Glycoside Hydrolase Family 1

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23); β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-β-1,4-glucanase (EC 3.2.1.74); 6-phospho-β-galactosidase (EC 3.2.1.85); 6-phospho-β-glucosidase (EC 3.2.1.86); strictosidine β-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin β-glucosidase (EC 3.2.1.117); prunasin β-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine β-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); β-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-β-apiosyl-β-glucosidase (EC 3.2.1.161); ABA-specific β-glucosidase (EC 3.2.1.175); DIMBOA β-glucosidase (EC 3.2.1.182); β-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental); absent in plant myrosinases
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (19256); Uniprot accession (2276); PDB accession (243); 3D entries (53); cryst (0)
All (17237) Archaea (143) Bacteria (16013) Eukaryota (1033) Viruses (1) unclassified (47) Structure (53) Characterized (336)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (Bgl595;NfBGL595;NFIA_060550) 3.2.1.21 Aspergillus fischeri NRRL 181 XP_001258596.1    
 aryl β-glucosidase (Bgl1;NfBGL1;BGL;NFIA_064710) 3.2.1.21 Aspergillus fischeri NRRL 181 XP_001263204.1    
 β-glucosidase (Bgl1) 3.2.1.21 Aspergillus niger AMS11 AAF74209.2 Q9P456  
 β-glucosidase B3 (Bgl3;AO090003000497) (fragment) 3.2.1.21 Aspergillus oryzae RIB40 BAE57671.1 Q2UL94  
 β-glucosidase B6 (AO090113000148) 3.2.1.21 Aspergillus oryzae RIB40 BAE63197.1 Q2U5G8  
 β-glucosidase I (avenacosidase;AsGlu1;As-Glu1;P60) 3.2.1.21 Avena sativa CAA55196.1
CAW42867.1
CAW48570.1
CBC08395.1
CBD21363.1
CBG21201.1
S50756
Q38786  
 β-glucosidase II (AsGlu2;As-Glu2;P60b) 3.2.1.21 Avena sativa AAD02839.1
CAW42887.1
CAW48590.1
CBC08415.1
CBD21383.1
CBG21243.1
Q9ZP27  
 β-glucosidase 3.2.1.21 Bombyx mori AAP13852.1 Q86D78  
 myrosinase (Myr1) 3.2.1.147 Brassica juncea CAA11412.1 Q9ZP01  
 myrosinase 3.2.1.147 Brassica juncea AAG54074.1
CAW42883.1
CAW48586.1
CBC08411.1
CBD21379.1
Q9AWB5  
 zeatin β-glucosidase (Bgl) 3.2.1.21 Brassica napus CAA57913.1
ACH11657.1
CAW42875.1
CAW48578.1
CBC08403.1
CBD21371.1
Q42618  
 myrosinase 3.2.1.147 Brassica napus CAA42775.1
AAQ79764.1
ABQ42337.1
ADP24126.1
ADP24127.1
CAA55685.1
CAW42868.1
CAW42890.1
CAW48571.1
CAW48593.1
CBC08396.1
CBC08418.1
CBD21364.1
CBD21386.1
CBD31889.1
CBD31921.1
Q00326
Q39343
 
 myrosinase 1 3.2.1.147 Brassica napus CAA79989.2
CAW42886.1
CAW48589.1
CBC08414.1
CBD21382.1
Q9STD7  
 myrosinase 2 3.2.1.147 Brassica napus CAA79990.1
CAW42876.1
CAW48579.1
CBC08404.1
CBD21372.1
Q42629  
 myrosinase (BMY1) 3.2.1.147 Brevicoryne brassicae AAL25999.1
CBG21232.1
Q95X01 1WCG[A,B]
 β-glucosidase (Klo-1;C50F7.10) 3.2.1.21 Caenorhabditis elegans Bristol N2 AAA83309.1
CCD67456.1
NP_501271.1
Q18758  
 β-glucosidase (Klo-2;E02H9.5) 3.2.1.21 Caenorhabditis elegans Bristol N2 AAC68766.1
CCD68636.1
NP_497558.1
Q9TZA0  
 β-glucosidase 1 GH1 family (GH1BG1;CsGH1BG1) 3.2.1.21 Camellia sinensis ARU79069.1    
 β-primeverosidase (Bgl;PD) 3.2.1.149 Camellia sinensis BAC78656.1
AAR76593.1
AAR76595.1
AAS83105.1
AAS83105.2
ACH11663.1
ADV40931.1
ADV40931.2
AHM10169.1
ANQ46489.1
CAK97604.1
CAK97604.2
CBG21219.1
Q7X9A9 3WQ4[A,B]
3WQ5[A,B]
3WQ6[A,B]
 β-glucosidase (BglB) 3.2.1.21 Candida wickerhamii CAPRIOTTI AAC49036.1 Q12601  
 ipecoside β-glucosidase (IpeGlu1) 3.2.1.21 Carapichea ipecacuanha BAH02544.1 B6ZKM3  
 myrosinase (β-thioglucoside glucohydrolase) (Tgg2) 3.2.1.147 Carica papaya ACO95143.1 C9WCQ1  
 myrosinase (β-thioglucoside glucohydrolase) (Tgg1) 3.2.1.147 Carica papaya ACO95142.1 C9WCQ0  
 strictosidine β-glucosidase 3.2.1.105 Catharanthus roseus AAF28800.1
ABW77570.1
CAC09045.1
Q9M7N7  
 β-glucosidase 3.2.1.21 Cavia porcellus AAB41058.1 P97265  
 furostanol glycoside 26-O-β-glucosidase 3.2.1.21 Cheilocostus speciosus BAA11831.1
CBG21206.1
Q42707  
 glandular β-glucosidase (ClgbGlc_B) 3.2.1.21 Chrysomela lapponica AJE75672.1    
 non-cyanogenic β-glucosidase (Bglc-2) 3.2.1.21 Cicer arietinum CAG14979.1
CAW42877.1
CAW48580.1
CBC08405.1
CBD21373.1
Q700B1  
 β-glucosidase (fragment) 3.2.1.21 Cicer arietinum CAC08209.2 Q9FSY8  
 β-glucosidase (Glu1B) 3.2.1.21 Coptotermes formosanus ADB23476.1 D2X5V7  
 β-glucosidase (Glu1A) 3.2.1.21 Coptotermes formosanus AEW67360.1    
 β-1,4-glucosidase (CgBG1) 3.2.1.21 Coptotermes gestroi AGS32242.1    
 β-glucosidase (Cel1A;CjCel1A) 3.2.1.21 Corbicula japonica BAG71912.1 B5U9B3  
 β-glucosidase (Cel1A;CjCel1A) 3.2.1.21 Corbicula japonica BAG71912.1
BAH14963.1
B5U9B3  
 dalcochinin β-glucosidase / β-fucosidase (Bglu1) (dalcochinase) 3.2.1.21
3.2.1.38
Dalbergia cochinchinensis AAF04007.1 Q9SPK3  
 isoflavonoid 7-O-β-apiosyl-β-glucose β-glycosidase (DnBglu) 3.2.1.161
3.2.1.21
3.2.1.38
Dalbergia nigrescens KURZ. AAV34606.1 Q5UB04  
 acyl-glucose:anthocyanin 7-O-glucosyltransferase (AA7-GT;DgAA7GT;BgluL) 2.4.1.- Delphinium grandiflorum BAJ33502.1 E3W9M3  
 acyl-glucose-dependent anthocyanin β-glucosyltransferase (DgAA7BG-GT1) 2.4.1.- Delphinium grandiflorum BAO04178.1    
 acyl-glucose-dependent anthocyanin β-glucosyltransferase (DgAA7BG-GT2) 2.4.1.- Delphinium grandiflorum BAO04181.1    
 acyl-glucose-dependent anthocyanin 5-O-glucosytransferase (BgluL;DcBgluL;AA5GT) 2.4.1.- Dianthus caryophyllus BAJ33501.1
BAL45928.1
E3W9M2  
 cardenolide 16'-O-glucohydrolase 3.2.1.21 Digitalis lanata CAB38854.2 Q9ZPB6  
 cardenolide 16'-O-glucohydrolase 3.2.1.21 Digitalis lanata CAB38854.2 Q9ZPB6  
 β-glucosidase (Bgl1;BGL) 3.2.1.21 Fusarium oxysporum KCTC 16909 AGF69228.1    
 hydroxyisourate hydrolase (HIUHase) 3.5.2.17 Glycine max AAL92115.1
CAW42880.1
CAW48583.1
CBC08408.1
CBD21376.1
Q8S3J3  
 isoflavone conjugate-specific β-glucosidase (GmICHG) 3.2.1.161
3.2.1.21
Glycine max BAF34333.1 Q08IT7  
 β-galactosidase/β-glucosidase (BglA) 3.2.1.21
3.2.1.23
Hamamotoa singularis ATCC 24193 BAD95570.1 Q564N5  
 lactase-phlorizin hydrolase (Lct) 3.2.1.108
3.2.1.62
Homo sapiens CAA30801.1
AAA59504.1
AAP12677.1
AAQ79768.1
AAX88924.1
ACM80708.1
ACM82337.1
NP_002290.1
P09848  
 lactase-phlorizin hydrolase (Lct) 3.2.1.108
3.2.1.62
Homo sapiens CAA30801.1
AAA59504.1
AAP12677.1
AAX88924.1
ACM80708.1
ACM82337.1
NP_002290.1
P09848  
 neutral β-glycosylceramidase / β-glucosidase (Gba3;CbgCBgl1;GluC;KLrP) (cytosolic) 3.2.1.21
3.2.1.62
Homo sapiens CAC08178.1
AAG39217.1
AAH29362.1
AAI01830.1
AAI09378.1
AAL37305.1
BAB18741.1
BAD96683.1
BAF85435.1
BAG36006.1
BAH12772.1
NP_066024.1
A8K9N1
Q9H227
2E9L[A]
2E9M[A]
2JFE[X]
2ZOX[A]
3VKK[A]
 β-mannosidase / β-glucosidase (HvbMANNOS1) 3.2.1.21
3.2.1.25
Hordeum vulgare AAA87339.1
CAW42869.1
CAW48572.1
CBC08397.1
CBD21365.1
CBG21202.1
Q40025  
 β-mannosidase / β-glucosidase (HvBII) 3.2.1.21
3.2.1.25
3.2.1.74
Hordeum vulgare subsp. vulgare ACF07998.1 B5A496  
 β-glucosidase (Bgl4;Bglhi) 3.2.1.21 Humicola grisea var. thermoidea IFO9854 / Humicola insolens RP86 BAA74958.1 O93784 4MDO[A]
4MDP[A]
 β-glucosidase 3.2.1.21 Lasiodiplodia theobromae CBS 247.96 CAJ81226.1    
 hydroxynitrile glucoside-cleaving β-glucosidase (Bglu1;LlBglu1 3.2.1.21 Leucaena leucocephala ABY48758.1
ABI34907.1
ABI34907.2
ABI34907.3
ABY84677.1
B0LJR5  
 hydroxynitrile β-glucosidase D2 (LjBGD2) 3.2.1.21 Lotus japonicus ACD65510.1 B2ZUU1  
 hydroxynitrile β-glucosidase D4 (LjBGD4) 3.2.1.21 Lotus japonicus ACD65509.1
AFK44931.1
B2ZUU0  
 β-glucosidase (MbmgBG1) 3.2.1.21 Macrotermes barneyi AFD33364.1    
 β-glucosidase (ASG) 3.2.1.21 Malus domestica AEN94900.1    
 β-glucosidase (linamarase) 3.2.1.21 Manihot esculenta AAB71381.1
CAW42866.1
CAW48569.1
CBC08394.1
CBD21362.1
O24524  
 β-glucosidase A 3.2.1.21 Manihot esculenta CAA64442.1
CAW42870.1
CAW48573.1
CBC08398.1
CBD21366.1
CBG21203.1
Q40283  
 β-glucosidase (linamarase) 3.2.1.21 Manihot esculenta AAB22162.1
CAW42872.1
CAW48575.1
CBC08400.1
CBD21368.1
CBG21204.1
Q41172  
 klotho (β-glucuronidase and sialidase activity) (KL) 3.2.1.18
3.2.1.31
Mus musculus AAQ41830.1
AAI38260.1
BAA23381.1
BAA25308.1
BAE22211.1
CAC42188.1
NP_038851.1
O35082  
 klotho (β-glucuronidase and sialidase activity) (KL) 3.2.1.18
3.2.1.31
Mus musculus AAQ41830.1
AAI38260.1
BAA23381.1
BAA25308.1
CAC42188.1
NP_038851.1
O35082  
 β-glucosidase (G1sgNtBG1;SgNtBG1;SgNtBG3) 3.2.1.21 Nasutitermes takasagoensis BAI50018.1
BAI50020.1
D0VYR5  
 β-glucosidase (SgNtBG2) 3.2.1.21 Nasutitermes takasagoensis BAI50019.1 D0VYR6  
 β-glucosidase (SgNtBG4) 3.2.1.21 Nasutitermes takasagoensis BAI50021.1 D0VYR8  
 β-glucanase (W5-CAT13) 3.2.1.21 Neocallimastix patriciarum W5 AEX92705.1    
 β-glucosidase (Bgl;NkBgl;NkBG;G1NkBG) 3.2.1.21 Neotermes koshunensis BAB91145.1 Q8T0W7 3AHZ[A]
3AI0[A]
3VIF[A]
3VIG[A]
3VIH[A]
3VII[A]
3VIJ[A]
3VIK[A]
3VIL[A]
3VIM[A]
3VIN[A]
3VIO[A]
3VIP[A]
 β-glucosidase (Bgl1;Gh1-1;NCU00130) 3.2.1.21 Neurospora crassa OR74A EAA26947.1
XP_322216.1
   
 oleuropein β-glucosidase (BglC;OeGLU) 3.2.1.21 Olea europaea subsp. europaea AAL93619.1
AKD49020.1
Q8GVD0  
 β-glucosidase (Bgl1) 3.2.1.21 Orpinomyces sp. PC-2 AAD45834.1 Q9UUQ3  
 lactase phlorizin hydrolase (LCT;LPH) 3.2.1.108
3.2.1.62
Oryctolagus cuniculus CAA30802.1 P09849  
 lactase phlorizin hydrolase (LCT;LPH) 3.2.1.108
3.2.1.62
Oryctolagus cuniculus AAQ79765.1 P09849  
 lactase-phlorizin hydrolase 3.2.1.108
3.2.1.62
Oryctolagus cuniculus CAA81690.1 Q29518  
 lactase-phlorizin hydrolase 3.2.1.108
3.2.1.62
Oryctolagus cuniculus CAA81690.1 Q29518  
 β-glucosidase isozyme 2 (Os09g0491100;Os9bglu30) 3.2.1.21
3.2.1.38
Oryza sativa Japonica Group BAF25453.1
AAL14713.1
BAT08727.1
BAT08728.1
BAT08729.1
Q0J0N4  
 β-glucosidase (Os1bglu4;Os01g0897600) 3.2.1.21 Oryza sativa Japonica Group BAB86071.1
BAC06894.1
BAD82183.1
BAD82346.1
BAF07003.1
BAS75715.1
   
 β-glucosidase (Os03g0212800;Os3bglu6) 3.2.1.21 Oryza sativa Japonica Group AAN01354.1
BAF11272.1
BAG99682.1
BAS82933.1
Q8L7J2 3GNO[A]
3GNP[A]
3GNR[A]
3WBA[A]
3WBE[A]
 β-mannosidase / β-glucosidase (Os7bglu26;Os07g0656200) 3.2.1.21
3.2.1.25
3.2.1.74
Oryza sativa Japonica Group BAC16123.1
BAC20802.1
BAF22416.1
BAT03001.1
   
 tuberonic acid glucoside-hydrolyzing β-glucosidase (OsTAGG1;Os4bglu13;Os04g0474900) 3.2.1.21 Oryza sativa Japonica Group CAE05485.2
BAF14985.1
BAS89677.1
CAE05491.1
A3AZS2
Q7XKV2
 
 β-glucosidase (OsTAGG2;Os04g0474800;Os4bglu12) (salicylic acid glucoside-hydrolyzing) 3.2.1.21 Oryza sativa Japonica Group CAE05483.2
BAF14984.1
BAG94781.1
BAS89674.1
BAS89675.1
BAS89676.1
CAE05489.1
Q7XKV4 3PTK[A,B]
3PTM[A,B]
3PTQ[A,B]
 monolignol β-glucosidase (Os4bglu16;Os04g0513400) 3.2.1.21 Oryza sativa Japonica Group CAE03398.1
BAF15217.1
BAS90059.1
BAS90060.1
CAE01908.1
CAE01908.2
CAE01909.1
CAE01909.2
CAE03399.2
CAE54544.1
Q7XPY5
Q7XPY6
Q7XSK2
Q7XSK2
 
 monolignol β-glucosidase (Os4bglu18;Os04g0513900) 3.2.1.21 Oryza sativa Japonica Group CAE01911.1
BAF15219.1
BAS90064.1
CAE01910.2
CAE54546.1
Q7XSJ9  
 β-glucosidase (Os3bglu8;Os03g0703100) 3.2.1.21
3.2.1.74
Oryza sativa Japonica Group AAT85323.1
AAS07251.1
AAX95520.1
BAF12928.1
BAH00173.1
BAS85955.1
BAS85956.1
BAS85957.1
CBD28470.1
Q53RI4  
 β-glucosidase (Bglu1;Os03g0703000;Os3bglu7) 3.2.1.21 Oryza sativa Japonica Group CBD28469.1
AAA84906.2
AAA84906.3
AAS07254.1
AAS07255.1
AAT85322.1
AAX95519.1
AKS44051.1
BAF12927.1
BAG94472.1
BAS85953.1
BAS85954.1
CBD28462.1
CBD28475.1
CBG21207.1
Q42975
Q75I93
2RGL[A,B]
2RGM[A,B]
3AHT[A,B]
3AHV[A,B]
3F4V[A,B]
3F5I[A,B]
3F5J[A,B]
3F5K[A,B]
3F5L[A,B]
3SCN[A,B]
3SCO[A,B]
3SCP[A,B]
3SCQ[A,B]
3SCR[A,B]
3SCS[A,B]
3SCT[A,B]
3SCU[A,B]
3SCV[A,B]
3SCW[A,B]
4QLJ[A,B]
4QLK[A,B]
4QLL[A,B]
 β-tranglucosidase (Os9bglu31;Os09g0511600) 2.4.1.- Oryza sativa Japonica Group BAF25552.1
BAH00605.1
BAT08912.1
B7F7K7
Q0J0G3
 
 β-glucosidase (Bglu1;PtBglu1) 3.2.1.21 Paecilomyces sp. J18 / Paecilomyces thermophila J18 ADM15720.1    
 β-glucosidase (Bgl2;BGL2;PdBgl2) (intracellular) 3.2.1.21 Penicillium decumbens 114-2 AGC10824.1    
 indican β-glucosidase 3.2.1.21 Persicaria tinctoria BAA78708.1
CBG21240.1
Q9XJ67  
 β-glucosidase (Bgl1A) 3.2.1.21 Phanerochaete chrysosporium K-3 BAE87008.1 Q25BW5 2E3Z[A,B]
2E40[A,B]
 β-glucosidase (Bgl1B;PcBgl1B) (Bgl1B) 3.2.1.21 Phanerochaete chrysosporium K-3 BAE87009.1
AHH92833.1
Q25BW4  
 β-glucosidase (Bgl1;Bgl1G5) 3.2.1.21 Phialophora sp. G5 / CGMCC 3328 AGC30579.1    
 myrosinase 3.2.1.147 Phyllotreta striolata AHZ59651.1    
 picein β-glucosidase (Pg?glu-1) 3.2.1.21 Picea glauca AII20122.1    
 monolignol β-glucosidase 3.2.1.21 Pinus contorta AAC69619.1
AAE33518.1
Q9ZT64  
 β-glucosidase (Bgl1A;Cel1A) (Bgl1A) 3.2.1.21 Piromyces sp. E2 CAC34952.1 Q9C122  
 β-glucosidase (Pa ?G) 3.2.1.21 Prunus avium AAA91166.1
ACH11661.1
Q43014  
 prunasin hydrolase (PH4;PH B;PH-L3) 3.2.1.118 Prunus serotina AAL06338.1
AAL39079.1
CAW42881.1
CAW48584.1
CBC08409.1
CBD21377.1
Q8W1W7
Q945N9
 
 prunasin hydrolase (PH5;PH C;PH-L4) 3.2.1.118 Prunus serotina AAL35324.1
AAL07434.1
Q8W594
Q945I4
 
  prunasin hydrolase (PH2;PH-L1) 3.2.1.118 Prunus serotina AAF34651.2 Q9M5X4  
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