Glycoside Hydrolase Family 5 / Subf 25

Activities in Sub FamilyEndo-β-1,4-glucanase (EC 3.2.1.4);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (505); Uniprot accession (15); PDB accession (24); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3DSubf
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8
pubmed
pubmed
Acetivibrio thermocellus ATCC 27405 ABN52701.1
CCF82162.1
H6SHY4
P16218
4U3A[A,B]
4U5I[A,B]
4U5K[A,B]
5BYW[A,B,C,D,E]
25
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4 pubmed
Acetivibrio thermocellus NCIB 10682 AAA23225.1 H6SHY4
P16218
  25
 Caul_1283 (Cel5A) 3.2.1.4 pubmed
Caulobacter sp. K31 ABZ70413.1 B0SYT2   25
 CDIF28668_02723 3.2.1.4 doi
Clostridioides difficile DSM 28668 AXU72614.1 A0A5Q9L120 6UJE[A]
6UJF[A]
25
 DICTH_0008 (Cel5A) 3.2.1.4 pubmed
Dictyoglomus thermophilum H-6-12 ACI18520.1 B5YAS2   25
 endoglucanase (LC1;CelA;Dtur_0670) (Cel5B) 3.2.1.4 pubmed
Dictyoglomus turgidum DSM 6724 ACK41955.1 B8DZM2   25
 endo-β-1,4-glucanase (FnCel5A;Fnod_1560) (Cel5A) 3.2.1.4 doi
Fervidobacterium nodosum Rt17-B1 ABS61403.1
ADD73709.1
A7HNC0
D4PEB3
3NCO[A,B]
3RJX[A]
3RJY[A]
25
 endoglucanase (BcelFp; Ferpe_1841) 3.2.1.4 pubmed
Fervidobacterium pennivorans DSM 9078 AFG35892.1   6KDD[A] 25
 endo-β-1,4-glucanase (MtGlu5; Mtai_v1c27890) 3.2.1.4 pubmed
Meiothermus taiwanensis WR-220 AWR88013.1   7VT4[A,B]
7VT5[A]
7VT6[A]
7VT7[A]
7VT8[A]
25
 endo-β-1,4-glucanase D (CelD;CelCCD;EGCCD;Ccel_0840) (Cel5D) 3.2.1.4 pubmed
Ruminiclostridium cellulolyticum H10 ACL75216.1
BAA14354.1
P25472.1
P25472   25
 endoglucanase / β-mannanase (Tm_Cel5A; TmCel5A; TM1751) (Cel5A) 3.2.1.4
3.2.1.78
pubmed
pubmed
Thermotoga maritima MSB8 AAD36816.1
AGL50683.1
AHD18355.1
AKE29506.1
NP_229549.1
Q9X273
R4P461
3AMC[A,B]
3AMD[A,B,C,D]
3AMG[A,B]
3AOF[A,B]
3AZR[A,B]
3AZS[A,B]
3AZT[A,B,C,D]
3MMU[A,B,C,D,E,F,G,H]
3MMW[A,B,C,D]
25
 endo-β-1,4-glucanase (Cel; CelH; CelRH5) 3.2.1.4 pubmed
uncultured bacterium QCI34346.1
QCI34340.1
VIO51607.1
    25
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 pubmed
uncultured bacterium ABE60714.1 Q1PDD8   25
 cellulase (C2P3) 3.2.1.4 pubmed
uncultured bacterium BAO65808.1     25
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 pubmed
uncultured bacterium AID57617.1 A0A068F0I2   25
 endoglucanase (EglDG) (fragment) 3.2.1.4 doi
uncultured Dictyoglomus sp. ARO76321.1 A0A1W6S733   25
 endoglucanase (Cel4; GC_Cel4) 3.2.1.4 pubmed
uncultured Dictyoglomus sp. QRN45943.1 A0A891XJK4   25
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