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Glycoside Hydrolase Family 27

Activities in FamilyGalactan:galactan α-galactosyltransferase (EC 2.4.1.-);
Galactomannan exo-α-1,6-galactosidase (EC 3.2.1.-);
α-galactosidase (EC 3.2.1.22);
α-N-acetylgalactosaminidase (EC 3.2.1.49);
[retaining] β-L-arabinopyranosidase / β-L-arabinosidase (EC 3.2.1.88);
[retaining] isomalto-dextranase (EC 3.2.1.94);
Mechanism Retaining a
ClanGH-D
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (5129); Uniprot accession (92); PDB accession (51); 3D entries (14); cryst (0)
Summary
Download GH27 (7678) Taxonomic display Structure (14) Characterized (70)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 isomaltodextranase (ImdA) 3.2.1.94 pubmed
 Arthrobacter dextranolyticus T6 BAD34648.1 Q6BE01  
 isomalto-dextranase (G2d;Imd) 3.2.1.94 pubmed
 Arthrobacter globiformis T6 BAC76886.2
BAA06424.1		 Q44052
Q7WSN5		 5AWO[A]
5AWP[A]
5AWQ[A]
 α-galactosidase (Gal27A) 3.2.1.22 pubmed
 Bacillus sp. N16-5 AML27059.1 A0A140EH88  
 α-galactosidase (BT4157;BT_4157) 3.2.1.22 pubmed
 Bacteroides thetaiotaomicron VPI-5482 AAO79262.1
NP_813068.1		 Q8A064  
 β-L-arabinofuranosidase (CpAbp27A) (fragment) (Abp27A) 3.2.1.88 pubmed
 Caldanaerobius polysaccharolyticus ATCC BAA-17 WP_035172167.1    
 α-galactosidase 27A (Aga27A) 3.2.1.22   Cellvibrio mixtus ATCC 12120 AAS19696.1 Q6QT41  
 β-L-arabinopyranosidase (CpArap27;Cpin_5740) 3.2.1.88 pubmed
 Chitinophaga pinensis DSM 2588 ACU63161.1 C7PCU7  
 β-L-arabinopyranosidase (Abp;HUS_CDS23) 3.2.1.88 pubmed
 Geobacillus stearothermophilus T-6 NCIMB 40222     4NX0[A,B,C,E,F,G,H]
4NXK[A,B,C,D,E,F,G,H]
4NZF[A,B,C,D,E,F,G,H]
4NX0[D]
 galactomannan exo-α-1,6-galactosidase 3.2.1.- pubmed
 Muricauda sp. MAR_2010_75 WP_036379578.1    
 α-galactosidase (Ccel_1237) (Gal27A) 3.2.1.22 pubmed
 Ruminiclostridium cellulolyticum H10 ACL75593.1
ABG76969.1		 B8I0L8
Q0PRN2		  
 α-galactosidase (AgaA) (Aga27A) 3.2.1.22 pubmed
 Ruminiclostridium josui FERM P-9684 BAB83765.1 Q8VV86  
 α-galactosidase (MelA;AgaB2;SACE_3139) 3.2.1.22 pubmed
 Saccharopolyspora erythraea NRRL 2338 AAC99325.1
CAM02417.1		 A4FEE2
Q9Z4N5		  
 β-L-arabinopyranosidase (AgaA2;SaArap27A;SAV_2186) (Arap27A) 3.2.1.88 pubmed
 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69897.1
NP_823362.1		 Q82L26 3A21[A,B]
3A22[A,B]
3A23[A,B]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 [Blood group A] α-N-acetylgalactosaminidase (NagA) 3.2.1.49 doi
 Acremonium sp. No.413 BAB08149.1 Q9HFB1  
 galactan:galactan α-galactosyltransferase 1 (GGT-1) 3.2.1.22
2.4.1.-		 pubmed
 Ajuga reptans AAR02007.1 Q6TW99  
 α-galactosidase 3 (AGAL3; At3g56310) 3.2.1.22 pubmed
 Arabidopsis thaliana AAL67017.1
AAM45068.1
AEE79507.1
AEE79508.1
CAB87430.1
NP_191190.2		 Q8VXZ7  
 β-L-arabinopyranosidase (APSE; At3g26380) 3.2.1.88 pubmed
 Arabidopsis thaliana NP_189269.2
AEE77151.1
ANM65951.1
BAB02198.1
NP_189269.1		 A0A1I9LTP3
A0A654FCS5
F4JCI4
Q9LIN8		  
 α-galactosidase 2 (AGAL2; At5g08370) 3.2.1.22 pubmed
 Arabidopsis thaliana AAL90902.1
AAM62753.1
AAN18186.1
ABI00031.1
AED91290.1
AED91291.1
BAH19885.1
CAC08337.1
NP_568193.1		 Q8RX86  
 α-galactosidase 27A (Gal27A) 3.2.1.22 pubmed
 Aspergillus fischeri P1 / CGMCC 3.15369 AGV79321.1
AGV79322.1		 A0A023IMK0
A0A088BDE2		  
 α-galactosidase 27B (Gal27B) 3.2.1.22 pubmed
 Aspergillus fischeri P1 / CGMCC 3.15369 AJA29661.1 A0A0A7R517  
 α-galactosidase B (AglB) 3.2.1.22 doi
 Aspergillus fumigatus IMI 385708 ACO72591.1 C3V6M2
Q4WE86		  
 α-galactosidase (AN7152.2) 3.2.1.22 pubmed
 Aspergillus nidulans FGSC A4 ABF50881.1
EAA61404.1		 Q5AX28  
 α-galactosidase B (AglB) 3.2.1.22 pubmed
 Aspergillus niger CBS 120.49 / N400 CAB46229.1 Q9Y865  
 α-N-acetylgalactosaminidase / α-galactosidase (AglA;An06g00170) 3.2.1.49 pubmed
 Aspergillus niger CBS 513.88 CAK44933.1 A2QL72  
 α-galactosidase II (AglB;An02g11150) (Gal27B) 3.2.1.22 pubmed
 Aspergillus niger CBS 513.88 CAK44445.1 A2QEJ9  
 α-N-acetylgalactosaminidase (partial) (fragment) 3.2.1.49 pubmed
 Aspergillus niger CCIM K2 AEQ39734.1 G5D7B5  
 α-galactosidase A (Ag1A;AglA) 3.2.1.22 pubmed
 Aspergillus niger N402 CAA44950.1
AAE69559.1		 P28351  
 α-galactosidase (AglB) 3.2.1.22 pubmed
 Aspergillus niger No.499 BAU20370.1 A0A0U5AE32  
 α-galactosidase (AgalB) 3.2.1.22 pubmed
 Bispora sp. MEY-1 ADN30030.1 E2E1R9  
 α-galactosidase (Pag2) 3.2.1.22 pubmed
 Carica papaya AAP04002.1 Q84QC9  
 α-galactosidase 3.2.1.22 pubmed
 Coffea arabica AAA33022.1
AAQ77888.1		 Q42656  
 α-galactosidase (Gal1) 3.2.1.22 pubmed
 Coffea arabica CATURRA ROJO T2308 CAI47559.1 Q5DUH8  
 α-galactosidase (Gal1) 3.2.1.22 pubmed
 Coffea canephora 97 CAI47560.1 Q5DUH7  
 α-galactosidase (fragment) 3.2.1.22 doi
 Colocasia esculenta MQL72187.1 A0A843TQA1  
 acid α-galactosidase 2 3.2.1.22 doi
 Cucumis sativus ABC88435.1 Q2HYY3  
 α-galactosidase (Aga27A) 3.2.1.22 pubmed
 Cyamopsis tetragonoloba CAA32772.1
AAA72859.1
AAE69558.1		 P14749  
 α-galactosidase (DEHA0F28490g) 3.2.1.22 pubmed
 Debaryomyces hansenii CBS767 CAG89932.1 Q6BJW5  
 α-galactosidase (Aga27A) 3.2.1.22 pubmed
 Evansstolkia leycettana JCM12802 AJF11712.1 A0A0H3V1A2  
 α-galactosidase / β-L-arabinopyranosidase (FoAp2) 3.2.1.22
3.2.1.88		 pubmed
pubmed
 Fusarium oxysporum 12S BAH10648.1 B7XH21  
 α-galactosidase / β-L-arabinopyranosidase (FoAp1) 3.2.1.22
3.2.1.88		 pubmed
pubmed
 Fusarium oxysporum 12S BAH10649.1 B7XH22  
 α-galactosidase / α-galactopyranosidase (FoGP1) 3.2.1.22 pubmed
 Fusarium oxysporum 12S BAJ23877.1    
 α-N-acetylgalactosaminidase (α-NAGAL) 3.2.1.49 pubmed
 Gallus gallus AAA16614.1
AAE69554.1		 Q90744 1KTB[A]
1KTC[A]
 α-galactosidase (Gla) 3.2.1.22 pubmed
 Helianthus annuus BAC66445.1 Q84VQ7  
 α-galactosidase A (Gla;α-GAL) 3.2.1.22 pubmed
 Homo sapiens AAH02689.1
AAA51676.1
AAA52514.1
AAA52559.1
AAB64203.1
AAE66433.1
AAE69556.1
AAN92813.1
AAP35510.1
AAQ31818.1
AAQ68716.1
AAQ81221.1
AAY03282.1
AAY71885.1
AAY71886.1
AAY71887.1
AAY71888.1
AAY71889.1
AAY71890.1
AAY71891.1
AAY71892.1
AAY71893.1
AAY71894.1
AAY72531.1
AAY72532.1
AAY72533.1
AAY72534.1
AAY72535.1
AAY72536.1
AAY72537.1
AAY72538.1
AAY72539.1
AAY72540.1
ABE23230.1
ABL16360.1
ABL21591.1
ACH14962.1
ACK10792.1
BAA34059.1
BAD96347.1
BAF83784.1
BAG59647.1
BAT62474.1
CAA29232.1
CAA32617.1
CAB55878.1
CAC09605.1
CAE85447.1
CAV33302.1
NP_000160.1		 A0A0S3Q2A7
B4DLT5
P06280
Q53HF3
Q53Y83		 1R46[A,B]
1R47[A,B]
3GXN[A,B]
3GXP[A,B]
3GXT[A,B]
3HG2[A,B]
3HG3[A,B]
3HG4[A,B]
3HG5[A,B]
3LX9[A,B]
3LXA[A,B]
3LXB[A,B]
3LXC[A,B]
3S5Y[A,B]
3S5Z[A,B]
3TV8[A,B]
4NXS[A,B]
6IBK[A,B]
6IBM[A,B]
6IBR[A,B]
6IBT[A,B]
 α-N-acetylgalactosaminidase / α-galactosidase B (bK250D10.5;NagA;α-NAGAL) 3.2.1.22
3.2.1.49		 pubmed
pubmed
 Homo sapiens AAA36351.1
AAA51677.1
AAA59902.1
AAB06718.1
AAE69555.1
AAH00095.1
ACM80412.1
ACM85401.1
ASU96594.1
CAB41237.1
CAG30413.1
CAX14869.1
CAX14870.1
NP_000253.1		 A0A024R1Q5
A0A248RGB1
P17050		 3H53[A,B]
3H54[A,B]
3H55[A,B]
3IGU[A,B]
4DO4[A,B]
4DO5[A,B]
4DO6[A,B]
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49   Mus musculus AAC28851.1
AAH21631.1
AAL87527.1
AAL87528.1
BAC36620.1
BAE21730.1
BAE31642.1
CAA11703.1
NP_032695.2		 Q3U6T2
Q3UZX5
Q9QWR8
Q9QWR8		  
 α-galactosidase A (Gls;Agl) (lysosomal) 3.2.1.22 pubmed
 Mus musculus AAA74453.1
AAA96749.1
AAB47244.1
AAC52583.1
AAC52584.1
AAH09021.1
BAC30508.1
BAC35819.1
BAE26260.1
BAE37692.1
BAE38627.1
BAE38657.1
CAM19136.1
CAM19137.1
NP_038491.1		 P51569
Q3TLY5
Q3UM38
Q8BGZ6		  
 α-galactosidase 3.2.1.22 pubmed
 Nicotiana benthamiana   A0A384E148 6F4C[B]
 α-galactosidase II (Os07g0452100) 3.2.1.22 pubmed
 Oryza sativa Japonica Group BAF21463.1
BAC55816.1
BAC84411.1
BAT01318.1		 A0A0P0X580
Q0D6R0
Q84Q36		  
 α-galactosidase III (Os07g0679300) 3.2.1.22 pubmed
 Oryza sativa Japonica Group BAC79549.1
BAD31216.1
BAF22553.1
BAG94006.1
BAT03227.1		 Q69R81
Q7XIV4		  
 α-galactosidase I (Os10g0493600) 3.2.1.22 pubmed
 Oryza sativa Japonica Group BAB12570.1
AAM92832.1
AAO85428.1
AAP54412.1
ABB47819.1
BAF26853.1
BAT11449.1
BAT11450.1
BAT11451.1
BAT11452.1
NP_922125.1		 A0A0N7KS02
A0A0P0XVT5
A0A0P0XW07
F4MGX5
Q9FXT4
Q9FXT4		 1UAS[A]
 α-galactosidase I (Agl1;AglI) 3.2.1.22 pubmed
 Penicillium simplicissimum VTT-D-78090 CAA08915.1 O94221  
 α-galactosidase (AgalB) 3.2.1.22 pubmed
 Phanerochaete chrysosporium ME446 AAG24510.1
AAG24511.1		 Q9HFZ9
Q9HG00		  
 α-galactosidase 3.2.1.22 doi
 Phaseolus vulgaris AAA73964.1
AAR65334.1		 Q41100  
 α-galactosidase 1 (Gal1) 3.2.1.22 pubmed
 Pisum sativum CAF34023.1 Q5ZP79  
 α-galactosidase (Gal1) 3.2.1.22 pubmed
 Rasamsonia emersonii ABU94728.1 A7XZT2  
 α-galactosidase (MEL) 3.2.1.22 pubmed
 Saccharomyces carlsbergensis NCYC396 AAA34769.1 Q03647  
 α-galactosidase 1 (Mel1;ScMel1) 3.2.1.22 pubmed
 Saccharomyces cerevisiae CAA26888.1
AAE69557.1
CBY84983.1
CBY84984.1
CUW00903.1
CUW00905.1
CUW00906.1		 F4N9N8
P04824		 3LRK[A]
3LRL[A]
3LRM[A,B,C,D]
 α-galactosidase (Mel1;SPAC869.07c) 3.2.1.22 pubmed
 Schizosaccharomyces pombe 972h- CAB60017.1
CAK8728200.1
NP_595012.1		 Q9URZ0  
 α-galactosidase (LeaGal) 3.2.1.22 pubmed
 Solanum lycopersicum AAF04591.1
AAG16693.1		 Q9FUR8
Q9SP05		  
 α-galactosidase (aGal) 3.2.1.22 pubmed
 Talaromyces purpureogenus 618 BAA22992.1 O13295  
 α-galactosidase (TcGal27A) (Gal27A) 3.2.1.22 doi
 Thermoascus crustaceus JCM12803 ATO91445.1 A0A2D1PE30  
 α-galactosidase (Aga1;aGal1) 3.2.1.22 pubmed
 Thermothelomyces thermophilus C1 AFJ59926.1 I2C093  
 α-galactosidase (Agl1) 3.2.1.22 pubmed
 Trichoderma reesei   Q92456 1T0O[A]
1SZN[A]
 α-galactosidase 1 (Agl1;AGLI) 3.2.1.22 pubmed
 Trichoderma reesei RUTC-30 CAA93244.1 Q92456  
 α-galactosidase 3 (Agl3;AGLIII) 3.2.1.22 pubmed
 Trichoderma reesei RUTC-30 CAA93246.1 Q92451  
 α-galactosidase I (GalI;UvGalI) 3.2.1.22 doi
 Umbelopsis vinacea     3A5V[A]
 α-galactosidase II 3.2.1.22 pubmed
 Umbelopsis vinacea BAA33931.1 O93816  
 α-galactosidase 3.2.1.22 pubmed
 Umbelopsis vinacea AAB35252.2 Q02402  
unclassified
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 α-galactosidase (GalR) 3.2.1.22 pubmed
 unidentified QCC19990.1
QCC19991.1		    
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