial   uncultured Neocallimastigomycetes ANI24561.1     4
 SM2735A02   uncultured symbiotic protist of Cryptocercus punctulatus BAF57456.1 A4UX46   2
 SM2736A91   uncultured symbiotic protist of Cryptocercus punctulatus BAF57457.1 A4UX47   2
 SM2736B44   uncultured symbiotic protist of Cryptocercus punctulatus BAF57458.1 A4UX48   2
 SM2738A77   uncultured symbiotic protist of Cryptocercus punctulatus BAF57459.1 A4UX49   2
 SM2739A08   uncultured symbiotic protist of Cryptocercus punctulatus BAF57460.1 A4UX50   2
 SM2739B21 (fragment)   uncultured symbiotic protist of Cryptocercus punctulatus BAF57461.1 A4UX51   1
 NT0283A44   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57326.1 A4UWR6   1
 NT0283A83   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57327.1 A4UWR7   2
 NT0285A72   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57328.1 A4UWR8   2
 NT0285A74   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57329.1 A4UWR9   2
 NT0285B14   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57330.1 A4UWS0   2
 NT0285B44   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57331.1 A4UWS1   1
 NT0287A37;NT0290A76;NT0290B18;NT0290B53   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57332.1
BAF57336.1
BAF57338.1
BAF57339.1
A4UWS2   2
 NT0287A89   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57333.1 A4UWS3   4
 NT0288A58   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57334.1 A4UWS4   2
 NT0288B91   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57335.1 A4UWS5   1
 NT0291B62;NT0290A90;NT0291A24   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57341.1
BAF57337.1
BAF57340.1
A4UWT1   2
 SM2760A61   uncultured symbiotic protist of Mastotermes darwiniensis BAF57413.1 A4UX03   2
 SM2763A16   uncultured symbiotic protist of Mastotermes darwiniensis BAF57414.1 A4UX04   1
 SM2765A45   uncultured symbiotic protist of Mastotermes darwiniensis BAF57415.1 A4UX05   1
 SM2632A46;SM2637A04   uncultured symbiotic protist of Neotermes koshunensis BAF57361.1
BAF57367.1
A4UWV1   2
 SM2632A58   uncultured symbiotic protist of Neotermes koshunensis BAF57362.1 A4UWV2   1
 SM2632B73;SM2637B70;SM2649A06;SM2649A59;SM2649B23   uncultured symbiotic protist of Neotermes koshunensis BAF57363.1
BAF57368.1
BAF57369.1
BAF57370.1
BAF57373.1
A4UWV3   2
 SM2635A05;SM2636A42;SM2649A74;SM2649A87   uncultured symbiotic protist of Neotermes koshunensis BAF57364.1
BAF57365.1
BAF57371.1
BAF57372.1
A4UWV4   1
 SM2636B47   uncultured symbiotic protist of Neotermes koshunensis BAF57366.1 A4UWV6   2
 SM2030A48   uncultured symbiotic protist of Reticulitermes speratus BAF57288.1 A4UWM8   1
 SM2040A21   uncultured symbiotic protist of Reticulitermes speratus BAF57289.1 A4UWM9   1
 SM2040A25   uncultured symbiotic protist of Reticulitermes speratus BAF57290.1 A4UWN0   2
 SM2041A08 (possible fragment)   uncultured symbiotic protist of Reticulitermes speratus BAF57291.1 A4UWN1   1
 SM2041A23   uncultured symbiotic protist of Reticulitermes speratus BAF57292.1 A4UWN2   2
 SM2041A77 (fragment)   uncultured symbiotic protist of Reticulitermes speratus BAF57293.1 A4UWN3   2
 UBRO_00370   Ustilago bromivora UB2112 SAM71258.1     9
 UBRO_00392   Ustilago bromivora UB2112 SAM71140.1     12
 UBRO_06823   Ustilago bromivora UB2112 SAM84188.1     9
 UBRO_08206   Ustilago bromivora UB2112 SAM85626.1     9
 UBRO_01770   Ustilago bromivora UB2112 SAM77391.1     50
 UBRO_08657   Ustilago bromivora UB2112 SAM86230.1    
 UBRO_00201   Ustilago bromivora UB2112 SAM72210.1     50
 UBRO_07788   Ustilago bromivora UB2112 SAM85236.1     16
 UBRO_01319   Ustilago bromivora UB2112 SAM75227.1     9
 UBRO_05824   Ustilago bromivora UB2112 SAM84544.1     12
 UM00128.1 (Umay-Bgl506)   Ustilago maydis 521 EAK81513.1     50
 endo-β-mannanase (Man1)   Vaccinium corymbosum ACN78666.1 C7A7Y0   7
 ORF   Vaucheria litorea AFA52581.1    
 β-1,6-endoglucanase (VegB)   Verticillium dahliae AGW80454.1     15
 ORF 1 (fragment)   Verticillium dahliae 76 AAX73408.1 Q56NK6   12
 β-1,6-glucanase (Bgn3) (fragment)   Verticillium dahliae 76 AAX73406.1 Q56NK8   15
 VIGAN_11175000 (Vigan.11g175000)   Vigna angularis var. angularis BAU02258.1     7
 VIGAN_07175900 (Vigan.07g175900)   Vigna angularis var. angularis BAT92896.1     14
 VIGAN_09003000 (Vigan.09g003000)   Vigna angularis var. angularis BAT96746.1     7
 VIGAN_09149100 (Vigan.09g149100)   Vigna angularis var. angularis BAT97907.1     11
 VIGAN_10160100 (Vigan.10g160100)   Vigna angularis var. angularis BAU00044.1     7
 VIGAN_06132000 (Vigan.06g132000)   Vigna angularis var. angularis BAT90136.1     7
 VIGAN_06158400 (Vigan.06g158400)   Vigna angularis var. angularis BAT90354.1     11
 VIGAN_01093100 (Vigan.01g093100)   Vigna angularis var. angularis BAT73448.1     11
 VIGAN_03283600 (Vigan.03g283600)   Vigna angularis var. angularis BAT82775.1     7
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