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Glycoside Hydrolase Family 5 / Subf 25

Activities in Sub FamilyEndo-β-1,4-glucanase (EC 3.2.1.4);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (515); Uniprot accession (15); PDB accession (24); 3D entries (6); cryst (0)
Summary
Download GH5_25 (502) Taxonomic display Structure (6) Characterized (17)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 LRS08_11625   Sphingomonas sp. J315 UUX98242.1     25
 E5673_04035   Sphingomonas sp. PAMC26645 QCB41493.1     25
 OIM94_10095   Sphingomonas sp. R1 UYY75887.1     25
 FPZ54_11695   Sphingomonas suaedae XS-10 QDX28242.1     25
 MC45_17220   Sphingomonas taxi ATCC 55669 AIT08352.1     25
 KNJ79_12290   Sphingopyxis indica MC4 WOF45418.1     25
 BWQ93_10755 (fragment)   Sphingopyxis sp. QXT-31 APZ98920.1     25
 LPB140_05385   Sphingorhabdus lutea LPB0140 APG62326.1     25
 EUU25_16410   Sphingorhabdus sp. IMCC1753 QGY82355.1     25
 ETR14_13230   Sphingosinicella sp. BN140058 QAY79887.1     25
 SAMN06298216_1039   Spirosomataceae bacterium TFI 002 SOE20551.1     25
 Pan189_29930 (CelH)   Stratiformator vulcanicus Pan189 QDT38598.1     25
 Sgly_1611   Syntrophobotulus glycolicus DSM 8271 ADY55909.1     25
 ElP_60590 (CelH)   Tautonia plasticadhaerens ElP QDV38110.1     25
 P0M04_26850   Telluria mixta ACM 1762 WEM95070.1     25
 DSM104635_02543 (CelH)   Terricaulis silvestris 0127_4 QGZ95692.1     25
 KUV46_06595 (fragment)   Thalassovita mediterranea DP8N14-7 QYJ02052.1     25
 THTE_0890   Thermogutta terrifontis R1 ASV73492.1     25
 endoglucanase / β-mannanase (Tm_Cel5A; TmCel5A; TM1751) (Cel5A) 3.2.1.4
3.2.1.78		 Thermotoga maritima MSB8 AAD36816.1
AGL50683.1
AHD18355.1
AKE29506.1
NP_229549.1		 Q9X273
R4P461		 3AMC[A,B]
3AMD[A,B,C,D]
3AMG[A,B]
3AOF[A,B]
3AZR[A,B]
3AZS[A,B]
3AZT[A,B,C,D]
3MMU[A,B,C,D,E,F,G,H]
3MMW[A,B,C,D] 		25
 THMB_1793   Thermotoga maritima Tma100 AKE31377.1     25
 THMC_1793   Thermotoga maritima Tma200 AKE27633.1     25
 TRQ2_1074   Thermotoga sp. RQ2 ACB09420.1     25
 GH5   uncultured bacterium AQQ75170.1     25
 endo-β-1,4-glucanase (Cel; CelH; CelRH5) 3.2.1.4 uncultured bacterium QCI34346.1
QCI34340.1
VIO51607.1		     25
 WG33_0281 (fragment)   uncultured bacterium QMS48082.1     25
 endoglucanase   uncultured bacterium QQK84797.1     25
 endo-β-1, 4-glucanase   uncultured bacterium UWJ06596.1     25
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 uncultured bacterium ABE60714.1 Q1PDD8   25
 ORF (fragment)   uncultured bacterium ADV57600.1     25
 ORF (fragment)   uncultured bacterium ADV57604.1     25
 ORF (fragment)   uncultured bacterium ADV57605.1     25
 ORF (fragment)   uncultured bacterium ADV57607.1     25
 ORF (fragment)   uncultured bacterium ADV57608.1     25
 ORF (fragment)   uncultured bacterium ADV57609.1     25
 ORF (fragment)   uncultured bacterium ADV57610.1     25
 ORF (fragment)   uncultured bacterium ADV57618.1     25
 ORF (fragment)   uncultured bacterium ADV57619.1     25
 ORF (fragment)   uncultured bacterium ADV57620.1     25
 ORF (fragment)   uncultured bacterium ADV57621.1     25
 ORF (fragment)   uncultured bacterium ADV57622.1     25
 ORF (fragment)   uncultured bacterium ADV57625.1     25
 ORF (fragment)   uncultured bacterium ADV57626.1     25
 ORF (fragment)   uncultured bacterium ADV57628.1     25
 ORF (fragment)   uncultured bacterium ADV57629.1     25
 ORF (fragment)   uncultured bacterium ADV57631.1     25
 ORF (fragment)   uncultured bacterium ADV57633.1     25
 cellulase (C2P3) 3.2.1.4 uncultured bacterium BAO65808.1     25
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 uncultured bacterium AID57617.1 A0A068F0I2   25
 ORF   uncultured bacterium A2_10 AEW47942.1     25
 B1_GH5   uncultured bacterium B1_8 AEW47944.1     25
 B2_GH5   uncultured bacterium B2_18 AEW47949.1     25
 endoglucanase   uncultured bacterium contig00103 AGS52466.1     25
 ORF   uncultured bacterium G2_7 AEW47966.1     25
 H2_GH5   uncultured bacterium H2_7 AEW47975.1     25
 endoglucanase (EglDG) (fragment) 3.2.1.4 uncultured Dictyoglomus sp. ARO76321.1 A0A1W6S733   25
 endoglucanase (Cel4; GC_Cel4) 3.2.1.4 uncultured Dictyoglomus sp. QRN45943.1 A0A891XJK4   25
 IMCC26134_05880   Verrucomicrobia bacterium IMCC26134 AKC82422.1     25
 SAMN05444156_2102   Verrucomicrobium sp. GAS474 SDU12473.1     25
 PYE67_15520   Vibrio aestuarianus U17 WGK87521.1     25
 PYE51_16520   Vibrio aestuarianus U29 WGK83996.1     25
 VA249_41970   Vibrio alfacsensis 04Ya249 BBM67551.1     25
 VA208B3_13240   Vibrio alginolyticus VA20-8B-3 BDP34953.1     25
 GT360_15135   Vibrio astriarenae HN897 QIA64898.1     25
 ISX50_11820   Vibrio cyclitrophicus ED008 UPR33764.1     25
 ITG09_05440   Vibrio cyclitrophicus ED287 UPR53068.1     25
 ITG13_09915   Vibrio cyclitrophicus ED582 UPR46670.1     25
 JCT84_07550   Vibrio parahaemolyticus HP1 QRH14272.1     25
 L3Q72_08105   Vibrio sp. JC009 WED20615.1     25
 MAO6_20750   Vibrio sp. MAO6 BFG48564.1     25
 IM698_03165   Vibrio splendidus ED144 UWZ98363.1     25
 XaFJ1_GM000265 (fragment)   Xanthomonas albilineans Xa-FJ1 QHQ27027.1     25
 NRY95_20790   Xanthomonas campestris pv. phormiicola CFBP 8444 UYC16088.1     25
 PG878_19360   Xanthomonas sp. A6251 WNH44638.1     25
 NG831_20150   Xanthomonas sacchari HR1-32 UYK66394.1     25
 NG825_19555   Xanthomonas sacchari HR3-46 UYK76579.1     25
 NG824_19455   Xanthomonas sacchari JR3-14 UYK88616.1     25
 NG829_19410   Xanthomonas sacchari LT6-16-1 UYK80476.1     25
 NG827_19520   Xanthomonas sacchari LT6-2 UYK84593.1     25
 NG828_19965   Xanthomonas sacchari YT9-19-2 UYK72434.1     25
 CJ027_019765   Xanthomonas sontii PPL1 UZK08763.1     25
 NUG21_19035   Xanthomonas sp. CFBP 8445 UYC11816.1     25
 MO328_18615 (fragment)   Xanthomonas translucens CIX207 WLA08323.1     25
 MO330_18500 (fragment)   Xanthomonas translucens CIX303 WLA00756.1     25
 MO326_17925 (fragment)   Xanthomonas translucens CIX40 WLA15747.1     25
 KM563_01095 (fragment)   Xanthomonas translucens pv. graminis ART-Xtg2 WIH12518.1     25
 KM433_00815 (fragment)   Xanthomonas translucens pv. graminis ART-Xtg29 WIH16147.1     25
 KM579_02125 (fragment)   Xanthomonas translucens pv. graminis ART-Xtg9 WIH09040.1     25
 KFS84_01460 (fragment)   Xanthomonas translucens pv. graminis LMG 726 UKE54653.1     25
 KM547_17965   Xanthomonas translucens pv. phlei LMG 730 UKE65514.1     25
 KFS85_18730   Xanthomonas translucens pv. phleipratensis LMG 843 UKE73025.1     25
 K8O61_17860 (fragment)   Xanthomonas translucens pv. pistacia ICMP 16317 UKE69272.1     25
 KM539_02425   Xanthomonas translucens pv. poae LMG 728 UKE62420.1     25
 RMA73_13280 (fragment)   Xanthomonas translucens pv. translucens CO236 WNJ25855.1     25
 WDV90_18225 (fragment)   Xanthomonas translucens pv. undulosa ARGTr 7-1 WXF83242.1     25
 RMA82_09250 (fragment)   Xanthomonas translucens pv. undulosa CO237 WNJ32514.1     25
 LTC53_18300 (fragment)   Xanthomonas translucens pv. undulosa MAI5034 UJB14860.1     25
 MZO50_05000 (fragment)   Xanthomonas translucens pv. undulosa Xtu-UPB513 UPU49801.1     25
 R9X41_19875   Xylophilus sp. GOD-11R WPB56374.1     25
 R9X41_19865   Xylophilus sp. GOD-11R WPB56372.1     25
 AABB29_00085   Yoonia sp. BS5-3 WZC49097.1     25
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