Glycoside Hydrolase Family 5 / Subf 25

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (168); Uniprot accession (23); PDB accession (16); 3D entries (3); cryst (0)
| 1 | 2 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Psesu_1585   Pseudoxanthomonas suwonensis 11-1 ADV27430.1     25
 UC35_16420   Ramlibacter tataouinensis 5-10 AMO25510.1     25
 Rta_10360   Ramlibacter tataouinensis TTB310 AEG92121.1     25
 RB5256   Rhodopirellula baltica SH 1 CAD78375.1
NP_866594.1
Q7UGF4   25
 Rpdx1_4768   Rhodopseudomonas palustris DX-1 ADU46314.1 D2M8H1   25
 AD2_02267   Ruminiclostridium thermocellum AD2 ALX09255.1     25
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8
Ruminiclostridium thermocellum ATCC 27405 ABN52701.1
CCF82162.1
P16218 4U3A[A,B]
4U5I[A,B]
4U5K[A,B]
5BYW[A,B,C,D,E]
25
 Clo1313_2234   Ruminiclostridium thermocellum DSM 1313 ADU75267.1     25
 LQRI_2266   Ruminiclostridium thermocellum DSM 2360 LQRI ANV77007.1     25
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4
3.2.1.73
Ruminiclostridium thermocellum NCIB 10682 AAA23225.1 H6SHY4
P16218
  25
 C1T17_01980   Sphingobium sp. SCG-1 AUW60024.1     25
 C1T17_03720 (fragment)   Sphingobium sp. SCG-1 AUW60059.1     25
 MC45_17220   Sphingomonas taxi ATCC 55669 AIT08352.1     25
 LPB140_05385   Sphingopyxis sp. LPB0140 APG62326.1     25
 BWQ93_10755 (fragment)   Sphingopyxis sp. QXT-31 APZ98920.1     25
 Sgly_1611   Syntrophobotulus glycolicus DSM 8271 ADY55909.1     25
 THTE_0890   Thermogutta terrifontis R1 ASV73492.1     25
 endoglucanase / β-mannanase (Tm_Cel5A;TM1751) (Cel5A) 3.2.1.4
3.2.1.78
Thermotoga maritima MSB8 AAD36816.1
AGL50683.1
AHD18355.1
AKE29506.1
NP_229549.1
Q9X273 3AMC[A,B]
3AMD[A,B,C,D]
3AMG[A,B]
3AOF[A,B]
3AZR[A,B]
3AZS[A,B]
3AZT[A,B,C,D]
3MMU[A,B,C,D,E,F,G,H]
3MMW[A,B,C,D]
25
 THMB_1793   Thermotoga maritima Tma100 AKE31377.1     25
 THMC_1793   Thermotoga maritima Tma200 AKE27633.1     25
 Sequence 27 from patent US 6368844   Thermotoga sp. CAH68695.1
AAM56794.1
CAT81458.1
    25
 TRQ2_1074   Thermotoga sp. RQ2 ACB09420.1 B1LAS2   25
 GH5   uncultured bacterium AQQ75170.1     25
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 uncultured bacterium ABE60714.1 Q1PDD8   25
 ORF (fragment)   uncultured bacterium ADV57600.1     25
 ORF (fragment)   uncultured bacterium ADV57604.1     25
 ORF (fragment)   uncultured bacterium ADV57605.1     25
 ORF (fragment)   uncultured bacterium ADV57607.1     25
 ORF (fragment)   uncultured bacterium ADV57608.1     25
 ORF (fragment)   uncultured bacterium ADV57609.1     25
 ORF (fragment)   uncultured bacterium ADV57610.1     25
 ORF (fragment)   uncultured bacterium ADV57618.1     25
 ORF (fragment)   uncultured bacterium ADV57619.1     25
 ORF (fragment)   uncultured bacterium ADV57620.1     25
 ORF (fragment)   uncultured bacterium ADV57621.1     25
 ORF (fragment)   uncultured bacterium ADV57622.1     25
 ORF (fragment)   uncultured bacterium ADV57625.1     25
 ORF (fragment)   uncultured bacterium ADV57626.1     25
 ORF (fragment)   uncultured bacterium ADV57628.1     25
 ORF (fragment)   uncultured bacterium ADV57629.1     25
 ORF (fragment)   uncultured bacterium ADV57631.1     25
 ORF (fragment)   uncultured bacterium ADV57633.1     25
 ORF   uncultured bacterium BAO65808.1     25
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 uncultured bacterium AID57617.1     25
 ORF   uncultured bacterium A2_10 AEW47942.1     25
 B1_GH5   uncultured bacterium B1_8 AEW47944.1     25
 B2_GH5   uncultured bacterium B2_18 AEW47949.1     25
 ORF   uncultured bacterium G2_7 AEW47966.1     25
 H2_GH5   uncultured bacterium H2_7 AEW47975.1     25
 endoglucanase   uncultured Dictyoglomus sp. ARO76321.1     25
 IMCC26134_05880   Verrucomicrobia bacterium IMCC26134 AKC82422.1     25
 SAMN05444156_2102   Verrucomicrobium sp. GAS474 SDU12473.1     25
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