Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1562); Uniprot accession (327); PDB accession (47); 3D entries (14); cryst (0)
All (1305) Archaea (1) Bacteria (955) Eukaryota (347) Viruses (1) unclassified (1) Structure (14) Characterized (69)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 WS02719_G07 (fragment)   Picea sitchensis ABR16121.1 B8LKE1  
 unknown   Picea sitchensis ADE77708.1 D5ADT9  
 unknown (WS02810_D08)   Picea sitchensis ABK24468.1 A9NV07  
 unknown (WS02910_M11)   Picea sitchensis ABK24922.1 A9NWB1  
 unknown (WS0294_N01)   Picea sitchensis ABK25009.1
ABR17777.1
A9NWJ8  
 α-galactosidase 1 (Gal1) 3.2.1.22 Pisum sativum CAF34023.1 Q5ZP79  
 Pa_5_6680   Podospora anserina S mat+ CAP65080.1
CDP29829.1
B2AM92  
 unnamed protein product   Podospora anserina S mat+ CAP71790.1
CDP31181.1
B2B3V4  
 ORF   Pristhesancus plagipennis ATU82754.1    
 V501_01477   Pseudogymnoascus sp. VKM F-4519 (FW-2642) KFZ17922.1    
 α-galactosidase (Gal1) 3.2.1.22 Rasamsonia emersonii ABU94728.1 A7XZT2  
 Unknown (protein for MGC:95262)   Rattus norvegicus AAH82084.1 Q66H12  
 ORF (fragment)   Rimicaris exoculata ACR78680.1 C5HTY1  
 ORF   Riptortus pedestris BAN20212.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces arboricola AS 2.3318 CUW00885.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces arboricola AS 2.3319 CUW00887.1    
 α-galactosidase (Mel) (fragment)   Saccharomyces bayanus CBS 380 AAQ17217.1 Q6WN36  
 α-galactosidase (Mel1)   Saccharomyces bayanus NRRL Y-1551 CBY84987.1    
 α-galactosidase (Mel1)   Saccharomyces bayanus type strain: CBS 380 CBY84985.1    
 galactosidase / melibiase   Saccharomyces carlsbergensis AAA34770.1    
 α-galactosidase (MEL) 3.2.1.22 Saccharomyces carlsbergensis NCYC396 AAA34769.1 Q03647  
 α-galactosidase 1 (Mel1;ScMel1) 3.2.1.22 Saccharomyces cerevisiae CAA26888.1
AAE69557.1
CBY84983.1
CBY84984.1
CUW00903.1
CUW00905.1
CUW00906.1
F4N9N8
P04824
3LRK[A]
3LRL[A]
3LRM[A,B,C,D]
 α-galactosidase 2 (Mel2) 3.2.1.22 Saccharomyces cerevisiae CAA85737.1 P41945  
 α-galactosidase 5 (Mel5) 3.2.1.22 Saccharomyces cerevisiae CAA85740.1 P41946  
 α-galactosidase 6 (Mel6) 3.2.1.22 Saccharomyces cerevisiae CAA85739.1 P41947  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae CBS 2444 CUW00896.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae CBS 4734 CUW00898.1    
 α-galactosidase (MEL)   Saccharomyces cerevisiae NCYC686 AAL07760.1 E9P8G8
Q96UV4
 
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 03.461.4 CUW00899.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 05.217.3 CUW00900.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 05.227.2 CUW00901.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 1260 SBT28030.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 2156 SBT28031.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 8834 SBT28032.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus x Saccharomyces uvarum NCAIM00676 SBT28034.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus x Saccharomyces uvarum NCAIM00677 SBT28035.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces kudriavzevii x Saccharomyces uvarum CBS 8614 (CID1) SBT28033.1    
 α-galactosidase (Mel1)   Saccharomyces eubayanus CBS 12357 CCG27770.1    
 α-galactosidase (MELj) 3.2.1.22 Saccharomyces mikatae IFO 1816 CAA64760.1 Q11129  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces mikatae NBRC 1816 CUW00891.1    
 α-galactosidase (MELp) 3.2.1.22 Saccharomyces paradoxus 61-248 CAA64759.1 Q09187  
 α-galactosidase (Mel1)   Saccharomyces pastorianus CBS 1503 CCG27771.1    
 α-galactosidase (Mel) (fragment)   Saccharomyces pastorianus CBS 1538 AAQ17218.1 Q6WN35  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces uvarum CBS 14186 (VN-5A) SBT28037.1    
 α-galactosidase (Mel1)   Saccharomyces uvarum CBS 1545 CBY84990.1    
 α-galactosidase (Mel1)   Saccharomyces uvarum CBS 2946 CBY84988.1
CBY84989.1
CCA89532.1
   
 α-galactosidase (Mel1)   Saccharomyces uvarum CBS 425 CCG27777.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces uvarum NCAIM00789 SBT28036.1    
 α-galactosidase (Mel1)   Saccharomyces uvarum type strain: CBS 395 CBY84986.1    
 α-N-acetylgalactosaminidase (NagaB) (fragment)   Salmo salar ACI33826.1 B5X3E5  
 AgaL   Salmo salar ACN10914.1 C0HA45  
 NagaB   Salmo salar ACN10976.1 C0HAA7  
 BT072612 (fragment)   Salmo salar ACN60308.1 C0PUN5  
 ORF   Salvia miltiorrhiza AAU86897.1 Q5XTZ3  
 α-N-acetylgalactosaminidase (NagA)   Schistosoma japonicum CAX70042.1
AAW26732.1
CAX70041.1
CAX70043.1
Q5DBS4  
 unknown (fragment)   Schistosoma japonicum AAX25755.1
AAX25755.2
Q5C3M0  
 SJCHGC03011 (fragment)   Schistosoma japonicum AAX25683.2 Q5C3U2  
 Smp_089290   Schistosoma mansoni Puerto Rico CAY17477.1
CCD80298.1
C1M0A5  
 Smp_170830 (fragment)   Schistosoma mansoni Puerto Rico CAY17473.1
CCD80294.1
C1M097  
 Smp_089270 (fragment)   Schistosoma mansoni Puerto Rico CAY17474.1
CCD80295.1
C1M098  
 Smp_170840 (fragment)   Schistosoma mansoni Puerto Rico CAY17475.1
CCD80296.1
C1M099  
 Smp_179260 (partial)   Schistosoma mansoni Puerto Rico CAZ37305.1
CCD80291.1
C4QPB8  
 Smp_179260 (partial)   Schistosoma mansoni Puerto Rico CAZ37305.1
CCD80291.1
C4QPB8  
 Smp_179250   Schistosoma mansoni Puerto Rico CAZ37304.1
CCD80292.1
C4QPB7  
 Smp_186710 (fragment)   Schistosoma mansoni Puerto Rico CAZ38188.1
CCD80293.1
C4QRV1  
 α-galactosidase (Mel1;SPAC869.07c) 3.2.1.22 Schizosaccharomyces pombe 972h- CAB60017.1
NP_595012.1
Q9URZ0  
 sscle_03g025620   Sclerotinia sclerotiorum 1980 UF-70 APA07792.1    
 sscle_02g015110   Sclerotinia sclerotiorum 1980 UF-70 APA06741.1    
 sscle_01g005950   Sclerotinia sclerotiorum 1980 UF-70 APA05825.1    
 sscle_07g056960   Sclerotinia sclerotiorum 1980 UF-70 APA10926.1    
 SMAX5B_009290   Scophthalmus maximus AWP11824.1    
 SMAX5B_008254   Scophthalmus maximus AWP19888.1    
 ORF (fragment)   Secale cereale ACJ06604.1 B6VCK1  
 unnamed protein product   Senna occidentalis CAA03733.1    
 PIIN_05502   Serendipita indica DSM 11827 CCA71565.1    
 PIIN_08399   Serendipita indica DSM 11827 CCA74446.1    
 PIIN_08905   Serendipita indica DSM 11827 CCA74935.1    
 α-galactosidase (LeaGal) 3.2.1.22 Solanum lycopersicum AAF04591.1
AAG16693.1
Q9FUR8
Q9SP05
 
 SRS1_15386   Sporisorium reilianum f. sp. reilianum SRS1_H2-8 SJX64569.1    
 SRS1_15067   Sporisorium reilianum f. sp. reilianum SRS1_H2-8 SJX64426.1    
 sr15067   Sporisorium reilianum SRZ2 CBQ68784.1    
 sr15386   Sporisorium reilianum SRZ2 CBQ68925.1    
 SPSC_05590   Sporisorium scitamineum SscI8 CDR88758.1    
 SPSC_04760   Sporisorium scitamineum SscI8 CDU24927.1    
 SRAE_1000106900   Strongyloides ratti ED321 Heterogonic CEF62800.1    
 α-galactosidase A   Sus scrofa ACD67895.1
ACD67896.1
D5FGE4  
 α-N-acetylgalactosaminidase (NagA)   Sus scrofa ACA43013.1 B1PK16  
 Agal   Takifugu rubripes CAC44626.1 Q90WL7  
 α-galactosidase (Aga27A) 3.2.1.22 Talaromyces leycettanus JCM12802 AJF11712.1    
 α-galactosidase (aGal) 3.2.1.22 Talaromyces purpureogenus 618 BAA22992.1 O13295  
 α-galactopyranosidase (Gla1;GLA1)   Talaromyces purpureogenus ATCC MYA-38 AKH40275.1    
 α-galactosidase (TcGal27A) (Gal27A) 3.2.1.22 Thermoascus crustaceus JCM12803 ATO91445.1    
 MYCTH_2119446 (Aga1)   Thermothelomyces thermophila ATCC 42464 AEO59170.1    
 MYCTH_2313137 (Aga2)   Thermothelomyces thermophila ATCC 42464 AEO62124.1    
 α-galactosidase (Aga2)   Thermothelomyces thermophila C1 AFJ59927.1    
 α-galactosidase (Aga1;aGal1) 3.2.1.22 Thermothelomyces thermophila C1 AFJ59926.1    
 α-galactosidase   Thielavia terrestris CAU709 ARI48112.1    
 THITE_2124844   Thielavia terrestris NRRL 8126 AEO71949.1    
 α-galactosidase (MELt) 3.2.1.22 Torulaspora delbrueckii BAA86883.1 Q9UVD6  
 TDEL_0E00170 (Tdel0e00170) (fragment)   Torulaspora delbrueckii type strain:CBS 1146 CCE92260.1    
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