Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1394); Uniprot accession (327); PDB accession (46); 3D entries (13); cryst (0)
All (1138) Archaea (1) Bacteria (807) Eukaryota (329) unclassified (1) Structure (13) Characterized (66)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 isomaltodextranase (ImdA) 3.2.1.94 Arthrobacter dextranolyticus T6 BAD34648.1 Q6BE01  
 isomalto-dextranase (G2d;Imd) 3.2.1.94 Arthrobacter globiformis T6 BAC76886.2
BAA06424.1
Q44052
Q7WSN5
5AWO[A]
5AWP[A]
5AWQ[A]
 α-galactosidase 27A (Aga27A) 3.2.1.22 Cellvibrio mixtus ATCC 12120 AAS19696.1 Q6QT41  
 β-L-arabinopyranosidase (CpArap27;Cpin_5740) 3.2.1.88 Chitinophaga pinensis DSM 2588 ACU63161.1 C7PCU7  
 α-galactosidase (Ccel_1237) (Gal27A) 3.2.1.22 [Clostridium] cellulolyticum H10 ACL75593.1
ABG76969.1
B8I0L8  
 α-galactosidase (AgaA) (Aga27A) 3.2.1.22 Clostridium josui FERM P-9684 BAB83765.1 Q8VV86  
 β-L-arabinopyranosidase (Abp;HUS_CDS23) 3.2.1.88 Geobacillus stearothermophilus T-6 NCIMB 40222     4NX0[A,B,C,E,F,G,H]
4NXK[A,B,C,D,E,F,G,H]
4NZF[A,B,C,D,E,F,G,H]
4NX0[D]
 α-galactosidase (MelA;AgaB2;SACE_3139) 3.2.1.22 Saccharopolyspora erythraea NRRL 2338 AAC99325.1
CAM02417.1
Q9Z4N5  
 β-L-arabinopyranosidase (AgaA2;SaArap27A;SAV_2186) (Arap27A) 3.2.1.88 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69897.1
NP_823362.1
  3A21[A,B]
3A22[A,B]
3A23[A,B]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 [Blood group A] α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Acremonium sp. No.413 BAB08149.1 Q9HFB1  
 galactan:galactan galactosyltransferase 1 (GGT-1) 2.4.1.- Ajuga reptans AAR02007.1 Q6TW99  
 α-galactosidase 27A (Gal27A) 3.2.1.22 Aspergillus fischeri P1 / CGMCC 3.15369 AGV79321.1
AGV79322.1
   
 α-galactosidase 27B (Gal27B) 3.2.1.22 Aspergillus fischeri P1 / CGMCC 3.15369 AJA29661.1    
 α-galactosidase B (AglB) 3.2.1.22 Aspergillus fumigatus IMI 385708 ACO72591.1 C3V6M2
Q4WE86
 
 α-galactosidase (AN7152.2) 3.2.1.22 Aspergillus nidulans FGSC A4 ABF50881.1
EAA61404.1
Q5AX28  
 α-galactosidase B (AglB) 3.2.1.22 Aspergillus niger CBS 120.49 / N400 CAB46229.1 Q9Y865  
 α-N-acetylgalactosaminidase / α-galactosidase (AglA;An06g00170) 3.2.1.22
3.2.1.49
Aspergillus niger CBS 513.88 CAK44933.1 A2QL72  
 α-galactosidase II (AglB;An02g11150) (Gal27B) 3.2.1.22 Aspergillus niger CBS 513.88 CAK44445.1 A2QEJ9  
 α-N-acetylgalactosaminidase (fragment) 3.2.1.49 Aspergillus niger CCIM K2 AEQ39734.1    
 α-galactosidase A (Ag1A;AglA) 3.2.1.22 Aspergillus niger N402 CAA44950.1
AAE69559.1
P28351  
 α-galactosidase (AglB) 3.2.1.22 Aspergillus niger No.499 BAU20370.1    
 α-galactosidase (AgalB) 3.2.1.22 Bispora sp. MEY-1 ADN30030.1 E2E1R9  
 α-galactosidase 3.2.1.22 Coffea arabica AAA33022.1
AAQ77888.1
Q42656  
 α-galactosidase (Gal1) 3.2.1.22 Coffea arabica CATURRA ROJO T2308 CAI47559.1 Q5DUH8  
 α-galactosidase (Gal1) 3.2.1.22 Coffea canephora 97 CAI47560.1 Q5DUH7  
 acid α-galactosidase 2 3.2.1.22 Cucumis sativus ABC88435.1 Q2HYY3  
 α-galactosidase (Aga27A) 3.2.1.22 Cyamopsis tetragonoloba CAA32772.1
AAA72859.1
AAE69558.1
P14749  
 α-galactosidase (DEHA0F28490g) 3.2.1.22 Debaryomyces hansenii CBS767 CAG89932.1 Q6BJW5  
 α-galactosidase / β-L-arabinopyranosidase (FoAp2) 3.2.1.22
3.2.1.88
Fusarium oxysporum 12S BAH10648.1 B7XH21  
 α-galactosidase / β-L-arabinopyranosidase (FoAp1) 3.2.1.22
3.2.1.88
Fusarium oxysporum 12S BAH10649.1 B7XH22  
 α-N-acetylgalactosaminidase (α-NAGAL) 3.2.1.49 Gallus gallus AAA16614.1
AAE69554.1
Q90744 1KTB[A]
1KTC[A]
 α-galactosidase 3.2.1.22 Glycine max AAA73963.1
AAR65332.1
ACU23822.1
Q39811  
 α-galactosidase (Gla) 3.2.1.22 Helianthus annuus BAC66445.1 Q84VQ7  
 α-galactosidase A (Gla;α-GAL) 3.2.1.22 Homo sapiens AAH02689.1
AAA51676.1
AAA52514.1
AAA52559.1
AAB64203.1
AAE66433.1
AAE69556.1
AAN92813.1
AAP35510.1
AAQ31818.1
AAQ68716.1
AAQ81221.1
AAY03282.1
AAY71885.1
AAY71886.1
AAY71887.1
AAY71888.1
AAY71889.1
AAY71890.1
AAY71891.1
AAY71892.1
AAY71893.1
AAY71894.1
AAY72531.1
AAY72532.1
AAY72533.1
AAY72534.1
AAY72535.1
AAY72536.1
AAY72537.1
AAY72538.1
AAY72539.1
AAY72540.1
ABE23230.1
ABL16360.1
ABL21591.1
ACH14962.1
ACK10792.1
BAA34059.1
BAD96347.1
BAF83784.1
BAG59647.1
BAT62474.1
CAA29232.1
CAA32617.1
CAB55878.1
CAC09605.1
CAE85447.1
CAV33302.1
NP_000160.1
P06280
Q53Y83
1R46[A,B]
1R47[A,B]
3GXN[A,B]
3GXP[A,B]
3GXT[A,B]
3HG2[A,B]
3HG3[A,B]
3HG4[A,B]
3HG5[A,B]
3LX9[A,B]
3LXA[A,B]
3LXB[A,B]
3LXC[A,B]
3S5Y[A,B]
3S5Z[A,B]
3TV8[A,B]
4NXS[A,B]
 α-N-acetylgalactosaminidase / α-galactosidase B (bK250D10.5;NagA;α-NAGAL) 3.2.1.22
3.2.1.49
Homo sapiens AAA36351.1
AAA51677.1
AAA59902.1
AAB06718.1
AAE69555.1
AAH00095.1
ACM80412.1
ACM85401.1
ASU96594.1
CAB41237.1
CAG30413.1
CAX14869.1
CAX14870.1
NP_000253.1
P17050 3H53[A,B]
3H54[A,B]
3H55[A,B]
3IGU[A,B]
4DO4[A,B]
4DO5[A,B]
4DO6[A,B]
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Mus musculus AAC28851.1
AAH21631.1
AAL87527.1
AAL87528.1
BAC36620.1
BAE21730.1
BAE31642.1
CAA11703.1
NP_032695.2
Q9QWR8
Q9QWR8
 
 α-galactosidase A (Gls;Agl) (lysosomal) 3.2.1.22 Mus musculus AAA74453.1
AAA96749.1
AAB47244.1
AAC52583.1
AAC52584.1
AAH09021.1
BAC30508.1
BAC35819.1
BAE26260.1
BAE37692.1
BAE38627.1
BAE38657.1
CAM19136.1
CAM19137.1
NP_038491.1
P51569
Q8BGZ6
 
 α-galactosidase II (Os07g0452100) 3.2.1.22 Oryza sativa Japonica Group BAF21463.1
BAC55816.1
BAC84411.1
BAT01318.1
Q0D6R0  
 α-galactosidase III (Os07g0679300) 3.2.1.22 Oryza sativa Japonica Group BAC79549.1
BAD31216.1
BAF22553.1
BAG94006.1
BAT03227.1
Q7XIV4  
 α-galactosidase I (Os10g0493600) 3.2.1.22 Oryza sativa Japonica Group BAB12570.1
AAM92832.1
AAO85428.1
AAP54412.1
ABB47819.1
BAF26853.1
BAT11449.1
BAT11450.1
BAT11451.1
BAT11452.1
NP_922125.1
F4MGX5
Q9FXT4
Q9FXT4
1UAS[A]
 α-galactosidase I (Agl1;AglI) 3.2.1.22 Penicillium simplicissimum VTT-D-78090 CAA08915.1 O94221  
 α-galactosidase (AgalB) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24511.1 Q9HFZ9  
 α-galactosidase (AgalA) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24510.1 Q9HG00  
 α-galactosidase 3.2.1.22 Phaseolus vulgaris AAA73964.1
AAR65334.1
Q41100  
 α-galactosidase 1 (Gal1) 3.2.1.22 Pisum sativum CAF34023.1 Q5ZP79  
 α-galactosidase (Gal1) 3.2.1.22 Rasamsonia emersonii ABU94728.1 A7XZT2  
 α-galactosidase (MEL) 3.2.1.22 Saccharomyces carlsbergensis NCYC396 AAA34769.1 Q03647  
 α-galactosidase 1 (Mel1;ScMel1) 3.2.1.22 Saccharomyces cerevisiae CAA26888.1
AAE69557.1
CBY84983.1
CBY84984.1
CUW00903.1
CUW00905.1
CUW00906.1
F4N9N8
P04824
3LRK[A]
3LRL[A]
3LRM[A,B,C,D]
 α-galactosidase 2 (Mel2) 3.2.1.22 Saccharomyces cerevisiae CAA85737.1 P41945  
 α-galactosidase 5 (Mel5) 3.2.1.22 Saccharomyces cerevisiae CAA85740.1 P41946  
 α-galactosidase 6 (Mel6) 3.2.1.22 Saccharomyces cerevisiae CAA85739.1 P41947  
 α-galactosidase (MELj) 3.2.1.22 Saccharomyces mikatae IFO 1816 CAA64760.1 Q11129  
 α-galactosidase (MELp) 3.2.1.22 Saccharomyces paradoxus 61-248 CAA64759.1 Q09187  
 α-galactosidase (Mel1;SPAC869.07c) 3.2.1.22 Schizosaccharomyces pombe 972h- CAB60017.1
NP_595012.1
Q9URZ0  
 α-galactosidase (LeaGal) 3.2.1.22 Solanum lycopersicum AAF04591.1
AAG16693.1
Q9FUR8
Q9SP05
 
 α-galactosidase (Aga27A) 3.2.1.22 Talaromyces leycettanus JCM12802 AJF11712.1    
 α-galactosidase (aGal) 3.2.1.22 Talaromyces purpureogenus 618 BAA22992.1 O13295  
 α-galactosidase (Aga1;aGal1) 3.2.1.22 Thermothelomyces thermophila C1 AFJ59926.1    
 α-galactosidase (MELt) 3.2.1.22 Torulaspora delbrueckii BAA86883.1 Q9UVD6  
 α-galactosidase (Agl1) 3.2.1.22 Trichoderma reesei   Q92456 1T0O[A]
1SZN[A]
 α-galactosidase 1 (Agl1;AGLI) 3.2.1.22 Trichoderma reesei RUTC-30 CAA93244.1 Q92456  
 α-galactosidase 3 (Agl3;AGLIII) 3.2.1.22 Trichoderma reesei RUTC-30 CAA93246.1 Q92451  
 α-galactosidase I (GalI;UvGalI) 3.2.1.22 Umbelopsis vinacea     3A5V[A]
 α-galactosidase II 3.2.1.22 Umbelopsis vinacea BAA33931.1 O93816  
 α-galactosidase 3.2.1.22 Umbelopsis vinacea AAB35252.2 Q02402  
 α-galactosidase (MELr) 3.2.1.22 Zygotorulaspora mrakii IFO 1835 BAA99555.1 Q9P4V4  
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