Glycoside Hydrolase Family 1

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23); β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-β-1,4-glucanase (EC 3.2.1.74); 6-phospho-β-galactosidase (EC 3.2.1.85); 6-phospho-β-glucosidase (EC 3.2.1.86); strictosidine β-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin β-glucosidase (EC 3.2.1.117); prunasin β-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine β-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); β-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-β-apiosyl-β-glucosidase (EC 3.2.1.161); ABA-specific β-glucosidase (EC 3.2.1.175); DIMBOA β-glucosidase (EC 3.2.1.182); β-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-); β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-); protodioscin 26-O-β-D-glucosidase (EC 3.2.1.186)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental); absent in plant myrosinases
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (53605); Uniprot accession (433); PDB accession (291); 3D entries (80); cryst (0)
| 1 | 2 | 3 | 4 |
Archaea
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 multifunctional β-glycosidase (β-Gly;Asβ-Gly;ASAC_1390) 3.2.1.21
3.2.1.23
3.2.1.-
pubmed
pubmed
pubmed
Acidilobus saccharovorans 345-15 ADL19795.1 D9PZ08 4HA3[A]
4HA4[A]
 Cmaq_0408 3.2.1.21 pubmed
Caldivirga maquilingensis IC-167 ABW01253.1 A8MBR0  
 Cmaq_0652 3.2.1.21 pubmed
Caldivirga maquilingensis IC-167 ABW01492.1 A8MCI6  
 β-galactosidase (CelB) 3.2.1.23 pubmed
Pyrococcus furiosus B232 AHW49177.1 Q51723  
 β-mannosidase (BglB;PF0356) 3.2.1.25 pubmed
Pyrococcus furiosus DSM 3638 NP_578085.1
AAL80480.1
Q8U3U9  
 β-glucosidase / β-rutinosidase (Cel1A;CelB;BGLPf;PfBgl1;PFTG;PF0073;Pf-β-gly) 3.2.1.21
3.2.1.-
pubmed
pubmed
Pyrococcus furiosus DSM 3638 AAL80197.1
AAC25555.1
ABC06396.1
NP_577802.1
E7FHY4
Q51723
3APG[A,B,C,D]
3WDP[P,Q,R,S]
3WQ8[A,B,C,D,E,F,G,H,I,J,K,L]
 β-mannosidase / β-galactosidase (BmnA;PF1208) 3.2.1.23
3.2.1.25
pubmed
pubmed
Pyrococcus furiosus DSM 3638 AAL81332.1
AAC44387.1
AAM56789.1
ABC06395.1
CAH68690.1
CAT81449.1
NP_578937.1
E7FHC0
Q51733
 
 β-glucosidase (BglA;PF0442) (Cel1B) 3.2.1.21 pubmed
Pyrococcus furiosus DSM 3638 AAL80566.1
AAG28457.1
NP_578171.1
E7FI48
Q9HHB3
 
 alkyl β-glucosidase (membrane-bound) (BGPh;BglA;PH0366) 3.2.1.21 pubmed
Pyrococcus horikoshii OT3 BAA29440.1
ABC06393.1
NP_142340.1
O58104 1VFF[A]
 β-mannosidase (BglB;PH0501) 3.2.1.25 pubmed
Pyrococcus horikoshii OT3 BAA29589.1
ABC06394.1
NP_142473.1
O58237  
 β-galactosidase 3.2.1.23 pubmed
Pyrococcus woesei AAB97862.1 O52629  
 β-glycosidase (Bgly;SSG) 3.2.1.21 pubmed
Saccharolobus shibatae AAA79030.1 P50388  
 β-glycosidase / β-galactosidase 3.2.1.21
3.2.1.23
doi
doi
Saccharolobus solfataricus DSM1616 CAA34074.1 P14288  
 β-glycosidase S (LacS;Ss-β-gly;SSO3019) 3.2.1.21
3.2.1.23
pubmed
pubmed
Saccharolobus solfataricus P2 AAA72843.1
AAE29896.1
AAK43121.1
ABC06397.1
ACW34039.1
CAC24042.1
CAJ18790.1
NP_344331.1
P22498 1GOW[A,B]
1UWI[A,B,C,D]
1UWQ[A,B]
1UWR[A,B]
1UWS[A,B]
1UWT[A,B]
1UWU[A,B]
2CEQ[A,B]
2CER[A,B]
4EAM[A,B]
4EAN[A,B]
5I3D[A,B,C,D]
5IXE[A,B]
 β-glycosidase (BgaS;Saci_1849) 3.2.1.21
3.2.1.-
pubmed
pubmed
Sulfolobus acidocaldarius DSM 639 AAY81155.1
YP_256448.1
P14288  
 β-glycosidase (TK1827) 3.2.1.21
3.2.1.23
pubmed
pubmed
Thermococcus kodakarensis KOD1 BAD86016.1
CAT70991.1
Q5JDV2  
 β-glycosidase (Tkbgly;TK1761) 3.2.1.21
3.2.1.23
pubmed
pubmed
Thermococcus kodakarensis KOD1 BAA78713.1
BAD85950.1
CAT70557.1
Q5JDT7
Q9YGB8
 
 β-glucosidase (BglT) 3.2.1.21 pubmed
Thermococcus sp. AL662 CAA94187.1 O08324  
 TVG0691226 3.2.1.21
3.2.1.23
pubmed
pubmed
Thermoplasma volcanium GSS1 BAB59827.1
NP_111204.1
Q97AX4  
 β-glucosidase (Tα-β-gly;Gly) 3.2.1.21 pubmed
Thermosphaera aggregans M11TL AAD43138.1
AAM56782.1
Q9YGA8 1QVB[A,B]
 β-glucosidase (Bgl1) 3.2.1.- pubmed
uncultured archaeon CDG15325.1 W8W3B8  
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 exo-β-glucosidase 1A (BglA; β-G;Cthe_0212) (Glc1A) 3.2.1.21 pubmed
Acetivibrio thermocellus ATCC 27405 CAA42814.1
AAQ79758.1
ABN51453.1
P26208 5OGZ[A,B]
 Acel_0133 3.2.1.21 pubmed
Acidothermus cellulolyticus 11B ABK51908.1 A0LR48  
 β-glucosidase (Abg) 3.2.1.21 pubmed
Agrobacterium sp. ATCC21400 AAA22085.1
AAQ79763.1
P12614  
 β-glucosidase (AacGH1) 3.2.1.21 pubmed
Alicyclobacillus acidiphilus WP_067621817.1   BBB[nd]
CCC[nd]
DDD[nd]
EEE[nd]
FFF[nd]
GGG[nd]
HHH[nd]
6ZIV[AAA]
 β-glycosidase (GlyB;Aaci_1895) 3.2.1.21
3.2.1.23
3.2.1.-
pubmed
pubmed
pubmed
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 ACV58907.1
AAZ81839.1
C8WXU5
Q0R5R7
 
 β-glucosidase 3.2.1.- pubmed
Alicyclobacillus herbarius     B[nd]
C[nd]
D[nd]
6YN7[A]
 Aflv_2360 3.2.1.21 pubmed
Anoxybacillus flavithermus WK1 ACJ34717.1 B7GM33  
 β-glucosidase (BglZ) 3.2.1.21 pubmed
Bacillus amyloliquefaciens ABBD AFS64714.1 J9ZZW8  
 BLi04199 / BL01946 3.2.1.21 pubmed
Bacillus licheniformis DSM 13 = ATCC 14580 AAU43012.1
AAU25633.1
CBG21160.1
Q65D52  
 BLi00387 or BL01718 (YckE) 3.2.1.38 pubmed
Bacillus licheniformis DSM 13 = ATCC 14580 AAU39345.1
AAU21991.1
CBG21156.1
  B[nd]
C[nd]
D[nd]
7M1R[A]
 6-P-β-glucosidase (GII88_21755;AscB) 3.2.1.86 pubmed
Bacillus licheniformis P8_B2 QGI45652.1 A0A5Q3BW14 B[nd]
C[nd]
6WGD[A]
 β-glucosidase A 3.2.1.21 pubmed
Bacillus sp. GL1 BAA36160.1
CBG21242.1
Q9ZNN7  
 aryl β-glucosidase (BglC) 3.2.1.- pubmed
Bacillus sp. SJ-10 AHC94275.1 V9VGK4  
 6-P-β-glucosidase (YdhP;BSU05840) 3.2.1.86 pubmed
Bacillus subtilis subsp. subtilis str. 168 BAA19708.1
AIY91871.1
AQR80536.1
AQR84749.1
CAB12403.1
CBG21028.1
NP_388465.1
A0A6M3Z8A5
O05508
 
 6-P-β-glucosidase (BglA;BSU40110) 3.2.1.86 pubmed
Bacillus subtilis subsp. subtilis str. 168 AAA22660.1
AIY95329.1
AQR84054.1
AQR88269.1
BAA11270.1
CAB16048.1
CBG21250.1
NP_391891.1
A0A6M4JR50
P42973
 
 6-P-β-glucosidase 1 (BglH;N17D;BSU39260) 3.2.1.86 pubmed
Bacillus subtilis subsp. subtilis str. 168 CAB15962.2
AIY95585.1
AQR83968.1
AQR88183.1
CAA84287.1
CBG21247.1
NP_391805.1
A0A6M3ZHY9
P40740
 
 6-P-β-glucosidase (YckE;BglC;BSU03410) 3.2.1.86 pubmed
Bacillus subtilis subsp. subtilis str. 168 CAB12135.1
AIY91623.1
AQR80279.1
AQR84492.1
BAA06429.1
BAA08975.1
CBG21248.1
NP_388223.1
A0A6M3ZAF5
P42403
 
 β-glucosidase / β-xylosidase (BglB;P11-6B) 3.2.1.21
3.2.1.37
pubmed
pubmed
bacterium enrichment culture clone P11-6B ADT62000.1 E9KYU3  
 β-glucosidase / β-D-fucosidase 3.2.1.21
3.2.1.38
pubmed
pubmed
Bifidobacterium breve 203 / clb BAA19881.1
CBG21199.1
P94248  
 β-glucosidase / cellodextrinase (CldC; Bbr_0109) 3.2.1.21 pubmed
Bifidobacterium breve UCC2003 ACT78497.1
ABE94821.1
F1LL52  
 β-glucosidase / cellodextrinase (CbBgl1A;CbCdx1A;Athe_0458) (Bgl1A=Cdx1A) 3.2.1.21 doi
Caldicellulosiruptor bescii DSM 6725 ACM59590.1 B9MNR1  
 β-glucosidase (Bgl13;Calkr_2207) 3.2.1.21 URL
Caldicellulosiruptor kristjanssonii I77R1B ADQ41669.1 E4S6B1  
 β-glucosidase A (BglA) 3.2.1.21 pubmed
Caldicellulosiruptor saccharolyticus CAA31087.1
AAQ79759.1
CBG21257.1
P10482  
 β-glucosidase (BglA;Csac_1089) 3.2.1.21 pubmed
Caldicellulosiruptor saccharolyticus DSM 8903 ABP66702.1 A4XIG7  
 β-galactosidase 3.2.1.23 doi
Caldicellulosiruptor sp. enrichment culture clone YTY-70 AFQ98284.1    
 β-glucosidase (BlgA) 3.2.1.21 pubmed
Caldicellulosiruptor sp. F32 AFO70070.1 I7DLX2  
 CCNA_02220 3.2.1.21 pubmed
Caulobacter vibrioides NA1000 ACL95685.1 A0A0H3C9V1
B8GXX8
 
 cellobiase (Cba3) 3.2.1.21 pubmed
Cellulomonas biazotea ATCC 486 AEM45802.1 G1C1T5  
 β-glucosidase (CfBgl1;Celf_2783) 3.2.1.21 pubmed
Cellulomonas fimi ATCC 484 AEE46907.1 F4H7E6  
 Cfla_1084 3.2.1.21 pubmed
Cellulomonas flavigena DSM 20109 ADG73989.1 D5ULE7  
 Rsph17025_1146 3.2.1.21 pubmed
Cereibacter sphaeroides ATCC 17025 ABP70047.1 A4WRN3  
 β-glucosidase A (BglA;BG) 3.2.1.21 pubmed
Clostridium cellulovorans AAQ00997.1
CBG21209.1
Q53EH2 3AHX[A,B,C,D]
 6-P-β-glucosidase (AbgA) 3.2.1.86 pubmed
Clostridium longisporum AAC05714.1 Q46130  
 ESA_02547 3.2.1.86 pubmed
Cronobacter sakazakii ATCC BAA-894 ABU77792.1 A7MJ23  
 Deide_00550 3.2.1.21 pubmed
Deinococcus deserti VCD115 ACO44852.1 C1CXP6  
 β-glucosidase A (BglA;DP2448) 3.2.1.21 pubmed
Desulfotalea psychrophila LSv54 CAG37177.1
YP_066184.1
Q6AKE8  
 β-glucosidase (DtGH;DICTH_1689) 3.2.1.21 pubmed
Dictyoglomus thermophilum H-6-12 ACI19973.1 B5YAN1  
 β-glucosidase (Dtur_0462) 3.2.1.21 pubmed
Dictyoglomus turgidum DSM 6724 ACK41762.1 B8E1X9  
 β-galactosidase (Dtur_1799) 3.2.1.- pubmed
Dictyoglomus turgidum DSM 6724 ACK43071.1 B8E0Q1  
 6-P-β-glucosidase (AscB;ECs3572) 3.2.1.86 pubmed
Escherichia coli O157:H7 str. Sakai BAB36995.1
NP_311599.1
Q8X841  
 6-P-β-glucosidase (BglB;b3721) 3.2.1.86 pubmed
Escherichia coli str. K-12 substr. MG1655 AAC76744.1
AAA23511.1
AAA62072.1
AAA83838.1
AAQ79757.1
AIZ93475.1
ALI38586.1
AMC96613.1
AUG18433.1
AVI53891.1
AYG21461.1
NP_418177.1
P11988  
 6-P-β-glucosidase 2 (AscB;b2716) 3.2.1.86 pubmed
Escherichia coli str. K-12 substr. MG1655 AAA69226.1
AAA16430.1
AAC75758.1
AIZ93701.1
ALI42228.1
AMC98974.1
AUG19188.1
AVI56782.1
AYG21513.1
NP_417196.1
P24240  
 6-P-β-glucosidase A (BglA;b2901) 3.2.1.86 pubmed
Escherichia coli str. K-12 substr. MG1655 AAC75939.1
AAA83082.1
AUG17619.1
AVI53071.1
AYG18126.1
CBG20988.1
NP_417377.1
Q46829 2XHY[A,B,C,D]
 β-glucosidase (BglA;EaBglA;EaBgl1A;Eab7_0297) 3.2.1.21 pubmed
Exiguobacterium antarcticum B7 Eab7 AFS69459.1 K0A8J9 5DT5[A,B,C,D,E,F,G,H]
5DT7[A,B,C,D]
 EAT1b_2183 3.2.1.21 doi
Exiguobacterium sp. AT1b ACQ71106.1 C4L1S4 6WIU[A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P]
 β-glucosidase (BglA) 3.2.1.21 doi
Exiguobacterium sp. DAU5 ADK47980.1 E0X9H4  
 β-glucosidase (FiBgl1A) (Bgl1A) 3.2.1.21 pubmed
Fervidobacterium islandicum CCA60742.1 G8YZD7  
 Fnod_1558 3.2.1.21 pubmed
Fervidobacterium nodosum Rt17-B1 ABS61401.1 A7HNB8  
 β-glucosidase (BglA) 3.2.1.21 pubmed
Fervidobacterium sp. YNP AAN60220.1 Q8GKQ8  
 6-P-β-glucosidase (PbgA) 3.2.1.86 pubmed
Fusobacterium mortiferum AAB49339.1 P94793  
 β-galactosidase (GKGal1A;GK2337) (Gal1A) 3.2.1.23 doi
Geobacillus kaustophilus HTA426 BAD76622.1
CBG21168.1
Q5KXG4  
 6-phospho-β-glycosidase (GK3214) 3.2.1.85
3.2.1.86
pubmed
pubmed
Geobacillus kaustophilus HTA426 BAD77499.1
CBG21169.1
Q5KUY7  
 6-phospho-β-glycosidase (GK1856) 3.2.1.85
3.2.1.86
pubmed
pubmed
Geobacillus kaustophilus HTA426 BAD76141.1
CBG21167.1
Q5KYU5  
 6-P-β-galactosidase (Gan1D) 3.2.1.85
3.2.1.86
pubmed
pubmed
Geobacillus stearothermophilus T-1 AHL67640.1 W8QF82 4ZE4[A,B]
4ZE5[A,B,C,D]
4ZEH[A,B,C,D]
4ZEN[A,B]
4ZEP[A,B]
4ZFM[A,B,C,D]
5OK7[A,B,C,D]
5OKA[A,B,C,D]
5OKB[A,B,C,D]
5OKE[A,B,C,D]
5OKG[A,B,C,D]
5OKH[A,B]
5OKJ[A,B]
5OKK[A,B]
5OKQ[A,B]
5OKR[A,B]
5OKS[A,B]
 HCH_06907 3.2.1.21 pubmed
Hahella chejuensis KCTC 2396 ABC33525.1 Q2S749  
 β-glucosidase (BglA;BH1923) 3.2.1.21 pubmed
Alkalihalobacillus halodurans C-125 BAB05642.1
CBG20998.1
NP_242789.1
Q9KBK3  
 β-galactosidase (BgalH) 3.2.1.23 pubmed
Halomonas sp. S62 AFA35120.1 H6WX44  
 β-glucosidase A (BglA;HoBGLA;Hore_15280) 3.2.1.21 pubmed
Halothermothrix orenii H 168 ACL70277.1 B8CYA8 3TA9[A,B]
4PTV[A,B]
4PTW[A,B]
4PTX[A,B]
 β-glucosidase (BglD5; JMA_34740) 3.2.1.21   Jeotgalibacillus malaysiensis D5 AJD92791.1    
 6-P-β-glucosidase (BglB) 3.2.1.86 pubmed
Klebsiella aerogenes AN292 AAM82757.1 Q8KP24  
 6-P-β-glucosidase / phospho-cellobiase (CasB) 3.2.1.86 pubmed
Klebsiella oxytoca P2 AAB51564.1
CBG21258.1
Q48409  
 6-P-β-galactosidase 3.2.1.85 pubmed
Lacticaseibacillus casei AAD15134.1
AAA25238.1
AAQ79754.1
CAB02557.1
CBG21260.1
P14696  
 aryl 6-P-β-glucosidase (BglH;BglT) 3.2.1.86 pubmed
Lactiplantibacillus plantarum B21 CAA75906.1 O86291  
 6-P-β-galactosidase 3.2.1.85 doi
Lactobacillus acidophilus BAA07122.1
CBG21259.1
P50977  
 6-P-β-glucosidase (Pbg1;LGAS_0185) 3.2.1.86 pubmed
Lactobacillus gasseri ATCC 33323 = JCM 1131 ABJ59596.1 Q046M6  
 6-P-β-galactosidase (LacG1;LGAS_0344) 3.2.1.85 pubmed
Lactobacillus gasseri ATCC 33323 = JCM 1131 ABJ59750.1 Q045X2  
 6-P-β-galactosidase (LacG2;LGAS_0502) 3.2.1.85 pubmed
Lactobacillus gasseri ATCC 33323 = JCM 1131 ABJ59900.1 Q045H2  
 6-P-β-glucosidase (Pbg2;LGAS_1668) 3.2.1.86 pubmed
Lactobacillus gasseri ATCC 33323 = JCM 1131 ABJ60960.1 Q041B2  
 6-P-β-galactosidase 1 (Pbg1) 3.2.1.86 pubmed
Lactobacillus gasseri JCM1031 BAA20086.1
BAD95552.1
CBG21210.1
O06532
Q588H0
 
 6-P-β-galactosidase II (Pbg2) 3.2.1.86 pubmed
Lactobacillus gasseri JCM1031 BAA25004.1
CBG21197.1
O50658  
 llmg_1046 3.2.1.86 pubmed
Lactococcus lactis subsp. cremoris MG1363 CAL97639.1 A2RK29  
 6-P-β-galactosidase (LacG) 3.2.1.85 pubmed
Lactococcus lactis Z268 AAA25183.1
AAA25173.1
AAA26949.1
AAQ79752.1
CBG21261.1
P11546 1PBG[A,B]
2PBG[A]
3PBG[A,B]
4PBG[A,B]
 amb0219 3.2.1.21 pubmed
Magnetospirillum magneticum AMB-1 BAE49023.1 Q2WAV2  
 β-glucosidase (BglM1;Mmwyl1_4295) (cold-active) 3.2.1.21 doi
Marinomonas sp. MWYL1 ABR73190.1 A6W3B1  
 Mrub_0288 3.2.1.21 pubmed
Meiothermus ruber DSM 1279 ADD27066.1
AGK03521.1
D3PLV5  
 MCA1578 (Bgl) 3.2.1.21 pubmed
Methylococcus capsulatus str. Bath AAU92142.1
CBG21162.1
Q608B9  
 β-glycosidase (BGL167;BglG167c) 3.2.1.- pubmed
Microbacterium sp. Gsoil167 AGA60135.1 L0ELG0 4R27[A,B]
 β-glucosidase (Glu1A; MaGlu1A) 3.2.1.21 pubmed
Microbulbifer sp. ALW1 QRV71704.1    
 β-glucosidase (Bgl;BglU) 3.2.1.21 pubmed
Micrococcus antarcticus ACM66669.1
AMB49877.1
AMB49878.1
AMB49879.1
A0A0Y0GAW6
A0A0Y0KCV2
A0A0Y0M4F4
B9V8P5
3W53[A]
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