Glycoside Hydrolase Family 5 / Subf 18

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (204); Uniprot accession (21);
All (201) Bacteria (201)
| 1 | 2 | 3 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ALW22_07375   Cutibacterium acnes PA_30_2_L1 ALT33333.1     18
 HMPREF0675_4517   Cutibacterium acnes SK137 ADD99013.1 D4HEZ6   18
 TIIST44_00285   Cutibacterium acnes subsp. defendens ATCC 11828 AER04593.1     18
 TIA2EST22_07285   Cutibacterium acnes TypeIA2 P.acn17 AEW81769.1     18
 TIA2EST36_07270   Cutibacterium acnes TypeIA2 P.acn31 AEW84036.1     18
 TIA2EST2_07195   Cutibacterium acnes TypeIA2 P.acn33 AEW79524.1     18
 PALO_03800   Cutibacterium avidum 44067 AGJ77370.1     18
 BFS79_11990   Cutibacterium avidum DPC 6544 AOG29094.1     18
 COP05_09690   Dermabacter jinjuensis 32T ATH97316.1     18
 DAD186_02050   Dermabacter vaginalis AD1-86 ANP26764.1     18
 Kfla_5464   Kribbella flavida DSM 17836 ADB34475.1 D2PMA7   18
 KALB_7803   Kutzneria albida DSM 43870 AHI01161.1     18
 BBK82_04670   Lentzea guizhouensis DHS C013 ANZ35479.1     18
 VV02_12290   Luteipulveratus mongoliensis MN07-A0370 AKU16465.1     18
 B2G67_16940   Microbacterium foliorum 122 AQY02959.1     18
 DXT68_15600   Microbacterium foliorum NRRL B-24224 AXL13396.1     18
 BO218_13700   Microbacterium paludicola CC3 APF35869.1     18
 SAMN04489809_1783   Microbacterium paraoxydans DSM 15019 SDS40580.1     18
 BMW26_16160   Microbacterium sp. 1.5R APH46312.1     18
 AKG07_11415   Microbacterium sp. CGR1 AKV86804.1     18
 AXH82_05045   Microbacterium sp. PAMC 28756 AMG82826.1     18
 C6C15_15760   Microbacterium sp. str. China AVL98436.1     18
 AB663_000615   Microbacterium sp. XT11 ALX65853.1     18
 A4R40_00250   Photorhabdus luminescens DSPV002N AWK40069.1     18
 BWO91_14120 (fragment)   Plantibacter flavus 251 AQX82249.1     18
 BCB70_11200   Propionibacterium sp. oral taxon 193 F0672 AOH46374.1     18
 AFB00_25645   Pseudonocardia sp. HH130630-07 ANY09081.1     18
 UM93_09880   Arthrobacter sp. IHBB 11108 AJT41747.1     18
 SACE_5271 (fragment)   Saccharopolyspora erythraea NRRL 2338 CAM04510.1     18
 Sare_1078   Salinispora arenicola CNS-205 ABV96986.1 A8M5B2   18
 Strop_1185   Salinispora tropica CNB-440 ABP53655.1 A4X455   18
 Sked_14820   Sanguibacter keddieii DSM 10542 ACZ21418.1 D1BFQ7   18
 Snas_2011   Stackebrandtia nassauensis DSM 44728 ADD41706.1 D3Q0H0   18
 DMT42_33560   Streptomyces actuosus ATCC 25421 AWT46729.1     18
 SMD11_0766   Streptomyces albireticuli SMD11 ARZ66432.1     18
 SMD44_07664   Streptomyces alboflavus MDJK44 ARX88177.1     18
 DC74_7129   Streptomyces albulus NK660 AIA07557.1     18
 SAZ_36960   Streptomyces albulus ZPM AKA07371.1     18
 SLNHY_1504   Streptomyces albus BK3-25 AOU76195.1     18
 SLNWT_1503   Streptomyces albus DSM 41398 AJE81879.1     18
 SAM40697_6661   Streptomyces ambofaciens DSM 40697 ANB10614.1     18
 SAV7274   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC74985.1
NP_828450.1
    18
 SBI_00829   Streptomyces bingchenggensis BCW-1 ADI03950.1 D7C4C8   18
 SCAT_p1024   Streptomyces cattleya NRRL 8057 = DSM 46488 CCB72048.1     18
 SCATT_p07120   Streptomyces cattleya NRRL 8057 = DSM 46488 AEW98905.1     18
 SCO0949 or SCM11.04c   Streptomyces coelicolor A3(2) CAB61915.1
NP_625246.1
Q9RIV7   18
 B446_31815   Streptomyces collinus Tu 365 AGS73167.1     18
 BN159_1456   Streptomyces davaonensis JCM 4913 CCK25835.1     18
 KY5_7386   Streptomyces formicae KY5 ATL32404.1     18
 B1H19_36315   Streptomyces gilvosporeus F607 ARF58923.1     18
 C0216_07410   Streptomyces globosus LZH-48 AXE27344.1     18
 AVL59_16115   Streptomyces griseochromogenes ATCC 14511 ANP56544.1     18
 SHJG_0530   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY85807.1     18
 SHJGH_0363   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF60029.1     18
 SHL15_8397   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO99347.1     18
 ABB07_03975   Streptomyces incarnatus NRRL 8089 AKJ09211.1     18
 SLAV_11005   Streptomyces lavendulae subsp. lavendulae CCM 3239 ATZ24069.1     18
 SLCG_1944   Streptomyces lincolnensis LC-G AXG53099.1     18
 SLCG_1944   Streptomyces lincolnensis LC-G AXG53099.1     18
 SLINC_6472   Streptomyces lincolnensis NRRL 2936 ANS68696.1     18
 SLIV_33190   Streptomyces lividans TK24 AIJ17522.1     18
 SL103_21365   Streptomyces lydicus 103 AOP48446.1     18
 DC008_30540   Streptomyces nigra 452 AWE53593.1     18
 SNOD_04995   Streptomyces nodosus ATCC 14899 AJE39452.1     18
 SNOUR_06490   Streptomyces noursei ATCC 11455 ANZ14617.1     18
 B1H29_04150   Streptomyces pactum ACT12 AQS66237.1     18
 Spa2297_28905   Streptomyces parvulus 2297 ANJ10645.1     18
 LK06_001720   Streptomyces pluripotens MUSC 135 ARP73894.1     18
 LK07_02800   Streptomyces pluripotens MUSC 137 ASN28157.1     18
 SPRI_6676   Streptomyces pristinaespiralis HCCB 10218 ALC24982.1     18
 BFF78_05005   Streptomyces puniciscabiei TW1S1 AOR36892.1     18
 TUE45_00150   Streptomyces reticuli CUW25440.1     18
 A7J05_04260   Streptomyces silaceus ACCC40021 APY85054.1     18
 SAMN05428941_1007   Streptomyces sp. 2114.2 SDS71412.1     18
 GZL_01518   Streptomyces sp. 769 AJC54118.1     18
 T261_0639   Streptomyces sp. A02 AJT62328.1     18
 C2142_32270   Streptomyces sp. CB01881 AUY52806.1     18
 C4J65_01285   Streptomyces sp. CB09001 AXL87093.1     18
 NI25_03335   Streptomyces sp. CCM_MD2014 AIV32684.1     18
 AS200_07935   Streptomyces sp. CdTB01 ALV31970.1     18
 B1K54_26600   Streptomyces sp. fd1-xmd AQT74744.1     18
 C1703_30575   Streptomyces sp. Go-475 AXE89370.1     18
 DVK44_29925   Streptomyces sp. GSSD-12 AXG81212.1     18
 DVK44_33230   Streptomyces sp. GSSD-12 AXG81785.1     18
 DDW44_01210   Streptomyces sp. HNM0039 AWI27544.1     18
 DRB96_42080   Streptomyces sp. ICC1 AWZ17569.1     18
 DRB89_42000   Streptomyces sp. ICC4 AWZ09883.1     18
 M444_25515   Streptomyces sp. Mg1 AKL68224.1     18
 STRMOE7_34330   Streptomyces sp. MOE7 ARH94536.1     18
 DKG71_38990   Streptomyces sp. NEAU-S7GS2 AWN31267.1     18
 QR97_37890   Streptomyces sp. PBH53 AKN74717.1     18
 A8713_28445   Streptomyces sp. SAT1 ANH94624.1     18
 B6R96_09720   Streptomyces sp. Sge12 ARE74178.1     18
 SAMN05216371_6717   Streptomyces sp. TLI_053 SDT81587.1     18
 BSL84_24760   Streptomyces sp. TN58 APU42518.1     18
 DN051_07010   Streptomyces sp. ZFG47 AWW36418.1     18
 DDQ41_09690   Streptomyces spongiicola HNM0071 AWK09149.1     18
 BN2537_14531   Streptomyces venezuelae ATCC 15439 CUM42783.1     18
 AQF52_1325   Streptomyces venezuelae ATCC 15439 ALO06921.1     18
 Sros_5000   Streptosporangium roseum DSM 43021 ACZ87799.1 D2B8I9   18
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