Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1384); Uniprot accession (327); PDB accession (46); 3D entries (13); cryst (0)
All (1128) Archaea (1) Bacteria (797) Eukaryota (329) unclassified (1) Structure (13) Characterized (66)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-galactosidase (fragment)   Hordeum vulgare CAA74160.1 O04944  
 predicted protein   Hordeum vulgare subsp. vulgare BAK08274.1    
 ORF (fragment)   Hymenochirus curtipes AEQ18278.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56430.1    
 ORF (NagA)   Ictalurus punctatus AHH42335.1    
 α-galactosidase   Lachancea cidri AAA35280.1 Q99172  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 2861 BAD26713.1 Q6F3P6  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4104 BAD26714.1 Q6F3P8  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4566 BAD26715.1 Q6F3P5  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4568 BAD26716.1 Q6F3P6  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4569 BAD26717.1 Q6F3P5  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4570 BAD26718.1 Q6F3P4  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4798 BAD26719.1 Q6F3P4  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4799 BAD26720.1 Q6F3P4  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4800 BAD26721.1 Q6F3P4  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4801 BAD26722.1 Q6F3P4  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 5828 BAD26723.1 Q6F3P6  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 6545 BAD26724.1 Q6F3P5  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 6546 BAD26725.1 Q6F3N7  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 6547 BAD26726.1 Q6F3N5  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 6548 BAD26727.1 Q6F3N5  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 6626 BAD26728.1 Q6F3N5  
 α-galactosidase (MELk4) (fragment)   Lachancea kluyveri IFO 10847 BAB18272.1 Q9HGJ7  
 α-galactosidase (MELk5) (fragment)   Lachancea kluyveri IFO 10848 BAB18273.1 Q9HGJ6  
 α-galactosidase (MELk1) (fragment)   Lachancea kluyveri IFO 1685 BAB16832.1 Q9HGK0  
 α-galactosidase (MELk2) (fragment)   Lachancea kluyveri IFO 1811 BAB16833.1 Q9HGJ9  
 α-galactosidase (MELk3) (fragment)   Lachancea kluyveri IFO 1892 BAB16834.1 Q9HGJ8  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri NBRC 10955 BAD26712.1 Q6F3P4  
 α-galactosidase (MELth1)   Lachancea thermotolerans NBRC 10066 BAE93465.1 Q1MW33  
 α-galactosidase (MELth2)   Lachancea thermotolerans NBRC 10067 BAE93466.1 Q1MW32  
 α-N-acetylgalactosaminidase (NagAB)   Lepeophtheirus salmonis Pacific form ACO11760.1 C1BRV7  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX98481.1 E5A4D6  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX98927.1 E5A5M9  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX99070.1 E5A625  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX98985.1 E5A5U0  
 α-galactosidase (Agl1)   Leucoagaricus gongylophorus Ae322 CDJ79834.1    
 LRAMOSA00774   Lichtheimia ramosa CDS03372.1    
 LRAMOSA10906   Lichtheimia ramosa CDS09546.1    
 LRAMOSA02824   Lichtheimia ramosa CDS10147.1    
 ORF   Linum usitatissimum AND01154.1    
 ORF   Linum usitatissimum AND01164.1
AND01175.1
   
 ORF   Linum usitatissimum AND01152.1    
 ORF   Linum usitatissimum AFN53695.1    
 unknown (fragment)   Lotus japonicus AFK38956.1    
 unknown (fragment)   Lotus japonicus AFK44983.1    
 α-galactosidase A precursor, partial (GlA) (fragment)   Macaca mulatta AFE67944.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE73192.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE74309.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE69394.1    
 MG09805.4   Magnaporthe oryzae 70-15 XP_364960.1
EAA53842.1
G4NIK9  
 MG09989.4   Magnaporthe oryzae 70-15 XP_365144.1
EAA49825.1
G4N9L9  
 MGG_11374   Magnaporthe oryzae 70-15 XP_003713653.1
EAA50899.1
XP_362213.1
   
 MGG_16425   Magnaporthe oryzae 70-15 XP_003710505.1
XP_360246.1
   
 MTYFL_FM_FN_FO1G-H-16   Medicago truncatula ACJ85800.1 B7FM17  
 unknown (fragment)   Medicago truncatula AFK36253.1    
 unknown (fragment)   Medicago truncatula AFK41337.1    
 MtrDRAFT_AC149210g12v2   Medicago truncatula ABD32283.2
ABO80215.1
Q2HU62  
 MtrDRAFT_AC164249g26v1 or MtrDRAFT_AC153004g1v1   Medicago truncatula ABE26636.1
ABE26636.2
ABE87553.1
   
 MtrDRAFT_AC138580g35v1   Medicago truncatula ABE81161.1
ABE81161.2
   
 BN887_05747   Melanopsichium pennsylvanicum 4 CDI53950.1    
 BN887_03085   Melanopsichium pennsylvanicum 4 CDI54870.1    
 BN887_03027   Melanopsichium pennsylvanicum 4 CDI55002.1    
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Mus musculus AAC28851.1
AAH21631.1
AAL87527.1
AAL87528.1
BAC36620.1
BAE21730.1
BAE31642.1
CAA11703.1
NP_032695.2
Q9QWR8
Q9QWR8
 
 α-galactosidase A (Gls;Agl) (lysosomal) 3.2.1.22 Mus musculus AAA74453.1
AAA96749.1
AAB47244.1
AAC52583.1
AAC52584.1
AAH09021.1
BAC30508.1
BAC35819.1
BAE26260.1
BAE37692.1
BAE38627.1
BAE38657.1
CAM19136.1
CAM19137.1
NP_038491.1
P51569
Q8BGZ6
 
 ORF (fragment)   Musca domestica ALHF AFP62361.1    
 α-galactosidase (partial)   Mustela putorius furo AER99093.1    
 ORF   Mustela putorius furo AES02586.1    
 NGATSA_2059200 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69054.1    
 NCLIV_054050   Neospora caninum Liverpool CBZ54978.1    
 NCLIV_009150   Neospora caninum Liverpool CBZ50446.1    
 ORF   Nepenthes mirabilis AMN14859.1    
 ORF   Nepenthes mirabilis AMN14860.1    
 α-galactosidase   Nicotiana tabacum AEB98600.1    
 α-galactosidase   Nicotiana tabacum AEB98601.1    
 α-N-acetylgalactosaminidase   Nilaparvata lugens ANJ04640.1    
 Os01g0518500   Oryza sativa Japonica Group BAD73696.1
BAB91950.1
BAF05117.1
BAG90573.1
BAS72430.1
Q5QLK3  
 α-galactosidase II (Os07g0452100) 3.2.1.22 Oryza sativa Japonica Group BAF21463.1
BAC55816.1
BAC84411.1
BAT01318.1
Q0D6R0  
 α-galactosidase III (Os07g0679300) 3.2.1.22 Oryza sativa Japonica Group BAC79549.1
BAD31216.1
BAF22553.1
BAG94006.1
BAT03227.1
Q7XIV4  
 α-galactosidase I (Os10g0493600) 3.2.1.22 Oryza sativa Japonica Group BAB12570.1
AAM92832.1
AAO85428.1
AAP54412.1
ABB47819.1
BAF26853.1
BAT11449.1
BAT11450.1
BAT11451.1
BAT11452.1
NP_922125.1
F4MGX5
Q9FXT4
Q9FXT4
1UAS[A]
 Os10g0492900   Oryza sativa Japonica Group AAG13536.1
AAP54408.1
BAF26849.1
BAT11444.1
NP_922121.1
Q9FWV8  
 α-N-acetylgalactosaminidase (fragment)   Oryzias melastigma AEA51135.1    
 α-N-acetylgalactosaminidase (NagA)   Ovis aries ACB87536.1 B2LSM7  
 ORF   Papilio xuthus BAM17755.1    
 Pc21g14820   Penicillium rubens Wisconsin 54-1255 CAP96379.1 B6HIL7  
 α-galactosidase I (Agl1;AglI) 3.2.1.22 Penicillium simplicissimum VTT-D-78090 CAA08915.1 O94221  
 α-galactosidase (fragment)   Petunia x hybrida AAQ82455.1 Q6UAY5  
 α-galactosidase (AgalB) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24511.1 Q9HFZ9  
 α-galactosidase (AgalA) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24510.1 Q9HG00  
 α-galactosidase 3.2.1.22 Phaseolus vulgaris AAA73964.1
AAR65334.1
Q41100  
 BE285   Phaseolus vulgaris AHA84202.1    
 WS0285_J03   Picea sitchensis ABR17992.1 B8LQR2  
 WS02719_G07 (fragment)   Picea sitchensis ABR16121.1 B8LKE1  
 unknown   Picea sitchensis ADE77708.1 D5ADT9  
 unknown (WS02810_D08)   Picea sitchensis ABK24468.1 A9NV07  
 unknown (WS02910_M11)   Picea sitchensis ABK24922.1 A9NWB1  
 unknown (WS0294_N01)   Picea sitchensis ABK25009.1
ABR17777.1
A9NWJ8  
 α-galactosidase 1 (Gal1) 3.2.1.22 Pisum sativum CAF34023.1 Q5ZP79  
 Pa_5_6680   Podospora anserina S mat+ CAP65080.1
CDP29829.1
B2AM92  
 unnamed protein product   Podospora anserina S mat+ CAP71790.1
CDP31181.1
B2B3V4  
 V501_01477   Pseudogymnoascus sp. VKM F-4519 (FW-2642) KFZ17922.1    
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