Glycoside Hydrolase Family 5 / Subf 18

Activities in Sub Familyb-mannosidase (EC 3.2.1.25)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (503); Uniprot accession (5); PDB accession (12); 3D entries (5); cryst (0)
Bacteria
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 β-mannosidase active on Man-β-1,4-GlcNAc (BLD_0195)   Bifidobacterium longum DJO10A ACD97641.1  
6MOY[A,B] β-D-GlcpNAc
2.50
6MP2[A,B] 1.98
6MP7[A,B] β-D-GlcpNAc
1.75
6MPA[A,B] β-D-GlcpNAc
1.90
6MPC[A,B] 1.80
18
 Blon_2377   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53432.1  
7LQX[A] 1.30
18
 β-1,4-mannosidase (BlGH5_18; HMPREF0175_1989) 3.2.1.25 Bifidobacterium longum subsp. longum ATCC 55813 EEI79871.1 C2GY91
7LR1[A] 1.80
7LR2[A] β-D-GlcpNAc
2.40
7LR6[A] β-D-Manp-(1-4)-β-D-GlcpNAc
2.30
18
 exo-β-1,4-mannosidase (CaMan5_18; PAZ_c15370) 3.2.1.25 Cutibacterium acnes 266 AEE72695.1 A0A2B7I7A6
6GVB[A,B,C,D] 1.80
18
 β-1,4-mannosidase (ScGH5_18; SCATT_p07120) 3.2.1.25 Streptomyces cattleya NRRL 8057 = DSM 46488 AEW98905.1 F8JJ04
7LR7[A] β-D-GlcpNAc
1.95
7LR8[A] β-D-Manp-(1-4)-β-D-GlcpNAc
1.60
18
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