Glycoside Hydrolase Family 1

Known Activitiesβ-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23); β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-β-1,4-glucanase (EC 3.2.1.74); 6-phospho-β-galactosidase (EC 3.2.1.85); 6-phospho-β-glucosidase (EC 3.2.1.86); strictosidine β-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin β-glucosidase (EC 3.2.1.117); prunasin β-glucosidase (EC 3.2.1.118); raucaffricine β-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); β-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-β-apiosyl-β-glucosidase (EC 3.2.1.161); ABA-specific β-glucosidase (EC 3.2.1.175); DIMBOA β-glucosidase (EC 3.2.1.182); β-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental); absent in plant myrosinases
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (7128); Uniprot accession (2273); PDB accession (187); 3D entries (41); cryst (0)
All (5487) Archaea (91) Bacteria (4652) Eukaryota (725) unclassified (19) Structure (41 ) Characterized (279)
| 1 | 2 | 3 |
Archaea
Protein Name EC#OrganismGenBankUniprotPDB/3D
 β-glycosidase (β-Gly;Asβ-Gly;ASAC_1390) 3.2.1.- Acidilobus saccharovorans 345-15 ADL19795.1 D9PZ08 4HA3[A]
4HA4[A]
 β-mannosidase (BglB;PF0356) 3.2.1.25 Pyrococcus furiosus DSM 3638 AAL80480.1
NP_578085.1
Q8U3U9  
 β-glucosidase / β-glycosidase / β-rutinosidase (Cel1A;CelB;BGLPf;PFTG;PF0073;Pf-β-gly) 3.2.1.21
3.2.1.-
Pyrococcus furiosus DSM 3638 AAL80197.1
AAC25555.1
ABC06396.1
NP_577802.1
E7FHY4
Q51723
3APG[A,B,C,D]
3WDP[P,Q,R,S]
 β-glucosidase (BglA;PF0442) (Cel1B) 3.2.1.21 Pyrococcus furiosus DSM 3638 AAL80566.1
AAG28457.1
NP_578171.1
E7FI48
Q9HHB3
 
 β-mannosidase / β-galactosidase (BmnA;PF1208) 3.2.1.23
3.2.1.25
Pyrococcus furiosus DSM 3638 AAL81332.1
AAC44387.1
AAM56789.1
ABC06395.1
CAH68690.1
CAT81449.1
NP_578937.1
E7FHC0
Q51733
 
 alkyl β-glucosidase (membrane-bound) (BGPh;BglA;PH0366) 3.2.1.21 Pyrococcus horikoshii OT3 BAA29440.1
ABC06393.1
NP_142340.1
O58104 1VFF[A]
 β-mannosidase (BglB;PH0501) 3.2.1.25 Pyrococcus horikoshii OT3 BAA29589.1
ABC06394.1
NP_142473.1
O58237  
 β-galactosidase 3.2.1.23 Pyrococcus woesei AAB97862.1 O52629  
 β-glycosidase (BgaS;Saci_1849) 3.2.1.- Sulfolobus acidocaldarius DSM 639 AAY81155.1
YP_256448.1
P14288  
 β-glycosidase (Bgly;SSG) 3.2.1.- Sulfolobus shibatae AAA79030.1 P50388  
 β-glycosidase (LacS;Ssol98_010100014373) 3.2.1.21
3.2.1.23
Sulfolobus solfataricus 98/2 AAD21094.1
AET42942.1
G8GCT7  
 β-glycosidase / β-galactosidase 3.2.1.- Sulfolobus solfataricus DSM1616 CAA34074.1 P14288  
 β-glycosidase S (LacS;Ss-β-gly;SSO3019) 3.2.1.21
3.2.1.23
3.2.1.-
Sulfolobus solfataricus P2 AAA72843.1
AAE29896.1
AAK43121.1
ABC06397.1
ACW34039.1
CAC24042.1
CAJ18790.1
NP_344331.1
P22498 1GOW[A,B]
1UWI[A,B,C,D]
1UWQ[A,B]
1UWR[A,B]
1UWS[A,B]
1UWT[A,B]
1UWU[A,B]
2CEQ[A,B]
2CER[A,B]
4EAM[A,B]
4EAN[A,B]
 β-glycosidase (TK1827) 3.2.1.- Thermococcus kodakarensis KOD1 BAD86016.1
CAT70991.1
Q5JDV2  
 β-glycosidase (TK1761) 3.2.1.- Thermococcus kodakarensis KOD1 BAA78713.1
BAD85950.1
CAT70557.1
Q9YGB8  
 β-glucosidase (BglT) 3.2.1.21 Thermococcus sp. AL662 CAA94187.1 O08324  
 TVG0691226 3.2.1.23 Thermoplasma volcanium GSS1 BAB59827.1
NP_111204.1
Q97AX4  
 β-glycosidase (Tα-β-gly) 3.2.1.- Thermosphaera aggregans M11TL AAD43138.1
AAM56782.1
Q9YGA8 1QVB[A,B]
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 β-glucosidase (Abg) 3.2.1.21 Agrobacterium sp. ATCC21400 AAA22085.1
AAQ79763.1
P12614  
 β-glycosidase (GlyB;Aaci_1895) 3.2.1.- Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 ACV58907.1
AAZ81839.1
C8WXU5  
 β-glucosidase (BglZ) 3.2.1.21 Bacillus amyloliquefaciens ABBD AFS64714.1    
 β-glucosidase (BglA) 3.2.1.21 Bacillus circulans subsp. alkalophilus AAA22266.1
AAQ79761.1
CBG21249.1
Q03506 1QOX[A]
 β-glucosidase (BglA;BH1923) 3.2.1.21 Bacillus halodurans C-125 BAB05642.1
CBG20998.1
NP_242789.1
Q9KBK3  
 β-glucosidase A 3.2.1.21 Bacillus sp. GL1 BAA36160.1
CBG21242.1
Q9ZNN7  
 6-P-β-glucosidase (YdhP;BSU05840) 3.2.1.86 Bacillus subtilis subsp. subtilis str. 168 BAA19708.1
CAB12403.1
CBG21028.1
NP_388465.1
O05508  
 6-P-β-glucosidase (BglA;BSU40110) 3.2.1.86 Bacillus subtilis subsp. subtilis str. 168 AAA22660.1
BAA11270.1
CAB16048.1
CBG21250.1
NP_391891.1
P42973  
 6-P-β-glucosidase 1 (BglH;N17D;BSU39260) 3.2.1.86 Bacillus subtilis subsp. subtilis str. 168 CAB15962.2
CAA84287.1
CBG21247.1
NP_391805.1
P40740  
 6-P-β-glucosidase (YckE;BglC;BSU03410) 3.2.1.86 Bacillus subtilis subsp. subtilis str. 168 CAB12135.1
BAA06429.1
BAA08975.1
CBG21248.1
NP_388223.1
P42403  
 β-glucosidase / β-xylosidase (BglB;P11-6B) 3.2.1.21
3.2.1.37
bacterium enrichment culture clone P11-6B ADT62000.1    
 β-glucosidase / β-D-fucosidase 3.2.1.21
3.2.1.38
Bifidobacterium breve 203 / clb BAA19881.1
CBG21199.1
P94248  
 β-glucosidase / cellodextrinase (CldC; Bbr_0109) 3.2.1.21 Bifidobacterium breve UCC2003 ACT78497.1
ABE94821.1
   
 β-glucosidase (BglS) 3.2.1.21 Caldicellulosiruptor 14B CAA10354.1    
 β-glucosidase / cellodextrinase (CbBgl1A;CbCdx1A;Athe_0458) (Bgl1A=Cdx1A) 3.2.1.21 Anaerocellum thermophilum DSM 6725 ACM59590.1 B9MNR1  
 β-glucosidase A (BglA) 3.2.1.21 Caldicellulosiruptor saccharolyticus CAA31087.1
AAQ79759.1
CBG21257.1
P10482  
 β-glucosidase (BglA;Csac_1089) 3.2.1.21 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66702.1 A4XIG7  
 cellobiase (Cba3) 3.2.1.21 Cellulomonas biazotea ATCC 486 AEM45802.1    
 β-glucosidase 3.2.1.21 Cellulomonas fimi ATCC 484 AAA23091.1 Q46043  
 cellodextrin glucohydrolase (Ccel_0374) 3.2.1.21
3.2.1.23
3.2.1.74
Clostridium cellulolyticum H10 ATCC 35319 ACL74759.1 B8I5U2  
 β-glucosidase A (BglA;BG) 3.2.1.21 Clostridium cellulovorans AAQ00997.1
CBG21209.1
Q53EH2 3AHX[A,B,C,D]
 6-P-β-glucosidase (AbgA) 3.2.1.86 Clostridium longisporum AAC05714.1 Q46130  
 exo-β-glucosidase 1A (BglA; β-G;Cthe_0212) (Glc1A) 3.2.1.21 Clostridium thermocellum ATCC 27405 CAA42814.1
AAQ79758.1
ABN51453.1
P26208  
 β-glucosidase A (BglA;DP2448) 3.2.1.21 Desulfotalea psychrophila LSv54 CAG37177.1
YP_066184.1
Q6AKE8  
 β-glucosidase (DtGH;DICTH_1689) 3.2.1.21 Dictyoglomus thermophilum H-6-12 ATCC 35947 ACI19973.1 B5YAN1  
 6-P-β-glucosidase (BglB) 3.2.1.86 Enterococcus faecium BFE 900 AAD28227.1
CBG21239.1
Q9X564  
 6-P-β-glucosidase (ArbB) 3.2.1.86 Erwinia chrysanthemi 3665 AAA24815.1
AAQ79756.1
CBG21244.1
P26206  
 6-P-β-glucosidase (BglB;b3721) 3.2.1.86 Escherichia coli K-12 MG1655 AAC76744.1
AAA23511.1
AAA62072.1
AAA83838.1
AAQ79757.1
NP_418177.1
P11988  
 6-P-β-glucosidase 2 (AscB) 3.2.1.86 Escherichia coli K-12 MG1655 AAA69226.1
AAA16430.1
AAC75758.1
NP_417196.1
P24240  
 6-P-β-glucosidase A (BglA;b2901) 3.2.1.86 Escherichia coli K-12 MG1655 AAC75939.1
AAA83082.1
CBG20988.1
NP_417377.1
Q46829 2XHY[A,B,C,D]
 β-glucosidase (BglA) 3.2.1.21 Exiguobacterium sp. DAU5 ADK47980.1 E0X9H4  
 β-glucosidase (FiBgl1A) (Bgl1A) 3.2.1.21 Fervidobacterium islandicum CCA60742.1    
 β-glucosidase (BglA) 3.2.1.21 Fervidobacterium sp. YNP AAN60220.1 Q8GKQ8  
 6-P-β-glucosidase (PbgA) 3.2.1.86 Fusobacterium mortiferum AAB49339.1 P94793  
 6-phospho-β-glycosidase (GK3214) 3.2.1.85
3.2.1.86
Geobacillus kaustophilus HTA426 BAD77499.1
CBG21169.1
Q5KUY7  
 6-phospho-β-glycosidase (GK1856) 3.2.1.85
3.2.1.86
Geobacillus kaustophilus HTA426 BAD76141.1
CBG21167.1
Q5KYU5  
 β-glucosidase A (BglA;Hore_15280) 3.2.1.21 Halothermothrix orenii H 168 H 168; DSM 9562 ACL70277.1 B8CYA8 3TA9[A,B]
 6-P-β-glucosidase / phospho-cellobiase (CasB) 3.2.1.86 Klebsiella oxytoca P2 AAB51564.1
CBG21258.1
Q48409  
 6-P-β-galactosidase 3.2.1.85 Lactobacillus acidophilus BAA07122.1
CBG21259.1
P50977  
 6-P-β-galactosidase 3.2.1.85 Lactobacillus casei AAD15134.1
AAA25238.1
AAQ79754.1
CAB02557.1
CBG21260.1
P14696  
 6-P-β-glucosidase (Pbg1;LGAS_0185) 3.2.1.86 Lactobacillus gasseri ATCC 33323 ABJ59596.1 Q046M6  
 6-P-β-galactosidase (LacG1;LGAS_0344) 3.2.1.85 Lactobacillus gasseri ATCC 33323 ABJ59750.1 Q045X2  
 6-P-β-galactosidase (LacG2;LGAS_0502) 3.2.1.85 Lactobacillus gasseri ATCC 33323 ABJ59900.1 Q045H2  
 6-P-β-glucosidase (Pbg2;LGAS_1668) 3.2.1.86 Lactobacillus gasseri ATCC 33323 ABJ60960.1 Q041B2  
 6-P-β-galactosidase 1 (Pbg1) 3.2.1.86 Lactobacillus gasseri JCM1031 BAA20086.1
BAD95552.1
CBG21210.1
O06532  
 6-P-β-galactosidase II (Pbg2) 3.2.1.86 Lactobacillus gasseri JCM1031 BAA25004.1
CBG21197.1
O50658  
 aryl 6-P-β-glucosidase (BglH;BglT) 3.2.1.86 Lactobacillus plantarum B21 CAA75906.1 O86291  
 6-P-β-galactosidase (LacG) 3.2.1.85 Lactococcus lactis Z268 AAA25183.1
AAA25173.1
AAA26949.1
AAQ79752.1
CBG21261.1
P11546 1PBG[A,B]
2PBG[A]
3PBG[A,B]
4PBG[A,B]
 β-glucosidase (BglM1;Mmwyl1_4295) (cold-active) 3.2.1.21 Marinomonas sp. MWYL1 ABR73190.1 A6W3B1  
 β-glucosidase (Bgl;BglU) 3.2.1.21 Micrococcus antarcticus ACM66669.1 B9V8P5 3W53[A]
 6-P-β-glucosidase (BglD;OEOE_0224) 3.2.1.86 Oenococcus oeni PSU-1 ABJ56211.1 Q04H61  
 6P-β-glucosidase (CelD;OEOE_0341) 3.2.1.86 Oenococcus oeni PSU-1 ABJ56315.1 Q04GV7  
 β-glucosidase (BglPm;KNP414_03656) 3.2.1.21 Paenibacillus mucilaginosus KNP414 AEI42200.1    
 β-glucosidase A (BglA) 3.2.1.21 Paenibacillus polymyxa AAA22263.1
AAQ79760.1
CBG21252.1
P22073 1BGA[A,B,C,D]
1BGG[A,B,C,D]
1E4I[A]
1TR1[A,B,C,D]
1UYQ[A]
 β-glucosidase B (BglB) 3.2.1.21 Paenibacillus polymyxa AAA22264.1
AAQ79762.1
CBG21256.1
P22505 2JIE[A]
2O9P[A]
2O9R[A]
2O9T[A]
2Z1S[A]
 β-glucosidase (BglA) 3.2.1.21 Paenibacillus sp. HC1 BAE48718.1 Q2WGB4  
 β-1,4-glucosidase (Gluc1C) 3.2.1.21 Paenibacillus sp. ICGEB2008 / MTCC 5639 AFQ36783.1    
 β-glucosidase A 3.2.1.21 Pantoea agglomerans WD4 WILD STRAIN CAA56282.1 Q59437  
 6-P-β-glucosidase (AscB) 3.2.1.21
3.2.1.86
Pectobacterium carotovorum subsp. carotovorum LY34 AAT45375.1 Q6IV14  
 6-P-β-glucosidase (BglA) 3.2.1.21
3.2.1.86
Pectobacterium carotovorum subsp. carotovorum LY34 AAV37466.1 Q5UAU4  
 β-glucosidase (CasB) 3.2.1.21 Pectobacterium carotovorum subsp. carotovorum LY34 AAX57580.1 Q4VK76  
 β-glucosidase (BglY) 3.2.1.21 Pectobacterium carotovorum subsp. carotovorum LY34 AAX76617.1 Q2TI56  
 β-glucosidase (CelG) 3.2.1.21 Pectobacterium carotovorum subsp. carotovorum LY34 ABL14155.1 A1C3J9  
 β-glucosidase 1B (Sde_1394) (Bgl1B) 3.2.1.21 Saccharophagus degradans 2-40 ABD80656.1 Q21KX3  
 β-glucosidase 1A (Sde_3603) (Bgl1A) 3.2.1.21 Saccharophagus degradans 2-40 ABD82858.1 Q21EM1  
 β-glucosidase (SMc03160) 3.2.1.21 Sinorhizobium meliloti 1021 CAC47470.1
ADA60163.1
NP_386997.1
Q92LX2  
 β-glucosidase (Bgl1) 3.2.1.21 Sphingomonas paucimobilis AAG59862.1 Q9APE3  
 β-glucosidase (BglSp) 3.2.1.21 Sphingomonas sp. 2F2 ADY18331.1    
 ginsenoside β-glucosidase (Sala_1019) 3.2.1.21 Sphingopyxis alaskensis RB2256 ABF52736.1 Q1GUD6  
 6-P-β-galactosidase (SAV2189) 3.2.1.85 Staphylococcus aureus subsp. aureus Mu50 AAA26650.1
AAQ79753.1
BAB45117.1
BAB58351.1
CBG21263.1
NP_372713.1
P11175  
 6-P-β-glucosidase (SAV0266;BglA) 3.2.1.86 Staphylococcus aureus subsp. aureus Mu50 BAB56428.1
CBG21027.1
NP_370790.1
Q99WV9  
 6-P-β-glucosidase (BglA;MW0242) 3.2.1.86 Staphylococcus aureus subsp. aureus MW2 BAB94107.1
NP_645057.1
Q8NYG9  
 6-P-β-galactosidase (LacG;SGO_1512) 3.2.1.85 Streptococcus gordonii str. Challis substr. CH1 ABV10357.1
AAG39001.1
CBG21234.1
Q9EV38  
 β-glucosidase (BglA) 3.2.1.86 Streptococcus mutans NG8 AAF89979.1
CBG21238.1
Q9KJ76  
 6-P-β-galactosidase (LacG) 3.2.1.85 Streptococcus mutans UA130 AAA16450.1
CBG21265.1
P50978  
 6-P-β-glucosidase (BglA;SMU.985) 3.2.1.86 Streptococcus mutans UA159 AAN58686.1
CBG21066.1
NP_721380.1
   
 6-P-β-glucosidase (Arb;AscB;SMU.1102) 3.2.1.86 Streptococcus mutans UA159 AAN58797.1
CBG21067.1
NP_721491.1
   
 6-P-β-galactosidase (LacG;SMU.1490) 3.2.1.85 Streptococcus mutans UA159 AAN59144.1
NP_721838.1
   
 6-P-β-glucosidase (CelA;Bgl;SmBgl;SMU.1601;SMU_1601) 3.2.1.86 Streptococcus mutans UA159 AAN59243.1
CBG21068.1
NP_721937.1
  3PN8[A,B]
4DDE[A,B]
4F66[A,B]
4F79[A]
4GPN[A,B]
 6-P-β-glucosidase (BglA-2;SP0578) 3.2.1.86 Streptococcus pneumoniae TIGR4 AAK74732.1
CBG21011.1
NP_345092.1
Q97S37 4IPL[A,B]
4IPN[B,E]
 6-phospho-β-glucosidase (SPy_1599;SPy1599) 3.2.1.86 Streptococcus pyogenes M1 GAS SF370 AAK34377.1
NP_269656.1
Q99YP9 4B3K[A,B,C,D,E,F]
4B3L[A,B,C,D,E,F]
 β-glucosidase (SCO1059;SCG22.05) 3.2.1.21 Streptomyces coelicolor A3(2) CAB95278.1
CBG21059.1
NP_625353.1
Q9K440  
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Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2014-04-03 © Copyright 1998-2014
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