Glycoside Hydrolase Family 5 / Subf 25

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (135); Uniprot accession (23); PDB accession (16); 3D entries (3); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 Caul_1283 (Cel5A) 3.2.1.4 Caulobacter sp. K31 ABZ70413.1 B0SYT2   25
 endo-β-1,4-glucanase D (CelD;CelCCD;EGCCD;Ccel_0840) (Cel5D) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75216.1
BAA14354.1
P25472.1
P25472   25
 DICTH_0008 (Cel5A) 3.2.1.4 Dictyoglomus thermophilum H-6-12 ACI18520.1 B5YAS2   25
 endoglucanase (LC1;CelA;Dtur_0670) (Cel5B) 3.2.1.4 Dictyoglomus turgidum DSM 6724 ACK41955.1 B8DZM2   25
 endoglucanase (FgCel5A;Cel14.1) (Cel5A) 3.2.1.4 Fervidobacterium gondwanense AB39 AFY97404.1     25
 endo-β-1,4-glucanase (FnCel5A;Fnod_1560) (Cel5A) 3.2.1.4 Fervidobacterium nodosum Rt17-B1 ABS61403.1
ADD73709.1
A7HNC0 3NCO[A,B]
3RJX[A]
3RJY[A]
25
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8
Ruminiclostridium thermocellum ATCC 27405 ABN52701.1
CCF82162.1
P16218 4U3A[A,B]
4U5I[A,B]
4U5K[A,B]
5BYW[A,B,C,D,E]
25
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4
3.2.1.73
Ruminiclostridium thermocellum NCIB 10682 AAA23225.1 H6SHY4
P16218
  25
 endoglucanase / β-mannanase (Tm_Cel5A;TM1751) (Cel5A) 3.2.1.4
3.2.1.78
Thermotoga maritima MSB8 AAD36816.1
AGL50683.1
AHD18355.1
AKE29506.1
NP_229549.1
Q9X273 3AMC[A,B]
3AMD[A,B,C,D]
3AMG[A,B]
3AOF[A,B]
3AZR[A,B]
3AZS[A,B]
3AZT[A,B,C,D]
3MMU[A,B,C,D,E,F,G,H]
3MMW[A,B,C,D]
25
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 uncultured bacterium ABE60714.1 Q1PDD8   25
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 uncultured bacterium AID57617.1     25
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