Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (2172); Uniprot accession (327); PDB accession (51); 3D entries (14); cryst (0)
All (1914) Archaea (1) Bacteria (1472) Eukaryota (430) Viruses (1) unclassified (10) Structure (14) Characterized (70)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF   Linum usitatissimum AFN53695.1    
 unknown (fragment)   Lotus japonicus AFK38956.1    
 unknown (fragment)   Lotus japonicus AFK44983.1    
 α-galactosidase   Lycium barbarum AZA15164.1    
 α-galactosidase A precursor, partial (GlA) (fragment)   Macaca mulatta AFE67944.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE73192.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE74309.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE69394.1    
 MTYFL_FM_FN_FO1G-H-16   Medicago truncatula ACJ85800.1 B7FM17  
 unknown (fragment)   Medicago truncatula AFK36253.1    
 unknown (fragment)   Medicago truncatula AFK41337.1    
 MtrDRAFT_AC149210g12v2   Medicago truncatula ABD32283.2
ABO80215.1
Q2HU62  
 MtrDRAFT_AC164249g26v1 or MtrDRAFT_AC153004g1v1   Medicago truncatula ABE26636.1
ABE26636.2
ABE87553.1
   
 MtrDRAFT_AC138580g35v1   Medicago truncatula ABE81161.1
ABE81161.2
   
 BN887_05747   Melanopsichium pennsylvanicum 4 CDI53950.1    
 BN887_03085   Melanopsichium pennsylvanicum 4 CDI54870.1    
 BN887_03027   Melanopsichium pennsylvanicum 4 CDI55002.1    
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Mus musculus AAC28851.1
AAH21631.1
AAL87527.1
AAL87528.1
BAC36620.1
BAE21730.1
BAE31642.1
CAA11703.1
NP_032695.2
Q9QWR8
Q9QWR8
 
 α-galactosidase A (Gls;Agl) (lysosomal) 3.2.1.22 Mus musculus AAA74453.1
AAA96749.1
AAB47244.1
AAC52583.1
AAC52584.1
AAH09021.1
BAC30508.1
BAC35819.1
BAE26260.1
BAE37692.1
BAE38627.1
BAE38657.1
CAM19136.1
CAM19137.1
NP_038491.1
P51569
Q8BGZ6
 
 ORF (fragment)   Musca domestica ALHF AFP62361.1    
 α-galactosidase (partial)   Mustela putorius furo AER99093.1    
 ORF   Mustela putorius furo AES02586.1    
 NGATSA_2059200 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69054.1    
 NCLIV_054050   Neospora caninum Liverpool CBZ54978.1    
 NCLIV_009150   Neospora caninum Liverpool CBZ50446.1    
 ORF   Nepenthes mirabilis AMN14859.1    
 ORF   Nepenthes mirabilis AMN14860.1    
 α-galactosidase 3.2.1.22 Nicotiana benthamiana     6F4C[B]
 α-galactosidase   Nicotiana tabacum AEB98600.1    
 α-galactosidase   Nicotiana tabacum AEB98601.1    
 α-N-acetylgalactosaminidase   Nilaparvata lugens ANJ04640.1    
 NYM_LOCUS29683 (fragment)   Nymphaea colorata VVW87053.1    
 NYM_LOCUS29306 (fragment)   Nymphaea colorata VVW85713.1    
 NYM_LOCUS29683 (fragment)   Nymphaea colorata VVW87052.1    
 NYM_LOCUS29306 (fragment)   Nymphaea colorata VVW85714.1    
 Os01g0518500   Oryza sativa Japonica Group BAD73696.1
BAB91950.1
BAF05117.1
BAG90573.1
BAS72430.1
Q5QLK3  
 α-galactosidase II (Os07g0452100) 3.2.1.22 Oryza sativa Japonica Group BAF21463.1
BAC55816.1
BAC84411.1
BAT01318.1
Q0D6R0  
 α-galactosidase III (Os07g0679300) 3.2.1.22 Oryza sativa Japonica Group BAC79549.1
BAD31216.1
BAF22553.1
BAG94006.1
BAT03227.1
Q7XIV4  
 α-galactosidase I (Os10g0493600) 3.2.1.22 Oryza sativa Japonica Group BAB12570.1
AAM92832.1
AAO85428.1
AAP54412.1
ABB47819.1
BAF26853.1
BAT11449.1
BAT11450.1
BAT11451.1
BAT11452.1
NP_922125.1
F4MGX5
Q9FXT4
Q9FXT4
1UAS[A]
 Os10g0492900   Oryza sativa Japonica Group AAG13536.1
AAP54408.1
BAF26849.1
BAT11444.1
NP_922121.1
Q9FWV8  
 α-N-acetylgalactosaminidase (fragment)   Oryzias melastigma AEA51135.1    
 α-N-acetylgalactosaminidase (NagA)   Ovis aries ACB87536.1 B2LSM7  
 ORF   Papilio xuthus BAM17755.1    
 Pc21g14820   Penicillium rubens Wisconsin 54-1255 CAP96379.1 B6HIL7  
 α-galactosidase I (Agl1;AglI) 3.2.1.22 Penicillium simplicissimum VTT-D-78090 CAA08915.1 O94221  
 α-galactosidase (fragment)   Petunia x hybrida AAQ82455.1 Q6UAY5  
 α-galactosidase (AgalB) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24511.1 Q9HFZ9  
 α-galactosidase (AgalA) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24510.1 Q9HG00  
 α-galactosidase 3.2.1.22 Phaseolus vulgaris AAA73964.1
AAR65334.1
Q41100  
 BE285   Phaseolus vulgaris AHA84202.1    
 WS0285_J03   Picea sitchensis ABR17992.1 B8LQR2  
 WS02719_G07 (fragment)   Picea sitchensis ABR16121.1 B8LKE1  
 unknown   Picea sitchensis ADE77708.1 D5ADT9  
 unknown (WS02810_D08)   Picea sitchensis ABK24468.1 A9NV07  
 unknown (WS02910_M11)   Picea sitchensis ABK24922.1 A9NWB1  
 unknown (WS0294_N01)   Picea sitchensis ABK25009.1
ABR17777.1
A9NWJ8  
 α-galactosidase 1 (Gal1) 3.2.1.22 Pisum sativum CAF34023.1 Q5ZP79  
 Pa_5_6680   Podospora anserina S mat+ CAP65080.1
CDP29829.1
B2AM92  
 unnamed protein product   Podospora anserina S mat+ CAP71790.1
CDP31181.1
B2B3V4  
 PODCO_607390   Podospora comata VBB84423.1    
 PODCO_506680   Podospora comata VBB81648.1    
 ORF   Pristhesancus plagipennis ATU82754.1    
 Prudu_002226 (fragment)   Prunus dulcis BBG94034.1    
 Prudu_010947 (fragment)   Prunus dulcis BBH00848.1    
 Prudu_007455 (fragment)   Prunus dulcis BBG98129.1    
 V501_01477   Pseudogymnoascus sp. VKM F-4519 (FW-2642) KFZ17922.1    
 PoMZ_08769   Pyricularia oryzae QBZ61811.1    
 PoMZ_00390   Pyricularia oryzae QBZ55492.1    
 PoMZ_05656   Pyricularia oryzae QBZ63965.1    
 PoMZ_07004   Pyricularia oryzae QBZ65297.1    
 MG09805.4   Pyricularia oryzae 70-15 XP_364960.1
EAA53842.1
G4NIK9  
 MG09989.4   Pyricularia oryzae 70-15 XP_365144.1
EAA49825.1
G4N9L9  
 MGG_11374   Pyricularia oryzae 70-15 XP_003713653.1
EAA50899.1
XP_362213.1
   
 MGG_16425   Pyricularia oryzae 70-15 XP_003710505.1
XP_360246.1
   
 α-galactosidase (Gal1) 3.2.1.22 Rasamsonia emersonii ABU94728.1 A7XZT2  
 Unknown (protein for MGC:95262)   Rattus norvegicus AAH82084.1 Q66H12  
 ORF (fragment)   Rimicaris exoculata ACR78680.1 C5HTY1  
 ORF   Riptortus pedestris BAN20212.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces arboricola AS 2.3318 CUW00885.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces arboricola AS 2.3319 CUW00887.1    
 α-galactosidase (Mel) (fragment)   Saccharomyces bayanus CBS 380 AAQ17217.1 Q6WN36  
 α-galactosidase (Mel1)   Saccharomyces bayanus NRRL Y-1551 CBY84987.1    
 α-galactosidase (Mel1)   Saccharomyces bayanus type strain: CBS 380 CBY84985.1    
 galactosidase / melibiase   Saccharomyces carlsbergensis AAA34770.1    
 α-galactosidase (MEL) 3.2.1.22 Saccharomyces carlsbergensis NCYC396 AAA34769.1 Q03647  
 α-galactosidase 1 (Mel1;ScMel1) 3.2.1.22 Saccharomyces cerevisiae CAA26888.1
AAE69557.1
CBY84983.1
CBY84984.1
CUW00903.1
CUW00905.1
CUW00906.1
F4N9N8
P04824
3LRK[A]
3LRL[A]
3LRM[A,B,C,D]
 α-galactosidase 2 (Mel2) 3.2.1.22 Saccharomyces cerevisiae CAA85737.1 P41945  
 α-galactosidase 5 (Mel5) 3.2.1.22 Saccharomyces cerevisiae CAA85740.1 P41946  
 α-galactosidase 6 (Mel6) 3.2.1.22 Saccharomyces cerevisiae CAA85739.1 P41947  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae CBS 2444 CUW00896.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae CBS 4734 CUW00898.1    
 α-galactosidase (MEL)   Saccharomyces cerevisiae NCYC686 AAL07760.1 E9P8G8
Q96UV4
 
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 03.461.4 CUW00899.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 05.217.3 CUW00900.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 05.227.2 CUW00901.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 1260 SBT28030.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 2156 SBT28031.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 8834 SBT28032.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus x Saccharomyces uvarum NCAIM00676 SBT28034.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus x Saccharomyces uvarum NCAIM00677 SBT28035.1    
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