Glycoside Hydrolase Family 5 / Subf 18

Activities in Sub Family	β-mannosidase (EC 3.2.1.25);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (733); Uniprot accession (5); PDB accession (12); 3D entries (5); cryst (0)

Summary

Download GH5_18 (728) Taxonomic display Structure (5) Characterized (5)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
GCM10025732_32200		Glycomyces mayteni JCM 16217	BFF25255.1			18
RGQ21_09360		Kitasatospora aureofaciens Tu117	BET45954.1			18
KPHV_14660		Kitasatospora purpeofusca HV058	BEK64239.1			18
RMN57_07385		Kitasatospora sp. CM 4170	WNM44546.1			18
O1G21_33225		Kitasatospora sp. HUAS 3-15	WBP90247.1			18
KitaXyl93_09130		Kitasatospora sp. Xyl93	BFD89553.1			18
Kfla_5464		Kribbella flavida DSM 17836	ADB34475.1			18
F1D05_08415		Kribbella qitaiheensis SPB151	QNE17909.1			18
OX958_10920		Kribbella sp. CA-293567	WBQ07294.1			18
KALB_7803		Kutzneria albida DSM 43870	AHI01161.1			18
Q4V64_40090		Kutzneria buriramensis DSM 45791	WKX13395.1			18
JJ691_88150		Kutzneria sp. CA-103260	QUQ71032.1			18
F1C12_10880		Leifsonia shinshuensis INR9	QNE35583.1			18
BBK82_04670		Lentzea guizhouensis DHS C013	ANZ35479.1			18
V1227_20670		Myxococcaceae DG1S-22	WVH77538.1			18
ND450_24370		Lentzea sp. HUAS12	USX48611.1			18
VV02_12290		Luteipulveratus mongoliensis MN07-A0370	AKU16465.1			18
FrondiHNR_04550		Lysinibacter sp. HNR	WGD38190.1			18
QUC20_13450		Microbacterium arborescens SSF12	WJM15268.1			18
KV397_01060		Microbacterium aurugineum KSW4-10	UPL16442.1			18
NFX31_15465		Microbacterium azadirachtae CNUC13	UXW85583.1			18
HCR76_12125		Microbacterium chengjingii HY60	QPZ37572.1			18
L2X98_03325 (fragment)		Microbacterium elymi KUDC0405	UJP13705.1			18
L2X98_03330 (fragment)		Microbacterium elymi KUDC0405	UJP13706.1			18
FVO59_04250		Microbacterium esteraromaticum B24	QMU96507.1			18
PTQ19_14220		Microbacterium esteraromaticum DEHP-1	WDH78652.1			18
B2G67_16940		Microbacterium foliorum 122	AQY02959.1			18
FIV50_16300		Microbacterium foliorum M2	QDE36208.1			18
DXT68_15600		Microbacterium foliorum NRRL B-24224	AXL13396.1			18
GCM10017544_17960		Microbacterium imperiale JCM 1378	BFE40840.1			18
T9R20_01565		Microbacterium invictum X-18	WQB70671.1			18
PWF71_15905		Microbacterium liquefaciens B1075	WEF20756.1			18
NMQ05_16765		Microbacterium liquefaciens DND4	UTT52712.1			18
QYR02_04465		Microbacterium liquefaciens MWF001	WKT90186.1			18
F6J85_06355		Microbacterium lushaniae L-031	QEW02761.1			18
KV395_00180		Microbacterium luteolum KACC 14465	WDM41775.1			18
JSY13_11580		Microbacterium neungamense EF45044	UWF78752.1			18
CVS54_03462		Microbacterium oxydans HG3	AZS42100.1			18
LRQ07_16580		Microbacterium oxydans J1-1	UUE20388.1			18
MME74_16830		Microbacterium oxydans ML-6	WAA65874.1			18
CVS53_03482		Microbacterium oxydans VIU2A	AZS48760.1			18
BO218_13700		Microbacterium paludicola CC3	APF35869.1			18
IZR02_15505		Microbacterium paraoxydans 70447	QXE29738.1			18
SAMN04489809_1783		Microbacterium paraoxydans DSM 15019	SDS40580.1			18
K8F61_15115		Microbacterium resistens MZT7	UGS25960.1			18
BMW26_16160		Microbacterium sp. 1.5R	APH46312.1			18
FGL91_03250		Microbacterium sp. CBA3102	QEA27661.1			18
AKG07_11415		Microbacterium sp. CGR1	AKV86804.1			18
JRG78_11590		Microbacterium sp. EF45047	WCM56917.1			18
V8Z62_04535		Microbacterium sp. GJ_SRA_44_2022	WWS85496.1			18
MNR00_01635		Microbacterium sp. H1-D42	UNK71177.1			18
L2X99_16105 (fragment)		Microbacterium sp. KUDC0406	UJP09876.1			18
L2X99_16100 (fragment)		Microbacterium sp. KUDC0406	UJP09875.1			18
LMS4_001777		Microbacterium sp. LMS4	WXK54131.1			18
LTA6_001480		Microbacterium sp. LTA6	WXH16074.1			18
AXH82_05045		Microbacterium sp. PAMC 28756	AMG82826.1			18
K1X59_19030		Microbacterium sp. Se5.02b	QYM64139.1			18
G4G29_18975		Microbacterium sp. Se63.02b	QNA93843.1			18
KV396_04955		Microbacterium sp. SSW1-36	UPL13864.1			18
KV396_01300 (fragment)		Microbacterium sp. SSW1-36	UPL16043.1			18
KV394_03815		Microbacterium sp. SSW1-51	UPL10287.1			18
C6C15_15760		Microbacterium sp. str. China	AVL98436.1			18
AB663_000615 (MiGH)		Microbacterium sp. XT11	ALX65853.1 WP_067195711.1			18
CSX12_17190		Microbacterium sp. Y-01	AZH80057.1			18
GCM10025863_28490 (fragment)		Microbacterium suwonense NBRC 106310	BDZ40235.1			18
GCM10025863_28480 (fragment)		Microbacterium suwonense NBRC 106310	BDZ40234.1			18
E4K62_06620		Microbacterium wangchenii dk512	QBR88390.1			18
MOP44_11655		Occallatibacter riparius DSM 25168	UWZ86574.1			18
QEH68_20025		Paenarthrobacter sp. OM7	WGM20272.1			18
QEH68_20205		Paenarthrobacter sp. OM7	WGM20304.1			18
B0X70_00255		Photorhabdus akhurstii 0813-124 phase II	QXF31783.1			18
A4R40_00250		Photorhabdus luminescens DSPV002N	AWK40069.1			18
BWO91_14120 (fragment)		Plantibacter flavus 251	AQX82249.1			18
GCM10025730_16380		Promicromonospora thailandica JCM 17130	BFF18117.1			18
BCB70_11200		Propionibacterium sp. oral taxon 193 F0672	AOH46374.1			18
GCE65_15090		Pseudactinotalea sp. HY158	QGH70669.1			18
EWM63_01710		Pseudoduganella lutea DSM 17473	QBE61870.1			18
AFB00_25645		Pseudonocardia sp. HH130630-07	ANY09081.1			18
UM93_09880		Psychromicrobium lacuslunae IHBB 11108	AJT41747.1			18
IM660_14780		Ruania alkalisoli RN3S43	QOR69901.1			18
IM660_17295		Ruania alkalisoli RN3S43	QOR70330.1			18
LQF10_13540		Ruania halotolerans M4N3S171	UFU05463.1			18
LQF10_17245 (fragment)		Ruania halotolerans M4N3S171	UFU06150.1			18
LQF10_17240 (fragment)		Ruania halotolerans M4N3S171	UFU06149.1			18
LQF12_02965		Ruania suaedae LR1S40	UFU03586.1			18
JQX30_26680 (fragment)		Saccharopolyspora erythraea NRRL 23338	QRK88253.1			18
SACE_5271 (fragment)		Saccharopolyspora erythraea NRRL 2338	CAM04510.1			18
HUO13_29370 (fragment)		Saccharopolyspora erythraea SCSIO 07745	QUH06343.1			18
GCM10017745_69140		Saccharothrix mutabilis subsp. capreolus JCM 4248	BFE53487.1			18
Sare_1078		Salinispora arenicola CNS-205	ABV96986.1			18
Strop_1185		Salinispora tropica CNB-440	ABP53655.1			18
Sked_14820		Sanguibacter keddieii DSM 10542	ACZ21418.1			18
SANBI_001420		Sanguibacter sp. 4.1	WPF83725.1			18
SAMN04489714_2031		Schaalia radingae DSM 9169	SDU07880.1			18
I6B53_02445		Schaalia sp. 19OD2882	QWW20596.1			18
Snas_2011		Stackebrandtia nassauensis DSM 44728	ADD41706.1			18
SCAT_p1024		Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488	CCB72048.1			18
β-1,4-mannosidase (ScGH5_18; SCATT_p07120)	3.2.1.25	Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488	AEW98905.1	F8JJ04	7LR7[A] 7LR8[A,B]	18
DMT42_33560		Streptomyces actuosus ATCC 25421	AWT46729.1			18
K1J60_38625		Streptomyces akebiae MG28	QYX83412.1			18
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