Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (50556); Uniprot accession (250); PDB accession (256); 3D entries (65); cryst (2)

Archaea
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
β-glucuronidase (GusB;Ssol98_010100007956)	3.2.1.31	pubmed	Saccharolobus solfataricus 98/2	AET42956.1	G8GCV1
Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
β-galactosidase (LacZ)	3.2.1.23	pubmed	Actinobacillus pleuropneumoniae CM5	AAB17954.1	P70753
β-galactosidase (AgWH2A)	3.2.1.23	pubmed	Agarivorans gilvus WH0801	AXA12974.1	A0A2Z4WWH8
β-mannosidase (ManA; AfMan2; Atu1523)	3.2.1.25	pubmed	Agrobacterium fabrum str. C58	AAL42528.1 AAK87314.1 AAK87314.2 NP_354529.1 NP_532212.1	Q7CZ23
β-galactosidase	3.2.1.23	pubmed	Alkalilactibacillus ikkensis 517	ACO52514.1	C1KC07
β-galactosidase (GalA)	3.2.1.23	pubmed	Alteromonas sp. ANT48	QGZ98840.1	A0A6B9KBH1
β-galactosidase (Bgal)	3.2.1.23	doi	Alteromonas sp. ML117	AZK90254.1	A0A3S8S8V3
β-galactosidase	3.2.1.23	pubmed	Alteromonas sp. ML52	AZK90255.1	A0A3Q8SL57
β-galactosidase (Gal2A)	3.2.1.23	pubmed	Alteromonas sp. QD01	QPF69526.1	A0A7U3PJ41
exo-β-glucosaminidase / exochitosanase (CsxA)	3.2.1.165	pubmed	Amycolatopsis orientalis	AAX62629.2 AAX62629.1	Q56F26	2VZO[A,B] 2VZS[A,B] 2VZT[A,B] 2VZU[A,B] 2VZV[A,B] 2X05[A,B] 2X09[A,B]
β-glucuronidase / β-galacturonidase (AqGalA)	3.2.1.31 3.2.1.-	pubmed pubmed	Aquimarina sp. SCSIO21287	UER37076.1	A0A8X6EH35	7VQM[A,B,C,D]
β-galactosidase (BglA)	3.2.1.23	pubmed	Arthrobacter psychrolactophilus F2	BAF33372.1	Q08KN3
β-galactosidase (BgaS)	3.2.1.23	pubmed	Arthrobacter sp. 20B	ACI41243.1	B6EAX7
β-galactosidase (ArthβDG)	3.2.1.23	pubmed	Arthrobacter sp. 32cB	AHY00656.1	A0A023UGN9	6ETZ[A] 6H1P[A] 6SE8[A] 6SE9[A] 6SEA[A] 6SEB[A] 6SEC[A] 6SED[A] 6ZJP[A] 6ZJQ[A] 6ZJR[A] 6ZJS[A] 6ZJT[A] 6ZJU[A] 6ZJV[A] 6ZJW[A] 6ZJX[A]
β-galactosidase (LacZ)	3.2.1.23	pubmed	Arthrobacter sp. B7	AAA69907.1	Q59140
β-galactosidase (LacZ)	3.2.1.23	doi	Arthrobacter sp. C2-2	CAD29775.1	Q8KRF6	1YQ2[A,B,C,D,E,F]
β-galactosidase (GalA)	3.2.1.23	pubmed	Arthrobacter sp. ON14	ADJ18283.1	D9IU58
β-glucuronidase (Gus)	3.2.1.31	pubmed	Arthrobacter sp. RP10	AAV91790.1	Q5MJX7
β-glucuronidase (Gus)	3.2.1.31	pubmed	Arthrobacter sp. RP40.7	AAV91792.1	Q5MJX5
β-galactosidase (BgaS)	3.2.1.23	pubmed	Arthrobacter sp. SB	AAQ19029.1	Q7WTU5
β-xylosidase (BcellWH2_03638; BACWH2_3409; Lacz_21)	3.2.1.37	pubmed	Bacteroides cellulosilyticus WH2	ALJ60861.1 WP_029427454.1	A0A0P0GUA9
β-glucuronidase (BcellWH2_04226; BACWH2_3980; Lacz_22)	3.2.1.31	pubmed	Bacteroides cellulosilyticus WH2	ALJ61443.1 WP_029428765.1	A0A0N7IFX8
β-glucuronidase (BfGUS; BF0328)	3.2.1.31	pubmed	Bacteroides fragilis NCTC 9343	CAH06099.1	Q5LIC7	3CMG[A] 5Z1A[A]
β-galactosidase (BgaA; BF1738)	3.2.1.23	pubmed	Bacteroides fragilis YCH46	BAD48485.1 BAC56904.1 BAC56904.2	G8K035 Q84ID4
β-mannosidase (BmnA; BF1733)	3.2.1.25	pubmed	Bacteroides fragilis YCH46	BAD48480.1 BAC56899.1 BAC56899.2	G8K032 Q84ID9
β-galactosidase (Lacz_13;BoGH2A;BACOVA_02645;Bovatus_03065)	3.2.1.23	pubmed	Bacteroides ovatus ATCC 8483	ALJ47673.1
β-glucuronidase (Bovatus_02309;BACOVA_03100;Uida_1)	3.2.1.31	pubmed	Bacteroides ovatus ATCC 8483	ALJ46942.1
β-glucuronidase (BMSP;HMPREF2532_04191)	3.2.1.31	pubmed	Bacteroides ovatus KLE1656	KXT42440.1	A0A139KTC9	6D8K[B,C,D] 6D8K[A]
β-galacturonidase (BT0992; BT_0992)	3.2.1.-	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76099.1 NP_809905.1	Q8A925
β-mannosidase (BT0458;BT_0458) (Man2A)	3.2.1.25	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO75565.1 NP_809371.1	Q8AAK6	2JE8[A,B] 2VJX[A,B] 2VL4[A,B] 2VMF[A,B] 2VO5[A,B] 2VOT[A,B] 2VQT[A,B] 2VQU[A,B] 2VR4[A,B] 2WBK[A,B] 7OP6[A,B] 7OP7[A,B]
bimodular β-L-arabinofuranosidase / β-glucuronidase (cleaves L-Araf-β-1,2-L-Rha) (BT0996; BT_0996)	3.2.1.31	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76103.1 NP_809909.1	Q8A921
β-galactosidase (BT4151;BT_4151)	3.2.1.23	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79256.1 NP_813062.1	Q8A070
α-L-arabinopyranosidase (cleaves L-Arap-α-1,4-D-Gal) ( BT0983; BT_0983)	3.2.1.-	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76090.1 NP_809896.1	Q8A934
β-galactosidase (BT4156;BT_4156)	3.2.1.23	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79261.1 NP_813067.1	Q8A065
β-glucuronidase (BT4181;BT_4181)	3.2.1.31	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79286.1 NP_813092.1	Q8A040
β-galactosidase (BT0461; BT_0461)	3.2.1.23	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO75568.1 NP_809374.1	Q8AAK3
β-galactosidase (cleaves D-Galp-β-1,2-L-Acef; BT0993)	3.2.1.23	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76100.1 NP_809906.1	Q8A924
β-galactosidase (BT4667;BT_4667)	3.2.1.23	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO79772.1 NP_813578.1	Q89YR4
exo-β-galactosidase porphyran-specific (NP1_22; BuGH2A)	3.2.1.23	pubmed	Bacteroides uniformis NP1	WP_234130811.1	A0A2D0TCC8	5T98[A,B] 5T99[A,B]
agarolytic β-galactosidase (BuGH2C)	3.2.1.23	pubmed	Bacteroides uniformis NP1		A0A2D0TCC9	5T9A[B,C,D] 5T9G[A,B,C,D] 5T9A[A]
β-glucuronidase (BuGUS-2; M094_3283)	3.2.1.31	pubmed	Bacteroides uniformis str. 3978 T3 i	KDS62590.1	A0A078SUX9 A0A414F142	5UJ6[A,B] 6D50[A,B] 6D8G[A,B] 6NZG[A,B]
β-glucuronidase (BuGUS-1; ERS417307_01040; Uida_4)	3.2.1.31	pubmed	Bacteroides uniformis str. 3978 T3 i	CUO13985.1	A0A174CQK8	6D1N[A,B] 6D41[A,B] 6D6W[A,B,C,D] 6D7F[A,B,C,D,E,F] 6D89[A,B,C,D]
β-galactosidase (BgaC;BAD_1582)	3.2.1.23	pubmed	Bifidobacterium adolescentis ATCC 15703	BAF40363.1	A1A3T0
β-galactosidase (BIF1;OLGA1)	3.2.1.23	pubmed	Bifidobacterium bifidum DSM 20215	CAB75342.1	Q9L3L4
β-galactosidase (BIF3)	3.2.1.23	pubmed	Bifidobacterium bifidum DSM 20215	CAC14566.2 AAP64961.1 ABI07182.1 CAD19366.1	Q9F4D5	6QUB[A,B] 6QUC[A,B] 6QUD[A] 7NIT[A,B,C,D,E,F]
β-galactosidase (BIF2)	3.2.1.23	pubmed	Bifidobacterium bifidum DSM 20215	CAC14565.1	Q9F4D6
lacto-N-neotetraose β-galactosidase (BbgIII)	3.2.1.23	pubmed	Bifidobacterium bifidum JCM 1254	BAI94821.1	D4QAP3	5DMY[A,B,C]
β-galactosidase P1 (BbgI;Bbg1)	3.2.1.23	pubmed	Bifidobacterium bifidum NCIMB 41171	ABE27151.1 ABE27151.2	Q0ZI53
β-galactosidase S1 specific for lactose (BbgIII)	3.2.1.108	pubmed	Bifidobacterium bifidum NCIMB 41171	ABE27152.1	A4K5H9
β-galactosidase K2 (BbgIV)	3.2.1.23	pubmed	Bifidobacterium bifidum NCIMB 41171	ABE00939.1	Q0ZII7
β-1,3-galactosidase (BgaA; LacZ2; Bbr_0285)	3.2.1.145	pubmed	Bifidobacterium breve UCC2003	ABE94991.1
β-galactosidase (LacZ;Lacz6;Bbr_1552_lacZ;Bbr_1552)	3.2.1.23	pubmed	Bifidobacterium breve UCC2003	ABE96223.1
β-galactosidase (Lacz1; Bbr_0010)	3.2.1.23	pubmed	Bifidobacterium breve UCC2003	ABE94727.1
β-glucuronidase (HMPREF0168_2111;UidA)	3.2.1.31	pubmed	Bifidobacterium dentium ATCC 27679	WP_003843201.1	E0QAF3	5Z1B[A,B,C,D]
β-galactosidase (Bdg2A)	3.2.1.23	pubmed	Bifidobacterium dentium Y510	UGN49370.1
β-galactosidase 2A (Blon_2334) (Bga2A)	3.2.1.23	pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ53392.1	B7GNN6
β-galactosidase (Blon_0268)	3.2.1.23	pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ51396.1	B7GTV5
β-galactosidase I (β-GalI)	3.2.1.23	pubmed	Bifidobacterium longum subsp. infantis HL96	AAL02052.1	Q93GI6
β-galactosidase (LacZ)	3.2.1.23	pubmed	Bifidobacterium longum subsp. longum MB219	CAB44428.1	Q9X6Y5
β-galactosidase (B8809_0611)	3.2.1.23	pubmed	Bifidobacterium longum subsp. longum NCIMB8809	ALO72284.1
β-galactosidase (B8809_1361)	3.2.1.23	pubmed	Bifidobacterium longum subsp. longum NCIMB8809	ALO73032.1
α-L-arabinopyranosidase (AbpBs; BKA19_1748)	3.2.1.-	pubmed	Blastococcus saxobsidens DSM 44509 / KACC 20608T	RZU32059.1 WP_104529000.1
galactomannan-binding β-1,4-mannosidase (CbMan2A;Athe_0227) (Man2A)	3.2.1.25	pubmed	Caldicellulosiruptor bescii DSM 6725	ACM59377.1	B9MME5
β-mannosidase 2A (CfMan2A) (Man2A)	3.2.1.25	pubmed	Cellulomonas fimi ATCC 484	AAD42775.1 AEE46894.1	F4H7D3 Q9XCV4
β-galactosidase	3.2.1.23	pubmed	Clostridium acetobutylicum	AAA23216.1	P24131
β-glucuronidase (BglR; CPGUS; CPE0147)	3.2.1.31	pubmed	Clostridium perfringens str. 13	BAB79853.1 CAD12654.1 NP_561063.1	Q8VNV4 Q8XP19	4JKM[A,B] 6CXS[A,B]
β-glucuronidase (UidA)	3.2.1.31	pubmed	Clostridium sp. Marseille-P299	WP_066714276.1
agarolytic β-galactosidase (J4772_24985; CL4994)	3.2.1.23	pubmed	Cohnella sp. LGH	QTH40796.1
β-glucuronidase (DtGlcA; DICTH_1429)	3.2.1.31	pubmed	Dictyoglomus thermophilum H-6-12	ACI18585.1	B5YFE0	6XXW[A]
β-mannosidase (DtMan;DICTH_1692)	3.2.1.25	pubmed	Dictyoglomus thermophilum H-6-12	ACI19676.1	B5YAN4	5N6U[A,B,C,D]
β-galacturonidase (EtGalAse)	3.2.1.-	pubmed	Eisenbergiella tayi	WP_069152983.1	A0A1E3AEY6	6NCW[A,B,C,D] 6NCX[A,B,C,D]
β-galactosidase (Bga;BgaB5)	3.2.1.23	doi	Enterobacter cloacae B5	ABB73039.1	Q2XQU3
β-galactosidase (LacZ)	3.2.1.23	pubmed	Enterobacter cloacae GAO	BAA07673.1	Q47077
β-galactosidase (LacZ)	3.2.1.23	pubmed	Erwinia rhapontici E602	AYC35409.1	A0A385ZAF4
β-galactosidase (LacZ;EcDH1_3262)	3.2.1.23	pubmed	Escherichia coli DH1	ACX40886.1 BAJ42187.1	C9QQT4
β-galactosidase Z (LacZ;Lac-Z;b0344;EO53_16565)	3.2.1.23	pubmed	Escherichia coli str. K-12 substr. MG1655	AAA24053.1 AAB18068.1 AAC73447.1 AAW06767.1 AAY73171.1 ABN72582.1 AEL16982.1 AIZ92504.1 ALI41840.1 AMC97588.1 AUG15134.1 AVI54877.1 CAA23573.1 CAC87491.1 NP_414878.1	B8LFD6 G0ZKW2 P00722 Q8VNN2	1BGL[A] 1BGM[I] 1DP0[A] 1F49[A] 1F4A[A] 1F4H[A] 1GHO[I] 1HN1[A,B,C,D] 1JYN[A] 1JYV[A] 1JYW[A] 1JYX[A] 1JYY[A] 1JYZ[I] 1JZ0[A] 1JZ1[I] 1JZ2[A] 1JZ3[A] 1JZ4[A] 1JZ5[A] 1JZ6[A] 1JZ7[A] 1JZ8[A] 1PX3[A,B,C,D] 1PX4[A,B,C,D] 3CZJ[A,B,C,D] 3DYM[A,B,C,D] 3DYO[A,B,C,D] 3DYP[A,B,C,D] 3E1F[1,2,3,4] 3I3B[A,B,C,D] 3I3D[A,B,C,D] 3I3E[A,B,C,D] 3IAP[A,B,C,D] 3IAQ[A,B,C,D] 3J7H[A,B,C,D] 3MUY[1,2,3,4] 3MUZ[1,2,3,4] 3MV0[1,2,3,4] 3MV1[1,2,3,4] 3SEP[A,B,C,D] 3T08[A,B,C,D] 3T09[A,B,C,D] 3T0A[A,B,C,D] 3T0B[A,B,C,D] 3T0D[A,B,C,D] 3T2O[A,B,C,D] 3T2P[A,B,C,D] 3T2Q[A,B,C,D] 3VD3[A,B,C,D] 3VD4[A,B,C,D] 3VD5[A,B,C,D] 3VD7[A,B,C,D] 3VD9[A,B,C,D] 3VDA[A,B,C,D] 3VDB[A,B,C,D] 3VDC[A,B,C,D] 4CKD[A,B,C,D] 4DUV[A,B,C,D] 4DUW[A,B,C,D] 4DUX[A,B,C,D] 4TTG[A,B,C,D] 4V40[A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P] 4V41[A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P] 4V44[A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P] 4V45[A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P] 5A1A[A,B,C,D] 6CVM[A,B,C,D] 6DRV[A,B,C,D] 6KUZ[A,B,C,D] 6X1Q[A,B,C,D] 7BRS[A,B,C,D] 7BTK[A,B,C,D] 8BK7[A,B,C,D] 8BK8[A,B,C,D] 8BKG[A,B,C,D] 8Q7Y[A,B,C,D] 8RI6[A,B,C,D] 8RI7[A,B,C,D] 8RI8[A,B,C,D] 8VT0[A,B,C,D]
β-glucuronidase (UidA; GusA; GurA; EcGUS; b1617)	3.2.1.31	pubmed	Escherichia coli str. K-12 substr. MG1655	AAC74689.1 AAA68923.1 AAB30197.1 AAR75623.1 ABE20937.1 ACR88323.1 AIZ91278.1 ALI40610.1 AMC98822.1 AUG16387.1 AVI56132.1 AYG19328.1 CAJ55495.1 CAJ55496.1 CAJ55497.1 CAJ55498.1 CAJ55499.1 CAJ55500.1 NP_416134.1 WP_001551153.1	A0A0D8WFE1 A0A1X3I6P5 A0A7Z1D535 A9DEX9 A9DEY7 A9DEZ1 A9DEZ6 A9DF00 A9DF05 P05804 U4Q148	3K46[A,B] 3K4A[A,B] 3K4D[A,B] 3LPF[A,B] 3LPG[A,B] 4JHZ[A,B] 5CZK[A,B] 6LEG[A,B,C,D] 6LEJ[A,B] 6LEL[A,B] 6LEM[A,B] 7PR6[A,B] 8OHX[A,B]
evolved β-galactosidase (EbgA;b3076)	3.2.1.23	pubmed	Escherichia coli str. K-12 substr. MG1655	AAA61971.1 AAA57877.1 AAC76111.1 AAT48164.1 AIZ89904.1 ALI39224.1 AMC95983.1 AUG17794.1 AVI53249.1 AYG17960.1 CAA36274.1 NP_417547.2	P06864
β-glucuronidase (CG447_12395)	3.2.1.31	pubmed	Faecalibacterium prausnitzii A2165	ATP00638.1 EEU97254.1	C7H4D2	6ED2[A]
β-glucuronidase (C4Q21_10165)	3.2.1.31	pubmed	Faecalibacterium prausnitzii APC918/95b	AXB29257.1	A0A3F3JX71	6U7I[A,B,C,D]
β-glucuronidase (Fp2GUS; FP2_04120)	3.2.1.31	pubmed	Faecalibacterium prausnitzii L2-6 L2/6	CBK98066.1	D4K3H3	6MVF[A,B,C,D,E,F]
β-galacturonidase (FcGalAse; BHW29_02690)	3.2.1.-	pubmed	Faecalibacterium sp. CAG:74_58_120	OLA24209.1	A0A1Q6Q230
β-galactosidase (Gal4214-1)	3.2.1.23	pubmed	Flavobacterium sp. 4214	AAX48919.1	Q2VT50
[ulvan] β-1,2-glucuronidase (BN863_22060)	3.2.1.31	pubmed	Formosa agariphila KMM 3901	CDF79918.1	T2KN75	6HPD[A]
FsGUS (β-galacturonidase/β-glucuronidase)	3.2.1.31 3.2.1.-	pubmed pubmed	Fusicatenibacter saccharivorans		A0A174EHD1	6NCY[B] 6NCZ[A,B,C,D,E,F] 6NCY[A]
β-galactosidase (BglP)	3.2.1.23	pubmed	gamma proteobacterium NT2-2	AMK07416.1	A0A140D6D2
β-galactosidase (LacZ)	3.2.1.23	pubmed	Klebsiella pneumoniae 285	AEA30145.1	F2X2W7
β-galactosidase (GalB)	3.2.1.23	pubmed	Klebsiella sp. T17-2	AMK07522.1	A0A126QG41
β-glucuronidase (EeGUS; EUBELI_20590)	3.2.1.31	pubmed	Lachnospira eligens ATCC 27750	ACR73734.1	A0A174ZZA3 C4Z6Z2	6BJQ[A] 6BJW[A] 6BO6[A] 6D4O[A] 8GEN[A] 8GEO[A] 8GEQ[A] 8GER[A] 8UGT[A]
β-glucuronidase (HMPREF0539_0313; UidA)	3.2.1.31	pubmed	Lacticaseibacillus rhamnosus LMS2-1	EEN81625.1	A0A2A5L2J1 C2JTS9	6ECA[A,B]
β-galactosidase (LacL+LacM)	3.2.1.23	pubmed	Lactiplantibacillus plantarum ATCC 8014	AAL09167.1 ATQ34817.1	Q938Q6
β-galactosidase (LacL+LacM)	3.2.1.23	pubmed	Lactiplantibacillus plantarum FUA3112	CAZ66936.1	C6H176
β-galactosidase (LacL+LacM,lp_3483+lp_3484)	3.2.1.23	pubmed	Lactiplantibacillus plantarum WCFS1	CAD65569.1 CCC80451.1 NP_786691.1	F9UUE9
β-galactosidase large subunit (LacL)	3.2.1.23	pubmed	Lactobacillus acidophilus ATCC 4356	ACC38286.1	B2LWG2
β-galactosidase Z	3.2.1.23	pubmed	Lactobacillus delbrueckii	AAA25240.1 AAA25244.1 AAY08349.1 ACW22137.1 CAC07488.1	P0C1Y0 Q1G9Z4
β-galactosidase Z (LacZ; Lbulagal; Ldb1201)	3.2.1.23	pubmed	Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002	CAI98003.1 AEN14565.1	Q1G9Z4
β-galactosidase (BgaL3)	3.2.1.23	doi	Lactobacillus delbrueckii subsp. bulgaricus L3	ACE06986.1	B3GS90
β-glucuronidase (GusA)	3.2.1.31	pubmed	Lactobacillus gasseri ADH	AAK07836.1 AAS22718.1	Q9AHJ8
β-galactosidase (LacL; EcoliBL21Lhβ-gal) (large subunit)	3.2.1.23	pubmed	Lactobacillus helveticus DSM 20075 = CGMCC 1.1877 ATCC 15009	CAD55499.1	Q7WTB4
β-galactosidase large subunit (LacL;WANG_0293)	3.2.1.23	pubmed	Lactobacillus kefiranofaciens ZW3	AEG39988.1
β-galactosidase (LacZ)	3.2.1.23	doi	Lactococcus lactis ATCC 7962	AAD11504.1 AAC63020.1 CAA56341.1	O87523 Q48727
β-galactosidase (LacZ;L0025)	3.2.1.23	pubmed	Lactococcus lactis subsp. lactis Il1403	AAK06078.1 NP_268137.2	Q48727
β-galactosidase L+S (LacL+LacS) (heterodimer)	3.2.1.23	pubmed	Latilactobacillus sakei subsp. sakei DSM 20017	CAA57730.1	Q48846
β-galactosidase L+M (LacL+LacM)	3.2.1.23	pubmed	Leuconostoc lactis	AAA25267.1 CAL48858.1	Q02603
β-galactosidase (LVIS_2259 + LVIS_2258)	3.2.1.23	pubmed	Levilactobacillus brevis ATCC 367	ABJ65308.1	Q03NB4
β-glucuronidase (Gus)	3.2.1.31	pubmed	Levilactobacillus brevis RO1	ACU21612.1	D2DMF3
β-galactosidase (LacLM;LacL+LacM)	3.2.1.23	pubmed	Limosilactobacillus fermentum K4	AEJ32720.1	F8T7X0
β-galactosidase (Lreubgal) (LacL + LacM)	3.2.1.23	pubmed	Limosilactobacillus reuteri L103	ABF72116.1	Q19R72
β-galactosidase (BgaB;MsBgaB;MS0749)	3.2.1.23	pubmed	[Mannheimia] succiniciproducens MBEL55E	AAU37356.1	Q65UK4
β-galactosidase (BgaA;MsBgaA;MS0806)	3.2.1.23	pubmed	[Mannheimia] succiniciproducens MBEL55E	AAU37413.1	Q65UE7
β-glucuronidase (Rg3GUS)	3.2.1.31	pubmed	Mediterraneibacter gnavus	WP_118581144.1		6MVG[A,B,C]
β-glucuronidase (UidA)	3.2.1.31	pubmed	Mediterraneibacter gnavus E1	AAQ76046.1	A0A2N5PVZ8 Q6W7J7	5Z18[A,B,C,D,E,F] 5Z19[A,B,C,D,E,F] 6EC6[A,B] 6JZ1[A,B] 6JZ2[A,B] 6JZ3[A,B] 6JZ4[A,B] 6JZ5[A,B] 6JZ6[A,B] 6JZ7[A,B] 6JZ8[A,B]
α-L-arabinopyranosidase (Bgp2)	3.2.1.-	pubmed	Microbacterium esteraromaticum GS514	AFC90218.1	H9A6H2
β-galactosidase (GalM)	3.2.1.23	pubmed	Microvirga sp. MC18	WLC21218.1
β-glucuronidase (B160DRAFT_01711)	3.2.1.31	pubmed	Niabella aurantiaca DSM 17617	WP_018628801.1
β-galactosidase A / B / C / D / 91 (Bga; BgaD; β-Gal-A; β-Gal-B; β-Gal-C; β-Gal-D; β-Glα-91; GALA)	3.2.1.23	pubmed	Niallia circulans ATCC 31382	BAJ61032.1 QEP29033.1	E5RWQ2	4YPJ[A,B] 8Q2H[A] 8Q4Y[A] 8Q51[A]
β-galactosidase II (BgaB)	3.2.1.23	pubmed	Niallia circulans ATCC 31382	QJU69416.1	A0A6M5K904	7CWD[A] 7CWI[A]
β-galactosidase (PbBGal2A)	3.2.1.23	pubmed	Paenibacillus barengoltzii CAU904	AJP16550.1	A0A0C5GSQ2	9M0E[A,B,C,D,E,F]
β-glucuronidase (PBOR_13360)	3.2.1.31	doi	Paenibacillus borealis DSM 13188	AIQ57810.1	A0A089LCJ8
β-mannosidase (ManB; MANB)	3.2.1.25	pubmed	Paenibacillus polymyxa A-8 / A8	AGX85875.1	U5N3E2
β-galactosidase	3.2.1.23	pubmed	Pantoea agglomerans B1	ABN42680.1	A3FEW8
β-glucuronidase (PmGUS; ZP_02032394.1; PARMER_02407) (26901)	3.2.1.31	pubmed	Parabacteroides merdae ATCC 43184	ZP_02032394.1	A7AG62 K5ZWV5	6D7J[A,B,C,D] 6DXU[A,B,C,D]
β-galactosidase (BgaL; ParbDG)	3.2.1.23	pubmed	Paracoccus sp. 32d	ACY69080.1	D1LZK0	5EUV[A,B] 5LDR[A,B]
agarolytic β-galactosidase (Ph1566)	3.2.1.23	pubmed	Paraglaciecola hydrolytica S66	QEP52088.1	A0A5C2I9P9
β-glucuronidase (BSEG_01974)	3.2.1.31	pubmed	Phocaeicola dorei 5_1_36/D4	EEO45833.1	C3R9X4	6ED1[A,B,C,D]
β-1,3-galactosidase (tolerant for 6O-methylation) (BpGH2C; BACPLE_01706)	3.2.1.23	doi	Phocaeicola plebeius DSM 17135	EDY95440.1	B5CYA9
β-galactosidase (BgaBM)	3.2.1.23	pubmed	Priestia megaterium 2-37-4-1	ABN13675.1	A3FFK4
β-galactosidase (BgaM)	3.2.1.23	pubmed	Priestia megaterium DSM 319	CAA04267.1 ADF38979.1	O52847
β-galactosidase (MbgA;BG04_4479)	3.2.1.23	pubmed	Priestia megaterium NBRC 15308 = ATCC 14581	AJI24329.1 AAC34375.1	A0A0B6AWT5 O85167
β-galactosidase (LacZ)	3.2.1.23	pubmed	Pseudoalteromonas haloplanktis TAE 79	CAA10470.1 AAU97746.1	P81650
β-galactosidase (LacZ)	3.2.1.23	pubmed	Pseudoalteromonas sp. 22b	AAR92204.1	Q6RGS1
α-L-arabinofuranosidase (TtAFase;Theth_0328)	3.2.1.55	pubmed	Pseudothermotoga thermarum DSM 5069	AEH50423.1	F7YVC0
β-glucuronidase (Rh2GUS)	3.2.1.31	pubmed	Roseburia hominis	WP_118096903.1	A0A395V8I7	6MVH[A,B,C,D] 8GES[A,B,C,D] 8GET[A,B,C,D]
β-glucuronidase (ERS852391_01800; Uida_2)	3.2.1.31	pubmed	Roseburia hominis 2789STDY5608834	CUO31707.1
β-glucuronidase	3.2.1.31	pubmed	Roseburia inulinivorans	WP_055167711.1	A0A173RPS8
β-galactosidase	3.2.1.23	pubmed pubmed	Saccharopolyspora rectivirgula	BAA34817.1	Q9ZBD1
β-galactosidase	3.2.1.23	pubmed pubmed	Saccharopolyspora rectivirgula	BAA34817.1	Q9ZBD1
β-galactosidase Z (LacZ)	3.2.1.23	pubmed	Sinorhizobium meliloti 102F34	AAA26296.1	Q59750
β-glucuronidase (Gus)	3.2.1.31	pubmed	Staphylococcus sp. RLH1	AAK29422.1 AAR75615.1 AAR75620.1 AAR75621.1 ABP04762.1	Q9AFA2
β-galactosidase (LacH)	3.2.1.23	pubmed	Staphylococcus xylosus	CAA74937.1	O33815
β-glucuronidase (SAG0698)	3.2.1.31	pubmed	Streptococcus agalactiae 2603V/R	AAM99585.1 NP_687713.1 Q8E0N2		4JKK[A] 4JKL[A,B]
β-galactosidase (BgaA;SPD0562;SPD_0562)	3.2.1.23	pubmed	Streptococcus pneumoniae D39	ABJ53768.1	A0A0H2ZMI1 Q04LN6
β-galactosidase (BgaA)	3.2.1.23	pubmed	Streptococcus pneumoniae KNR7/87	AAF97242.1	Q9KGU0
β-galactosidase (BgaA;spr0565; specific for β-1,4-bonds))	3.2.1.23	pubmed	Streptococcus pneumoniae R6	AAK99369.1 NP_358159.1	Q8DQP4
β-1,4-galactosidase A (BgaA;SP0648;SP_0648)	3.2.1.23	pubmed	Streptococcus pneumoniae TIGR4	AAK74795.1 ABA35731.1 NP_345155.1	A0A0H2UP19 Q9KGU0	4CU6[A] 4CU7[A] 4CU8[A] 4CUC[A]
β-galactosidase (LacZ)	3.2.1.23	pubmed	Streptococcus thermophilus FUA3194	CAZ66940.1	C6H180
β-galactosidase (STER_1366)	3.2.1.23	pubmed	Streptococcus thermophilus LMD-9	ABJ66539.1	Q03JT3
exo-β-glucosaminidase (CsxA; SAV1223; SAV_1223)	3.2.1.165	pubmed	Streptomyces avermitilis MA-4680 = NBRC 14893	BAC68933.1 NP_822398.1	Q82NR8
β-galactosidase (SCO3479; SCE65.15c)	3.2.1.23	pubmed	Streptomyces coelicolor A3(2)	CAB61803.1 NP_627682.1	Q9RKF8
β-D-galactofuranosidase (ORF1110)	3.2.1.146	pubmed	Streptomyces sp. JHA19	BAS29529.1	A0A0K2SRV3	9J6M[A,B] 9J6N[A,B]
β-D-galactofuranosidase (ORF0643)	3.2.1.146	pubmed	Streptomyces sp. JHA26	BAW98477.1	A0A1Q2U3E4
β-mannosidase (Bma;Man2S27)	3.2.1.25	pubmed	Streptomyces sp. S27 ACCC 41168	ACN78887.1 ADK91096.1	D2DFB5
β-glucuronidase (TfGUSL2;TFKS16_0857)	3.2.1.31	pubmed	Tannerella forsythia KS16	BAR51149.1	A0A0E4FSB9 G8UKC1	8DHL[A,B]
β-glucuronidase (TfGUSmL1;TFKS16_2216)	3.2.1.31	pubmed	Tannerella forsythia KS16	BAR52418.1	A0A0E4FP39	8DHE[A,B,C,D]
β-galactosidase (LacA;Teth39_0611)	3.2.1.23	pubmed	Thermoanaerobacter pseudethanolicus ATCC 33223	CAA69850.1 ABY94275.1	P77989
β-galactosidase (LacZ;LacA)	3.2.1.23	pubmed	Thermoanaerobacterium thermosulfurigenes EM1	AAA23249.1 CAA38462.1	P26257 Q53WT4
β-mannosidase (ManB)	3.2.1.25	pubmed	Thermobifida fusca TM51	CAD33708.1	Q8KLI9
β-mannosidase (ManB;Tfu_0915)	3.2.1.25	pubmed	Thermobifida fusca YX	AAZ54953.1	Q47RG4
β-galactosidase 2D (Bga2D; Lacz1;Cst_c02440)	3.2.1.23	pubmed	Thermoclostridium stercorarium subsp. stercorarium DSM 8532	AGC67268.1 AGI38337.1	L7VP00
β-galactosidase 2C (Bga2C; Lacz2; Cst_c06190)	3.2.1.23	pubmed	Thermoclostridium stercorarium subsp. stercorarium DSM 8532	AGC67637.1 AGI38685.1	L7VLR6
β-galactosidase 2B (Bga2B; Lacz3; Cst_c09830)	3.2.1.23	pubmed	Thermoclostridium stercorarium subsp. stercorarium DSM 8532	AGC67981.1 AGI39016.1	L7VND8
β-glucuronidase 2A (Uid2A; Cst_c13910)	3.2.1.31 3.2.1.-	pubmed pubmed	Thermoclostridium stercorarium subsp. stercorarium DSM 8532	AGI39403.1 AGC68382.1	L7VNM6
β-galactosidase 2E (Bga2E; Cst_c01600)	3.2.1.23	pubmed	Thermoclostridium stercorarium subsp. stercorarium DSM 8532	AGI38265.1 AGC67186.1	L7VL47
β-galactosidase Z (LacZ;TmLac;TM1193)	3.2.1.23	pubmed	Thermotoga maritima MSB8	AAD36268.1 AAA50597.1 AGL50124.1 AHD18900.1 AKE28970.1 CAA04513.1 NP_228998.1	G4FEF3 Q56307	6S6Z[A,B,C,D,E,F,G,H] 6SD0[A,B,C,D]
β-glucuronidase (Gus;TmGUS;TM1062;Tmari_1066)	3.2.1.31	pubmed	Thermotoga maritima MSB8	AAD36143.1 AAR75619.1 AAR75627.1 AGL49990.1 AHD19030.1 AKE28838.1 NP_228868.1	Q9X0F2 R4NQD9
β-mannosidase (ManA; TM1624) (Man2)	3.2.1.25	doi	Thermotoga maritima MSB8	AAD36691.1 AAM56797.1 AGL50557.1 AHD18479.1 AKE29383.1 CAB56855.1 NP_229424.1	Q9RIK8 Q9X1V9 R4P1P3
β-mannosidase (TnMan2) (Man2)	3.2.1.25	pubmed	Thermotoga neapolitana 5068	AAK52304.1	Q93M25
β-glucosidase (Gh2;TaGH2)	3.2.1.21	doi	Thermus antranikianii	CDO50493.1	A0A0F7RRH2
β-glucosidase (Gh2;TbGH2)	3.2.1.21	doi	Thermus brockianus	CDO50494.1	A0A0F7RR59
β-galactosidase (pTsbg; TSC_c19230)	3.2.1.23	pubmed	Thermus scotoductus SA-01	ADW22536.1 WP_015717801.1	E8PMS3
β-N-acetylglucosaminidase (TTP0222)	3.2.1.21 3.2.1.23 3.2.1.52	doi doi	Thermus thermophilus HB27	AAS82550.1	Q745T5
β-glucuronidase (TlGUSL1)	3.2.1.31	pubmed	Treponema lecithinolyticum		A0AA82WPE8	8DHW[A,B] 8E72[A,B] 8DHV[A,B]
β-glucuronidase (H11G11-BG)	3.2.1.31	pubmed	uncultured bacterium	CBJ55484.1	D5GU71
β-glucuronidase (C7D2-BG)	3.2.1.31	pubmed	uncultured bacterium	CBJ55485.1	D5GU72
β-glucuronidase (uidA_2)	3.2.1.31	pubmed	uncultured Clostridium sp.		A0A1C5YG41	6U7J[A,B,C,D]
agarolytic β-galactosidase (VejABG;VEJY3_09170)	3.2.1.23	pubmed	Vibrio sp. EJY3	AEX22320.1
β-galactosidase (Gal02II;GalB)	3.2.1.23	pubmed	Xanthomonas campestris pv. campestris	AAP86765.1	Q6X1E3
β-galactosidase (XC2985; XC_2985)	3.2.1.23	pubmed	Xanthomonas campestris pv. campestris str. 8004	AAY50033.1	A0A0H2X9M6
[N-glycan] β-1,4-mannosidase (NixH;XCC2891)	3.2.1.25	pubmed	Xanthomonas campestris pv. campestris str. ATCC 33913	AAM42163.1 NP_638239.1	Q8P6S4
exo-β-mannanase (XacMan2A; XAC3075) (XacMan2A)	3.2.1.25	pubmed	Xanthomonas citri pv. citri str. 306	AAM37920.1 NP_643384.1	A0AAI8ETJ7 Q8PI23	6BYC[A] 6BYE[A,B] 6BYG[A,B] 6BYI[A,B]
β-galactosidase (BgaB; zobellia_3633)	3.2.1.23	pubmed	Zobellia galactanivorans DsijT	CAZ97771.1	G0L1N0
agarolytic β-galactosidase (BgaF; zobellia_4655)	3.2.1.23	pubmed	Zobellia galactanivorans DsijT	CAZ98790.1	G0L4M6
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
β-D-galactofuranosidase (AaGH2)	3.2.1.146	pubmed	Amesia atrobrunnea	UOO01254.1
β-mannosidase (AkMnsD)	3.2.1.25	pubmed	Aplysia kurodai	BAL43431.1	H1AFK3
mannosylglycoprotein endo-β-mannosidase (AtEBM; At1g09010/F7G19.12)	3.2.1.152	pubmed	Arabidopsis thaliana	BAD15284.1 AAB70407.1 AAK76608.1 AAM14288.1 AEE28382.1 NP_172375.1 NP_563833.1	A0A178WLW7 O04029 Q75W54
β-mannosidase (ManB) (fragment)	3.2.1.25	pubmed	Aspergillus aculeatus F-50	BAA29029.1	O74168
α-L-arabinofuranosidase / β-D-galactofuranosidase (Afu2g14520; AFUA_2G14520)	3.2.1.55 3.2.1.146	pubmed pubmed	Aspergillus fumigatus Af293	EAL93747.2	Q4X068
β-D-galactofuranosidase (GfgA; AN2395)	3.2.1.146	pubmed	Aspergillus nidulans FGSC A4	EAA64506.1	A0A1U8QH40
β-1,5-D-galactofuranosidase (GfgB; AN3200)	3.2.1.146	pubmed	Aspergillus nidulans FGSC A4	EAA62925.1 AFD22629.1	A0A1U8QGM2 H9N4D0
β-mannosidase (AN3368.2; MndB)	3.2.1.25	pubmed	Aspergillus nidulans FGSC A4	ABF50864.1 EAA63336.1	Q5B7W2
intracellular β-galactosidase (BgaD)	3.2.1.23	pubmed	Aspergillus nidulans WG355	ADM36015.1	G8Z4I7
β-mannosidase (MndA) (Mnd2A)	3.2.1.25	pubmed	Aspergillus niger CBS 120.49 / N400	CAB63902.1	Q9UUZ3
β-mannosidase (MndA;AnigerBM2;An11g06540)	3.2.1.25	pubmed	Aspergillus niger CBS 513.88	CAK96951.1 XP_001394632.2	A2QWU9	cryst
exo-β-glucosaminidase (Csx;AorCsxA)	3.2.1.165	pubmed	Aspergillus oryzae FL402	AHJ61328.1	W8E1X9
glycyrrhizin β-glucuronidase (PGUS; GUS)	3.2.1.31	doi	Aspergillus oryzae Li-3 / Penicillium purpurogenum Li-3	ABU68712.1	A7XS03	5C70[A,B] 5C71[A,B,C,D]
exo-β-glucosaminidase (Csx;ChiA)	3.2.1.165	pubmed	Aspergillus sp. CJ22-326	ACO94980.1	C3U4R9
glycyrrhizin β-glucuronidase (AtGUS)	3.2.1.128	pubmed	Aspergillus terreus Li-20	AEP39213.1	G4XPL5
glycyrrhizin β-glucuronidase (AuGUS)	3.2.1.128	pubmed	Aspergillus ustus Li-62	AEK69352.1	G1FNU5
β-mannosidase	3.2.1.25	pubmed	Bos taurus	AAC48460.1 AAD39352.1 AAE16437.1 AAI47901.1 NP_776812.1	A6QLB0 Q29444 Q9TTG6
endo-β-mannosidase (Ebm)	3.2.1.152	pubmed	Brassica oleracea	BAE97370.1	Q14U56
β-glucuronidase (GusB)	3.2.1.31	pubmed	Canis lupus familiaris	AAC48809.1	O18835
β-mannosidase	3.2.1.25	pubmed	Capra hircus (MANBA)	AAC48665.1	Q95327
glycyrrhizin β-glucuronidase (cg-GUS)	3.2.1.128	pubmed	Chaetomium globosum DX-THS3	QIM55348.1	A0A6G8IQN4
β-glucuronidase (GusB)	3.2.1.31	pubmed	Felis catus	AAD01498.1 AAD01499.1	O97524
β-glucuronidase b (GusB;GUSB)	3.2.1.31	pubmed	Homo sapiens	AAA52561.1 AAH14142.1 AAQ96851.1 AAR75622.1 ABH92596.1 ACH09936.1 ACM86199.1 BAD97126.1 BAG35619.1 BAG61991.1 BAG64768.1 CAC41170.1 NP_000172.1 SJX44098.1	B2R6X2 B4DTH9 P08236	1BHG[A,B] 3HN3[A,B,D,E]
β-mannosidase (ManBA)	3.2.1.25	pubmed	Homo sapiens	AAC39573.1 AAH15743.1 ABS29701.1 BAD93083.1 BAF84287.1 BAG61830.1	A7LFP5 A8K6D3 B4DT18 O00462 Q59EG5
β-galactosidase (Lac4;BgaL)	3.2.1.23	pubmed	Kluyveromyces lactis CBS2359	AAA35265.1	P00723	3OB8[A,B,C,D] 3OBA[A,B,C,D]
β-galactosidase (BglKL)	3.2.1.23	pubmed	Kluyveromyces lactis F61	AHW49176.1	X5D4M1
β-galactosidase (BgaL;KLLA0B14883g)	3.2.1.23	pubmed	Kluyveromyces lactis NRRL Y-1140	CAH02587.1	P00723
β-galactosidase	3.2.1.23	pubmed	Kluyveromyces marxianus DSM5418	AAS18310.1	Q6QTF4
mannosylglycoprotein endo-β-mannosidase (Ebm)	3.2.1.152	pubmed	Lilium longiflorum	BAD89079.2 BAD89079.1	Q5H7P5
β-glucuronidase (GusB;Gus-S)	3.2.1.31	pubmed	Mus musculus	AAA37696.1 AAA37697.1 AAA63307.1 AAA63308.1 AAA63309.1 AAA98623.1 AAH71226.1 AAQ41980.1 BAE23021.1 BAE29265.1 BAE34865.1 BAE35155.1 BAE35384.1 BAE36917.1 CAC41171.1 NP_034498.1	P12265 Q3TW82
β-mannosidase	3.2.1.25	pubmed	Mus musculus	AAK18177.1 AAH31409.1 BAE24954.1 BAE38715.1 BAE41690.1 NP_081564.1	A0A0R4J092 Q8K2I4 Q99MS1	6DDT[A] 6DDU[A]
β-mannosidase (GH2-1; NCU00890.1)	3.2.1.25	pubmed	Neurospora crassa OR74A	EAA35570.1	Q7SFE1
β-glucuronidase (Gus)	3.2.1.31	pubmed	Penicillium canescens DSM1215	AAV91787.1	Q5MJY0
β-glucuronidase (Gus)	3.2.1.31	pubmed	Penicillium canescens RPK	AAV91785.1	Q5MJY2
β-glucuronidase (GusB;Gus)	3.2.1.31	pubmed	Rattus norvegicus	AAA41228.1 AAP86274.1 CAA68705.1 NP_058711.1	P06760 Q7TPJ3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Scopulariopsis sp. RP38.3	AAV91788.1	Q5MJX9
β-mannosidase (Man9;bMann9)	3.2.1.25	pubmed	Thermothelomyces thermophilus C1	AFJ59925.1	I2C092
β-mannosidase (ThMan2A) (Man2A)	3.2.1.25	pubmed	Trichoderma harzianum IOC-3844	AID21733.1	A0A068CMC5 A0A075B5H6	4CVU[A] 4UOJ[A,B]
exo-β-glucosaminidase (Gls93)	3.2.1.165	pubmed	Trichoderma reesei PC-3-7	BAD99604.1	Q4R1C4	cryst
β-mannosidase (5475)	3.2.1.25	pubmed	Trichoderma reesei RUT C-30	ETR97552.1	A0A024RXG4
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