Glycoside Hydrolase Family 1

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23); β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-β-1,4-glucanase (EC 3.2.1.74); 6-phospho-β-galactosidase (EC 3.2.1.85); 6-phospho-β-glucosidase (EC 3.2.1.86); strictosidine β-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin β-glucosidase (EC 3.2.1.117); prunasin β-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine β-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); β-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-β-apiosyl-β-glucosidase (EC 3.2.1.161); ABA-specific β-glucosidase (EC 3.2.1.175); DIMBOA β-glucosidase (EC 3.2.1.182); β-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental); absent in plant myrosinases
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (18476); Uniprot accession (2276); PDB accession (232); 3D entries (53); cryst (0)
All (16460) Archaea (143) Bacteria (15249) Eukaryota (1026) Viruses (1) unclassified (41) Structure (53) Characterized (336)
| 1 | 2 | 3 | 4 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (BglA) 3.2.1.21 Paenibacillus sp. HC1 BAE48718.1 Q2WGB4  
 β-1,4-glucosidase (Gluc1C) 3.2.1.21 Paenibacillus sp. ICGEB2008 / MTCC 5639 AFQ36783.1    
 β-glucosidase A 3.2.1.21 Pantoea agglomerans WD4 WILD STRAIN CAA56282.1 Q59437  
 6-P-β-glucosidase (AscB) 3.2.1.21
3.2.1.86
Pectobacterium carotovorum subsp. carotovorum LY34 AAT45375.1 Q6IV14  
 6-P-β-glucosidase (BglA) 3.2.1.21
3.2.1.86
Pectobacterium carotovorum subsp. carotovorum LY34 AAV37466.1 Q5UAU4  
 β-glucosidase (CasB) 3.2.1.21 Pectobacterium carotovorum subsp. carotovorum LY34 AAX57580.1 Q4VK76  
 β-glucosidase (BglY) 3.2.1.21 Pectobacterium carotovorum subsp. carotovorum LY34 AAX76617.1 Q2TI56  
 β-glucosidase (CelG) 3.2.1.21 Pectobacterium carotovorum subsp. carotovorum LY34 ABL14155.1 A1C3J9  
 Pmob_0493 3.2.1.21 Petrotoga mobilis SJ95 ABX31229.1 A9BFQ9  
 β-glucosidase (BglAch;Achl_0421) 3.2.1.21 Pseudarthrobacter chlorophenolicus A6 ACL38420.1 B8HAF9  
 β-glucosidase (Bgl;Tt-BGL;Theth_1013) 3.2.1.21 Pseudothermotoga thermarum DSM 5069 AEH51094.1    
 Rsph17025_1146 3.2.1.21 Rhodobacter sphaeroides ATCC 17025 ABP70047.1 A4WRN3  
 Rpal_1936 3.2.1.21 Rhodopseudomonas palustris TIE-1 ACF00459.1 B3Q9I7  
 Rcas_0521 3.2.1.21 Roseiflexus castenholzii DSM 13941 ABU56651.1 A7NGQ8  
 exo-β-glucosidase 1A (BglA; β-G;Cthe_0212) (Glc1A) 3.2.1.21 Ruminiclostridium thermocellum ATCC 27405 CAA42814.1
AAQ79758.1
ABN51453.1
P26208  
 RUM_10120 3.2.1.21 Ruminococcus champanellensis 18P13 = JCM 17042 CBL17177.1 D4LC32  
 β-glucosidase 1B (Sde_1394) (Bgl1B) 3.2.1.21 Saccharophagus degradans 2-40 ABD80656.1 Q21KX3  
 β-glucosidase 1A (Sde_3603) (Bgl1A) 3.2.1.21 Saccharophagus degradans 2-40 ABD82858.1 Q21EM1  
 6-P-β-glucosidase (BglB;SSO_1595) 3.2.1.86 Shigella sonnei Ss046 AAZ88293.1 Q3Z1R9  
 β-glucosidase (SMc03160) 3.2.1.21 Sinorhizobium meliloti 1021 CAC47470.1
ADA60163.1
NP_386997.1
Q92LX2  
 β-glucosidase (Bgl1) 3.2.1.21 Sphingomonas paucimobilis AAG59862.1 Q9APE3  
 β-glucosidase (BglSp) 3.2.1.21 Sphingomonas sp. 2F2 ADY18331.1    
 ginsenoside β-glucosidase (Sala_1019) 3.2.1.21 Sphingopyxis alaskensis RB2256 ABF52736.1 Q1GUD6  
 6-P-β-galactosidase (SAV2189) 3.2.1.85 Staphylococcus aureus subsp. aureus Mu50 AAA26650.1
AAQ79753.1
BAB45117.1
BAB58351.1
CBG21263.1
NP_372713.1
P11175  
 6-P-β-glucosidase (SAV0266;BglA) 3.2.1.86 Staphylococcus aureus subsp. aureus Mu50 BAB56428.1
CBG21027.1
NP_370790.1
Q99WV9  
 6-P-β-glucosidase (BglA;MW0242) 3.2.1.86 Staphylococcus aureus subsp. aureus MW2 BAB94107.1
NP_645057.1
Q8NYG9  
 6-P-β-galactosidase (LacG;SGO_1512) 3.2.1.85 Streptococcus gordonii str. Challis substr. CH1 ABV10357.1
AAG39001.1
CBG21234.1
Q9EV38  
 6-P-β-galactosidase (LacG) 3.2.1.85 Streptococcus mutans UA130 AAA16450.1
CBG21265.1
P50978  
 6-P-β-glucosidase (BglA;SMU.985) 3.2.1.86 Streptococcus mutans UA159 AAN58686.1
CBG21066.1
NP_721380.1
   
 6-P-β-glucosidase (Arb;AscB;SMU.1102) 3.2.1.86 Streptococcus mutans UA159 AAN58797.1
CBG21067.1
NP_721491.1
   
 6-P-β-galactosidase (LacG;SMU.1490) 3.2.1.85 Streptococcus mutans UA159 AAN59144.1
NP_721838.1
P50978  
 6-P-β-glucosidase (CelA;Bgl;SmBgl;SMU.1601;SMU_1601) 3.2.1.86 Streptococcus mutans UA159 AAN59243.1
CBG21068.1
NP_721937.1
  3PN8[A,B]
4DDE[A,B]
4F66[A,B]
4F79[A]
4GPN[A,B]
 6-P-β-glucosidase (BglA3;SPD_0247) 3.2.1.86 Streptococcus pneumoniae D39 ABJ54846.1 Q04MI3  
 6-P-β-glucosidase (BglA-2;SP0578) 3.2.1.86 Streptococcus pneumoniae TIGR4 AAK74732.1
CBG21011.1
NP_345092.1
Q97S37 4IPL[A,B]
4IPN[B,E]
 6-phospho-β-glucosidase (SPy_1599;SPy1599) 3.2.1.86 Streptococcus pyogenes M1 GAS AAK34377.1
NP_269656.1
Q99YP9 4B3K[A,B,C,D,E,F]
4B3L[A,B,C,D,E,F]
5FOO[A,B,C,D,E,F]
 β-glucosidase (SCO1059;SCG22.05) 3.2.1.21 Streptomyces coelicolor A3(2) CAB95278.1
CBG21059.1
NP_625353.1
Q9K440  
 β-glucosidase (SCO7558;SC5F1.12) 3.2.1.21 Streptomyces coelicolor A3(2) CAC16438.1
CBG21061.1
NP_631601.1
Q9F3B7  
 SGR_2426 3.2.1.21 Streptomyces griseus subsp. griseus NBRC 13350 BAG19255.1 B1W1N0  
 β-glucosidase (Bgsl) 3.2.1.21 Streptomyces rochei A2 CAA52344.1 Q55000  
 β-glucosidase (Bgl3) 3.2.1.21 Streptomyces sp. QM-B814 CAA82733.1
CBG21211.1
Q59976 1GNX[A,B]
1GON[A,B]
 β-glucosidase (CglT;BglT) 3.2.1.21 Thermoanaerobacter brockii ATCC 53556 / DSM 1457 CAA91220.1
CBG21215.1
Q60026  
 β-glucosidase (BglA) 3.2.1.21 Thermoanaerobacter ethanolicus JW 200 ADD25173.1 D3Y2V4  
 Thit_0299 3.2.1.- Thermoanaerobacter italicus Ab9 ADD01617.1 D3T6K4  
 β-glucosidase (Bgl;Tthe_1813) 3.2.1.21 Thermoanaerobacterium thermosaccharolyticum DSM 571 ADL69309.1 D9TR57  
 Tter_1939 3.2.1.21 Thermobaculum terrenum ATCC BAA-798 ACZ42845.1 D1CGH4  
 β-glucosidase (BglC) (Bgl1C) 3.2.1.21 Thermobifida fusca ER1 AAF37730.1
AHH92834.1
Q9LAV5  
 β-glucosidase (BglC;BGL;Tfu_0937;Tfu0937) (Bgl1C) 3.2.1.21 Thermobifida fusca YX AAZ54975.1
CBG21191.1
Q47RE2  
 Tbis_1896 3.2.1.21 Thermobispora bispora DSM 43833 ADG88608.1 D6YBP8  
 Tbis_2605 3.2.1.21 Thermobispora bispora DSM 43833 ADG89307.1 D6Y5B2  
 Tbis_1894 3.2.1.21 Thermobispora bispora DSM 43833 ADG88606.1 D6YBP6  
 β-glucosidase B / cellobiase (BglB) 3.2.1.21 Thermobispora bispora NRRL 15568 AAA25311.1 P38645  
 trd_1758 3.2.1.21 Thermomicrobium roseum DSM 5159 ACM06095.1 B9L147  
 Tcur_1733 3.2.1.21 Thermomonospora curvata DSM 43183 ACY97307.1 D1AC41  
 THA_775 3.2.1.21 Thermosipho africanus TCF52B ACJ75238.1 B7IGM4  
 THA_1926 3.2.1.- Thermosipho africanus TCF52B ACJ76349.1 B7IEC2  
 β-glucosidase A (BglA;Tmari_1862) 3.2.1.21 Thermotoga maritima MSB8 CAA52276.1
AEP25088.1
AGL50786.1
AHD18256.1
AKE29603.1
CBG21253.1
G4FGN9
Q08638
1OD0[A,B]
1OIF[A,B]
1OIM[A,B]
1OIN[A,B]
1UZ1[A,B]
1W3J[A,B]
2CBU[A,B]
2CBV[A,B]
2CES[A,B]
2CET[A,B]
2J75[A,B]
2J77[A,B]
2J78[A,B]
2J79[A,B]
2J7B[A,B]
2J7C[A,B]
2J7D[A,B]
2J7E[A,B]
2J7F[A,B]
2J7G[A,B]
2J7H[A,B]
2JAL[A,B]
2VRJ[A,B]
2WBG[A,B,C,D]
2WC3[A,B,C,D]
2WC4[A,B,C,D]
5N6S[A,B,C,D]
5N6T[A,B]
 β-glucosidase A / 1A (BglA;GghA;TnBgl1A;CTN_0782) (Bgl1A) 3.2.1.21 Thermotoga neapolitana DSM 4359 AAB95492.2
CAB10165.1
CBG21254.1
O33843 5IDI[A,B]
 β-glucosidase (BG-A;BglA;TCel12;TpBgl1;Tpet_0952) 3.2.1.21 Thermotoga petrophila RKU-1 ABQ46970.1 A5IL97  
 β-glycosidase / β-glucosidase (BglT;BglA) 3.2.1.21
3.2.1.-
Thermus caldophilus GK24 AAO15361.1 Q8GHE5  
 β-glycosidase (tfi β-gly) 3.2.1.- Thermus filiformis WAI33 A1 AAN05440.1 Q8GEB2  
 β-glycosidase (Gly) 3.2.1.21 Thermus nonproteolyticus HG102 AAF36392.1 Q9L794 1NP2[A,B]
 β-glycosidase (BglA) 3.2.1.- Thermus sp. IB-21 AAN05441.1 Q8GEB1  
 β-glycosidase (BglB) 3.2.1.- Thermus sp. IB-21 AAN05442.1 Q8GEB0  
 β-glucosidase 3.2.1.21 Thermus sp. Z-1 BAA86923.1 Q9RA58  
 β-glycosidase (Tat) 3.2.1.- Thermus thermophilus AT-62 AAN05438.1 Q8GEB4  
 β-glycosidase (BglT;Bgl;B-gly;Bgly;TTP0042;TT_P0042) 3.2.1.- Thermus thermophilus HB27 AAS82372.1
CAB42553.3
CBG21120.1
Q746L1  
 β-glycosidase / β-glucosidase (TTHB087) 3.2.1.21 Thermus thermophilus HB8 AAN05439.1
BAD71883.1
CBG21166.1
Q53W75
Q8GEB3
1UG6[A]
4BCE[A,B,C]
 β-glycosidase (β-gly) 3.2.1.- Thermus thermophilus HJ6 ABW87307.1 A8WAC9  
 β-glycosidase (β-gly) 3.2.1.21
3.2.1.23
Thermus thermophilus KNOUC202 ABI35984.1 Q0GA07  
 β-glycosidase (BglT;B-gly) 3.2.1.- Thermus thermophilus TH125 AAD32630.2 Q9RA61 3ZJK[A,B,C]
 β-glucosidase (Bgl6;BGL6) 3.2.1.21 uncultured bacterium AKH41028.1   5GNX[A,B]
5GNY[A,B,C,D]
5GNZ[A,B,C,D,H,I,J,K]
 β-glucosidase (Bgl1B;PB47B2) (Bgl1B) 3.2.1.21 uncultured bacterium ACY09072.1 D0VEC8  
 β-glucosidase (Bgl1A;PB42H12) (Bgl1A) 3.2.1.21 uncultured bacterium ADD96762.1 D5KX75  
 β-glycosidase (BglMKg;Bgl1;pBADinsMK) 3.2.1.- uncultured bacterium ADI56259.2
ADI56259.1
D7RTU9  
 β-glucosidase (Bgl1269) 3.2.1.21 uncultured bacterium AFN70956.1    
 β-glucosidase / β-glycosidase (BglA) (Bgl1A) 3.2.1.21 uncultured bacterium ABI18350.1 Q0GMU3 3CMJ[A]
3FIY[A]
3FIZ[A]
3FJ0[A]
4HZ6[A]
4HZ7[A]
4HZ8[A]
 β-glucosidase (AS-Esc10) 3.2.1.21 uncultured bacterium AHG23303.1    
 β-glucosidase (AmBGL18) 3.2.1.21 uncultured bacterium AHI85742.1    
 β-glucosidase (Bgl-gs1;contig00059.2) 3.2.1.21 uncultured bacterium contig00059 AGS52251.1    
 β-glucosidase (D2_GH1) 3.2.1.21 uncultured bacterium D2_11 AEW47954.1    
 β-glucosidase (F2_GH1) 3.2.1.21 uncultured bacterium F2_16 AEW47962.1    
 β-galactosidase (Mbgl) 3.2.1.23 uncultured Meiothermus sp. AEQ38581.1    
 VVA0128 3.2.1.21 Vibrio vulnificus YJ016 BAC96154.1
CBG21112.1
NP_936184.1
Q7MG41  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 acyl-glucose-dependent anthocyanin 7-O-glucosyltransferase (Aa7gT) 2.4.1.- Agapanthus africanus BAM29304.1    
 At3g03640 (β-glucosidase;Gluc;Bglu25) 3.2.1.21 Arabidopsis thaliana AAC31962.1
AAC32194.1
AAF03468.1
AEE73966.1
NP_187014.1
O82772  
 ER β-glucosidase (Psr3.2;Bglu21;At1g66270) 3.2.1.21 Arabidopsis thaliana AAB64244.1
AAG51761.1
AAG52157.1
AAK74056.1
AAO11600.1
AEE34488.1
AEE34489.1
NP_176801.1
NP_849848.1
O23656
Q9C525
 
 myrosinase (TGG1;Bglu38;At5g26000) 3.2.1.147 Arabidopsis thaliana AAC18869.1
AAD40143.1
AAK74039.1
AAL25596.1
AAL91284.1
AAN60236.1
AED93511.1
AED93512.1
BAH20253.1
CAA55786.1
CAH40799.1
CAH40800.1
CAH40801.1
CAH40802.1
CAH40803.1
CAH40804.1
CAH40805.1
CAH40806.1
CAH40807.1
CAH40808.1
CAH40809.1
CAH40810.1
CAH40811.1
CAH40812.1
CAH40813.1
CAH40814.1
CAH40815.1
CAH40816.1
CAH40817.1
CAH40818.1
CAH40819.1
CAH40820.1
CAH40821.1
CAH40822.1
CAH40823.1
CAH40824.1
CAH40825.1
CAH40826.1
NP_197972.1
NP_851077.1
P37702  
 myrosinase 2 (TGG2;Bglu37;At5g25980) (leaf) 3.2.1.147 Arabidopsis thaliana AAK28645.1
AAD40134.1
AAK32833.1
AAL77743.1
AAM44928.1
AAN60275.1
AED93507.1
AED93508.1
BAD94532.1
BAD94810.1
BAE98479.1
CAA55787.1
NP_568479.1
Q42595
Q8H7E3
Q9ASV0
Q9C5C2
 
 myrosinase (TGG4;Bglu34;At1g47600) 3.2.1.147 Arabidopsis thaliana AAO00818.1
AAD46026.1
AAN17448.1
AAN72213.1
ACO95139.1
AEE32191.1
AEE32192.1
NP_175191.2
Q8GRX1
Q9SX92
 
 flavonol bisglycoside β-glucosidase (Bglu15;At2g44450) 3.2.1.21 Arabidopsis thaliana AAC16091.1
AEC10421.1
ANM63069.1
NP_181973.1
O64879  
 monolignol β-glucosidase (Bglu45;At1g61810) 3.2.1.21 Arabidopsis thaliana AAC28501.1
AEE33889.1
AEE33889.2
AEE33890.1
AEE33891.1
ANM59961.1
ANM59962.1
NP_176374.1
O80689  
 monolignol β-glucosidase (Bglu46;At1g61820) 3.2.1.21 Arabidopsis thaliana AAC28502.1
AAN60285.1
AAU05454.1
AAU45206.1
AEE33892.1
AEE33893.1
NP_176375.1
O80690
Q8H7D5
 
 ER β-glucosidase (Pyk10;Bglu23;Psr3.1;At3g09260) 3.2.1.21 Arabidopsis thaliana AAF14024.1
AAB38783.1
AAK62412.1
AAM97105.1
AAM98201.1
AAN15549.1
AEE74744.1
BAD94012.1
BAE98937.1
BAF02144.1
BAH20034.1
BAH20110.1
NP_187537.1
O24433
Q9SR37
 
 ER β-glucosidase / ABA-β-glucosidase (BG1;Bgl1;Bglu18;AtBG1;At1g52400) 3.2.1.21
3.2.1.175
Arabidopsis thaliana AAF22295.1
AAG21562.1
AAG51546.1
AAK63959.1
AAL08271.1
AAN18084.1
AAN31804.1
AAN60329.1
AEE32799.1
AEE32800.1
AEE32801.1
BAD94819.1
CAC19786.1
CBG20990.1
CBG21227.1
CBG21235.1
CBG21246.1
NP_175649.1
Q8H169
Q8H7A3
Q9FNZ3
Q9SE50
 
 β-glucosidase (Sfr2;At3g06510) 3.2.1.21 Arabidopsis thaliana CAD36512.1
AAF23823.1
AAG51335.1
AAL24371.1
AAL31914.1
AAM65250.1
AAN72111.1
AEE74404.1
AEE74405.1
CAD36513.1
NP_187303.1
NP_566285.1
Q8LAN2
Q8LGU5
Q8W578
Q93Y07
Q9C8Z2
Q9SDL5
 
 β-mannosidase/β-glucosidase (Bglu44;At3g18080) 3.2.1.21
3.2.1.25
Arabidopsis thaliana AAM61427.1
AAK25950.1
AAK64096.1
AEE76044.1
BAB02020.1
BAH19552.1
BAH19607.1
CBD33469.1
CBG20992.1
NP_188436.1
Q9LV33  
 ER β-glucosidase (Bglu22;At1g66280) 3.2.1.21 Arabidopsis thaliana AAG52159.1
AAG12895.1
AAL67074.1
AEE34490.1
BAH56964.1
CAK32149.1
NP_176802.1
Q9C8Y9  
 myrosinase (TGG5;Bglu35;At1g51470) 3.2.1.147 Arabidopsis thaliana NP_175558.3
AAG12767.1
AAG52628.1
ACO95140.1
AEE32671.1
NP_175558.1
Q3ECS3
Q9C8J9
 
 myrosinase (M1;ArMY1) 3.2.1.147 Armoracia rusticana AAV71147.1 Q5PXK2  
 myrosinase 2 (MYRII;ArMY2) 3.2.1.147 Armoracia rusticana AEZ01595.2
AEZ01595.1
   
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