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Glycoside Hydrolase Family 5 / Subf 25

Activities in Sub FamilyEndo-β-1,4-glucanase (EC 3.2.1.4);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (515); Uniprot accession (15); PDB accession (24); 3D entries (6); cryst (0)
Summary
Download GH5_25 (502) Taxonomic display Structure (6) Characterized (17)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 DA436_13195   Clostridioides difficile 020711 AYD25742.1     25
 C3348_13235   Clostridioides difficile 08-00495 AVB50523.1     25
 TW87_15900   Clostridioides difficile 08ACD0030 AMM58636.1     25
 C3353_13230   Clostridioides difficile 09-00072 AVB61456.1     25
 C3349_13235   Clostridioides difficile 10-00071 AVB57828.1     25
 C3351_13240   Clostridioides difficile 10-00078 AVB65027.1     25
 C3352_13240   Clostridioides difficile 10-00253 AVB68617.1     25
 C3347_13230   Clostridioides difficile 12-00008 AVB34576.1     25
 C3350_13245   Clostridioides difficile 12-00011 AVB54202.1     25
 KFK07_13020   Clostridioides difficile 2015 QUP85780.1     25
 JMW46_04230   Clostridioides difficile 2016 QQY76902.1     25
 CD2546   Clostridioides difficile 630 CAJ69433.1
AJP12293.1		     25
 CDIF630erm_02798   Clostridioides difficile 630 delta erm ARE63472.1     25
 CD630DERM_25460   Clostridioides difficile 630Derm CEJ99169.1     25
 JMW47_16745   Clostridioides difficile 7009825 QQY72254.1     25
 BN1095_620120   Clostridioides difficile 7032989 CDT65567.1     25
 BN1097_680032   Clostridioides difficile 7032994 CDS88444.1     25
 C4J70_12430   Clostridioides difficile AK AVI13053.1     25
 CDIF1296T_02673   Clostridioides difficile ATCC 9689 = DSM 1296 AKP43506.1     25
 BZ168_05215   Clostridioides difficile BR81 AQU09054.1     25
 DF008_09305   Clostridioides difficile CBA7204 QHG00830.1     25
 C3W74_13230   Clostridioides difficile CD-10-00484 AVB41920.1     25
 DDG63_13560   Clostridioides difficile CD161 AWH81987.1     25
 JMW48_01710   Clostridioides difficile CD1801 QQY69355.1     25
 CD196_2386   Clostridioides difficile CD196 CBA64573.1     25
 JMW54_02510   Clostridioides difficile CD2315 QQY66714.1     25
 JMW51_08085   Clostridioides difficile CD4401 QQY64929.1     25
 JMW55_10640   Clostridioides difficile CD9001 QQY58718.1     25
 JMW49_13685   Clostridioides difficile CD9301 QQY55884.1     25
 JMW52_07450   Clostridioides difficile CD9501 QQY54605.1     25
 JMW50_09750   Clostridioides difficile CD9701 QQY48447.1     25
 DDG61_13980   Clostridioides difficile CDT4 AWH78246.1     25
 GLV80_05795   Clostridioides difficile CFSAN096664 QOX86469.1     25
 CGC51_13185   Clostridioides difficile DH/NAP11/106/ST-42 ASN90242.1     25
 CDIF101085_02667   Clostridioides difficile DSM 101085 QPL00890.1     25
 CDIF102859_02851   Clostridioides difficile DSM 102859 AXU28558.1     25
 CDIF102860_02876   Clostridioides difficile DSM 102860 AXU32354.1     25
 CDIF102978_02876   Clostridioides difficile DSM 102978 AXU36142.1     25
 DSM105001_02811   Clostridioides difficile DSM 105001 QNG65755.1     25
 CDIF27638_02633   Clostridioides difficile DSM 27638 AXB61665.1     25
 CDIF27639_02666   Clostridioides difficile DSM 27639 AXB65394.1     25
 CDIF27640_02632   Clostridioides difficile DSM 27640 AXB69111.1     25
 CDIF28196_02645   Clostridioides difficile DSM 28196 AXU57982.1     25
 CDIF28666_02656   Clostridioides difficile DSM 28666 AXU61682.1     25
 cellulose endo-β-1,4-glucosidase (CDIF28668_02723) 3.2.1.4 Clostridioides difficile DSM 28668 AXU72614.1 A0A5Q9L120 6UJE[A]
6UJF[A] 		25
 CDIF28669_02680   Clostridioides difficile DSM 28669 AXU65284.1     25
 CDIF28670_02844   Clostridioides difficile DSM 28670 AXU76404.1     25
 CDIF29020_02735   Clostridioides difficile DSM 29020 AXU69003.1     25
 CDIF29627_02711   Clostridioides difficile DSM 29627 AXU47150.1     25
 CDIF29629_02667   Clostridioides difficile DSM 29629 AXU50808.1     25
 CDIF29632_02628   Clostridioides difficile DSM 29632 AXU83756.1     25
 CDIF29637_02704   Clostridioides difficile DSM 29637 AXU54427.1     25
 CDIF29688_02815   Clostridioides difficile DSM 29688 AXU80131.1     25
 CDIF29745_02714   Clostridioides difficile DSM 29745 AXU87502.1     25
 CDIF29747_02667   Clostridioides difficile DSM 29747 AXU91151.1     25
 A6J95_16270   Clostridioides difficile FDAARGOS_267 ARC16276.2     25
 FOC31_00985   Clostridioides difficile FDAARGOS_723 QGS41366.1     25
 JMW53_02465   Clostridioides difficile M120 QQY47039.1     25
 FQN08_13600   Clostridioides difficile Mta-79 QEK82219.1     25
 ERS445050_02541 (CelH)   Clostridioides difficile NCTC13307 CKH36269.1     25
 CWR57_12555   Clostridioides difficile R0104a AUA37788.1     25
 C4E25_05975   Clostridioides difficile R1 AVD42455.1     25
 C4E26_05970   Clostridioides difficile R2 AVD38929.1     25
 CDR20291_2433   Clostridioides difficile R20291 CBE05753.1     25
 C3L34_13715   Clostridioides difficile R20291 AVB38292.1     25
 CDIF27147_02709   Clostridioides difficile R20291 QPK97302.1     25
 C4E42_18635   Clostridioides difficile R3 AVD37620.1     25
 FTB24_05910   Clostridioides difficile TW11 QFS30906.1     25
 EUU24_05915   Clostridioides difficile TW11-RT078 QIF78115.1     25
 CWR54_12590   Clostridioides difficile W0003a AUA29857.1     25
 CWR55_12800   Clostridioides difficile W0022a AUA22565.1     25
 CWR56_12870   Clostridioides difficile W0023a AUA26314.1     25
 PCZ31_1913 (CelH)   Clostridioides difficile Z31 ALP03840.1     25
 JJC01_06650   Clostridioides sp. ES-S-0010-02 UDN60137.1     25
 JJC02_12330   Clostridioides sp. ES-S-0054-01 UDN53689.1     25
 JJC16_12635   Clostridioides sp. ES-S-0107-01 UDN50207.1     25
 JJJ25_13135   Clostridioides sp. ES-S-0173-01 UDN49407.1     25
 IC758_13875   Clostridioides sp. ES-W-0016-02 UDN63878.1     25
 HLV60_00760   Clostridium butyricum 16-3 QJU42938.1     25
 FBD77_15735   Clostridium butyricum 29-1 QCJ03910.1     25
 FBD76_06125   Clostridium butyricum 4-1 QCJ06003.1     25
 Q9978_16480   Clostridium butyricum CBM588 WLS67864.1     25
 KDJ93_15360   Clostridium butyricum CBUT QUF83084.1     25
 NPD4_734   Clostridium butyricum CDC_51208 APF24128.1     25
 HNS01_16510   Clostridium butyricum CFSA-TJ-E UTY54631.1     25
 EBL75_19620   Clostridium butyricum CFSA3987 QGH23711.1     25
 EBQ27_19625   Clostridium butyricum CFSA3989 QGH27756.1     25
 QVH08_17140   Clostridium butyricum DKU-11 WJV33950.1     25
 JZY05_16080   Clostridium butyricum DS501 QSX02554.1     25
 FF104_01705   Clostridium butyricum DSM 10702 QMW89696.1     25
 ATD26_15375   Clostridium butyricum JKY6D1 ALS18212.1     25
 ATN24_16655   Clostridium butyricum KNU-L09 ALP91715.1     25
 Cbu04g_32510   Clostridium butyricum NBRC 13949 BBK78243.1     25
 DRB99_01410   Clostridium butyricum S-45-5 AXB83642.1     25
 BBB49_14670   Clostridium butyricum TK520 AOR95284.1     25
 AZ909_15110   Clostridium butyricum TOA ANF15335.1     25
 O4N14_16170   Clostridium butyricum WQ1 WBP98792.1     25
 CNEO_4128   Clostridium neonatale CAH0438660.1     25
 ONV75_15870   Clostridium sp. LQ25 UZT06059.1     25
 A9D14_07150   Croceicoccus marinus E4A9 ARU16008.1     25
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