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Glycoside Hydrolase Family 12

Activities in FamilyXyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Mechanism Retaining e
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (2968); Uniprot accession (90); PDB accession (61); 3D entries (23); cryst (1)
Summary
Download GH12 (4778) Taxonomic display Structure (23 - 1 cryst) Characterized (89)
| 1 | ... | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | ... | 22 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 FNV68_38625   Streptomyces sp. S1D4-23 QDO11361.1    
 FNV68_38645   Streptomyces sp. S1D4-23 QDO11365.1    
 N6H00_28700   Streptomyces sp. S465 WAP58616.1    
 D7Y56_28705   Streptomyces sp. S501 QBR09552.1    
 SBE_005033   Streptomyces sp. SBE_14.2 WBO81201.1    
 SBE_004457   Streptomyces sp. SBE_14.2 WBO80661.1    
 PS467_29615   Streptomyces sp. SCA4-21 WNE99190.1    
 CAG99_17250   Streptomyces sp. SCSIO 03032 ARQ70357.1    
 CAG99_04545   Streptomyces sp. SCSIO 03032 ARQ68208.1    
 VM636_26425   Streptomyces sp. SCSIO 75703 WVW70777.1    
 C1N79_05985   Streptomyces sp. SGAir0924 QCR46303.1    
 C1N79_26705   Streptomyces sp. SGAir0924 QCR49913.1    
 QFA72_02970 (fragment)   Streptomyces sp. SH5 WGP08704.1    
 SACTE_5809   Streptomyces sp. SirexAA-E AEN13595.1    
 B9S64_00750   Streptomyces sp. SM18 AWL36809.1    
 HBB06_29815   Streptomyces sp. SNU607 WKV82042.1    
 HBB06_01555   Streptomyces sp. SNU607 WKV76906.1    
 C8250_003810   Streptomyces sp. So13.3 QNA71160.1    
 C8250_001390   Streptomyces sp. So13.3 QNA77655.1    
 E5N77_05680   Streptomyces sp. SS52 QCB21365.1    
 E5N77_25945   Streptomyces sp. SS52 QCB24882.1    
 U5640_10830   Streptomyces sp. SS7 WYV86120.1    
 A7X85_33750   Streptomyces sp. ST1015 QZZ30542.1    
 A7X85_44625   Streptomyces sp. ST1015 QZZ32345.1    
 GEV49_33340   Streptomyces sp. SYP-A7193 QFX85268.1    
 PBV52_05745   Streptomyces sp. T12 WDF36308.1    
 PBV52_04560   Streptomyces sp. T12 WDF36091.1    
 PBV52_35135   Streptomyces sp. T12 WDF41661.1    
 PBV52_03090   Streptomyces sp. T12 WDF35841.1    
 PBV52_35155   Streptomyces sp. T12 WDF41665.1    
 WBG99_08945   Streptomyces sp. TG1A-60 WXC20575.1    
 cellulase B (CelB)   Streptomyces sp. THW31 ADP65783.1    
 SAMN05216371_3219   Streptomyces sp. TLI_053 SDT62471.1    
 SAMN05216371_3760   Streptomyces sp. TLI_053 SDT68960.1    
 GLX30_32530   Streptomyces sp. Tu 2975 QIP87966.1    
 GLX30_33025   Streptomyces sp. Tu 2975 QIP88041.1    
 KE639_00890 (Cex_1)   Streptomyces sp. V17-9 QUW89714.1    
 KE639_05387 (CelS)   Streptomyces sp. V17-9 QUW94129.1    
 EZV63_04285   Streptomyces sp. VN1 QIP69187.1    
 PYR72_08020   Streptomyces sp. VNUA24 WEH13649.1    
 PYR72_15040   Streptomyces sp. VNUA24 WEH14968.1    
 Q3101_04280   Streptomyces sp. VNUA74 WML79097.1    
 DLM49_01125   Streptomyces sp. WAC 01438 AZM58333.1    
 ORF   Streptomyces sp. WAC1438 AFO53540.1    
 O7599_10390   Streptomyces sp. WMMC500 WBB62903.1    
 IPZ77_05345   Streptomyces sp. XC 2026 QQN76934.1    
 LXH13_28765   Streptomyces spinosirectus CRSS-Y-16 UIR20787.1    
 SSPO_033220   Streptomyces sporoclivatus NBRC 100767 BBJ40604.1    
 AY578_24050   Streptomyces thermocarboxydus K155 UVT12070.1    
 AY578_31580   Streptomyces thermocarboxydus K155 UVT13392.1    
 N6Q81_25415 (fragment)   Streptomyces vinaceusdrappus AC-40 UXI81133.1    
 N6Q81_05440 (fragment)   Streptomyces vinaceusdrappus AC-40 UXI77536.1    
 R2E43_10195   Streptomyces violaceoruber CGMCC 4.1801 WOY97802.1    
 R2E43_32540   Streptomyces violaceoruber CGMCC 4.1801 WOZ01928.1    
 Strvi_2018   Streptomyces violaceusniger Tu 4113 AEM81752.1    
 CP971_12360   Streptomyces viridifaciens ATCC 11989 QEU99975.1    
 BOQ63_019245   Streptomyces viridifaciens DSM 40239 UKZ06141.1    
 endo-β-1,4-glucanase S1 (CelS1) 3.2.1.4 Streptomyces viridosporus T7A AAD25090.1 Q9X602  
 CP969_27335   Streptomyces viridosporus T7A ATCC 39115 QEU87988.1    
 SXIM_44520   Streptomyces xiamenensis 318 AKG45836.1    
 endo-β-1,4-glucanase (Cel) 3.2.1.4 Streptomyces xylophagus KX6 ACN56471.1 D2D3J0  
 MOV08_42670 (fragment)   Streptomyces yunnanensis P86 WEB45341.1    
 DKM19_08810   Streptosporangium sp. caverna AWS41451.1    
 P0M04_24780   Telluria mixta ACM 1762 WEM94685.1    
 P5V12_02555   Teredinibacter sp. KSP-S5-2 WNO10045.1    
 WKI14_01535   Teredinibacter turnerae SR01903 WYH51510.1    
 WKW49_01575   Teredinibacter turnerae SR02026 WYH55543.1    
 TERTU_0353   Teredinibacter turnerae T7901 ACR14297.1    
 WKI13_19490   Teredinibacter turnerae T7902 WYH44973.1    
 Tbis_0352   Thermobispora bispora DSM 43833 ADG87082.1    
 CYL17_03680   Thermobispora bispora ZC4 QSI49622.1    
 KTC_26530   Thermosporothrix sp. COM3 BBH87902.1    
 endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) 3.2.1.4 Thermotoga maritima MSB8 AGL50456.1
AAD36591.1
AHD18579.1
AKE29285.1
CAA93273.1
NP_229324.1		 G4FFR2
Q60032
Q9S5X8		 3AMH[A,B]
3AMM[A,B]
3AMN[A,B]
3AMP[A,B]
3AMQ[A,B,C,D]
3O7O[A,B]
3VHN[A,B,C,D,E,F,G,H]
3VHO[A,B]
3VHP[A,B]
 endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) 3.2.1.4 Thermotoga maritima MSB8 AAD36592.1
AGL50457.1
AHD18578.1
AKE29286.1
CAA93274.1
NP_229325.1		 G4FFR3
Q60033
Q7DF96		  
 THMB_1558   Thermotoga maritima Tma100 AKE31157.1    
 THMB_1559   Thermotoga maritima Tma100 AKE31158.1    
 THMC_1558   Thermotoga maritima Tma200 AKE27413.1    
 THMC_1559   Thermotoga maritima Tma200 AKE27414.1    
 endoglucanase (N2) (fragment)   Thermotoga naphthophila CBH31132.1    
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Thermotoga neapolitana AAC95059.1
CAB06783.1		 O08428
P96491		  
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Thermotoga neapolitana AAC95060.1
CAB06782.1		 P96492
Q798L1		  
 CTN_1106   Thermotoga neapolitana DSM 4359 ACM23282.1    
 CTN_1107   Thermotoga neapolitana DSM 4359 ACM23283.1    
 cellulase (TCel2;Tpet_1267) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47281.1 A5IM58  
 cellulase (TCel5;Tpet_1268) 3.2.1.4 Thermotoga petrophila RKU-1 ABQ47282.1 A5IM59  
 Tnap_1284   Thermotoga petrophila RKU-10 ADA67369.1    
 Tnap_1285   Thermotoga petrophila RKU-10 ADA67370.1    
 T2812B_05950 (fragment)   Thermotoga sp. 2812B AIY86723.1    
 T2812B_05955   Thermotoga sp. 2812B AIY86724.1    
 T2812B_05935 (fragment)   Thermotoga sp. 2812B AIY86720.1    
 CELL2_06605   Thermotoga sp. Cell2 AIY88589.1    
 CELL2_06600   Thermotoga sp. Cell2 AIY88588.1    
 TRQ2_1187   Thermotoga sp. RQ2 ACB09531.1    
 TRQ2_1188   Thermotoga sp. RQ2 ACB09532.1    
 TRQ7_07010   Thermotoga sp. RQ7 AJG41199.1    
 TRQ7_07005   Thermotoga sp. RQ7 AJG41198.1    
 RM788_50210   Umezawaea sp. Da 62-37 WNV86207.1    
 RM788_11475   Umezawaea sp. Da 62-37 WNV88887.1    
 RM788_07275   Umezawaea sp. Da 62-37 WNV88083.1    
 GH12 protein   uncultured Bacillus sp. ALA15661.1    
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