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Glycoside Hydrolase Family 5 / Subf 5

Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (2595); Uniprot accession (64); PDB accession (35); 3D entries (9); cryst (0)
Summary
Download GH5_5 (10311) Taxonomic display Structure (9) Characterized (57) Activities in Sub Family (1)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3DSubf
 endoglucanase (Egl;EglA;azo2236) 3.2.1.4 pubmed
 Azoarcus sp. BH72 ABB92850.1
CAL94853.1		 A0S6A6   5
 endoglucanase (Cel5D) 3.2.1.4 pubmed
 Martelella mediterranea WP_018063499.1     5
 endoglucanase (CelX) (Cel5M) 3.2.1.4 pubmed
 Pseudomonas sp. MM15 AEM45646.1 G3EWG4   5
 endo-β-1,4-glucanase (Egl) 3.2.1.4 pubmed
 Ralstonia solanacearum AW AAA61980.1 P17974   5
 endoglucanase S (EndS) 3.2.1.4 pubmed
 Sinorhizobium meliloti M5N1CS AAG44364.1 Q9F0G8   5
 endo-β-1,4-glucanase (Cel5A ; Ps_Cel5A; PST_2494) 3.2.1.4 pubmed
 Stutzerimonas stutzeri A1501 ABP80146.1 A4VME5 4LX4[A,B,C,D]
6R2J[A,B,C,D] 		5
 endoglucanase (RBcel1) 3.2.1.4 pubmed
 uncultured bacterium ACO55737.1 C1JI15 4EE9[A]
4M24[A]
5LJF[A,B]
6ZZ3[A,B,C,D]
7P6G[A,B]
7P6H[A,B]
7P6I[A]
7P6J[A,B,C,D] 		5
 endo-β-1,4-glucanase (UmCel5A) (Cel5A) 3.2.1.4 pubmed
 uncultured bacterium ABB51612.1 Q308B6   5
 endoglucanase (C2A1) 3.2.1.4 pubmed
 uncultured bacterium BAO65799.1 X5IHI7   5
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3DSubf
 endoglucanase / cellulase (Egl2) 3.2.1.4 pubmed
 Aspergillus fumigatus Z5 ADX78144.1 F1DGF4   5
 endoglucanase / cellulase (Egl3) 3.2.1.4 pubmed
 Aspergillus fumigatus Z5 ADX78145.1 F1DGF5   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 pubmed
 Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 pubmed
 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1		 Q5BDU5   5
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 pubmed
 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1		 Q1HFS8   5
 endoglucanase B (EglB) 3.2.1.4 pubmed
 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-glucanase (Eng1; EgI; AnCel5A) 3.2.1.4 pubmed
 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7		 5I77[A]
5I78[A,B]
5I79[A,B] 		5
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 pubmed
 Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1 H2B656   5
 cellulase (CelA;CsCelA) 3.2.1.4 pubmed
 Ciboria shiraiana AIC79156.1 A0A068B5I5   5
 carboxymethylcellulase (CsCMCase) 3.2.1.4 pubmed
 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 endo-β-1,4-glucanase (GlCel5A; GL28282) (Cel5A) 3.2.1.4 pubmed
 Ganoderma lucidum QDK64599.1 A0A1A9TAJ1
A0A514YQS6		 5D8W[A,B]
5D8Z[A,B] 		5
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 pubmed
 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194		   5
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 pubmed
 Humicola grisea var. thermoidea IFO9854 BAA12676.1 Q12624   5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 pubmed
 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 endoglucanase (Cen1;En-1) 3.2.1.4 pubmed
 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 endoglucanase LbGH5-CBM1 3.2.1.4 pubmed
 Laccaria bicolor XP_001879429.1 B0D5M7   5
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 pubmed
 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 pubmed
 Macrophomina phaseolina AAB03889.1 Q12637   5
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 pubmed
 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1		 Q6MGI3
Q7SDR1		   5
 endo-β-1,4-glucanase (EGb1;EGb2) (Cel5C) 3.2.1.4 doi
 Penicillium brasilianum IBT 20888 ACB06750.1 B8Q961   5
 endoglucanase II / 5A (Eg2;Egl2) (Cel5A) 3.2.1.4 pubmed
 Penicillium decumbens 114-2 / JU-A10 ABY28340.1 A9Z054   5
 endoglucanase 1 (Egl1;Pe-Egl1) 3.2.1.4 pubmed
 Penicillium echinulatum 9A01S2 ACR82487.1 C5J4L7   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 pubmed
 Penicillium janthinellum Biourge IMET 43733 (C41) CAA61740.1 Q12665   5
 endo-β-1,4-glucanase (EgG5) 3.2.1.4 pubmed
 Phialophora sp. G5 / CGMCC 3328 ADZ44606.1 H6TJC5   5
 endo-β-1,4-glucanase (PpCel5A) (Cel5A) 3.2.1.4 pubmed
 Postia placenta Mad-698-R ADH51729.1 D7REW2   5
 endo-β-1,4-glucanase (PpCel5B) (Cel5B) 3.2.1.4 pubmed
 Postia placenta Mad-698-R XP_002475436.1
ADH51730.1		 B8PID6
D7REW3		   5
 broad specificity endo-β-glucanase (Egl5A; TeEgl5A) 3.2.1.4 pubmed
 Rasamsonia emersonii CBS 394.64 AHV83755.1
CAJ75961.1		 X4YXV3   5
 endo-β-1,4-glucanase (Eg1) 3.2.1.4 pubmed
 Rasamsonia emersonii IMI 392299 AAL33639.2
AAL33630.1
AAL33630.2
AAL33639.1		 Q8WZD7   5
 endo-β-1,4-glucanase I (Eg1) 3.2.1.4 pubmed
 Robillarda sp. Y-20 BAA90480.1
JX0131		 P23044
Q9P981		   5
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 pubmed
 Saitozyma flava MUT-6 AAC60541.1
BAA03070.1		 Q04469   5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 pubmed
 Schizophyllum commune H4-8 EFI96731.1 D8Q439
P81190		   5
 cellulase (SoCel5) 3.2.1.4 pubmed
 Stegonsporium opalus ARO48344.1 A0A1W6R2C1   5
 endoglucanase 2 (Eg2; EG2) 3.2.1.4 doi
 Talaromyces amestolkiae ATY39124.1 A0A2H4R4J8   5
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 pubmed
 Talaromyces cellulolyticus Y-94 GAM33994.1 A0A698XMA4   5
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 doi
 Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 pubmed
 Talaromyces verruculosus B221-151   A0A1U7Q1U3 5L9C[A,B,C,D]
6T9F[A,B,C,D]
6T9G[A,B,C,D]
6TPC[A,C]
6YON[A,B,C,D]
5I6S[A] 		5
 endo-β-1,4-glucanase (Eg1; Eng1; TaCel5A) (Cel5A) 3.2.1.4 pubmed
 Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1		 Q8TG26
Q96UI5		 1GZJ[A,B]
1H1N[A,B]
7R28[A,B]
7R29[A,B]
7R2A[A,B]
7R2C[A,B]
7R2D[A,B] 		5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 pubmed
 Thermothelomyces thermophilus ATCC 42464 AEO53769.1
AEM23898.1		 G2Q5D8
H2B658		   5
 endoglucanase (Eg-1) 3.2.1.4 pubmed
 Trametes hirsuta BAD01163.1
BAD01164.1		 Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 pubmed
 Trametes versicolor XP_008039932.1     5
 endo-β-1,4-glucanase II (EG2; EGII; Egl2 ;EG-II; TrEGII; TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 pubmed
 Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1		 P07982
Q2F8H3		 3QR3[A,B] 5
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 pubmed
 Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 endoglucanase III (EG3;EGIII) 3.2.1.4 pubmed
 Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
 endoglucanase VIII (EgvIII) 3.2.1.4 pubmed
 Trichoderma viride AS 3.3711 ACD36972.1 B4YEW2   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 pubmed
 Trichoderma viride MC300-1 BAA36216.1 O93833   5
 endoglucanase (TmEgl5A) (Egl5A) 3.2.1.4 pubmed
 Tricholoma matsutake NBRC 30605 BBG31500.1 A0A387K9G9   5
 endoglucanase I (EG1;EGI) 3.2.1.4 pubmed
 Volvariella volvacea V14 AAG59832.1
AEQ58914.1		 G4WYN8
Q9C3Z8		   5
 endoglucanase I (EgI;NCel5A) (Cel5A) 3.2.1.4 pubmed
 Volvariella volvacea WX32 ACE06751.1 B3GQ73   5
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