Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5822); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (5582) Archaea (1) Bacteria (5125) Eukaryota (415) Viruses (34) unclassified (7) Structure (21) Characterized (97)
| 1 | ... | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | ... | 53 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase   Friedmanniella sagamiharensis DSM 21743 SDV03301.1    
 Fuma_06499 (Neda_3)   Fuerstia marisgermanicae NH11 APZ96825.1    
 neuraminidase   Fuerstia marisgermanicae NH11 APZ92416.1    
 Fuma_01025 (Neda_1)   Fuerstia marisgermanicae NH11 APZ91437.1    
 Fuma_06711   Fuerstia marisgermanicae NH11 APZ97033.1    
 neuraminidase   Fuerstia marisgermanicae NH11 APZ91984.1    
 Fuma_05226 (Neda_2)   Fuerstia marisgermanicae NH11 APZ95567.1    
 Fuma_06543   Fuerstia marisgermanicae NH11 APZ96869.1    
 neuraminidase   Fuerstia marisgermanicae NH11 APZ92631.1    
 C4N19_02995 (fragment)   Fusobacterium mortiferum ATCC 9817 AVQ18135.1    
 C4N19_02990 (fragment)   Fusobacterium mortiferum ATCC 9817 AVQ18134.1    
 Galf_0202   Gallionella capsiferriformans ES-2 ADL54247.1 D9SIX1  
 sialidase A   Gardnerella vaginalis 114.2 AVI00648.1    
 sialidase A   Gardnerella vaginalis 47.3 AVI00643.1    
 sialidase A   Gardnerella vaginalis 58.4 AVI00644.1    
 sialidase A   Gardnerella vaginalis 60.1 AVI00645.1    
 sialidase A   Gardnerella vaginalis 79.2 AVI00646.1    
 sialidase A   Gardnerella vaginalis 86.1 AVI00647.1    
 GAVG_0056   Gardnerella vaginalis ATCC 14018 = JCM 11026 BAQ32708.1    
 sialidase A / 1A (HMPREF0421_20186)   Gardnerella vaginalis ATCC 14019 ADP38272.1
ZP_06945449.1
E3D837  
 SAMN04488545_0892   Gardnerella vaginalis DSM 4944 SDR88661.1    
 EGX90_01685   Gardnerella vaginalis FDAARGOS_568 AYZ21300.1    
 EGX90_01745   Gardnerella vaginalis FDAARGOS_568 AYZ21311.1    
 HMPREF9231_0063   Gardnerella vaginalis HMP9231 AEF32073.1    
 NCTC10287_00494 (NanA)   Gardnerella vaginalis NCTC10287 VEH17198.1    
 C1280_29950   Gemmata obscuriglobus DSM 5831 AWM40795.1
QEG25923.1
   
 neuraminidase   Gemmata obscuriglobus DSM 5831 AWM38855.1
QEG28144.1
   
 C1280_22045   Gemmata obscuriglobus DSM 5831 AWM39401.1
QEG27522.1
   
 VT84_27515 (NedA)   Gemmata sp. SH-PL17 AMV28186.1    
 VT84_17845   Gemmata sp. SH-PL17 AMV26266.1    
 VT84_34660   Gemmata sp. SH-PL17 AMV29588.1    
 PX52LOC_00021   Gemmataceae bacterium PX52 QEL13168.1    
 PX52LOC_04970   Gemmataceae bacterium PX52 QEL17956.1    
 PX52LOC_01811   Gemmataceae bacterium PX52 QEL14910.1    
 GEMMAAP_16565   Gemmatimonas phototrophica AP64 AMW06953.1    
 J421_4931   Gemmatirosa kalamazoonesis KBS708 AHG92466.1    
 GmarT_26950 (Neda_4)   Gimesia maris DSM 8797 QEG16826.1    
 GmarT_29290   Gimesia maris DSM 8797 QEG17053.1    
 GmarT_23840 (Neda_3)   Gimesia maris DSM 8797 QEG16519.1    
 GmarT_15580 (Neda_1)   Gimesia maris DSM 8797 QEG15715.1    
 GmarT_02490   Gimesia maris DSM 8797 QEG14414.1    
 GmarT_33500 (NanB)   Gimesia maris DSM 8797 QEG17469.1    
 GmarT_48220 (Neda_5)   Gimesia maris DSM 8797 QEG18927.1    
 GmarT_18020 (Neda_2)   Gimesia maris DSM 8797 QEG15941.1    
 neuraminidase (NanH)   Glaesserella parasuis 228/04 AFO42557.1    
 neuraminidase (NanH)   Glaesserella parasuis 264/99 AFO42555.1    
 B4U42_11815   Glaesserella parasuis 29755 AWY46572.1    
 neuraminidase (NanH)   Glaesserella parasuis 373/03A AFO42556.1    
 neuraminidase (NanH)   Glaesserella parasuis CA38-4 AFO42558.1    
 A2U20_00515   Glaesserella parasuis D74 ATW42399.1    
 FEF05_11525   Glaesserella parasuis HPS-1 QEM88993.1    
 neuraminidase (NanH)   Glaesserella parasuis IQ1N-6 AFO42553.1    
 neuraminidase (NanH)   Glaesserella parasuis ND14-1 AFO42552.1    
 neuraminidase (NanH) (fragment)   Glaesserella parasuis SH0165 ACL33167.1 B8F765  
 neuraminidase (NanH)   Glaesserella parasuis str. Nagasaki AFO42551.1
ATW46506.1
   
 neuraminidase (NanH)   Glaesserella parasuis SW114 AFO42550.1    
 neuraminidase (NanH)   Glaesserella parasuis VS6-2 AFO42554.1    
 K756_11020   Glaesserella parasuis ZJ0906 AGO17299.1    
 AOZ07_16730   Glutamicibacter arilaitensis KLBMP5180 ALG30462.1    
 FQA45_10515   Glutamicibacter halophytocola DR408 QDY66719.1    
 F0M17_08080   Glutamicibacter sp. ZJUTW QEP07182.1    
 C7S20_18790   Gramella sp. SH35 AVR47132.1    
 ENC22_24230   Hahella sp. KA22 AZZ94135.1
QAY57509.1
   
 Halsa_0570   Halanaerobium hydrogeniformans ADQ14035.1 E4RPL2  
 Halhy_4371   Haliscomenobacter hydrossis DSM 1100 AEE52215.1    
 neuraminidase   Haliscomenobacter hydrossis DSM 1100 AEE53841.1    
 Halhy_6270   Haliscomenobacter hydrossis DSM 1100 AEE54090.1    
 Halhy_3291   Haliscomenobacter hydrossis DSM 1100 AEE51150.1    
 neuraminidase   Hartmannibacter diazotrophicus type strain: E19 SON57480.1    
 neuraminidase   Helicobacter bilis AAQJH AQQ59642.1    
 HBZC1_15950   Helicobacter bizzozeronii CIII-1 CCB80581.1    
 HCW_06235   Helicobacter cetorum MIT 00-7128 AFI04507.1    
 HCD_01355   Helicobacter cetorum MIT 99-5656 AFI05303.1    
 NCTC13205_01210   Helicobacter cholecystus NCTC13205 VEJ25902.1    
 HCBAA847_1114   Helicobacter cinaedi CCUG 18818 = ATCC BAA-847 BAM32351.1    
 HC081234_09270   Helicobacter cinaedi MRY08-1234 BBB19750.1    
 HCN_0866   Helicobacter cinaedi PAGU611 BAM12120.1    
 neuraminidase   Helicobacter felis ATCC 49179 CBY82201.1    
 ORF   Helicobacter heilmannii ASB1.4 CCM11068.1    
 NCTC12198_00398   Helicobacter mustelae NCTC12198 SQH71148.1    
 neuraminidase   Helicobacter pylori SMA52593.1    
 CNX73_03735   Helicobacter pylori AVH12002.1    
 hp2017_0567   Helicobacter pylori 2017 ADZ49660.1    
 hp2018_0569   Helicobacter pylori 2018 ADZ51263.1    
 lipid A Kdo hydrolase (KdhA;HP0580;HP_0580) 3.2.1.- Helicobacter pylori 26695 AAD07646.1
NP_207375.1
   
 C694_02990   Helicobacter pylori 26695 AFV41799.1    
 SE87_03000   Helicobacter pylori 26695-1 AJF08862.1    
 SE88_03000   Helicobacter pylori 26695-1MET AJF10403.1    
 C2840_03015   Helicobacter pylori 26695-dR AUV77764.1    
 C2843_03010   Helicobacter pylori 26695-dRdM1dM2 AUV76274.1    
 C2842_03015   Helicobacter pylori 26695-dRdM2 AUV79273.1    
 OA23_03865   Helicobacter pylori 29CaP ALM79357.1    
 HMPREF4655_21021   Helicobacter pylori 35A ADU41116.1 D6UJN0  
 CV723_03740   Helicobacter pylori 7.13 QDY53307.1    
 BXP18_03735   Helicobacter pylori 7.13_1 AVG85439.1    
 BXP19_03730   Helicobacter pylori 7.13_2 AVG84000.1    
 BXP20_03765   Helicobacter pylori 7.13_3 AVG82582.1    
 BXP08_03740   Helicobacter pylori 7.13_D1a AVH00239.1    
 BXP09_03725   Helicobacter pylori 7.13_D1b AVH01687.1    
 BXP10_03730   Helicobacter pylori 7.13_D1c AVH03145.1    
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