Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1394); Uniprot accession (327); PDB accession (46); 3D entries (13); cryst (0)
All (1138) Archaea (1) Bacteria (807) Eukaryota (329) unclassified (1) Structure (13) Characterized (66)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 secreted protein   Achlya hypogyna ATCC 48635 AIG56321.1    
 [Blood group A] α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Acremonium sp. No.413 BAB08149.1 Q9HFB1  
 ORF (fragment)   Aegilops speltoides ACJ06603.1 B6VCK0  
 galactan:galactan galactosyltransferase 1 (GGT-1) 2.4.1.- Ajuga reptans AAR02007.1 Q6TW99  
 α-N-acetylgalactosaminidase (NagAB)   Anoplopoma fimbria ACQ58057.1 C3KHD5  
 ACCB12299   Apis cerana AEY61424.1    
 At3g56310   Arabidopsis thaliana AAL67017.1
AAM45068.1
AEE79507.1
AEE79508.1
CAB87430.1
NP_191190.2
Q8VXZ7
Q9LYL2
 
 At3g26380   Arabidopsis thaliana NP_189269.2
AEE77151.1
ANM65951.1
BAB02198.1
NP_189269.1
Q9LIN8  
 At5g08380   Arabidopsis thaliana CAC08338.1
AAM13199.1
AAP37856.1
AED91292.1
ANM70469.1
NP_196455.1
Q8RWB9
Q9FT97
 
 At5g08370   Arabidopsis thaliana AAL90902.1
AAM62753.1
AAN18186.1
ABI00031.1
AED91290.1
AED91291.1
BAH19885.1
CAC08337.1
NP_568193.1
Q8RX86
Q9FT98
 
 EGX47588.1   Arthrobotrys oligospora ATCC 24927 EGX47588.1    
 EGX44376.1   Arthrobotrys oligospora ATCC 24927 EGX44376.1    
 ORF (fragment)   Ascaris suum ADY44335.1    
 α-galactosidase 27A (Gal27A) 3.2.1.22 Aspergillus fischeri P1 / CGMCC 3.15369 AGV79321.1
AGV79322.1
   
 α-galactosidase 27B (Gal27B) 3.2.1.22 Aspergillus fischeri P1 / CGMCC 3.15369 AJA29661.1    
 AFUA_6G02560 (Afu6g02560)   Aspergillus fumigatus Af293 EAL85784.1 Q4WCV4  
 α-galactosidase A (AglA;AFUA_5G13830;Afu5g13830)   Aspergillus fumigatus Af293 EAL91233.1 Q4WVZ3  
 α-galactosidase B (AglB) 3.2.1.22 Aspergillus fumigatus IMI 385708 ACO72591.1 C3V6M2
Q4WE86
 
 α-galactosidase (AN7152.2) 3.2.1.22 Aspergillus nidulans FGSC A4 ABF50881.1
EAA61404.1
Q5AX28  
 AN7624.2   Aspergillus nidulans FGSC A4 ABF50888.1
EAA61810.1
Q5AVQ6  
 AN0022.2 (fragment)   Aspergillus nidulans FGSC A4 EAA65341.1 Q5BHG6  
 α-galactosidase B (AglB) 3.2.1.22 Aspergillus niger CBS 120.49 / N400 CAB46229.1 Q9Y865  
 An01g01320   Aspergillus niger CBS 513.88 CAK43504.1 A2Q7N1  
 α-N-acetylgalactosaminidase / α-galactosidase (AglA;An06g00170) 3.2.1.22
3.2.1.49
Aspergillus niger CBS 513.88 CAK44933.1 A2QL72  
 An11g06330   Aspergillus niger CBS 513.88 CAK96935.1 A2QWT3  
 An14g01800   Aspergillus niger CBS 513.88 CAK46492.1 A2R2S6  
 α-galactosidase II (AglB;An02g11150) (Gal27B) 3.2.1.22 Aspergillus niger CBS 513.88 CAK44445.1 A2QEJ9  
 α-N-acetylgalactosaminidase (fragment) 3.2.1.49 Aspergillus niger CCIM K2 AEQ39734.1    
 α-galactosidase A (Ag1A;AglA) 3.2.1.22 Aspergillus niger N402 CAA44950.1
AAE69559.1
P28351  
 α-galactosidase (AglB) 3.2.1.22 Aspergillus niger No.499 BAU20370.1    
 AO090005000217   Aspergillus oryzae RIB40 BAE55309.1 Q2UT06  
 AO090003001305 (AglB)   Aspergillus oryzae RIB40 BAE58368.1 Q2UJ97  
 AO090023000151   Aspergillus oryzae RIB40 BAE58728.1 Q2UI87  
 α-galactosidase   Aspergillus ustus AEG73867.1    
 α-galactosidase A (Gla) (fragment)   Ateles belzebuth chamek AAD16964.1 O97898  
 α-galactosidase (AgalB) 3.2.1.22 Bispora sp. MEY-1 ADN30030.1 E2E1R9  
 α-N-acetylgalactosaminidase   Bombyx mori ABD36218.1 Q2F5Z9  
 α-N-acetylgalactosaminidase (MGC140188;NagA)   Bos taurus AAX46465.1
AAI14814.1
Q58DH9  
 glycoside hydrolase family 27 protein (Bofut4_p052080.1)   Botrytis cinerea T4 CCD44859.1    
 glycoside hydrolase family 27 protein (Bofut4_p108800.1)   Botrytis cinerea T4 CCD48496.1    
 glycoside hydrolase family 27 protein (Bofut4_p049070.1)   Botrytis cinerea T4 CCD45889.1    
 glycoside hydrolase family 27 protein (Bofut4_p114580.1) (fragment)   Botrytis cinerea T4 CCD46752.1    
 R07B7.11   Caenorhabditis elegans Bristol N2 CAB00120.1
NP_506031.1
Q21801  
 ORF   Callorhinchus milii AFP01313.1    
 ORF   Callorhinchus milii AFP05413.1    
 ORF (fragment)   Callorhinchus milii AFP06661.1    
 Agal1   Camellia sinensis AHG94610.1    
 α-galactosidase (Pag2)   Carica papaya AAP04002.1 Q84QC9  
 α-galactosidase (fragment)   Cerastium arcticum ABN13605.1 A3EYF9  
 α-galactosidase (Gal;CpGal)   Chimonanthus praecox AFB73771.1    
 ORF   Chorthippus parallelus CAX20733.1 D2T1A8  
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04458.1    
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04456.1    
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04452.1    
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04454.1    
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04461.1    
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04460.1    
 α-D-galactosidase, partial (Alphα-gaL) (fragment)   Cocos nucifera ANF04453.1    
 alpha galactosidase isoform 2, partial (fragment)   Cocos nucifera AGB51443.1
ANF04420.1
ANF04421.1
ANF04422.1
ANF04423.1
ANF04424.1
ANF04425.1
ANF04426.1
ANF04427.1
ANF04428.1
ANF04429.1
ARF06275.1
ARF06276.1
ARF06290.1
   
 alpha galactosidase isoform 1, partial (fragment)   Cocos nucifera AGB51445.1    
 α-galactosidase isoform 2 (A-galII)   Cocos nucifera AIL28756.1
ANF04431.1
ANF04433.1
ANF04435.1
ANF04437.1
ANF04439.1
ANF04441.1
ANF04442.1
ANF04443.1
ANF04444.1
ANF04445.1
ANF04446.1
ANF04447.1
ANF04448.1
ANF04449.1
ANF04450.1
ANF04451.1
ANF04455.1
ANF04457.1
ANF04459.1
ANF04462.1
ARF06283.1
ARF06284.1
ARF06285.1
ARF06286.1
   
 α-galactosidase 3.2.1.22 Coffea arabica AAA33022.1
AAQ77888.1
Q42656  
 α-galactosidase (Gal1) 3.2.1.22 Coffea arabica CATURRA ROJO T2308 CAI47559.1 Q5DUH8  
 α-galactosidase (Gal1) 3.2.1.22 Coffea canephora 97 CAI47560.1 Q5DUH7  
 ORF (fragment)   Crotalus adamanteus AFJ50143.1    
 α-galactosidase 3 (Gal3)   Cucumis sativus AEQ94270.1    
 acid α-galactosidase 1   Cucumis sativus ABC55266.1 Q2MK92  
 acid α-galactosidase 2 3.2.1.22 Cucumis sativus ABC88435.1 Q2HYY3  
 Sequence 175 from patent US 7071380 (fragment)   Cucurbita ABH99998.1    
 α-galactosidase (Aga27A) 3.2.1.22 Cyamopsis tetragonoloba CAA32772.1
AAA72859.1
AAE69558.1
P14749  
 Unknown (protein for MGC:101584) (probable fragment)   Danio rerio AAH83209.1
AAI64755.1
Q5XJT6  
 Unknown (protein for MGC:123333) (fragment)   Danio rerio AAI08079.1 Q32PK7  
 Zgc:123333 protein (fragment)   Danio rerio AAI39644.1 A4QP41  
 α-galactosidase (DEHA0F28490g) 3.2.1.22 Debaryomyces hansenii CBS767 CAG89932.1 Q6BJW5  
 unknown   Dendroctonus ponderosae AEE61776.1    
 unknown   Dendroctonus ponderosae AEE62359.1    
 Dbus_chr3Rg783   Drosophila busckii ALC46033.1    
 Dbus_chr2Rg1085   Drosophila busckii ALC41506.1    
 CG5731   Drosophila melanogaster AAM29494.1
AAF52871.2
NP_609354.1
Q8MYY3
Q9VL27
 
 CG7997   Drosophila melanogaster AAL39572.1
AAF58008.2
AAM68519.1
NP_611119.1
NP_725571.1
Q7K127
Q9V7N9
 
 ORF (fragment)   Eimeria maxima Weybridge AGZ15735.1    
 FFUJ_13796   Fusarium fujikuroi IMI 58289 CCT72200.1    
 FFUJ_06678   Fusarium fujikuroi IMI 58289 CCT70688.1    
 FFUJ_11205   Fusarium fujikuroi IMI 58289 CCT75166.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF74290.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF88109.1    
 α-galactosidase / β-L-arabinopyranosidase (FoAp2) 3.2.1.22
3.2.1.88
Fusarium oxysporum 12S BAH10648.1 B7XH21  
 α-galactosidase / β-L-arabinopyranosidase (FoAp1) 3.2.1.22
3.2.1.88
Fusarium oxysporum 12S BAH10649.1 B7XH22  
 α-galactosidase / α-galactopyranosidase (FoGp1)   Fusarium oxysporum 12S BAJ23877.1 E2S091  
 α-N-acetylgalactosaminidase (α-NAGAL) 3.2.1.49 Gallus gallus AAA16614.1
AAE69554.1
Q90744 1KTB[A]
1KTC[A]
 Gal48   Glaciozyma antarctica ASS36260.1    
 unknown   Glycine max ACU23118.1 C6TJM8  
 unknown (fragment)   Glycine max ACU20569.1 C6TFG7  
 unknown (partial)   Glycine max ACU20662.1 C6TFR0  
 α-galactosidase 3.2.1.22 Glycine max AAA73963.1
AAR65332.1
ACU23822.1
Q39811  
 α-galactosidase (Gla) 3.2.1.22 Helianthus annuus BAC66445.1 Q84VQ7  
 ORF (fragment)   Heterocapsa triquetra AAW79376.1 Q5ENL7  
 α-galactosidase A (Gla;α-GAL) 3.2.1.22 Homo sapiens AAH02689.1
AAA51676.1
AAA52514.1
AAA52559.1
AAB64203.1
AAE66433.1
AAE69556.1
AAN92813.1
AAP35510.1
AAQ31818.1
AAQ68716.1
AAQ81221.1
AAY03282.1
AAY71885.1
AAY71886.1
AAY71887.1
AAY71888.1
AAY71889.1
AAY71890.1
AAY71891.1
AAY71892.1
AAY71893.1
AAY71894.1
AAY72531.1
AAY72532.1
AAY72533.1
AAY72534.1
AAY72535.1
AAY72536.1
AAY72537.1
AAY72538.1
AAY72539.1
AAY72540.1
ABE23230.1
ABL16360.1
ABL21591.1
ACH14962.1
ACK10792.1
BAA34059.1
BAD96347.1
BAF83784.1
BAG59647.1
BAT62474.1
CAA29232.1
CAA32617.1
CAB55878.1
CAC09605.1
CAE85447.1
CAV33302.1
NP_000160.1
P06280
Q53Y83
1R46[A,B]
1R47[A,B]
3GXN[A,B]
3GXP[A,B]
3GXT[A,B]
3HG2[A,B]
3HG3[A,B]
3HG4[A,B]
3HG5[A,B]
3LX9[A,B]
3LXA[A,B]
3LXB[A,B]
3LXC[A,B]
3S5Y[A,B]
3S5Z[A,B]
3TV8[A,B]
4NXS[A,B]
 α-N-acetylgalactosaminidase / α-galactosidase B (bK250D10.5;NagA;α-NAGAL) 3.2.1.22
3.2.1.49
Homo sapiens AAA36351.1
AAA51677.1
AAA59902.1
AAB06718.1
AAE69555.1
AAH00095.1
ACM80412.1
ACM85401.1
ASU96594.1
CAB41237.1
CAG30413.1
CAX14869.1
CAX14870.1
NP_000253.1
P17050 3H53[A,B]
3H54[A,B]
3H55[A,B]
3IGU[A,B]
4DO4[A,B]
4DO5[A,B]
4DO6[A,B]
 α-galactosidase (fragment)   Hordeum vulgare CAA74161.1 O04943  
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