Glycoside Hydrolase Family 1

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23); β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-β-1,4-glucanase (EC 3.2.1.74); 6-phospho-β-galactosidase (EC 3.2.1.85); 6-phospho-β-glucosidase (EC 3.2.1.86); strictosidine β-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin β-glucosidase (EC 3.2.1.117); prunasin β-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine β-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); β-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-β-apiosyl-β-glucosidase (EC 3.2.1.161); ABA-specific β-glucosidase (EC 3.2.1.175); DIMBOA β-glucosidase (EC 3.2.1.182); β-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-); β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-); protodioscin 26-O-β-D-glucosidase (EC 3.2.1.186)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental); absent in plant myrosinases
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (54203); Uniprot accession (433); PDB accession (291); 3D entries (80); cryst (0)
| 1 | 2 | 3 | 4 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-glucosidase (Bgl;BglU) 3.2.1.21 pubmed
Micrococcus antarcticus ACM66669.1
AMB49877.1
AMB49878.1
AMB49879.1
A0A0Y0GAW6
A0A0Y0KCV2
A0A0Y0M4F4
B9V8P5
3W53[A]
 MSMEG_5142 3.2.1.21 pubmed
Mycolicibacterium smegmatis MC2 155 ABK71329.1
AFP41454.1
AIU10178.1
A0R2K0
I7GEU5
 
 β-glucosidase (BglA) 3.2.1.21 pubmed
Niallia circulans subsp. alkalophilus AAA22266.1
AAQ79761.1
CBG21249.1
Q03506 1QOX[A]
 6-P-β-glucosidase (OB2763) 3.2.1.86   Oceanobacillus iheyensis HTE831 BAC14719.1
CBG21065.1
NP_693685.1
   
 6-P-β-glucosidase (BglD;OEOE_0224) 3.2.1.86 doi
Oenococcus oeni PSU-1 ABJ56211.1 Q04H61  
 6P-β-glucosidase (CelD;OEOE_0341) 3.2.1.86 doi
Oenococcus oeni PSU-1 ABJ56315.1 Q04GV7  
 β-glucosidase (BglPm;KNP414_03656) 3.2.1.21 pubmed
Paenibacillus mucilaginosus KNP414 AEI42200.1 F8FFH2  
 β-glucosidase A (BglA) 3.2.1.21 pubmed
Paenibacillus polymyxa AAA22263.1
AAQ79760.1
CBG21252.1
P22073 1BGA[A,B,C,D]
1BGG[A,B,C,D]
1E4I[A]
1TR1[A,B,C,D]
1UYQ[A]
6QWI[A,B]
6R4K[A,B]
 β-glucosidase B (BglB) 3.2.1.21 pubmed
Paenibacillus polymyxa AAA22264.1
AAQ79762.1
CBG21256.1
P22505 2JIE[A]
2O9P[A]
2O9R[A]
2O9T[A]
2Z1S[A]
 β-glucosidase (BglA) 3.2.1.21 pubmed
Paenibacillus sp. HC1 BAE48718.1 Q2WGB4  
 β-1,4-glucosidase (Gluc1C) 3.2.1.21 pubmed
Paenibacillus sp. ICGEB2008 / MTCC 5639 AFQ36783.1 J7IJ95  
 β-glucosidase (Bg1Pa) 3.2.1.21 pubmed
Paenibacillus xylanivorans A59 WP_053780132.1    
 β-glucosidase A 3.2.1.21 pubmed
Pantoea agglomerans WD4 WILD STRAIN CAA56282.1 Q59437  
 6-P-β-glucosidase (AscB) 3.2.1.21
3.2.1.86
pubmed
pubmed
Pectobacterium carotovorum subsp. carotovorum LY34 AAT45375.1 Q6IV14  
 6-P-β-glucosidase (BglA) 3.2.1.21
3.2.1.86
pubmed
pubmed
Pectobacterium carotovorum subsp. carotovorum LY34 AAV37466.1 Q5UAU4  
 β-glucosidase (CasB) 3.2.1.21 pubmed
Pectobacterium carotovorum subsp. carotovorum LY34 AAX57580.1 Q4VK76  
 β-glucosidase (BglY) 3.2.1.21 pubmed
Pectobacterium carotovorum subsp. carotovorum LY34 AAX76617.1 Q2TI56  
 β-glucosidase (CelG) 3.2.1.21 doi
Pectobacterium carotovorum subsp. carotovorum LY34 ABL14155.1 A1C3J9  
 Pmob_0493 3.2.1.21 pubmed
Petrotoga mobilis SJ95 ABX31229.1 A9BFQ9  
 β-glucosidase (BglAch;Achl_0421) 3.2.1.21 pubmed
Pseudarthrobacter chlorophenolicus A6 ACL38420.1 B8HAF9  
 β-glucosidase (Bgl;Tt-BGL;Theth_1013) 3.2.1.21 doi
Pseudothermotoga thermarum DSM 5069 AEH51094.1 F7YX70  
 Rpal_1936 3.2.1.21 pubmed
Rhodopseudomonas palustris TIE-1 ACF00459.1 B3Q9I7  
 Rcas_0521 3.2.1.21 pubmed
Roseiflexus castenholzii DSM 13941 ABU56651.1 A7NGQ8  
 cellodextrin glucohydrolase (Ccel_0374) 3.2.1.21
3.2.1.23
3.2.1.74
pubmed
pubmed
pubmed
Ruminiclostridium cellulolyticum H10 ACL74759.1 B8I5U2  
 RUM_10120 3.2.1.21 pubmed
Ruminococcus champanellensis 18P13 = JCM 17042 CBL17177.1 D4LC32  
 β-glucosidase 1B (Sde_1394) (Bgl1B) 3.2.1.21 pubmed
Saccharophagus degradans 2-40 ABD80656.1 Q21KX3  
 β-glucosidase 1A (Sde_3603) (Bgl1A) 3.2.1.21 pubmed
Saccharophagus degradans 2-40 ABD82858.1 Q21EM1  
 6-P-β-glucosidase (BglB;SSO_1595) 3.2.1.86 pubmed
Shigella sonnei Ss046 AAZ88293.1 Q3Z1R9  
 β-glucosidase (SMc03160) 3.2.1.21 doi
Sinorhizobium meliloti 1021 CAC47470.1
ADA60163.1
NP_386997.1
Q92LX2  
 β-glucosidase (Bgl1) 3.2.1.21 pubmed
Sphingomonas paucimobilis AAG59862.1 Q9APE3  
 β-glucosidase (BglSp) 3.2.1.21 pubmed
Sphingomonas sp. 2F2 ADY18331.1 F1JZ12  
 ginsenoside β-glucosidase (Sala_1019) 3.2.1.21 pubmed
Sphingopyxis alaskensis RB2256 ABF52736.1 Q1GUD6  
 6-P-β-galactosidase (SAV2189) 3.2.1.85 pubmed
Staphylococcus aureus subsp. aureus Mu50 AAA26650.1
AAQ79753.1
BAB45117.1
BAB58351.1
CBG21263.1
NP_372713.1
P11175
P67767
 
 6-P-β-galactosidase (LacG) 3.2.1.85 pubmed
Streptococcus mutans UA130 AAA16450.1
CBG21265.1
P50978  
 6-P-β-glucosidase (BglA;SMU.985) 3.2.1.86 pubmed
Streptococcus mutans UA159 AAN58686.1
CBG21066.1
NP_721380.1
Q8DUE7  
 6-P-β-glucosidase (Arb;AscB;SMU.1102) 3.2.1.86 pubmed
Streptococcus mutans UA159 AAN58797.1
CBG21067.1
NP_721491.1
Q8DU50  
 6-P-β-glucosidase (CelA;Bgl;SmBgl;SMU.1601;SMU_1601) 3.2.1.86 pubmed
Streptococcus mutans UA159 AAN59243.1
CBG21068.1
NP_721937.1
Q8DT00 3PN8[A,B]
4DDE[A,B]
4F66[A,B]
4F79[A]
4GPN[A,B]
 6-P-β-glucosidase (BglA3;SPD_0247) 3.2.1.86 pubmed
Streptococcus pneumoniae D39 ABJ54846.1 A0A0H2ZQ21
Q04MI3
 
 6-P-β-glucosidase (BglA-2;SP0578) 3.2.1.86 pubmed
Streptococcus pneumoniae TIGR4 AAK74732.1
CBG21011.1
NP_345092.1
A0A0H2UP35
Q97S37
4IPL[A,B]
4IPN[B,E]
 6-phospho-β-glucosidase (SPy_1599;SPy1599) 3.2.1.86 pubmed
Streptococcus pyogenes M1 GAS SF370 AAK34377.1
NP_269656.1
Q99YP9 4B3K[A,B,C,D,E,F]
4B3L[A,B,C,D,E,F]
5FOO[A,B,C,D,E,F]
 β-glucosidase (SCO1059;SCG22.05) 3.2.1.21 pubmed
Streptomyces coelicolor A3(2) CAB95278.1
CBG21059.1
NP_625353.1
Q9K440  
 β-glucosidase (SCO7558;SC5F1.12) 3.2.1.21 pubmed
Streptomyces coelicolor A3(2) CAC16438.1
CBG21061.1
NP_631601.1
Q9F3B7  
 SGR_2426 3.2.1.21 pubmed
Streptomyces griseus subsp. griseus NBRC 13350 BAG19255.1 B1W1N0  
 β-glucosidase (Bgsl) 3.2.1.21 doi
Streptomyces rochei A2 CAA52344.1 Q55000  
 β-glucosidase (Bgl3) 3.2.1.21 pubmed
Streptomyces sp. QM-B814 CAA82733.1
CBG21211.1
Q59976 1GNX[A,B]
1GON[A,B]
 β-glucosidase (CglT;BglT) 3.2.1.21 pubmed
Thermoanaerobacter brockii ATCC 53556 / DSM 1457 CAA91220.1
CBG21215.1
Q60026  
 β-glucosidase (BglA) 3.2.1.21 pubmed
Thermoanaerobacter ethanolicus JW 200 ADD25173.1 D3Y2V4  
 β-glycosidase (Thit_0299) 3.2.1.- pubmed
Thermoanaerobacter italicus Ab9 ADD01617.1 D3T6K4  
 β-glucosidase (Bgl) 3.2.1.21 pubmed
Thermoanaerobacterium aotearoense SCUT27 / P8G3#4 / CGMCC 9000 AKP45355.1    
 β-glucosidase (Bgl;Tthe_1813) 3.2.1.21 pubmed
Thermoanaerobacterium thermosaccharolyticum DSM 571 ADL69309.1 D9TR57  
 Tter_1939 3.2.1.21 pubmed
Thermobaculum terrenum ATCC BAA-798 ACZ42845.1 D1CGH4  
 β-glucosidase (BglC) (Bgl1C) 3.2.1.21 pubmed
Thermobifida fusca ER1 AAF37730.1
AHH92834.1
Q9LAV5  
 β-glucosidase (BglC;BGL;Tfu_0937;Tfu0937) (Bgl1C) 3.2.1.21 pubmed
Thermobifida fusca YX AAZ54975.1
CBG21191.1
Q47RE2  
 β-glucosidase (ThBGL1A) (fragment) 3.2.1.21 doi
Thermobifida halotolerans YIM 90462 QBC98235.1    
 Tbis_1896 3.2.1.21 pubmed
Thermobispora bispora DSM 43833 ADG88608.1 D6YBP8  
 Tbis_2605 3.2.1.21 pubmed
Thermobispora bispora DSM 43833 ADG89307.1 D6Y5B2  
 Tbis_1894 3.2.1.21 pubmed
Thermobispora bispora DSM 43833 ADG88606.1 D6YBP6  
 β-glucosidase B / cellobiase (BglB) 3.2.1.21 pubmed
Thermobispora bispora NRRL 15568 AAA25311.1 P38645  
 trd_1758 3.2.1.21 pubmed
Thermomicrobium roseum DSM 5159 ACM06095.1 B9L147  
 β-glucosidase (Bgl1; AaBGL1A) 3.2.1.21 pubmed
Thermomonospora amylolytica YIM 77502 QAB08112.1    
 β-glucosidase (Bgl2; AaBGL2) 3.2.1.21   Thermomonospora amylolytica YIM 77502 QAB08113.1    
 Tcur_1733 3.2.1.21 pubmed
Thermomonospora curvata DSM 43183 ACY97307.1 D1AC41  
 THA_775 3.2.1.21 pubmed
Thermosipho africanus TCF52B ACJ75238.1 B7IGM4  
 THA_1926 3.2.1.21
3.2.1.23
3.2.1.-
pubmed
pubmed
pubmed
Thermosipho africanus TCF52B ACJ76349.1 B7IEC2  
 β-glucosidase A (BglA; Tmari_1862) 3.2.1.21 pubmed
Thermotoga maritima MSB8 CAA52276.1
AEP25088.1
AGL50786.1
AHD18256.1
AKE29603.1
CBG21253.1
G4FGN9
G4XU74
Q08638
R4NU76
1OD0[A,B]
1OIF[A,B]
1OIM[A,B]
1OIN[A,B]
1UZ1[A,B]
1W3J[A,B]
2CBU[A,B]
2CBV[A,B]
2CES[A,B]
2CET[A,B]
2J75[A,B]
2J77[A,B]
2J78[A,B]
2J79[A,B]
2J7B[A,B]
2J7C[A,B]
2J7D[A,B]
2J7E[A,B]
2J7F[A,B]
2J7G[A,B]
2J7H[A,B]
2JAL[A,B]
2VRJ[A,B]
2WBG[A,B,C,D]
2WC3[A,B,C,D]
2WC4[A,B,C,D]
5N6S[A,B,C,D]
5N6T[A,B]
5OSS[A,B]
 β-glucosidase A / 1A (BglA;GghA;TnBgl1A;CTN_0782) (Bgl1A) 3.2.1.21 pubmed
Thermotoga neapolitana DSM 4359 AAB95492.2
ACM22958.1
CAB10165.1
CBG21254.1
B9K7M5
O33843
P0C946
5IDI[A,B]
 β-glucosidase (BG-A;BglA;TCel12;TpBgl1;Tpet_0952) 3.2.1.21 pubmed
Thermotoga petrophila RKU-1 ABQ46970.1 A5IL97  
 β-glycosidase / β-glucosidase (BglT;BglA) 3.2.1.21
3.2.1.23
3.2.1.38
doi
doi
doi
Thermus caldophilus GK24 AAO15361.1 Q8GHE5  
 β-glycosidase (tfi β-gly) 3.2.1.- URL
Thermus filiformis WAI33 A1 AAN05440.1 Q8GEB2  
 β-glycosidase (Gly) 3.2.1.21 pubmed
Thermus nonproteolyticus HG102 AAF36392.1 Q9L794 1NP2[A,B]
 β-glycosidase (BglA) 3.2.1.- pubmed
Thermus sp. IB-21 AAN05441.1 Q8GEB1  
 β-glycosidase (BglB) 3.2.1.21
3.2.1.23
pubmed
pubmed
Thermus sp. IB-21 AAN05442.1 Q8GEB0  
 β-glucosidase 3.2.1.21 doi
Thermus sp. Z-1 BAA86923.1 Q9RA58  
 β-glycosidase (Tat) 3.2.1.- doi
Thermus thermophilus AT-62 AAN05438.1 Q8GEB4  
 β-D-fucosidase (BglT;Bgl;B-gly;Bgly;TTP0042;TT_P0042) 3.2.1.21
3.2.1.38
pubmed
pubmed
Thermus thermophilus HB27 AAS82372.1
CAB42553.3
CBG21120.1
Q746L1
Q9RA61
 
 β-glycosidase / β-glucosidase (TTHB087) 3.2.1.21 pubmed
Thermus thermophilus HB8 AAN05439.1
BAD71883.1
CBG21166.1
Q53W75
Q8GEB3
1UG6[A]
4BCE[A,B,C]
 β-glycosidase (β-gly) 3.2.1.- pubmed
Thermus thermophilus HJ6 ABW87307.1 A8WAC9  
 β-glycosidase (β-gly) 3.2.1.21
3.2.1.23
pubmed
pubmed
Thermus thermophilus KNOUC202 ABI35984.1 Q0GA07  
 β-glycosidase (BglT;B-gly) 3.2.1.21
3.2.1.23
pubmed
pubmed
Thermus thermophilus TH125 AAD32630.2 Q9RA61 3ZJK[A,B,C]
 β-glucosidase (Bgl6;BGL6) 3.2.1.21 pubmed
uncultured bacterium AKH41028.1 A0A0F7KKB7 5GNX[A,B]
5GNY[A,B,C,D]
5GNZ[A,B,C,D,H,I,J,K]
 β-glucosidase (Bgl1B;PB47B2) (Bgl1B) 3.2.1.21 pubmed
uncultured bacterium ACY09072.1 D0VEC8  
 β-glucosidase (Bgl1A; PB42H12) (Bgl1A) 3.2.1.21 pubmed
uncultured bacterium ADD96762.1 D5KX75  
 β-glycosidase (BglMKg;Bgl1;pBADinsMK) 3.2.1.21 pubmed
uncultured bacterium ADI56259.2
ADI56259.1
D7RTU9  
 β-glucosidase (Bgl1317) 3.2.1.21 pubmed
uncultured bacterium QCG75868.1 A0A4D6T7S3
A0A5H1ZR35
6IER[A]
 β-glucosidase Bgl15 3.2.1.21 pubmed
uncultured bacterium QED88370.1   6JFP[A,B]
 β-glucosidase (Bgl1; PersiBGL1) 3.2.1.21 pubmed
uncultured bacterium QJT73065.1    
 β-glucosidase (Bgl1269) 3.2.1.21 pubmed
uncultured bacterium AFN70956.1 I6YQJ8  
 β-glucosidase / β-glycosidase (BglA) (Bgl1A) 3.2.1.21 pubmed
uncultured bacterium ABI18350.1 Q0GMU3 3CMJ[A]
3FIY[A]
3FIZ[A]
3FJ0[A]
4HZ6[A]
4HZ7[A]
4HZ8[A]
 β-glucosidase (AS-Esc10) 3.2.1.21 pubmed
uncultured bacterium AHG23303.1 W0LHR5  
 β-glucosidase (AmBGL18) 3.2.1.21 pubmed
uncultured bacterium AHI85742.1 W6CG73  
 β-glucosidase (Bgl-gs1;contig00059.2) 3.2.1.21 pubmed
uncultured bacterium contig00059 AGS52251.1 A0A0A6ZH67  
 β-glucosidase (D2_GH1) 3.2.1.21 pubmed
uncultured bacterium D2_11 AEW47954.1 G9IS31  
 β-glucosidase (F2_GH1) 3.2.1.21 pubmed
uncultured bacterium F2_16 AEW47962.1 G9IS39  
 β-galactosidase (Mbgl) 3.2.1.23 pubmed
uncultured Meiothermus sp. AEQ38581.1 G4Y624  
 β-glucosidase (Glu1; GC_Glu1) 3.2.1.21 pubmed
uncultured Thermoanaerobacter sp. QRN45944.1    
 VVA0128 3.2.1.21 pubmed
Vibrio vulnificus YJ016 BAC96154.1
CBG21112.1
NP_936184.1
Q7MG41  
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 acyl-glucose-dependent anthocyanin 7-O-glucosyltransferase (Aa7gT) 2.4.1.- pubmed
Agapanthus africanus BAM29304.1 I7GSQ8  
 ER β-glucosidase (Psr3.2;Bglu21;At1g66270) 3.2.1.21 pubmed
Arabidopsis thaliana AAB64244.1
AAG51761.1
AAG52157.1
AAK74056.1
AAO11600.1
AEE34488.1
AEE34489.1
NP_176801.1
NP_849848.1
A0A178WA93
O23656
Q9C525
 
 myrosinase (TGG1;Bglu38;At5g26000) 3.2.1.147 pubmed
Arabidopsis thaliana AAC18869.1
AAD40143.1
AAK74039.1
AAL25596.1
AAL91284.1
AAN60236.1
AED93511.1
AED93512.1
BAH20253.1
CAA55786.1
CAH40799.1
CAH40800.1
CAH40801.1
CAH40802.1
CAH40803.1
CAH40804.1
CAH40805.1
CAH40806.1
CAH40807.1
CAH40808.1
CAH40809.1
CAH40810.1
CAH40811.1
CAH40812.1
CAH40813.1
CAH40814.1
CAH40815.1
CAH40816.1
CAH40817.1
CAH40818.1
CAH40819.1
CAH40820.1
CAH40821.1
CAH40822.1
CAH40823.1
CAH40824.1
CAH40825.1
CAH40826.1
NP_197972.1
NP_851077.1
A0A178U7L7
P37702
 
 myrosinase 2 (TGG2;Bglu37;At5g25980) (leaf) 3.2.1.147 pubmed
Arabidopsis thaliana AAK28645.1
AAD40134.1
AAK32833.1
AAL77743.1
AAM44928.1
AAN60275.1
AED93507.1
AED93508.1
BAD94532.1
BAD94810.1
BAE98479.1
CAA55787.1
NP_568479.1
Q42595
Q8H7E3
Q9ASV0
Q9C5C2
 
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