Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1940); Uniprot accession (327); PDB accession (47); 3D entries (14); cryst (0)
All (1681) Archaea (1) Bacteria (1280) Eukaryota (395) Viruses (1) unclassified (4) Structure (14) Characterized (70)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Dbus_chr2Rg1085   Drosophila busckii ALC41506.1    
 CG5731   Drosophila melanogaster AAM29494.1
AAF52871.2
NP_609354.1
Q8MYY3
Q9VL27
 
 CG7997   Drosophila melanogaster AAL39572.1
AAF58008.2
AAM68519.1
NP_611119.1
NP_725571.1
Q7K127
Q9V7N9
 
 ORF (fragment)   Eimeria maxima Weybridge AGZ15735.1    
 FFUJ_13796   Fusarium fujikuroi IMI 58289 CCT72200.1    
 FFUJ_06678   Fusarium fujikuroi IMI 58289 CCT70688.1    
 FFUJ_11205   Fusarium fujikuroi IMI 58289 CCT75166.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF74290.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF88109.1    
 α-galactosidase / β-L-arabinopyranosidase (FoAp2) 3.2.1.22
3.2.1.88
Fusarium oxysporum 12S BAH10648.1 B7XH21  
 α-galactosidase / β-L-arabinopyranosidase (FoAp1) 3.2.1.22
3.2.1.88
Fusarium oxysporum 12S BAH10649.1 B7XH22  
 α-galactosidase / α-galactopyranosidase (FoGp1)   Fusarium oxysporum 12S BAJ23877.1 E2S091  
 FVRRES_10563   Fusarium venenatum A3/5 CEI70486.1    
 FVRRES_02440   Fusarium venenatum A3/5 CEI65928.1    
 α-N-acetylgalactosaminidase (α-NAGAL) 3.2.1.49 Gallus gallus AAA16614.1
AAE69554.1
Q90744 1KTB[A]
1KTC[A]
 Gal48   Glaciozyma antarctica ASS36260.1    
 unknown   Glycine max ACU23118.1 C6TJM8  
 unknown (fragment)   Glycine max ACU20569.1 C6TFG7  
 unknown (partial)   Glycine max ACU20662.1 C6TFR0  
 α-galactosidase 3.2.1.22 Glycine max AAA73963.1
AAR65332.1
ACU23822.1
Q39811  
 α-galactosidase (Gla) 3.2.1.22 Helianthus annuus BAC66445.1 Q84VQ7  
 ORF (fragment)   Heterocapsa triquetra AAW79376.1 Q5ENL7  
 ORF   Heterodera avenae AVA09680.1    
 α-galactosidase A (Gla;α-GAL) 3.2.1.22 Homo sapiens AAH02689.1
AAA51676.1
AAA52514.1
AAA52559.1
AAB64203.1
AAE66433.1
AAE69556.1
AAN92813.1
AAP35510.1
AAQ31818.1
AAQ68716.1
AAQ81221.1
AAY03282.1
AAY71885.1
AAY71886.1
AAY71887.1
AAY71888.1
AAY71889.1
AAY71890.1
AAY71891.1
AAY71892.1
AAY71893.1
AAY71894.1
AAY72531.1
AAY72532.1
AAY72533.1
AAY72534.1
AAY72535.1
AAY72536.1
AAY72537.1
AAY72538.1
AAY72539.1
AAY72540.1
ABE23230.1
ABL16360.1
ABL21591.1
ACH14962.1
ACK10792.1
BAA34059.1
BAD96347.1
BAF83784.1
BAG59647.1
BAT62474.1
CAA29232.1
CAA32617.1
CAB55878.1
CAC09605.1
CAE85447.1
CAV33302.1
NP_000160.1
P06280
Q53Y83
1R46[A,B]
1R47[A,B]
3GXN[A,B]
3GXP[A,B]
3GXT[A,B]
3HG2[A,B]
3HG3[A,B]
3HG4[A,B]
3HG5[A,B]
3LX9[A,B]
3LXA[A,B]
3LXB[A,B]
3LXC[A,B]
3S5Y[A,B]
3S5Z[A,B]
3TV8[A,B]
4NXS[A,B]
 α-N-acetylgalactosaminidase / α-galactosidase B (bK250D10.5;NagA;α-NAGAL) 3.2.1.22
3.2.1.49
Homo sapiens AAA36351.1
AAA51677.1
AAA59902.1
AAB06718.1
AAE69555.1
AAH00095.1
ACM80412.1
ACM85401.1
ASU96594.1
CAB41237.1
CAG30413.1
CAX14869.1
CAX14870.1
NP_000253.1
P17050 3H53[A,B]
3H54[A,B]
3H55[A,B]
3IGU[A,B]
4DO4[A,B]
4DO5[A,B]
4DO6[A,B]
 α-galactosidase (fragment)   Hordeum vulgare CAA74161.1 O04943  
 α-galactosidase (fragment)   Hordeum vulgare CAA74160.1 O04944  
 predicted protein   Hordeum vulgare subsp. vulgare BAK08274.1    
 ORF (fragment)   Hymenochirus curtipes AEQ18278.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56430.1    
 ORF (NagA)   Ictalurus punctatus AHH42335.1    
 α-galactosidase   Lachancea cidri AAA35280.1 Q99172  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 2861 BAD26713.1 Q6F3P6  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4104 BAD26714.1 Q6F3P8  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4566 BAD26715.1 Q6F3P5  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4568 BAD26716.1 Q6F3P6  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4569 BAD26717.1 Q6F3P5  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4570 BAD26718.1 Q6F3P4  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4798 BAD26719.1 Q6F3P4  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4799 BAD26720.1 Q6F3P4  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 4800 BAD26721.1 Q6F3P4  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 4801 BAD26722.1 Q6F3P4  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 5828 BAD26723.1 Q6F3P6  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 6545 BAD26724.1 Q6F3P5  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 6546 BAD26725.1 Q6F3N7  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 6547 BAD26726.1 Q6F3N5  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri CBS 6548 BAD26727.1 Q6F3N5  
 α-galactosidase (MELk) (fragment)   Lachancea kluyveri CBS 6626 BAD26728.1 Q6F3N5  
 α-galactosidase (MELk4) (fragment)   Lachancea kluyveri IFO 10847 BAB18272.1 Q9HGJ7  
 α-galactosidase (MELk5) (fragment)   Lachancea kluyveri IFO 10848 BAB18273.1 Q9HGJ6  
 α-galactosidase (MELk1) (fragment)   Lachancea kluyveri IFO 1685 BAB16832.1 Q9HGK0  
 α-galactosidase (MELk2) (fragment)   Lachancea kluyveri IFO 1811 BAB16833.1 Q9HGJ9  
 α-galactosidase (MELk3) (fragment)   Lachancea kluyveri IFO 1892 BAB16834.1 Q9HGJ8  
 α-galactosidase (MelK) (fragment)   Lachancea kluyveri NBRC 10955 BAD26712.1 Q6F3P4  
 α-galactosidase (MELth1)   Lachancea thermotolerans NBRC 10066 BAE93465.1 Q1MW33  
 α-galactosidase (MELth2)   Lachancea thermotolerans NBRC 10067 BAE93466.1 Q1MW32  
 α-N-acetylgalactosaminidase (NagAB)   Lepeophtheirus salmonis Pacific form ACO11760.1 C1BRV7  
 LSINAPIS_LOCUS7546   Leptidea sinapis VUY95965.1    
 LSINAPIS_LOCUS274   Leptidea sinapis VUY86386.1    
 LSINAPIS_LOCUS644   Leptidea sinapis VUY86840.1    
 ORF   Leptosphaeria maculans JN3 CBX98481.1 E5A4D6  
 ORF   Leptosphaeria maculans JN3 CBX98927.1 E5A5M9  
 ORF   Leptosphaeria maculans JN3 CBX99070.1 E5A625  
 ORF   Leptosphaeria maculans JN3 CBX98985.1 E5A5U0  
 α-galactosidase (Agl1)   Leucoagaricus gongylophorus Ae322 CDJ79834.1    
 LRAMOSA00774   Lichtheimia ramosa CDS03372.1    
 LRAMOSA10906   Lichtheimia ramosa CDS09546.1    
 LRAMOSA02824   Lichtheimia ramosa CDS10147.1    
 ORF   Linum usitatissimum AND01154.1    
 ORF   Linum usitatissimum AND01164.1
AND01175.1
   
 ORF   Linum usitatissimum AND01152.1    
 ORF   Linum usitatissimum AFN53695.1    
 unknown (fragment)   Lotus japonicus AFK38956.1    
 unknown (fragment)   Lotus japonicus AFK44983.1    
 α-galactosidase   Lycium barbarum AZA15164.1    
 α-galactosidase A precursor, partial (GlA) (fragment)   Macaca mulatta AFE67944.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE73192.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE74309.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE69394.1    
 MTYFL_FM_FN_FO1G-H-16   Medicago truncatula ACJ85800.1 B7FM17  
 unknown (fragment)   Medicago truncatula AFK36253.1    
 unknown (fragment)   Medicago truncatula AFK41337.1    
 MtrDRAFT_AC149210g12v2   Medicago truncatula ABD32283.2
ABO80215.1
Q2HU62  
 MtrDRAFT_AC164249g26v1 or MtrDRAFT_AC153004g1v1   Medicago truncatula ABE26636.1
ABE26636.2
ABE87553.1
   
 MtrDRAFT_AC138580g35v1   Medicago truncatula ABE81161.1
ABE81161.2
   
 BN887_05747   Melanopsichium pennsylvanicum 4 CDI53950.1    
 BN887_03085   Melanopsichium pennsylvanicum 4 CDI54870.1    
 BN887_03027   Melanopsichium pennsylvanicum 4 CDI55002.1    
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Mus musculus AAC28851.1
AAH21631.1
AAL87527.1
AAL87528.1
BAC36620.1
BAE21730.1
BAE31642.1
CAA11703.1
NP_032695.2
Q9QWR8
Q9QWR8
 
 α-galactosidase A (Gls;Agl) (lysosomal) 3.2.1.22 Mus musculus AAA74453.1
AAA96749.1
AAB47244.1
AAC52583.1
AAC52584.1
AAH09021.1
BAC30508.1
BAC35819.1
BAE26260.1
BAE37692.1
BAE38627.1
BAE38657.1
CAM19136.1
CAM19137.1
NP_038491.1
P51569
Q8BGZ6
 
 ORF (fragment)   Musca domestica ALHF AFP62361.1    
 α-galactosidase (partial)   Mustela putorius furo AER99093.1    
 ORF   Mustela putorius furo AES02586.1    
 NGATSA_2059200 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69054.1    
 NCLIV_054050   Neospora caninum Liverpool CBZ54978.1    
 NCLIV_009150   Neospora caninum Liverpool CBZ50446.1    
 ORF   Nepenthes mirabilis AMN14859.1    
 ORF   Nepenthes mirabilis AMN14860.1    
 α-galactosidase 3.2.1.22 Nicotiana benthamiana     6F4C[B]
 α-galactosidase   Nicotiana tabacum AEB98600.1    
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