Activities in Family | GDP-Man α-mannosyltransferase (EC 2.4.1.-); GDP-Man: β-mannosyltransferase (EC 2.4.1.-); GDP-β-L-Fuc : D-Glc-β-1,3-D-GalNAc-PP-Ph α-1,4-L-fucosyltransferase (EC 2.4.1.-); Hexosyltransferases (EC 2.4.1.-); LOS β-1,4-glucosyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); N-acetylglucosaminyltransferase (EC 2.4.1.-); UDP-Gal: α-GlcNAc-PP-lipid β-1,3-galactosyltransferase (EC 2.4.1.-); UDP-Gal: β-1,3-galactosyltransferase (EC 2.4.1.-); UDP-Gal:queuosine β-galactosyltransferase (EC 2.4.1.-); UDP-GalNAc: β-1,3-N-acetylgalactosaminyltrasferase (EC 2.4.1.-); UDP-GalNAc: undecaprenyl-P β-N-acetylgalactosaminyltransferase (EC 2.4.1.-); UDP-GalfNAc:glucuronamide β-1,4-N-acetylgalactofuranosyltransferase (EC 2.4.1.-); UDP-Glc : GalNAc-PP-Und β-1,3-glucosyltransferase (EC 2.4.1.-); UDP-Glc tubercidin/adenosine transferase (EC 2.4.1.-); UDP-Glc: β-1,6-glucan synthase (EC 2.4.1.-); UDP-Glc: β-glucosyltransferase (EC 2.4.1.-); UDP-Glc: bactoprenol β-glucosyltransferase (EC 2.4.1.-); UDP-Glc: teichoic acid β-glucosyltransferase (EC 2.4.1.-); UDP-GlcA: LOS β-glucuronyltransferase (EC 2.4.1.-); UDP-GlcA: [hyaluronan] β-1,4-glucuronyltransferase (EC 2.4.1.-); UDP-GlcNAc: [hyaluronan] β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-); [inverting] UDP-Glc: glycocin S-β-glucosyltransferase (EC 2.4.1.-); [inverting] UDP-Glc: protein O-β-glucosyltransferase (EC 2.4.1.-); [inverting] UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.-); [inverting] UDP-GlcNAc: teichoic acid β-N-acetylglucosaminyltransferase (EC 2.4.1.-); [inverting] β-1,6-glucosyltransferase (EC 2.4.1.-); [inverting] dTDP-L-Rha: α-L-rhamnosyltransferase (EC 2.4.1.-); [inverting] dTDP-spectinose: β-spectinosyltransferase (EC 2.4.1.-); [inverting] glucomannan synthase (EC 2.4.1.-); α-1,3-rhamnosyltransferase (unspecified donor) (EC 2.4.1.-); α-1,4-L-fucosyltransferase (EC 2.4.1.-); α-1,6-L-fucosyltransferase (EC 2.4.1.-); Alternating β-1,3/4-N-acetylmannan synthase (EC 2.4.1.-); Arabinoglucan synthase (EC 2.4.1.-); β-1,3-1,4-glucan synthase (EC 2.4.1.-); β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-); β-1,3-glucosyltransferase (EC 2.4.1.-); β-1,4-galactosyltransferase (EC 2.4.1.-); β-1,4-glucosyltransferase (EC 2.4.1.-); Chlorobactene β-glucosyltransferase (EC 2.4.1.-); Poly-β-1,6-N-acetylglucosamine synthase (EC 2.4.1.-); Staphyloxanthin β-glucosyltransferase (EC 2.4.1.-); Xyloglucan β-1,4-glucan synthase (EC 2.4.1.-); UDP-Glc: dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); UDP-Glc: β-1,4-glucan synthase / cellulose synthase (UDP-forming) (EC 2.4.1.12); UDP-Glc: 1,2-diacylglycerol 3-glucosyltransferase (EC 2.4.1.157); Chitin synthase (EC 2.4.1.16); UDP-GlcA: β-glucuronosyltransferase (EC 2.4.1.17); UDP-GalNAc: β-1,3-glucuronyl-N-acetylgalactosaminyl-proteoglycan β-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.175); β-Man-P-decaprenol: α-1,6-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); Hyaluronan synthase (EC 2.4.1.212); UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225); UDP-GlcA: N-acetylgalactosaminyl-proteoglycan β-1,3-glucuronosyltransferase (EC 2.4.1.226); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: [galactan] Galf-Galf-Rhα-GlcNAc-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); DTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289); β-1,3-glucosyltransferase (EC 2.4.1.305); [inverting] GDP-Man: β-mannan β-1,4-mannosyltransferase / glucomannan synthase (EC 2.4.1.32); Mannuronan synthase (EC 2.4.1.33); UDP-Glc: β-1,3-glucan synthase / callose synthase (EC 2.4.1.34); GDP-Man: Dol-P β-mannosyltransferase (EC 2.4.1.83); UDP-L-Arap-4N-formyl : undecaprenyl-P α-L-4N-formylarabinosyltransferase (EC 2.4.2.-); |
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Mechanism | Inverting |
3D Structure Status | GT-A |
Note | Distant similarity to families GT12, GT21, GT27, GT55, GT81 etc. |
External resources | Glymap; HOMSTRAD; |
Commercial Enzyme Provider(s) | CHEMILY; |
Statistics | GenBank accession (409848); Uniprot accession (404); PDB accession (110); 3D entries (35); cryst (0) |
Archaea | ||||||||||||||||||||||||||||||||||||
Protein Name | EC# | Organism | GenBank | Uniprot |
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GDP-Man : mannosyltransferase (PcManGT; Pcal_0472) | 2.4.1.- | Pyrobaculum calidifontis JCM 11548 | ABO07903.1 | A3MTD6 |
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GDP-Man: dolichyl-phosphate β-mannosyltransferase / dolichylphosphate mannose synthase (PfDPMS; PF0058) | 2.4.1.83 | Pyrococcus furiosus DSM 3638 | AAL80182.1 NP_577787.1 |
Q8U4M3 |
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Bacteria | ||||||||||||||||||||||||||||||||||||
Protein Name | EC# | Organism | GenBank | Uniprot |
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SpsA (BSU37910) | Bacillus subtilis subsp. subtilis str. 168 | CAB15817.1 AIY95105.1 AQR83830.1 AQR88045.1 CAA51619.1 NP_391670.1 |
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UDP-Glc: (sublancin 168) S-β-glucosyltransferase / sublancin S-glycosyltransferase (SunS; YolJ; BSU21450) | 2.4.1.- | Bacillus subtilis subsp. subtilis str. 168 | CAB14063.1 AAC12995.1 AAC38304.1 AIY93467.1 AQR82152.1 AQR86366.1 NP_390028.1 |
A0A6M3ZIB3 O31986 O64036 |
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[inverting] UDP-Glc: glycocin S/O-β-glucosyltransferase (ThusS; bthur0009_56280) | 2.4.1.- 2.4.1.- |
Bacillus thuringiensis serovar andalousiensis BGSC 4AW1 | EEM68351.1 | C3GCL5 |
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BF2801 | Bacteroides fragilis NCTC 9343 | CAH08495.1 |
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cellulose synthase subunit A (BcsA;RSP_0333) | 2.4.1.12 | Cereibacter sphaeroides 2.4.1 | ABA79509.1 AXC61721.1 |
Q3J125 |
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UDP-Glc: β-1,4-glucan synthase / cellulose synthase (BcsA; AKN41_3848) | 2.4.1.12 | Escherichia coli GE3 | ASO85436.1 | P37652 P37653 |
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chondroitin polymerase (KfoC; K4CP) | 2.4.1.226 | Escherichia coli K4 | BAC00523.1 CAD87418.1 CAD87419.1 CAV13380.1 CAV13381.1 |
Q8L0V4 |
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chondroitin polymerase (KfoC; K4CP) | 2.4.1.175 | Escherichia coli K4 | BAC00523.1 CAD87418.1 CAD87419.1 CAV13380.1 CAV13381.1 |
Q8L0V4 |
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cellulose synthase (YhjO) | 2.4.1.12 | Escherichia coli str. K-12 substr. MG1655 | AAC76558.2 AAB18510.1 AIZ89467.1 ALI38786.1 AMC96413.1 AUG18238.1 AVI53694.1 AYG17528.1 NP_417990.2 |
P37653 |
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LBJ_1113 | Leptospira borgpetersenii serovar Hardjo-bovis str. JB197 | ABJ75726.1 |
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IFI78_03440 | Listeria monocytogenes FSL F6-0367 | QOF60318.1 |
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JKV74_08865 | Listeria monocytogenes LM26 | QQX72823.1 |
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UDP-Galf; galactan b-(1,5)- / b-(1,6)-galactofuranosyltransferase (GlfT2;GlfT;Rv3808c) | 2.4.1.288 | Mycobacterium tuberculosis H37Rv | CAA17872.1 ACS09801.1 AFN51834.1 CCP46637.1 NP_218325.1 |
O53585 |
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heparosan synthase (HssB;PglA;PmHS2;PM0414) | 2.4.1.225 | Pasteurella multocida subsp. multocida str. Pm70 | AAK02498.1 ABY16656.1 ACW41673.1 NP_245351.1 |
Q9CNL4 |
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UDP-L-Arap-4N-formyl : undecaprenyl-P α-L-4N-formylarabinosyltransferase (ArnC;PmrF) | 2.4.2.- | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 | AAL21199.1 NP_461240.1 |
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UDP-GlcNAc: [wall teichoic acid] polyribitol phosphate β-1,4-N-acetylglucosaminyltransferase (TarS; SAV0258) | 2.4.1.- | Staphylococcus aureus subsp. aureus Mu50 | BAB56420.1 NP_370782.1 |
A0A0H3JPC6 Q99WW5 |
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UDP-GlcNAc: [wall teichoic acid] polyribitol phosphate β-1,3-N-acetylglucosaminyltransferase (TarP; SA1808) | 2.4.1.- | Staphylococcus aureus subsp. aureus N315 | BAB43088.1 NP_375109.1 |
A0A0H3JNB0 |
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bimodular dual β-glycosyltransferase, N-term GT101 transfers β-Glc; C-term GT2 transfers β-GlcNAc (​dGT1;Spaf_1933) | 2.4.1.- | Streptococcus parasanguinis FW213 | ACF35268.1 AFJ26875.1 |
B5A7M0 I1ZPA1 |
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UDP-Glc: tubercidin/adenosine 3'-O-glucosyltransferase (AvpGT; APS67_002972) | 2.4.1.- | Streptomyces sp. AVP053U2 | ODA72673.1 |
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UDP-Glc: undecaprenyl-P β-glucosyltransferase (GtrB;GtrBSyn;sll0501) | 2.4.1.- | Synechocystis sp. PCC 6803 | BAA10834.1 AGF53125.1 ALJ69004.1 BAK51619.1 NP_442763.1 QWO80272.1 |
Q55487 |
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Eukaryota | ||||||||||||||||||||||||||||||||||||
Protein Name | EC# | Organism | GenBank | Uniprot |
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At5g05170 (cellulose synthase A3;CesA3;Cev1;Rsw5) (AtCesA3) | 2.4.1.12 | Arabidopsis thaliana | AAC39336.1 AAN86168.1 AAO95208.1 AAY06383.1 AED90836.1 AHL38644.1 BAB09693.1 BAF01916.1 CAC09627.1 CAC09633.1 CAW91425.1 CAW94243.1 CBC96120.1 NP_196136.1 |
A0A384K963 O48948 Q941L0 W8Q6G0 |
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chitin transglycosylase (CAALFM_CR09020CA;Chs2) | 2.4.1.16 | Candida albicans SC5314 | AOW31570.1 | A0A1D8PTV3 P30572 |
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cellulose synthase (CesA3; GLYMA_12G237000v4) | 2.4.1.12 | Glycine max | KRH27476.1 |
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cellulose synthase (CesA1; GLYMA_06G069600v4) | 2.4.1.12 | Glycine max | KRH52459.1 |
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cellulose synthase (CesA6; GLYMA_02G080900v4) | 2.4.1.12 | Glycine max | KRH70281.1 |
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cellulose synthase (CESA7; GhCesA7) | 2.4.1.12 | Gossypium hirsutum | AFB18636.1 AIE38017.1 |
L7NUA2 |
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β-1,3;1,4-glucan synthase (CslF6) | 2.4.1.- | Hordeum vulgare | ABZ01578.1 AKJ66175.1 |
B1P2T4 F2DMH9 |
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Os07g0208500 (OsCesA8) | Oryza sativa Japonica Group | BAC57282.1 AAQ41474.1 BAD30175.1 BAF21076.1 BAG92935.1 BAT00571.1 CAW90431.1 CAW91297.1 CAW93006.1 CAW94112.1 CAW96299.1 CAW96907.1 CAW97564.1 CBC98617.1 NP_001059162.1 |
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chitin synthase | 2.4.1.16 | Phytophthora sojae | ARC77249.1 |
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cellulose synthase (CesA3-1; PttCesA8) | 2.4.1.12 | Populus tremula x Populus tremuloides | AAT09896.2 CAW90509.1 CAW91364.1 CAW93080.1 CAW94177.1 CAW96333.1 CAW96941.1 CAW97636.1 CBC98685.1 |
Q6J8X0 |
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chitin synthase 1 (Chs1;YNL192W;N1404) | 2.4.1.16 | Saccharomyces cerevisiae S288c | AAA34491.1 ABC16980.1 CAA96086.1 CAL85381.1 NP_014207.1 |
P08004 |
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hyaluronan synthase 1 (HAS1;DG42) | 2.4.1.212 | Xenopus laevis | AAA49699.1 AAH47963.1 AAI08481.1 AAN23419.1 AAO93603.1 AAR39743.1 ABA69790.1 ABJ29054.1 CAJ87393.1 CAL40934.1 CAL44798.1 CAL47715.1 |
P13563 |
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Viruses | ||||||||||||||||||||||||||||||||||||
Protein Name | EC# | Organism | GenBank | Uniprot |
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hyaluronan synthase (Cv-HAS; PBCVCZ2_118R; Cz-2_118R) | 2.4.1.212 | Paramecium bursaria Chlorella virus CZ-2 | AGE52748.1 | M1H2Q1 |
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