Glycoside Hydrolase Family 12

Activities in Family	Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151); Endo-β-1,4-glucanase (EC 3.2.1.4); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Mechanism	Retaining e
Clan	GH-C
3D Structure Status	β-jelly roll
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family H.
External resources	CAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (2968); Uniprot accession (90); PDB accession (61); 3D entries (23); cryst (1)

Summary

Download GH12 (4778) Taxonomic display Structure (23 - 1 cryst) Characterized (89)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
SPRI_6625		Streptomyces pristinaespiralis HCCB 10218	ALC24931.1
H3L99_03630		Streptomyces pristinaespiralis PR11	QMU12780.1
H3L99_03005		Streptomyces pristinaespiralis PR11	QMU12674.1
BFF78_11660		Streptomyces puniciscabiei TW1S1	AOR31621.1
A4E84_29055		Streptomyces qaidamensis S10(2016)	AMW13189.1
LUW77_23185		Streptomyces radiopugnans MRC003	URN13350.1
LIV37_15740		Streptomyces rapamycinicus NRRL 5491	UTP30683.1
M271_15500		Streptomyces rapamycinicus NRRL 5491	AGP54676.1
LJB45_10625		Streptomyces rapamycinicus SRMK07	UTO62725.1
TUE45_06190 (CelS)		Streptomyces reticuli	CUW31447.1
TUE45_pSRTUE45c_0481 (CeX)		Streptomyces reticuli	CUW33113.1
CP984_04225		Streptomyces rimosus ATCC 10970	QEV74346.1
SRIM_036335		Streptomyces rimosus subsp. rimosus ATCC 10970	QST84902.1
SRIMR7_04315 (CelS)		Streptomyces rimosus subsp. rimosus R7	UNZ01357.1
FMM49_04785		Streptomyces rimosus subsp. rimosus SRI-4018v0	QTL85153.1
CTZ40_04235		Streptomyces rimosus WT5260	QDA03073.1
endo-β-1,4-glucanase S (EglS)	3.2.1.4	Streptomyces rochei A2	CAA52139.1	Q59963
TR631_06695		Streptomyces rochei D21E05	WQC11510.1
TR631_27350		Streptomyces rochei D21E05	WQC15332.1
P7W03_26230		Streptomyces rochei JK1	WMC88876.1
P7W03_05895		Streptomyces rochei JK1	WMC85126.1
RBH85_09590		Streptomyces rochei S32	WMI57008.1
RBH85_29725		Streptomyces rochei S32	WMI60479.1
IAG44_42265		Streptomyces roseirectus CRXT-G-22	QNP75382.1
IAG44_42010		Streptomyces roseirectus CRXT-G-22	QNP75339.1
IAG44_10705		Streptomyces roseirectus CRXT-G-22	QNP69872.1
SCAB_5981 (CelB)		Streptomyces scabiei 87.22	CBG67793.1
SCAB_25571		Streptomyces scabiei 87.22	CBG69663.1
SCAB_90081		Streptomyces scabiei 87.22	CBG75942.1
HUT11_04080		Streptomyces seoulensis A01	QKW25403.1
HEK131_24530		Streptomyces seoulensis HEK131	BDH05226.1
D0Z67_26985		Streptomyces seoulensis KCTC 9819	QBJ93560.1
I1A49_43960		Streptomyces solisilvae HNM0141	QPI62263.1
I1A49_31760		Streptomyces solisilvae HNM0141	QPI58865.1
CGL27_33255		Streptomyces sp. 11-1-2	ASQ97258.1
cellulase 12A (Cel12A)	3.2.1.4	Streptomyces sp. 11AG8	AAF91283.1 AAE59731.1 AAQ25310.1 AAQ31830.1 AAR63648.1 AAR67701.1 ACP76251.1	Q9KIH1	1OA4[A]
P8T65_03325		Streptomyces sp. 11x1	WNZ06719.1
P8T65_12500		Streptomyces sp. 11x1	WNZ08328.1
SAMN05428941_5778		Streptomyces sp. 2114.2	SDT76171.1
SAMN05428941_1220		Streptomyces sp. 2114.2	SDS81576.1
SAMN05444521_2491		Streptomyces sp. 3214.6	SHH90108.1
ASR50_33355		Streptomyces sp. 4F	ALV53826.1
ASR50_25700		Streptomyces sp. 4F	ALV52474.1
GZL_09191 (fragment)		Streptomyces sp. 769	AJC61712.1
HC362_01885		Streptomyces sp. 891-h	UNZ16028.1
K5X85_05960		Streptomyces sp. A144	UAX52593.1
K5X85_25825		Streptomyces sp. A144	UAX56196.1
IOD14_22310		Streptomyces sp. A2-16	QUC59272.1
IOD14_18315		Streptomyces sp. A2-16	QUC58602.1
IOD14_09275		Streptomyces sp. A2-16	QUC56972.1
N7U49_34210		Streptomyces sp. AD2-2	UXX95652.1
N7U49_34230 (fragment)		Streptomyces sp. AD2-2	UXX95655.1
DKB30_04365		Streptomyces sp. Ae707_A7	QNF61088.1
glycosyl hydrolase family 5, partial (fragment)		Streptomyces sp. AGERI-TA1	BBE15447.1
AS97_59185		Streptomyces sp. AgN23	QTI91038.1
AS97_08490		Streptomyces sp. AgN23	AJZ82975.1
P8A21_34635		Streptomyces sp. Alt1	WLQ52317.1
P8A19_05440		Streptomyces sp. Alt2	WLQ54916.1
P8A20_04110		Streptomyces sp. Alt3	WLQ62828.1
PZB77_17990		Streptomyces sp. AM 2-1-1	WEH41236.1
P0D76_16455		Streptomyces sp. AM 3-1-1	WEH28793.1
RPQ02_32615		Streptomyces sp. AM8-1-1	WNO68227.1
RPQ02_12480		Streptomyces sp. AM8-1-1	WNO64564.1
CVT30_01915		Streptomyces sp. AMCC400023	UJV38791.1
CVT30_10980		Streptomyces sp. AMCC400023	UJV40308.1
CVT30_10925		Streptomyces sp. AMCC400023	UJV40299.1
RI578_33680		Streptomyces sp. BB1-1-1	WND38939.1
RI578_11100		Streptomyces sp. BB1-1-1	WND34798.1
OH540_30920		Streptomyces sp. BPPL-273	WHM34210.1
QIY60_30320		Streptomyces sp. BPTC-684	WHM40747.1
JIX56_11915		Streptomyces sp. CA-210063	UUU30554.1
JIX56_01060		Streptomyces sp. CA-210063	UUU28602.1
C2142_14235		Streptomyces sp. CB01881	AUY49888.1
C4J65_02545		Streptomyces sp. CB09001	AXL87313.1
C4J65_25330		Streptomyces sp. CB09001	AXL91258.1
NI25_10825		Streptomyces sp. CCM_MD2014	AIV33924.1
NI25_33295		Streptomyces sp. CCM_MD2014	AIV37792.1
AS200_04800		Streptomyces sp. CdTB01	ALV31448.1
AS200_13735		Streptomyces sp. CdTB01	ALV32999.1
RJD14_23605		Streptomyces sp. CGMCC 4.1456	WNF65386.1
VJ737_11575		Streptomyces sp. CGMCC 4.1772	WRT98282.1
Q2K21_08445 (fragment)		Streptomyces sp. CGMCC 4.7035	WNB98103.1
SJH97_24735		Streptomyces sp. CL7	WPP32332.1
SJH97_32425		Streptomyces sp. CL7	WPP33747.1
CAC01_14350		Streptomyces sp. CLI2509 CLI2905	ASY33705.1
NNW99_09245		Streptomyces sp. CRCS-T-1	UUA13320.1
NNW98_09245		Streptomyces sp. CRLD-Y-1	UUA05693.1
V8690_31310		Streptomyces sp. DG1A-41	WWT98429.1
JIX55_36255		Streptomyces sp. DSM 40750	UUU25272.1
HB370_29215		Streptomyces sp. DSM 40868	QIS73563.1
HB370_28685		Streptomyces sp. DSM 40868	QIS73477.1
EASAB2608_08165 (CelA)		Streptomyces sp. EAS-AB2608 NBRC 114648	BCM72831.1
EASAB2608_05170		Streptomyces sp. EAS-AB2608 NBRC 114648	BCM69836.1
SAM9427_27010		Streptomyces sp. ETH9427	AXI89035.1
SAM9427_34610		Streptomyces sp. ETH9427	AXI90289.1
DJ577_26075		Streptomyces sp. FG7	QNF40504.1
A6P39_013640		Streptomyces sp. FXJ1.172	WEO94972.1
A6P39_013625 (fragment)		Streptomyces sp. FXJ1.172	WEP00192.2 WEP00192.1
Q7C01_08695		Streptomyces sp. FXY-T5	WMD04465.1
endo-β-1,4-glucanase (Cel;CelStrep)	3.2.1.4	Streptomyces sp. G12	CCI74016.1	I7L8N7
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